Journal of rheumatology research最新文献_第4页

Correlation between lipid profile and lipoprotein (a) with inflammatory activity of rheumatoid arthritis 脂质谱和脂蛋白(a)与类风湿关节炎炎症活动的相关性

Journal of rheumatology research Pub Date : 2019-07-01 DOI: 10.22631/RR.2019.69997.1071

Z. Rezaieyazdi, Marzieh Maghrebi, K. Hashemzadeh, M. Hatef, H. Esmaily, Mandana Khodashahi

引用次数: 2

Anti-Annexin V and Cardiovascular Risk Factors in Systemic Lupus Erythematosus 抗膜联蛋白V与系统性红斑狼疮心血管危险因素

Journal of rheumatology research Pub Date : 2019-07-01 DOI: 10.22631/RR.2019.69997.1076

Z. Rezaieyazdi, Fatemeh Hajizadeh-Saffar, S. Sedighi, H. Mansouritorghabeh

{"title":"Anti-Annexin V and Cardiovascular Risk Factors in Systemic Lupus Erythematosus","authors":"Z. Rezaieyazdi, Fatemeh Hajizadeh-Saffar, S. Sedighi, H. Mansouritorghabeh","doi":"10.22631/RR.2019.69997.1076","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1076","url":null,"abstract":"Background and Objective: It has been proposed that anti-annexin V as a novel proposed mechanism for the increased prevalence of atherosclerosis among patients with Systemic Lupus Erythematosus (SLE). Here we aimed to compare anti-annexin V levels between SLE patients and healthy controls and to determine the correlation of anti-annexin with various cardiovascular risk factors. Materials and Method: Sixty patients with SLE and 30 healthy sex and age matched persons included in the current cross sectional study that was selected from outpatient Rheumatology clinics in the city of Mashhad-Iran. Anti-annexin V and the other parameters including cardiovascular risk factors(age, smoking, blood pressure, diabetes mellitus, lipoproteins levels, previous history of documented or clinically suspected atherosclerosis, obesity, premature ovarian failure, high sensitive C-reactive protein, vascular cell adhesion protein 1 and homocystein) measured using enzyme linked immuno-assay. Results: Anti-annexin V had a significant positive correlation with LDL levels in the SLE group (p=0.03). Anti-annexin V levels were not significantly different between the two groups (p=0.40). Conclusion: We could not show the role of anti-annexin V as a predictor of atherosclerosis risk in patients with lupus under study.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87898858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexual Dysfunction in Female Scleroderma Patients and Its Correlation with Vascular Involvement 女性硬皮病患者的性功能障碍及其与血管受累的关系

Journal of rheumatology research Pub Date : 2019-07-01 DOI: 10.22631/RR.2019.69997.1072

M. Nazarinia, E. Esmaeilzadeh, Zohre Khodamoradi

引用次数: 1

mRNA Detection with Fluorescence-base Imaging Techniques for Arthritis Diagnosis. 用荧光基成像技术检测mRNA诊断关节炎。

Journal of rheumatology research Pub Date : 2019-07-01 Epub Date: 2019-07-16

Anne Yau, Hongchuan Yu, Yupeng Chen

引用次数: 0

Evaluation of Mean Platelet Volume in Patients With Rheumatoid Arthritis and its Relation With Severity of Disease 类风湿关节炎患者平均血小板体积的评价及其与疾病严重程度的关系

Journal of rheumatology research Pub Date : 2019-07-01 DOI: 10.22631/RR.2019.69997.1075

Mandana Khodashahi, N. Saadati, Z. Rezaieyazdi, M. Sahebari, Z. Saremi

{"title":"Evaluation of Mean Platelet Volume in Patients With Rheumatoid Arthritis and its Relation With Severity of Disease","authors":"Mandana Khodashahi, N. Saadati, Z. Rezaieyazdi, M. Sahebari, Z. Saremi","doi":"10.22631/RR.2019.69997.1075","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1075","url":null,"abstract":"Background and Aims: Rheumatoid arthritis (RA) is the most common chronic inflammatory disease of the joints. To the best of our knowledge, inflammation is considered as the main stimulant of platelets, and there is an association between the mean platelet volume (MPV) and platelet reactivity. Increased platelet counts may be observed during the clinical active stages of RA patients and reduce in the remission period. The present study investigated the role of platelet indices in RA and its relationship with disease activity. Materials and Methods: This was an observational cross-sectional study, which was performed on 105 patients with RA and 35 participants as control group referred to Ghaem hospital of Mashhad in 2017. The participants were divided into 4 groups, including 1) the patients with newly diagnosed RA, 2) the patients with active RA, 3) the patients in remission, and 4) the controls. After completing the interview and questionnaire, 10 cc blood samples were obtained from all the subjects. The platelet number (PLT) and mean platelet volume (MPV) was measured. Results:The mean age of the participants was 49.06±11.08 years. MPV was higher in patients with RA than healthy control group (p","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81226959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Association of Vascular Endothelial Growth Factor A gene polymorphisms with susceptibility to Systemic lupus erythematosus in Iranian population 血管内皮生长因子A基因多态性与伊朗人群系统性红斑狼疮易感性的关系

Journal of rheumatology research Pub Date : 2019-07-01 DOI: 10.22631/RR.2019.69997.1074

S. Soltani, S. Aslani, S. Faezi, A. Jamshidi, E. Farhadi, M. Mahmoudi

{"title":"Association of Vascular Endothelial Growth Factor A gene polymorphisms with susceptibility to Systemic lupus erythematosus in Iranian population","authors":"S. Soltani, S. Aslani, S. Faezi, A. Jamshidi, E. Farhadi, M. Mahmoudi","doi":"10.22631/RR.2019.69997.1074","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1074","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is an autoimmune, autoinflammatory disorder in which genetic factors have been implicated in the etiopathogenesis of the disease. Elevated levels of vascular endothelial growth factor (VEGF) have been reported in patients with SLE. This study intended to evaluate the association of VEGFA gene rs833061 and rs2010963 single nucleotide polymorphisms (SNPs) with the risk of SLE susceptibility in the Iranian population.Methods: In this case-control study, 400 SLE patients and 400 age-, sex-, and ethnically-matched healthy controls were recruited. Genotyping of VEGFA gene rs833061 and rs2010963 polymorphisms in both SLE and control groups was done through the real-time PCR allelic discrimination technique.Results: It was detected that none of the alleles nor genotypes of both rs833061 and rs2010963 SNPs had a statistically significant difference between patient and control groups. Moreover, the haplotypes were not associated with the SLE susceptibility. However, rs833061 and rs2010963 polymorphisms were in linkage disequilibrium according to Dꞌ= 95 %, but not according to the r2= 42%. The associations between rs833061 (C vs. T: OR= 0.98, 95% CI= 0.80-1.20, P= 0.87) and rs2010963 (C vs. G: OR= 0.89, 95% CI= 0.73 - 1.09, P= 0.28) with risk of SLE were not significant. The clinical data of the patients, including anti-dsDNA (P= 0.036), anti-SSA (P= 0.039), and anti-SSAB (P= 0.036), were associated with the genotypes of VEGFA gene rs2010963 SNP.Conclusions: We recognize that VEGFA gene rs833061 and rs2010963 polymorphisms did not affect SLE susceptibility in the Iranian population.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82083042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Association Between Fibromyalgia and Mechanical Neck Lesions 纤维肌痛与机械性颈部病变的关系

Journal of rheumatology research Pub Date : 2019-07-01 DOI: 10.22631/RR.2019.69997.1073

Maryam Haghparast, E. Atabati, Vajihollah Raiisi, Ahmadreza Senzari, Gholamreza Sharifzadeh

{"title":"The Association Between Fibromyalgia and Mechanical Neck Lesions","authors":"Maryam Haghparast, E. Atabati, Vajihollah Raiisi, Ahmadreza Senzari, Gholamreza Sharifzadeh","doi":"10.22631/RR.2019.69997.1073","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1073","url":null,"abstract":"Background: Fibromyalgia is a painful syndrome with a non-joint origin. The disease is of relatively high prevalence and is more common in women and people over 40 years of age. Method: In this case-control study, 35 healthy individuals were enrolled as the control group and 35 patients with fibromyalgia as the case group. The cervical MRI was performed for all the participants, and the graphs were interpreted by a specialist who was blind to the patient group.Results: Lesions were severe in 94.3% of the case group, 80% of the controls (P>0.05). Between the groups in the number of involved surfaces and mean lesion levels was no significant difference. In the case and control groups, 48.5% and 92.9% of the members had only one lesion. The rates of concurrent lesions in the case and control groups were 51.5% and 7.1%, (p < 0.001). In 60.6% of the case group and 17.9% of the control group, the lesion was severe (p = 0.001). The prevalence of annular tearing and stenosis of the canal was significantly higher in the case group than in the control group (p = 0.05 and p = 0.044, respectively). However, there was no significant difference between the groups in other lesions.Conclusion: Given the similarity of some of the symptoms in fibromyalgia and mechanical neck lesions, it is crucial to have timely and correct differentiation of these two diseases. Also, these results may suggest that long-term fibromyalgia can potentially exacerbate the symptoms of mechanical neck lesions.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83612272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Anterior Uveitis in patients with ankylosing spondylitis in northeast of Iran 伊朗东北部强直性脊柱炎患者的急性前葡萄膜炎

Journal of rheumatology research Pub Date : 2019-04-01 DOI: 10.22631/RR.2019.69997.1062

M. Jokar, Mina Jokar

{"title":"Acute Anterior Uveitis in patients with ankylosing spondylitis in northeast of Iran","authors":"M. Jokar, Mina Jokar","doi":"10.22631/RR.2019.69997.1062","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1062","url":null,"abstract":"Personal non-commercial use only.Rheumatology Research Journal. Copyright © 2019. All rights reserved *Corresponding Author: Mohammadhassan Jokar, MD; Department of Internal Medicine, Imam Reza Hospital, Mashhad, Iran, Tel/Fax: (+98) 511-8598818 Received: 01 September 2018 ; Accepted: 05 January 2019 Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disorder with variable clinical manifestations. Acute anterior uveitis is the most common extra-articular manifestation of ankylosing spondylitis. This study assessed the prevalence of uveitis in patients with ankylosing spondylitis in Mashhad, Iran. In this retrospective study, the medical records of patients diagnosed with AS between January 1st, 2007 and December 31st, 2017 in a rheumatology clinic in Mashhad, Iran were reviewed. Diagnoses of ankylosing spondylitis were made based on the modified New York criteria. The records of 317 patients were reviewed (81.4% male, 18.6% female, with a male to female ratio of 4.3:1). The mean age at onset of AS was 27.01±8.63 years (minimum 12 years, maximum 55 years). The mean age at diagnosis of AS was 30.72±9.44 years. The mean age at diagnosis of uveitis was 32.40±10.49 years. The mean follow-up period of patients was 6.19±5.51 years. HLA-B27 was positive in 77% of patients. About 14% of patients had uveitis in the mean follow-up period of 6.19±5.51 years. The frequency of uveitis in patients with AS is lower in the study region than in most other regions. Future studies with a prospetive design, randomized patient selection, and lifelong follow up can provide a more accurate description of acute anterior uveitis in patients with AS.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80890119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Periodontitis and rheumatoid arthritis: A neglected association in developing countries 牙周炎和类风湿关节炎:在发展中国家被忽视的关联

Journal of rheumatology research Pub Date : 2019-04-01 DOI: 10.22631/RR.2019.69997.1060

Nasibeh Alebooyeh, J. Moghimi, A. Hasani, R. Ghorbani, Golmehr Taheri

引用次数: 1

Causes and types of disease in elderly patients leading to one or multiple hospital admissions in rheumatology wards of southwestern Iran: A 6-year review 伊朗西南部风湿病病房中导致一次或多次住院的老年患者的病因和疾病类型:6年回顾

Journal of rheumatology research Pub Date : 2019-04-01 DOI: 10.22631/RR.2019.69997.1059

S. Shenavandeh, E. Sadeghi

{"title":"Causes and types of disease in elderly patients leading to one or multiple hospital admissions in rheumatology wards of southwestern Iran: A 6-year review","authors":"S. Shenavandeh, E. Sadeghi","doi":"10.22631/RR.2019.69997.1059","DOIUrl":"https://doi.org/10.22631/RR.2019.69997.1059","url":null,"abstract":"Personal non-commercial use only.Rheumatology Research Journal. Copyright © 2019. All rights reserved *Corresponding Author: Saeedeh Shenavandeh, MD, Department of internal medicine, division of rheumatology Shiraz University of Medical Sciences, Namazee Hospital, Shiraz, Iran. Email: shenavande@sums.ac.ir, Tel/Fax: (+98)713-6474316 Po Box: 71345-1414. Received: 12 April 2018 ; Accepted: 20 November 2018 The physiological changes associated with aging and the presence of comorbid diseases may complicate the treatment of elderly patients with rheumatic diseases. This study aimed to determine the prevalence and main causes of admissions of elderly patients to rheumatology wards and the number and duration of their hospitalizations. Data was collected on patients aged ≥ 60 who were admitted to rheumatology wards from 2008 to 2013. To make a good comparison, the last diagnoses of younger patients admitted to these wards were also recorded. In the elderly group, the records of 399 patients admitted to hospitals with a flare-up of a new or known case of rheumatoid arthritis (RA) were compared with those of 480 young patients. No significant difference was seen between these two groups in the duration of hospital stay. In the elderly group, hypertension (62.4%) was the most common comorbidity. The presence of psychiatric problems showed a significant association with the number of admissions (P value=0.037) as well as patients receiving infliximab, rituximab, and IV IG (P value=<0.001). Recurrent admissions were seen mostly in patients with psoriatic arthritis (PsA), polymyositis, and Behçet’s disease. Flare-ups or new diagnoses of RA were the most prevalent causes for the admission of elderly patients to rheumatology wards. Recurrent admissions were seen mostly in patients with PsA and were associated with the presence of psychiatric problems and a need for IV medications. The results highlight the need for healthcare centers to support outpatient clinics for elderly patients.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83836717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0