Medical devices & sensors最新文献

{"title":"Stretchable triboelectric sensor for measurement of the forearm muscles movements and fingers motion for Parkinson's disease assessment and assisting technologies","authors":"David Vera Anaya,&nbsp;Mehmet Rasit Yuce","doi":"10.1002/mds3.10154","DOIUrl":"10.1002/mds3.10154","url":null,"abstract":"<p>Parkinson's disease (PD) is a degenerative, neurological disease that causes motor dysfunctions on the patient. Currently, the symptoms and progression of the disease are assessed by physicians who diagnose through careful observation, according to the Movement Disorder Society (MDS)-sponsored Revision of the Unified Parkinson's Disease Rating Scale (UPDRS). In this manuscript, we report a portable sensor device based on a flexible Triboelectric Nanogenerator (TENG) formed from a dielectric material with a size of 4 cm × 3.5 cm and an aluminium (Al) electrode with dimensions of 2 mm × 3 mm, to monitor the movement of forearm muscles and tendons. When the hand or fingers extend or flex, the short gap between the dielectric polymer and the small conductor changes, generating a voltage due to triboelectric contact. The device is used to assess localized bradykinesia and rigidity of fingers and hands, as well as wrist and arm tremors. The voltage signal of the proposed sensor shows different waveform shapes, time duration and amplitude for each level of classification from ‘normal’ to ‘moderate’ status, described on the MDS-UPDRS examination of hand movement, finger tapping and pronation–supination movement. Hence, we demonstrated that the proposed sensor can potentially be used for quantification of the symptoms and diagnosing. In addition, single finger motion tracking is also achieved by placing the triboelectric sensor in different positions around the forearm, close to the tendon connected to the finger under test. This way we avoid the placement of the sensor directly on the fingers, improving comfortability and long-term wearability. The presented TENG sensor is fully integrated with the processing and the transmission board exploring new opportunities for triboelectric transducers in small motion detection of muscles. The future aim of this research is to provide real-time monitoring of the disease progression as feedback for personalized treatment of the PD patients.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42233193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on recent developments in the biosynthesis of silver nanoparticles and its biomedical applications","authors":"Rizwan Arif,&nbsp;Rahis Uddin","doi":"10.1002/mds3.10158","DOIUrl":"10.1002/mds3.10158","url":null,"abstract":"<p>Green chemistry is the significant field of research as it offers simple, cost-effective, easy, biocompatible and eco-friendly methods for the synthesis of nanomaterials. With the development of nanotechnology, the synthesis of silver nanoparticles (AgNPs) has become important areas of research due to their various applications in industrial, pharmacological and medicinal fields as they exhibited good antibacterial, antifungal, antioxidant, anti-inflammatory, antiviral, anticoagulant, thrombolytic, cytotoxic and photocatalytic properties due to their chemical stability and good biocompatibility. The size, shape, concentration, agglomeration and some other factors of AgNPs depend on the methods used for the synthesis of nanomaterials. Various methods have been used by the researchers in the last few years for the synthesis of silver nanoparticles (AgNPs) using various microorganisms like bacteria, fungi, algae, different parts of plants, agricultural wastes, arthropods and metabolites of arthropods. The use of microorganisms and plants for the synthesis of silver nanoparticles is very eco-friendly, time-saving and inexpensive methods. In this review, we have discussed the various synthetic methods for the silver nanoparticles (AgNPs) by using microorganisms and plants. Also, the review explores the recent developments in antibacterial, antifungal, antioxidant and cytotoxic properties of silver nanoparticles reported by the researchers during the last decade.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47144336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper airway stimulation for Obstructive Sleep Apnoea (OSA): A new paradigm of treatment","authors":"Paolo Aluffi Valletti,&nbsp;Valeria Dell’Era,&nbsp;Filippo Farri,&nbsp;Alberto Braghiroli","doi":"10.1002/mds3.10159","DOIUrl":"https://doi.org/10.1002/mds3.10159","url":null,"abstract":"<p>Obstructive Sleep Apnoea (OSA) is a chronic condition, caused by anatomical factors associated with a progressive loss of muscular tone of the tongue and pharyngeal walls, producing upper airways collapse with oxygen desaturation during sleep. Hypoglossal nerve stimulation (HNS) is an innovative and physiological technique, with validated positive effects, to treat patients with OSA who have failed or refused continuous positive airway (cPAP) standard therapy. HNS is a mixed medical and surgical procedure consisting of an electrical stimulation of the medial branches of the hypoglossal nerve—activating the genioglossus muscle (GM) that is the primary protrusor muscle of the tongue—by an implanted cuff electrode connected to a pulse generator and to a respiratory-sensing lead. The purpose of HNS is to increase the neuromuscular activity and the tone of the tongue during sleep in order to avoid upper airway collapse and improve airflow. Compared to traditional surgical procedures, HNS is more conservative and produces a titratable and potentially reversible activation of upper airway dilatators muscles, without definitive anatomical modifications. A strict multidisciplinar approach, from patient clinical evaluation to neurostimulator programming and follow-up, is of crucial importance to achieve a successful implantation. Limitations of HNS are the uncertainty about the long-term adherence and effectiveness and high costs of the device. Further clinical studies are needed to improve the technological features of the current devices and to optimize patients selection criteria in order to identify best responders and to achieve higher cure rates.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92379730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesocrystal aggregation of biological apatite nanocrystals","authors":"Abdulelah S. Alrebaish,&nbsp;Otto C. Wilson Jr","doi":"10.1002/mds3.10155","DOIUrl":"10.1002/mds3.10155","url":null,"abstract":"<p>A broader revelation of the mechanisms which contribute to the formation, growth, healing and remodelling of bone tissue is essential for advancing the design and development of biomaterials and devices which directly enhance bone health. Hydroxyapatite and associated calcium phosphate-based minerals play an essential role in bone tissue formation. Further insights into how biomineral crystals form, grow and integrate within bone tissue will provide key information to direct efforts in more comprehensive bone tissue engineering products and therapies. While previous studies proposed the aggregation of amorphous calcium phosphate clusters as a precursor to biological hydroxyapatite, the exact formation mechanism of the plate-like biological hydroxyapatite is still unclear. Here we report the analysis of high-resolution electron microscopy images of bone biomineral precipitated in a biological environment. We propose that 3 nm primary biologically synthesized (biosynthesized) hydroxyapatite (BHAp) single crystal units assemble and coalesce via an oriented aggregation mechanism to form larger (approximately 46 nm × 25 nm) plate-like biological hydroxyapatite mesocrystals. A better understanding of the biomineralization process can provide insights to improve the in vitro precipitation of bone biominerals with tailored properties and unique functionality. This will help to usher in the next generation of biobased biomaterials and devices to enhance the healing and remodelling of bone at the tissue, cell and subcellular level.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46755174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current nanotechnology advances in diagnostic biosensors","authors":"Ana I. Barbosa,&nbsp;Rita Rebelo,&nbsp;Rui L. Reis,&nbsp;Mrinal Bhattacharya,&nbsp;Vitor M. Correlo","doi":"10.1002/mds3.10156","DOIUrl":"10.1002/mds3.10156","url":null,"abstract":"<p>Current diagnostics present challenges that are imposed by increased life expectancy in the worldwide population. These challenges are related, not only to satisfy the need for higher performance of diagnostic tests, but also to the capacity of creating point-of-care, wearable, multiplexing and implantable diagnostic platforms that will allow early detection, continuous monitoring and treatment of health conditions in a personalized manner. These health challenges are translated into technological issues that need to be solved with multidisciplinary knowledge. Nanoscience and technology play a fundamental role in the development of miniaturized sensors that are cheap, accurate, sensitive and consume less power. At nanometre scale, these materials possess higher volume-to-surface ratio and display novel properties (composition, charge, reactive sites, physical structure and potential) that are exploited for sensing purposes. These nanomaterials can therefore be integrated into diagnostic sensing platforms allowing the creation of novel technologies that tackle current health challenges. These nanomaterial-enhanced sensors are extremely diverse, since they use numerous types of materials, nanostructures and detection modes for a multitude of biomarkers. The purpose of this review is to summarize the current state-of-the-art of nanomaterial-enhanced sensors, emphasizing and discussing the diagnostic challenges that are addressed by the different engineering and nanotechnology approaches. This review also aims to identify the drawbacks of nanomaterial-enhanced sensors, as well as point out future developmental directions.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44740094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental plaque removal ability of different power toothbrushes: a preliminary study of a novel automated toothbrush","authors":"Mohammad Ali Saghiri,&nbsp;Ali Mohammad Saghiri,&nbsp;Armen Asatourian,&nbsp;Devyani Nath","doi":"10.1002/mds3.10157","DOIUrl":"10.1002/mds3.10157","url":null,"abstract":"<p>Although currently used power toothbrushes have shown promising results in comparison with manual toothbrushes, automated toothbrushes have risen recently to improve oral hygiene and fulfil the limitations of dexterity of users. The present study intends to evaluate the efficacy of dental plaque removal ability of two automated toothbrushes: V-White and a recently developed mechanical toothbrush, Cyberbrush, with an ultrasonic power toothbrush by using the typodont model. Typodonts were divided into four quadrants and further divided into four zones each (two teeth per zone). Photographs were taken from each area, with unstained typodonts - negative control (0% plaque), and typodonts were covered with black chalk and used as a positive control (100% plaque). Three typodonts were prepared according to three experimental groups, including (1) FairyWill, (2) Cyberbrush and (3) V-White toothbrush. Toothbrushing was performed for 2 min, and then, photographs were taken per zone of each typodont, imported into the ImageJ software, and the percentage of the remaining dental plaque was measured. Data were analysed by ANOVA and post hoc Tukey tests at the level of significance <i>p</i> &lt; .05. The highest percentage of dental plaque was detected in the V-White toothbrush group, and the lowest was seen in the FairyWill group. Significant differences were only noticed between the groups of V-White toothbrushes with the other two groups (<i>p &lt; </i>.05). Within 2 min of brushing time, neither the ultrasonic and nor the automated toothbrushes could completely remove the artificial dental plaque.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45296050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ti6Al4V mandibular devices by additive manufacturing: Assessment of as-built quality","authors":"Ilaria Campioni,&nbsp;Nikhil Gupta","doi":"10.1002/mds3.10153","DOIUrl":"10.1002/mds3.10153","url":null,"abstract":"<p>Additive manufacturing (AM) represents a promising healthcare innovation. Clinicians need ready-to-use devices in short time, which means high as-built quality and low uncertainty. Medical devices need to respect stringent quality requirements ensuring safety and effectiveness. The medical practitioners often outsource the manufacturing to hub services. This study aims to assess the as-built quality of AM mandibular plate prototypes manufactured by direct metal laser sintering technology using Ti6Al4V alloy and highlights several challenges that emerge from using the commercial printing services where user does not have control over the actual manufacturing process. Verification of dimensions, morphology, surface finish and mechanical properties is conducted. Finite element analysis on computer-aided design (CAD) models was performed for stress analysis. Non-destructive analysis by micro-computed tomography (micro-CT) allowed measurement of the dimensions, ascertaining the dimensional accuracy in reference to the CAD models, and the presence of pores and internal defects, while destructive analysis allowed determination of the mechanical properties. Although no large internal defects were detected, some regions of micro-porosity and incomplete fusion of feed particles were observed. Accurate production of fine details was also a concern in the printed parts. The proposed framework establishes a structured assessment scheme, which could be useful for other AM medical designs and for stakeholders involved in AM for biomedical applications.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47884668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gelatin/dextran-based hydrogel cross-linked by Diels–Alder click chemistry: the swelling and potassium diclofenac releasing","authors":"Rodolfo Debone Piazza,&nbsp;João Victor Brandt,&nbsp;Caio Carvalho dos Santos,&nbsp;Rodrigo Fernando Costa Marques,&nbsp;Miguel Jafelicci Junior","doi":"10.1002/mds3.10151","DOIUrl":"https://doi.org/10.1002/mds3.10151","url":null,"abstract":"<p>In the present work, gelatin and dextran were derivatized in order to obtain a chemically cross-linked hydrogel by Diels<b>–</b>Alder click chemistry reaction. The main interest in cross-linking by the Diels<b>–</b>Alder reaction is the absence of by-products and mild synthetic conditions, being a great advantage for biomedical applications. Thus, maleic anhydride (MA) and 2-furoic acid (FA) were successfully grafted onto gelatin and dextran, respectively, making available the diene and dienophile groups for further cross-linking. The derivatization was evaluated by nuclear magnetic resonance (NMR) spectroscopy, size-exclusion chromatography (SEC) and differential scanning calorimetry (DSC). The Diels<b>–</b>Alder cross-linking was confirmed by UV/Vis spectroscopy, and hydrogel behaviour was evaluated by rheological measurements. The hydrogel swelling properties and the cumulative release profile of diclofenac potassium (DFK) were studied in different dissolution media. The increase in swelling capacity was followed by faster DFK releasing from the platform, being the gelatin/dextran-based Diels<b>–</b>Alder click hydrogel suitable for biomedical applications.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92306794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the triad of biocompatibility, medical device functionality and biological safety","authors":"David F. Williams","doi":"10.1002/mds3.10150","DOIUrl":"https://doi.org/10.1002/mds3.10150","url":null,"abstract":"<p>Implantable medical devices, including sensors and contrast agents, have crucial roles in diagnostic and therapeutic procedures that are intended to improve quality of life. They are usually very successful, but all too often they fail to deliver optimal satisfaction. Device performance, which is at the heart of patient safety, is dependent on the biocompatibility of the materials used, the functionality of the devices and overall biological safety of the system. The interdependence of this triad of critical properties is rarely considered within the testing and regulatory regimes that control access of the products to clinical applications. This paper analyses the details of a series of product types (intra-ocular lenses, metal-on-metal hips, coronary artery stents, nanoparticle contrast agents and closed-loop sensor-drug delivery systems) and identifies the difficulties when the connectivity between these characteristics is overlooked. The paper then addresses the generic weaknesses in preclinical testing programs and identifies a series of changes that could assist in resolving these problems, providing better assurance of patient safety.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92305670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of neural cell behaviour on anisotropic electrically conductive polymeric biodegradable scaffolds reinforced with carbon nanotubes","authors":"Souvik Ghosh,&nbsp;Ananya Shrivastava,&nbsp;Pallavi Jha,&nbsp;Partha Roy,&nbsp;Debrupa Lahiri","doi":"10.1002/mds3.10152","DOIUrl":"https://doi.org/10.1002/mds3.10152","url":null,"abstract":"<p>The advent of biocompatible and biodegradable scaffolds has opened up a plethora of possibilities in neural tissue engineering. An emerging approach to overcome some existing drawbacks of neural scaffold design and functioning is a natural conductive polymeric scaffold. It is analogous to the extracellular matrix and provides an environment conducive to neural growth. This study focuses on the fabrication of soft polymeric neural scaffold, reinforced with multi-walled carbon nanotubes (MWCNTs) in a chitosan matrix, for directional neuronal growth. The scaffolds were fabricated by varying the nanofiller content as 0.5, 1.0 and 2.0. wt%, which were aligned in the chitosan matrix by an alternating bias electric field and compared with their random counterpart. The uniform distribution of the nanofillers in the matrix, good combinatorial bonding, and the directional alignment of the MWCNTs resulted in enhancement of mechanical properties and electrical conductivity in comparison to scaffolds with randomly arranged reinforcements. Additionally, the degradation kinetics of the fabricated scaffolds was tuned to the regeneration regime of peripheral nerves. After physical characterization, the biocompatibility of the designed scaffolds was evaluated by culturing HT-22 neuronal cells on the scaffolds. Along with biocompatibility, the suitability of anisotropic conductivity of the scaffolds was evaluated by the directional growth of cells cultured on aligned MWCNT–chitosan scaffold. The preferential direction of neurite growth achieved on chitosan-aligned MWCNT films and the improved mechanical and electrical properties in the MWCNT alignment direction are very encouraging for their potential use in neural tissue engineering.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92303848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}