Medical devices & sensors最新文献_第10页

Design and manufacture of a high precision personalized electron bolus device for radiation therapy 用于放射治疗的高精度个性化电子丸装置的设计与制造

Medical devices & sensors Pub Date : 2020-03-12 DOI: 10.1002/mds3.10077

Faisal Khaled Aldawood, Sha X. Chang, Salil Desai

{"title":"Design and manufacture of a high precision personalized electron bolus device for radiation therapy","authors":"Faisal Khaled Aldawood, Sha X. Chang, Salil Desai","doi":"10.1002/mds3.10077","DOIUrl":"10.1002/mds3.10077","url":null,"abstract":"This paper investigates a novel design and manufacturing methodology for an unmet need in radiation therapy—dose optimization of electron beam bolus. A thin-walled bolus design was proposed which when filled with water, optimized the dose distribution for the electron beam radiation therapy. The fabrication of this design was accomplished by the fused deposition modelling (FDM) additive manufacturing (3D Printing) technique. Acrylonitrile butadiene styrene (ABS) and polycarbonate (PC) materials were employed for fabricating the electron boluses. Our data show that both the materials displayed expected radiation modulation. The designed boluses were subjected to higher radiation doses (50 Gy) and revealed permissible deformations based on the dimensional deviation analysis. Mechanical deformation tests were performed to evaluate the bolus design and materials under different loading conditions. The results showed that the ABS material had superior mechanical strength and deformation behaviour as compared to PC. Finite element analysis of the bolus designs revealed regions of stress concentration and potential failure modes which were validated by experimental results. The design of experiments analysis showed that bolus thickness and material type had a profound influence on the mechanical deformation of the bolus. The proposed radiation device technology is cost-effective, eco-friendly and amenable to changes in the tumour size and shape, compared to current methods. This paper provides a framework for the design and manufacture of radiation modulation devices that can be implemented for proton, electron and photon cancer therapies.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49418899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Nano modified zirconia dental implants: Advances and the frontiers for rapid osseointegration 纳米改性氧化锆牙种植体:快速骨整合的进展和前沿

Medical devices & sensors Pub Date : 2020-03-12 DOI: 10.1002/mds3.10076

Saurabh Gupta, Sammy Noumbissi, Marcel F. Kunrath

{"title":"Nano modified zirconia dental implants: Advances and the frontiers for rapid osseointegration","authors":"Saurabh Gupta, Sammy Noumbissi, Marcel F. Kunrath","doi":"10.1002/mds3.10076","DOIUrl":"10.1002/mds3.10076","url":null,"abstract":"Nanotechnology has created a revolution in implant dentistry. It is an established technology in the field of titanium implant dentistry and is slowly evolving when it comes to ceramic implants. The aim of this review article was to survey the use of nanotechnology for the purpose of implant surface modification in order to improve the osseointegration process of ceramic implants, but also, the various techniques and methods by which nano features can be applied to zirconia implant surfaces. With the application of this advanced technology, the composition, surface energy, roughness and topography of dental implants can be modified for enhanced and potentially faster osseointegration. Furthermore, nanotechnology implant surface modification can also influence the biological processes that occur at the bone–implant interface. The cellular activity and tissue responses occurring at the bone-zirconia interface can be enhanced by nanomodifications and result in better treatment outcomes. This review also highlights the ‘state of the art’ of nanomodified zirconia surfaces and the perspectives of introducing new technologies in biomedical implantology.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45551847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

A pathogen imprinted hybrid polymer capacitive sensor for selective Escherichia coli detection 病原菌印迹杂化聚合物电容式传感器用于选择性检测大肠杆菌

Medical devices & sensors Pub Date : 2020-03-07 DOI: 10.1002/mds3.10071

Samuel M. Mugo, Weihao Lu, Dhanjai Dhanjai

引用次数: 7

Transdermal drug delivery and patches—An overview 经皮给药和贴剂综述

Medical devices & sensors Pub Date : 2020-03-07 DOI: 10.1002/mds3.10069

David Bird, Nuggehalli M. Ravindra

引用次数: 33

Portable, low-cost hypoxia chamber for simulating hypoxic environments: Development, characterization and applications 用于模拟低氧环境的便携式低成本缺氧室:开发、表征和应用

Medical devices & sensors Pub Date : 2020-03-02 DOI: 10.1002/mds3.10064

Shivanjali Saxena, Ishan Agrawal, Pratibha Singh, Sushmita Jha

引用次数: 7

Three-dimensional in vitro cell culture devices using patient-derived cells for high-throughput screening of drug combinations 三维体外细胞培养装置使用病人来源的细胞高通量筛选药物组合

Medical devices & sensors Pub Date : 2020-02-29 DOI: 10.1002/mds3.10067

Seok-Joon Kwon, Dongwoo Lee, Sneha Gopal, Ashlyn Ku, Hosang Moon, Jonathan S. Dordick

{"title":"Three-dimensional in vitro cell culture devices using patient-derived cells for high-throughput screening of drug combinations","authors":"Seok-Joon Kwon, Dongwoo Lee, Sneha Gopal, Ashlyn Ku, Hosang Moon, Jonathan S. Dordick","doi":"10.1002/mds3.10067","DOIUrl":"https://doi.org/10.1002/mds3.10067","url":null,"abstract":"Drug discovery using traditional animal models is often inefficient because test animal models cannot accurately represent human responses, particularly in terms of toxicology and pathophysiology. For these reasons, there is an urgent need to develop in vitro human disease models to accelerate new drug development. This is especially the case for precision medicine, where current in vitro and ex vivo models are not sufficient to predict individual drug efficacy and safety across the enormous heterogeneity of populations and individuals. In addition, model cell lines cultured under non-physiological conditions do not recapitulate the complex microenvironment of patient tissues. Precision medicine using patient-derived cells and drug combination therapies may be a promising solution to overcome these limitations. Three-dimensional (3D) cell culture models can simultaneously simulate complex in vivo tissue microenvironments and be miniaturized for large-scale screening of drug combinations using limited available patient-derived cells. Recently, microfluidic and microarray platforms have been developed to mimic multiple human organs and human-specific disease states, and are becoming more commonly used in high-throughput drug screening. Herein, we highlight the current status of microfluidic-based 3D cell culture devices, such as organ/body-on-chip systems, as well as microarray-based 3D cell culture platforms, which can be combined with patient-derived cells. Miniaturized cell culture systems using patient-derived cells represent promising tools for identifying new drug combinations and also biological mechanisms that underlie drug synergies.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137709611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Surface modification of TiO2 for photoelectrochemical DNA biosensors 光电化学DNA生物传感器中TiO2的表面修饰

Medical devices & sensors Pub Date : 2020-02-29 DOI: 10.1002/mds3.10066

Sadman Sakib, Richa Pandey, Leyla Soleymani, Igor Zhitomirsky

{"title":"Surface modification of TiO2 for photoelectrochemical DNA biosensors","authors":"Sadman Sakib, Richa Pandey, Leyla Soleymani, Igor Zhitomirsky","doi":"10.1002/mds3.10066","DOIUrl":"10.1002/mds3.10066","url":null,"abstract":"A photoelectrochemical (PEC) DNA biosensor is developed using surface-modified TiO2 nanoparticles (NPs) as a sensitive transducer. Different catecholates and gallates are used as sensitizers for TiO2 NPs. The molecules are adsorbed on TiO2 via the catecholate type bonding mechanism to enhance light absorption in the visible range. The adsorbed molecules act as charge transfer mediators and enhance photocurrent. Despite the similar bonding mechanism of the molecules, the TiO2 NPs exhibit significant differences in photocurrent. The modified TiO2 films showed photocurrent increase in the order: 3,4-dihydroxy-L-phenylalanine < 2,3,4-trihydroxybenzoic acid < 3,4-dihydroxybenzoic acid < 2,3,4-trihydroxybenzaldehyde < 3,4-dihydroxyphenylacetic acid < 3,4-dihydroxybenzaldehyde < caffeic acid. Testing results provide an insight into the influence of the structure and properties of the organic molecules on their adsorption and photocurrents of modified TiO2 films. The TiO2 NPs modified with caffeic acid are used for the fabrication of PEC DNA biosensor by forming photoelectrodes and immobilizing probe single-stranded DNA on their surface. The caffeic acid-modified TiO2-based photoelectrodes offer the required signal magnitude to distinguish between complementary and non-complementary DNA sequences in the 100 nM–1 pM DNA concentration range and with a limit of detection of 1.38 pM, paving the way towards PEC DNA sensing.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"104697460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Time-domain chemical vapour mass sensor using a functionalized subordinate array 采用功能化附属阵列的时域化学蒸气质量传感器

Medical devices & sensors Pub Date : 2020-02-25 DOI: 10.1002/mds3.10062

Aldo A. Glean, Noah A. Sonne, John A. Judge, Joseph F. Vignola, Teresa J. Ryan

{"title":"Time-domain chemical vapour mass sensor using a functionalized subordinate array","authors":"Aldo A. Glean, Noah A. Sonne, John A. Judge, Joseph F. Vignola, Teresa J. Ryan","doi":"10.1002/mds3.10062","DOIUrl":"10.1002/mds3.10062","url":null,"abstract":"This work describes a chemical vapour detection scheme based on observing changes in the time-domain impulse response of a single structure to which an array of smaller cantilevers is attached. The distribution of properties of the cantilevers in the array is chosen to transfer vibration energy to the array and confine it there for a specified duration . Accumulation of added mass on the cantilevers changes the array properties, altering the duration for which energy is confined. When every second cantilever is functionalized to adsorb mass, a portion of the vibration energy returns to the primary structure in half the original time. The amount of added mass can be estimated by comparing the vibration energy in the primary structure to the total energy in the array at the return time . Numerical analysis is used to investigate the performance of the proposed detection scheme. It is shown that increasing the number of sensing elements reduces errors in mass predictions due to mass adsorption variability and increases mass sensitivity. However, reducing the number of sensing elements improves the signal-to-noise ratio. These opposing effects require consideration for a specific sensing application. Experimental results using a centimetre scale prototype demonstrate feasibility of this interferometric approach for MEMS-scale implementation.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"95227837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in predicting patient exposure to medical device leachables 预测患者接触医疗器械浸出液的进展

Medical devices & sensors Pub Date : 2020-02-21 DOI: 10.1002/mds3.10063

David M. Saylor, Vaishnavi Chandrasekar, Robert M. Elder, Alan M. Hood

引用次数: 6

A novel antimicrobial electrochemical glucose biosensor based on silver–Prussian blue-modified TiO2 nanotube arrays 基于银普鲁士蓝修饰TiO2纳米管阵列的新型抗菌电化学葡萄糖生物传感器

Medical devices & sensors Pub Date : 2020-01-19 DOI: 10.1002/mds3.10061

Nasim Farajpour, Ram Deivanayagam, Abhijit Phakatkar, Surya Narayanan, Reza Shahbazian-Yassar, Tolou Shokuhfar

{"title":"A novel antimicrobial electrochemical glucose biosensor based on silver–Prussian blue-modified TiO2 nanotube arrays","authors":"Nasim Farajpour, Ram Deivanayagam, Abhijit Phakatkar, Surya Narayanan, Reza Shahbazian-Yassar, Tolou Shokuhfar","doi":"10.1002/mds3.10061","DOIUrl":"10.1002/mds3.10061","url":null,"abstract":"Glucose biosensors play an important role in the diagnosis and continued monitoring of the disease, diabetes mellitus. This report proposes the development of a novel enzymatic electrochemical glucose biosensor based on TiO2 nanotubes modified by AgO and Prussian blue (PB) nanoparticles (NPs), which has an additional advantage of possessing antimicrobial properties for implantable biosensor applications. In this study, we developed two high-performance glucose biosensors based on the immobilization of glucose oxidase (GOx) onto Prussian blue (PB)-modified TiO2 nanotube arrays functionalized by Au and AgO NPs. AgO-deposited TiO2 nanotubes were synthesized through an electrochemical anodization process followed by Ag electroplating process in the same electrolyte. Deposition of PB particles was performed from an acidic ferricyanide solution. The surface morphology and elemental composition of the two fabricated biosensors were investigated by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) which indicate the successful deposition of Au and AgO nanoparticles as well as PB nanocrystals. Cyclic voltammetry and chronoamperometry were used to investigate the performance of the modified electrochemical biosensors. The results show that the developed electrochemical biosensors display excellent properties in terms of electron transmission, low detection limit and high stability for the determination of glucose. Under the optimized conditions, the amperometric response shows a linear dependence on the glucose concentration to a detection limit down to 4.91 µM with sensitivity of 185.1 mA M−1 cm−2 in Au-modified biosensor and detection limit of 58.7 µM with 29.1 mA M−1 cm−2 sensitivity in AgO-modified biosensor.","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"96903566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2