Journal of rheumatology research最新文献_第3页

Anodal stimulation of primary motor cortex in elderly women with fibromyalgia: A randomized, double-blind, placebo-controlled trial 老年女性纤维肌痛患者初级运动皮质的阳极刺激:一项随机、双盲、安慰剂对照试验

Journal of rheumatology research Pub Date : 2020-10-01 DOI: 10.22631/RR.2020.69997.1107

Zhaleh Zandieh, Maryam Niksolat, S. Larijani, Hosna Mirfakhraee

{"title":"Anodal stimulation of primary motor cortex in elderly women with fibromyalgia: A randomized, double-blind, placebo-controlled trial","authors":"Zhaleh Zandieh, Maryam Niksolat, S. Larijani, Hosna Mirfakhraee","doi":"10.22631/RR.2020.69997.1107","DOIUrl":"https://doi.org/10.22631/RR.2020.69997.1107","url":null,"abstract":"It is thought that an excessive motor cortical facilitation is involved in the physiopathology of chronic pain in fibromyalgia. Studies have shown that transcranial direct current stimulation (tDCS) changes motor cortex excitability according to the stimulation polarity. Based on these effects, it is conceivable to hypothesize that tDCS, which can modulate brain activity, may induce pain relief in patients with fibromyalgia. Fifty older women with fibromyalgia were included in this randomized, doubleblind, single-center placebo controlled trial study. Patients received sham stimulation or real tDCS with the anode centered over the primary motor cortex (M1) and the cathode over the contralateral supraorbital area (2 mA for 20 minutes for 10 sessions). Pain intensity was evaluated using the visual analog scale for pain. Assessments were done before treatment and 30 days after the last session of stimulations. The mean age of participants was 58.20 years (SD = 7.80) with an age range from 55 to 74 years.Results showed no statistically significant baseline difference among patients in demographics and clinical characteristics. Comparing visual pain analogue between the sham and treatment groups revealed a statistically significant difference (p value < 0.001) for VAS immediately after intervention and 1 month post intervention between the sham and treatment groups. Analysis of data also showed a significant reduction in pain immediately after intervention and one month post-intervention in the treatment group compared to the sham group. Anodal tDCS is an effective non-invasive technique for pain reduction in elderly women with FM. The clinical improvements observed in the current study may have considerable impacts on pain experienced by elderly women with FM.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"61 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89805625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weekly versus daily leflunomide 每周来氟米特vs每日来氟米特

Journal of rheumatology research Pub Date : 2020-07-01 DOI: 10.22631/rr.2020.69997.1096

Seyed Ruhollah Mousavinasab, M. Owlia

{"title":"Weekly versus daily leflunomide","authors":"Seyed Ruhollah Mousavinasab, M. Owlia","doi":"10.22631/rr.2020.69997.1096","DOIUrl":"https://doi.org/10.22631/rr.2020.69997.1096","url":null,"abstract":"Chronic rheumatic diseases, diabetes mellitus, hypertension, depression, psychosis, inflammatory bowel diseases, multiple sclerosis, coronary vascular disease, dyslipidemia and also chronic rheumatic disorders are among the most common chronic conditions need chronic drug therapy. Most researchers and pharmaceutical companies are constantly trying to develop new drugs with more specific measures based on the pathophysiology of the disease. Finding ideal approach in practice guidelines with minimum adverse drug effects is a utopian. Post-drug effects deal with the biological effects of a medicine long lasted more than expected from pharmacological half-life. This could be more evident for many drugs including Hydroxychloroquine, methotrexate, leflunomide, dexamethasone, fluoxetine and lipid lowering. This effect not only maintains the therapeutic effect of the drugs, but also reduces the side effects. Leflunomide is an immunomodulatory drug of antirheumatic and diseases modifying class that is used to treat rheumatoid arthritis and some other inflammatory arthritis (namely psoriatic arthritis) by inhibiting the synthesis of pyrimidine. Due to the metabolite of leflunomide in the body and the long half-life of this drug, it is possible to prescribe this drug on a weekly basis. The results of studies on weekly administration versus daily administration of leflunomide indicate that weekly administration of leflunomide has advantages such as the same therapeutic effect as daily administration, ease of administration, lower cost of treatment, less side effects of medication, and more patient compliance. According to the results obtained from weekly administration of leflunomide, it can be recommended that leflunomide be administered weekly.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74454161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Resolved of Respiratory Failure Following the Use Pulse-Doses of Methylprednisolone in a Cytokine Storm Related to 2019 novel coronavirus 在与2019年新型冠状病毒相关的细胞因子风暴中使用脉冲剂量甲基强的松龙后呼吸衰竭的解决

Journal of rheumatology research Pub Date : 2020-07-01 DOI: 10.22631/RR.2020.69997.1102

Hamid Khederlou, A. Rostamian, Elham Nezhadseifi, Hourvash Ebrahimi-louyeh

引用次数: 0

Review of the Clinical Applications of Trabecular Bone Score 骨小梁评分的临床应用综述

Journal of rheumatology research Pub Date : 2020-07-01 DOI: 10.22631/rr.2020.69997.1097

Hossein Yermohammadi, Alireza Mirzaei, M. Zabihiyeganeh

引用次数: 0

IRF7 and STAT1 gene expression profile in peripheral blood mononuclear cells of patients with systemic sclerosis 系统性硬化症患者外周血单个核细胞中IRF7和STAT1基因表达谱

Journal of rheumatology research Pub Date : 2020-07-01 DOI: 10.22631/rr.2020.69997.1099

R. Rezaei, H. Kavosi, F. Gharibdoost, Hanieh Mojtahedi, M. Vodjgani, M. Mahmoudi

{"title":"IRF7 and STAT1 gene expression profile in peripheral blood mononuclear cells of patients with systemic sclerosis","authors":"R. Rezaei, H. Kavosi, F. Gharibdoost, Hanieh Mojtahedi, M. Vodjgani, M. Mahmoudi","doi":"10.22631/rr.2020.69997.1099","DOIUrl":"https://doi.org/10.22631/rr.2020.69997.1099","url":null,"abstract":"The critical role of IFN signature genes has increasingly been surveyed to determine the etiology and pathogenesis of systemicsclerosis (SSc). Interferon-regulatory factors (IRFs) and signal transducers and activators of transcription (STATs) are mainlyconsidered as transcriptional modulators of IFN-signature genes and type I interferon and play a major role in the regulation ofnumerous aspects of an immune response. The current study aimed to assess the transcriptional levels of IRF7 (interferonregulatory factor 7) and STAT1 (signal transducers and activators of transcription 1) mRNAs in PBMCs of scleroderma patientsand compare them with those of healthy subjects.In this study, PBMCs were obtained from 50 scleroderma patients and 30 healthy individuals. Subsequently, total RNA wasextracted from isolated PBMCs and cDNA synthesis was carried out. IRF7 and STAT1 mRNA expressions were assessed byapplying quantitative real-time PCR, SYBR Green method, and specific primers for IRF7 and STAT1.Relative expression of IRF7 was significantly increased in the patient group compared with the control group. Moreover, relativeexpression of IRF7 in limited SSc (lSSc) and diffuse SSc (dSSc) was significantly increased compared with healthy subjects (p< 0.05). The relative expression of STAT1 transcripts in PBMCs was not statistically significantly different between the patientgroup and the control group. The correlation between IRF7 expression and the Rodnan score (RS) of the disease was significant.Considering the overexpression of IRF7 in SSc patients and significant correlation between the IRF7 and the Rodnan score ofthe disease, it is suggested that impaired expression of IRF7 is involved in the pathogenesis of SSc.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79557460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility and Toxicity of Intra-Articular 188Re-tin Colloid Injection in Patients with Rheumatoid Arthritis with Three-Phase Positive Bone Scan and Refractory Knee Pain, a pilot study 关节内注射188re -锡胶体治疗伴有三期骨扫描阳性和难治性膝关节疼痛的类风湿关节炎患者的可行性和毒性:一项初步研究

Journal of rheumatology research Pub Date : 2020-07-01 DOI: 10.22631/rr.2020.69997.1098

Z. Mirfeizi, Nasim Norouzbeigi, M. Sahebari, M. Jokar, Z. R. Yazdi, S. Zakavi, Sousan Shafiei, Atena Aghaee

{"title":"Feasibility and Toxicity of Intra-Articular 188Re-tin Colloid Injection in Patients with Rheumatoid Arthritis with Three-Phase Positive Bone Scan and Refractory Knee Pain, a pilot study","authors":"Z. Mirfeizi, Nasim Norouzbeigi, M. Sahebari, M. Jokar, Z. R. Yazdi, S. Zakavi, Sousan Shafiei, Atena Aghaee","doi":"10.22631/rr.2020.69997.1098","DOIUrl":"https://doi.org/10.22631/rr.2020.69997.1098","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes chronic synovial inflammation. Reactor-producedβ-particle emitting radionuclides is a new therapeutic strategy in the management of RA. This study was conducted in 2019and analyzed the toxicity and feasibility of 188Re-tin colloid injection, Three-Phase Positive Bone Scan, and Refractory KneePain. Ten patients with RA were administered radiosynovectomy with 188Re-tin colloid. The main complications after theintervention were assessed and compared with patients’ pre-intervention condition. Patients showed alleviation of pain,tenderness, and morning stiffness after the administration of radiosynovectomy. Only one RA patient received a corticosteroidinjection; the other 6 patients did not need a corticosteroid injection after radiosynovectomy. Intra-articular 188Re-tin colloidinjection seems to be an effective treatment modality for refractory knee joint pain in rheumatoid arthritis patients. Thus, it issuggested as a safe and effective strategy to apply.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"122 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82877944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seropositive rheumatoid arthritis in a patient with familial hypercholesterolemia: case report and literature Review 家族性高胆固醇血症患者血清阳性类风湿关节炎1例报告及文献复习

Journal of rheumatology research Pub Date : 2020-05-30 DOI: 10.22631/rr.2019.69997.1082

M. Mobini, A. Bahar, Z. Kashi

引用次数: 0

Surgical denervation significantly reduces articular synovitis in patients with osteoarthritis of the first carpometacarpal joint 手术去神经能显著减轻第一腕掌关节骨性关节炎患者的关节滑膜炎

Journal of rheumatology research Pub Date : 2019-10-01 DOI: 10.22631/RR.2019.69997.1078

Joan Arenas-Prat, Cerc oacute, s-Casal eacute, Daniel

引用次数: 0

The prevalence of temporomandibular joint involvement in rheumatoid arthritis patients: A cross-sectional study 类风湿关节炎患者颞下颌关节受累的患病率:一项横断面研究

Journal of rheumatology research Pub Date : 2019-09-01 DOI: 10.22631/rr.2019.69997.1079

F. Akhlaghi, S. Azizi, Neda Amirimehr

{"title":"The prevalence of temporomandibular joint involvement in rheumatoid arthritis patients: A cross-sectional study","authors":"F. Akhlaghi, S. Azizi, Neda Amirimehr","doi":"10.22631/rr.2019.69997.1079","DOIUrl":"https://doi.org/10.22631/rr.2019.69997.1079","url":null,"abstract":"Objectives: Temporomandibular joint (TMJ) involvement in rheumatoid arthritis (RA) patients has been described in the literature; however, its incidence varies greatly. In this study, we aimed to determine the prevalence and clinical characteristics of TMJ involvement in RA patients.Materials and Methods: The present study consisted of 60 individuals with RA. The patients were assigned to two groups, based on TMJ involvement: patients with TMJ involvement and patients without TMJ involvement. We defined TMJ involvement based on the findings of the questionnaires and clinical examination by a rheumatologist. The symptoms and signs were recorded by a single trained dentist.Results: The majority of the participants were women (n=49, 81.66%), with the mean age of 43.9±15.52 years (range: 21-78 years). Thirty-five patients (58.3%) had clinical evidence of TMJ involvement. The levels of C-reactive protein (CRP) and rheumatoid factor (RF) were found to be correlated with TMJ involvement. There was no significant correlation between TMJ involvement and erythrocyte sedimentation rate (ESR), age, gender, treatment duration, and disease duration.Conclusion: The high level of CRP in RA patients with TMJ involvement was reported. TMJ pain was reported in almost half of the patients. There was also a significant correlation between TMJ involvement and RF.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79679376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Simultaneous Occurrence of Sarcoidosis and Anti-neutrophil Cytoplasmic Antibody in a Patient presented with chronic sinusitis 慢性鼻窦炎患者同时发生结节病和抗中性粒细胞胞浆抗体

Journal of rheumatology research Pub Date : 2019-09-01 DOI: 10.22631/rr.2019.69997.1081

E. Banimostafavi, Z. Torabizadeh, M. Aliyali, M. Mobini

引用次数: 0