Medical devices & sensors最新文献

{"title":"Biodegradable oxygen biosensors via electrospinning","authors":"Daniel B. Cybyk,&nbsp;Bonnie M. Reinsch,&nbsp;Kayla F. Presley,&nbsp;Ryan M. Schweller,&nbsp;Andrea Tedeschi,&nbsp;Teresa Burns,&nbsp;Francisco J. Chaparro,&nbsp;Jack T. Ly,&nbsp;Matthew J. Dalton,&nbsp;Monica Lozano,&nbsp;Tod A. Grusenmeyer,&nbsp;John J. Lannutti","doi":"10.1002/mds3.10149","DOIUrl":"https://doi.org/10.1002/mds3.10149","url":null,"abstract":"<p>Monitoring oxygenation in vivo is critical to ensuring human health, particularly in the context of ‘silent’ hypoxia. Utilizing blends of biodegradable polycaprolactone (PCL) and gelatine, we sought to develop an electrospun oxygen sensor that maintains the advantages of robust, phosphorescent oxygen-sensing chromophores while providing resorbable polymeric scaffolds benefiting from tailorable degradation times ranging from hours to weeks. Electrospun sensors successfully provide accurate oxygen measurements for periods &gt;1 month. In vitro testing took place in a custom aqueous testing system over five weeks in 37°C phosphate-buffered saline (PBS); dissolved oxygen concentrations were maintained at 0–5% O₂ where physoxia characteristic of the subdermal environment is defined as 2–5% O₂. Excited state chromophore lifetime (τ) is quenched in the presence of dissolved diatomic oxygen and is influenced by characteristics of the surrounding matrix. The observed final deoxygenated τ (τ₀) values were split into 3 groups: polysulphone (PSU)-PCL (~397 µs) &gt;75:25, 50:50 and 25:75 PCL:gelatine (~191–182 µs) &gt; PCL, 10:90 PCL:gelatine, 1:99 crosslinked PCL:gelatine (~145–135 µs). Highly linear Stern–Volmer activity enabling accurate and precise calibration was observed even after 35 days of exposure; this proves that non-core–shell fibres consisting of blends of PCL and gelatine can yield predictable lifetime values for &gt;30 days in vitro. Scanning electron microscopy and mass loss data revealed that sensor degradation is highly tailorable, allowing for the fabrication of sensors engineered for a specific biomedical time frame. In contrast, core–shell fibre sensors showed more variability in lifetime following internal degradation likely caused by caproic acid entrapment by the PCL ‘shell’. This work demonstrates that biodegradable and biocompatible optically monitored sensors can be fabricated to provide direct, accurate assessments of oxygenation, even as the sensor platform degrades in a controlled manner. Such technologies have the potential to substantially change respiratory disease management.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92303849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical approaches towards sensing viruses: A mini review","authors":"Kalathur S. V. Santhanam","doi":"10.1002/mds3.10148","DOIUrl":"https://doi.org/10.1002/mds3.10148","url":null,"abstract":"<p>This mini review focusses the development of electrochemical sensors for a variety of viruses, for example, West Nile virus, dengue (DENV-2, DENV-3, DENV-4), human phenotypes, H5N1, human norovirus, Japanese encephalitis (JEV), diarrhoea virus and rotavirus. These sensors are classified into four types based on Faradaic current measurement, impedance, conductivity and the current flow in a field effect transistor. While the first two have been well investigated, the latter two albeit in preliminary stages show great promise. Their simplicity, precision, sensitivity and rapid analysis make them valuable over conventional methods. The Middle East respiratory syndrome coronavirus (MERS-CoV) can be assayed in 20 min with detection limit of 1 pg/ml. The combination of biology with chemistry and material science could be utilized to develop disposable sensors for the rapid detection of SARS-CoV-2, a virus that has caused havoc around the globe.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92336831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrin-based biomaterial systems to enhance anterior cruciate ligament healing","authors":"Grant Scull,&nbsp;Matthew B. Fisher,&nbsp;Ashley C. Brown","doi":"10.1002/mds3.10147","DOIUrl":"10.1002/mds3.10147","url":null,"abstract":"<p>Anterior cruciate ligament (ACL) tears are a common and potentially career-ending injury, particularly for athletes and soldiers. Partial and complete ruptures of this ligament cause instability in the knee, and the ACL does not have the capacity for healing due, in part, to its position within the highly thrombolytic synovial fluid environment of the knee joint. Traditional methods of ACL reconstruction, such as graft replacement, restore stability but do not prevent the development of post-traumatic osteoarthritis. To enhance therapeutic treatment options, novel fibrin-based technologies and repair techniques have been recently explored and show promise for improved patient outcomes. Through modification of existing surgical methods, such as the use of fibrin glues incorporating growth factors and cells and the implementation of scaffolds containing platelet-rich plasma, platelet-rich fibrin and other blood derivatives, surgeons are attempting to overcome the shortcomings of traditional treatments. This mini-review will detail current efforts using fibrin-based treatments and discuss opportunities to further enhance ACL healing.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39368432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UV-induced DNA damage response in blood cells for cancer detection","authors":"Negin Farivar,&nbsp;Morgan E. Roberts,&nbsp;Gholamreza Safaee Ardakani,&nbsp;Peter C. Black,&nbsp;Mads Daugaard,&nbsp;Fariborz Taghipour","doi":"10.1002/mds3.10146","DOIUrl":"https://doi.org/10.1002/mds3.10146","url":null,"abstract":"<p>Detection and diagnosis of cancer often require a combination of tests that are inconvenient and invasive for patients. There is therefore a need for new simple non-invasive tests able to detect cancer at various stages. Here, a novel photochemical assay for cancer detection in liquid biopsies is described. This proof of concept study shows that the response of peripheral blood mononuclear cells (PBMCs) to light-emitting diode (LED)-transmitted UV radiation can be used as an indicator of malignant disease. When exposed to UVB/C radiation, isolated PBMCs from prostate cancer patients presented with an acute dose-dependent DNA damage response that is distinct from that of PBMCs from healthy individuals. Importantly, this assay achieves sensitivity and specificity comparable to standard methods currently in clinical use. In summary, this work demonstrates that photochemical interrogation of PBMCs from cancer patients can be utilized for detection of malignant diseases. As such, the assay could potentially complement current gold standard cancer detection strategies for the benefit of patients and healthcare economy.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92335794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation Antimicrobial Peptides (AMPs) incorporated nanofibre wound dressings","authors":"Ayda Afshar,&nbsp;Esra Yuca,&nbsp;Cate Wisdom,&nbsp;Hussain Alenezi,&nbsp;Jubair Ahmed,&nbsp;Candan Tamerler,&nbsp;Mohan Edirisinghe","doi":"10.1002/mds3.10144","DOIUrl":"https://doi.org/10.1002/mds3.10144","url":null,"abstract":"<p>Antimicrobial peptides (AMPs) containing polymer-based nanodelivery systems offer to overcome many challenges in wound care. While preventing the contact of the external agents on the wound, it also addresses a rising concern on the drug resistance. AMPs as the host defence peptides have been increasingly recognized for therapeutic potential owning to their critical role in innate immunity. Here we investigated a nanofibre mesh approach using AMPs incorporated polyethylene oxide (PEO) for wound healing applications. PEO was prepared to carry GH12-COOH-M2 (type 1 AMP) and AMP2 (type 2 AMP), and their antibacterial activity was assessed against <i>Staphylococcus epidermidis (S</i>.<i> epidermidis)</i>. PEO-AMP nanofibre meshes were successfully formed by using pressurized gyration (PG), which allows rapid mass production. Bacterial viability of the nanofibre meshes was investigated using the AlamarBlue assay. Fibre morphology, size distribution and AMP incorporation in the nanofibres were characterized by scanning electron microscopy (SEM), fluorescence microscopy (polarization contrast images) and Fourier transform infrared spectroscopy (FTIR). While both PEO-AMP1 and PEO-AMP2 nanofibres indicate promising bacterial inhibition at 105 µg/ml, PEO-AMP2 fibres showed the highest <i>S</i>.<i> epidermidis</i> reduction. The results demonstrated that increase in the AMP content reduced the bacterial growth. Another important implementation of the PEO-AMP nanofibres is that they can be tuned to rapidly releasing the peptides. Antimicrobial peptide-loaded nanofibres represent a viable biologically active solution to next-generation wound dressings.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92192355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idealized force decay of orthodontic elastomeric chains follows Nutting Equation","authors":"David H. Freeman,&nbsp;William M. Johnston,&nbsp;William A. Brantley,&nbsp;Allen R. Firestone","doi":"10.1002/mds3.10145","DOIUrl":"https://doi.org/10.1002/mds3.10145","url":null,"abstract":"<p>The force decay of orthodontic elastomeric modules has been of considerable interest since these biomechanical force-generating appliances were introduced five decades ago. Two mathematical approaches, a power-law equation and a Maxwell–Weichert model, have been used by previous investigators to predict the in vitro force degradation under idealized conditions. In this study, the principal sensor approach had the test specimen being strained continuously using a digital force gauge. Test specimens of 13 products from 8 manufacturers were stretched to 25 mm and tested in an artificial saliva at 37°C in both the as-received condition and after 24 h conditioning. Measurements for specimens strained continuously on the digital force gauge were compared with intermittent measurements for other specimens transferred to this gauge after 19.2 h ageing on a stretching rack, the approach in most past studies. Force data at equally spaced logarithmic time points, normalized to initial force and induced strain, were used to present degradation curves for individual products. Nonlinear regression analyses were used to fit both mathematical models to each product and conditioning state. Statistical analyses show that the power-law equation (historically the Nutting equation) provides a more accurate prediction of idealized in vitro force decay for the elastomeric products.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92192490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D inkjet printing of biomaterials: Principles and applications","authors":"Srimanta Barui","doi":"10.1002/mds3.10143","DOIUrl":"10.1002/mds3.10143","url":null,"abstract":"<p>This article reviews the fundamental process physics and key applications of binder jetting and “direct” inkjet printing, as the two broad categories of 3D inkjet printing in biomedical device fabrication. Inkjet printing is prospective in contactless bioprinting for both hard and soft tissue regeneration in one hand, whereas on the other, it is immensely beneficial in the near-net-shaped manufacturing of patient/design-specific implants for static load bearing (dental crown, denture frame), articulating (osteochondral cartilage implant) or in vivo blood vessel formation and tissue regeneration applications. With a comprehensive understanding of the governing theories of the transient process physics of both binder jetting and “direct” inkjet printing, the “processing-3D microstructure-property” correlation demonstrates the promise of this less explored technique in “reliable” medical manufacturing. Facilitated by the “on-demand” delivery of small droplets (10–50 pL), inkjet printing can also be deployed to precisely deposit anti-cancer/anti-diabetic drugs on sophisticated medical devices for painless transdermal administration.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46052714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable conducting polymeric materials for biomedical applications: a review","authors":"Sapana Jadoun,&nbsp;Ufana Riaz,&nbsp;Vaibhav Budhiraja","doi":"10.1002/mds3.10141","DOIUrl":"10.1002/mds3.10141","url":null,"abstract":"<p>The biodegradable conducting polymers have attracted considerable attention for the last two decades, as a unique class of new biomaterials for emerging both the properties of conducting polymers, that is electrical conductivity, and biocompatible polymers, that is biodegradability. These new biomaterials emerged as the best option for immense potential in biomedical applications. Here, we review the recent developments towards biodegradable conducting polymers and their applications in biomedical fields. Firstly, we introduce the biomaterials and their biocompatibility, followed by a short discussion on conducting polymers and their new hybrid biodegradable conducting polymers along with their applications in biomedical fields such as tissue engineering, drug delivery, biosensors and antibacterial activity. At last, we sum up this review with current challenges and future perspectives.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48350185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface modification of PDMS substrates for tumour cell adhesion: Influence of roughness parameters","authors":"Gabriel Augusto Teixeira da Silveira,&nbsp;João Batista Maia Rocha Neto,&nbsp;Jonas Kerwald,&nbsp;Hernandes Faustino Carvalho,&nbsp;Marisa Masumi Beppu","doi":"10.1002/mds3.10142","DOIUrl":"https://doi.org/10.1002/mds3.10142","url":null,"abstract":"<p>Surface properties play a key role in how biomaterials interact with the environment. Surface topography has also been reported to be influential in some research, although its effect is still not well elucidated. In this study, nano-roughened polydimethylsiloxane (PDMS) substrates were developed through a chemically etched intermediate surface. Additionally, PDMS substrates containing 10–30 μm diameter micropillars were functionalized with multilayers of chitosan (CHI) and hyaluronic acid (HA) via layer-by-layer. Such substrates were submitted to cell adhesion assays with PC3 tumour cells. The characterization of these substrates was carried out using an atomic force microscopy (AFM), and some roughness parameters were estimated. Through a statistical description of the topography, we investigated the effects of these surface parameters on PC3 cell adhesion. AFM results indicated a significant modification in the PDMS surface topography and the cell adhesion assays suggest that smoother surfaces induce the PC3 cell adhesion, especially the ones with a high Hurst exponent value. In addition to the AFM analysis, the surface modification of the LbL-functionalized substrates was monitored by contact angle and UV-visible measurements. The improved wettability and the significant Alcian Blue absorbance of the functionalized substrates suggest that the HA/CHI film deposition was successfully accomplished. The LbL functionalization increased the cell capture potential of the PDMS substrates, in which lower diameter micropillars favour the cell adhesion mechanism. Although much work is still needed, the findings advance progress towards the fundamental understanding of the role of nanoscale fractal roughness in cell adhesion and can contribute to the development of new biomaterials with applications in biomedical systems, such as biosensors.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92314397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pre-existing diseases on COVID-19 infection and role of new sensors and biomaterials for its detection and treatment","authors":"Angaraj Singh,&nbsp;Manoj Kumar,&nbsp;Ashutosh Kumar Dubey","doi":"10.1002/mds3.10140","DOIUrl":"10.1002/mds3.10140","url":null,"abstract":"<p>The entire world is suffering from a new type of viral disease, occurred by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The present article briefly discussed the genome sequencing and interaction of host cells with SARS-CoV-2. The influence of pre-existing diseases such as diabetes, heart disease and age of the patients on COVID-19 infection is reviewed. The possible treatments of SARS-CoV-2 including antiviral drugs, Chinese traditional treatment and plasma therapy are elaborately discussed. The proper vaccine for COVID-19 is not available till date. However, the trials of pre-existing antiviral vaccines such as, chloroquine/hydroxychloroquine, remdesivir, ritonavir and lopinavir and their consequences are briefly presented. Further, the importance of new materials and devices for the detection and treatment of COVID-19 has also been reviewed. The polymerase chain reaction (PCR)-based, and non-PCR-based devices are used for the detection of COVID-19 infection. The non-PCR-based devices provide rapid results as compared to PCR-based devices.</p>","PeriodicalId":87324,"journal":{"name":"Medical devices & sensors","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/mds3.10140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38588396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}