Journal of pregnancy and child health最新文献

{"title":"Twin Reversed Arterial Perfusion Sequence in Dichorionic Triamniotic TripletPregnancy: Case Report","authors":"A. Rm","doi":"10.4172/2376-127X.1000327","DOIUrl":"https://doi.org/10.4172/2376-127X.1000327","url":null,"abstract":"Twin reversed arterial perfusion sequence (TRAP) is a rare complication of spontaneous Dichorionic triamniotic triplet pregnancy and only few cases are documented. We report a case of twin reversed arterial perfusion (TRAP) sequence in a dichorionic triamniotic triplet spontaneous pregnancy, which was diagnosed at 27 weeks of gestation by four-dimensional ultrasound and revealed. The acardiac twin with omphalocele and the pump twin with cleft lip and palate. It highlights the risk of monochorionicity-associated morbidity in dichorionic triamniotic triplet pregnancies and role of four-dimensional ultrasound for diagnosis of trap and congenital anomalies.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41715226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Retro-Cerebellar Arachnoidal Cyst: Prognosis and Literature Review","authors":"B. Jat, F. Aboubakar, Z. Olatoundji, C. Latoundji, O. Aaa, K. Salifou, Hounkponou Anf, Sidi Ir, Vodouhe Mm, R. Perrin","doi":"10.4172/2376-127X.1000330","DOIUrl":"https://doi.org/10.4172/2376-127X.1000330","url":null,"abstract":"Arachnoid cysts are collections of cerebrospinal fluid developed within the arachnoid. The arachnoid cyst of the posterior fossa is sometimes responsible for neurological, motor, severe and irreversible disorders. We report a case of an arachnoid retro cerebellar cyst’s antenatal diagnosis on a fetus during an ultrasound performed at 33 WG and confirmed by a MRI at day of life. Treatment consisted of ventriculoperitoneal Shunt at six months of life with immediate decrease of the cyst volume. The eleven-month control found a complete resorption of the arachnoid cyst but a minor psychomotor retardation. It results that the prognosis is mainly related to the presence of associated lesions whose research requires the availability of magnetic resonance imaging.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-127X.1000330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43632205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inherited Risk Factors for Hemorrhagic Complications in the I Trimester ofPregnancy","authors":"Donnikov Ae, Kuznetsova Nb, Bushtyreva Io, Barinov Vv","doi":"10.4172/2376-127X.1000328","DOIUrl":"https://doi.org/10.4172/2376-127X.1000328","url":null,"abstract":"Aim: The purpose of the study was to assess the role of genetic risk factors in the development of retrochorial hematoma. Materials and methods: Genotyping of four polymorphisms of the folate cycle (MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G) and eight polymorphisms of hemostasis system (F2 G20210A, F5 G1691A, F7 G10976A, F13 G103T, FGB G-455A, ITGA2 C807T, ITGB3 T1565S, SERPINE1-675 5G/4G) was performed to identify genetic risk factors of retrochorial hematoma accompanied by bleeding in the I trimester of pregnancy. The study was conducted among 238 pregnant women with retrochorial hematoma and 67 pregnant women without retrochorial hematoma. Results: The risk of retrochorial hematoma increases in the presence of rare alleles of polymorphic loci of proconvertin F7 gene (sensitivity 62,61 (56,12-68,77), specificity 16,42 (8,49-27,48), PPV 72,68 (66,04-78,66)) and fibrin stabilizing factor F13 gene (sensitivity 73,11 (67-78,63), specificity 5,97 (1,65-14,59), PPV 73,42 (67,31-78,93)), while the presence of polymorphic alleles of these genes in homozygous state is the most unfavorable combination. The chance of developing a retrochorial hematoma increases 5.5 times with the combination of F7 G10976A (genotype G/A and A/A) and F 13 G103T (genotype G/T and T/T). Conclusion: Since the genotype G/A or A/A of G10976A F7 gene polymorphism and genotype G/T or T/T of G103T F13 polymorphism are associated with a predisposition to hypocoagulation.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43506615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Glycated Haemoglobin Reflect Blood Glucose Levels in Women withGestational Diabetes","authors":"V. Wong","doi":"10.4172/2376-127X.1000322","DOIUrl":"https://doi.org/10.4172/2376-127X.1000322","url":null,"abstract":"Background: The value of performing glycated haemoglobin (HbA1c) at a late stage of pregnancy to assess glycaemic status for women with gestational diabetes (GDM) is unclear, and the correlation between HbA1c and blood glucose level (BGL) in women with GDM is unknown. This study examined the association between 36 week HbA1c and BGL readings from daily blood glucose monitoring over the previous 28 day period. Methods: HbA1c was measured in 120 consecutive women with GDM at 36 week’s gestation and their glycaemic profiles from self-monitoring of BGL in the previous 4 weeks were documented. Results: HbA1c performed at 36 weeks was found to have weak correlation with capillary BGLs: with mean fasting BGL (R2=0.0624, p=0.006) and with mean post-prandial BGL (R2=0.1117, p=0.001) in the prior 28 days. When the 36 week HbA1c was divided into quartiles, women in the higher HbA1c quartiles had greater proportion of their BGLs above 2 sets of treatment targets (target 1: fasting BGL 20% of their BGLs that exceeded treatment targets (which would indicate need for insulin therapy at our institution) increased across HbA1c quartiles in a stepwise fashion. Conclusion: HbA1c will not replace BGL monitoring in women with GDM, but may be a useful supportive tool to assess glycaemic status, especially in women who perform limited BGL monitoring.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45280851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Hypoglycaemia Restricts Foetal Growth and Skeletal Ossification in the Rat","authors":"J. Fh, Mølck Anne-Marie, O. BerthelsenLine, B. Ingrid, Andersen Lene, Demozay Damien, Renaut Ruth","doi":"10.4172/2376-127X.1000321","DOIUrl":"https://doi.org/10.4172/2376-127X.1000321","url":null,"abstract":"Maternal blood glucose level during gestation is crucial for normal foetal development. In the non- clinical studies in non-diabetic rats required by authorities, long-acting insulin analogous being developed to decrease blood glucose levels persistently generate safety data on embryo-foetal effects, which may be challenging to interpret. Separating potential toxicological effects of the insulin analogue from those caused by the hypoglycaemia becomes problematic, when the effects of the latter are unknown. Therefore, the aim of the present study was to investigate foetal effects of persistent maternal hypoglycaemia in rats after continuous maternal insulin-infusion throughout gestation. Effects on foetal size were measured and foetal skeletons were examined after alizarin red and alcian blue staining. Foetal hepatic glycogen content and foetal exposure to exogenous, i.e. human insulin, as well as endogenous plasma insulin levels were measured. Persistently 50% lowering maternal blood glucose throughout gestation caused a 10% decrease of foetal blood glucose levels on GD 20 and decreased foetal growth and development. Generalised decreased ossification and skeletal malformations of ribs, cranial bones, and long bones were seen with high incidences in foetuses. Furthermore, foetal but not maternal hepatic glycogen stores were decreased up to 50%. Foetuses were hypoinsulinaemic, and had no detectable exposure to exogenous insulin. The results indicate the existence of mechanisms which down-regulate placental glucose transfer to the foetus and consequently affect the foetal glucose metabolism and development reflected by counter-regulatory mobilisation of hepatic glycogen, decreased growth and delayed ossification of the skeleton as well skeleton malformations. As the foetuses were hypoinsulinaemic, these changes were most likely secondary to the maternal hypoglycaemia leading to foetal hypoglycaemia, and delayed development. This study provides novel data, which will aid the interpretation of findings in safety studies with longer-acting insulin analogues allowing differentiation between foetal effects of toxicological origin and those due to the persistent hypoglycaemia.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-127X.1000321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47276393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imperforate Hymen as Cause of Acute Urinary Retention","authors":"C. Duarte, I. Reis, R. Caldas, C. Pina, L. Sousa, H. Machado","doi":"10.4172/2376-127X.1000324","DOIUrl":"https://doi.org/10.4172/2376-127X.1000324","url":null,"abstract":"The imperforate hymen is one of the most frequent malformations of the female genital tract. The clinical presentation varies from the asymptomatic form to symptoms caused by the obstructive effect of the hematocolpometra such as primary amenorrhea, abdominal and lumbar pain, constipation, dysuria and urinary retention. We report the case of an adolescent whose only symptoms were acute urinary retention associated with severe pelvic pain.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-127X.1000324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70310084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Demographic and Placental Risk Factors in Term Low Birth Weight in Ghana","authors":"Aleksenko Larysa, T. Yao, G. K. Richard, Obed Samuel, F. John, Quaye Isaac Kweku","doi":"10.4172/2376-127X.1000325","DOIUrl":"https://doi.org/10.4172/2376-127X.1000325","url":null,"abstract":"Background: Several studies report on factors that associate preterm birth and intrauterine growth restriction with low birth weight (LBW). However, few studies discuss risk factors that associate with LBW for full-term births. No such studies exist that involve a population from Ghana. Method: We used a nested case-control study approach to examine maternal socio-demographic and placental factors that contribute significantly to term LBW in Ghana. We assessed also the incidence of LBW in general at a major teaching hospital facility in Ghana. Results: Univariate and multivariate logistic regression analysis were used to investigate maternal sociodemographic and placental factors that associate with LBW. Following the preliminary univariate analysis, a stepwise logistic regression analysis showed that unstable income source, single motherhood, combined effect of pre-eclampsia and anaemia; ORs of 5.366 (95% CI: 1.986 to 14.497), 21.390 (95% CI: 3.610 to 126.734) and 3.246 (95% CI: 1.074 to 9.814), respectively, and placental weight and irregular insertion of the umbilical cord (variables scaled by a factor of 10-2 to aid interpretation) ORs 0.28 (95% CI: 0.115 to 0.683), 0.010 (95% CI: 0.001 to 0.173 respectively) on the chorionic plate, were risk factors for LBW. The socio-demographic and placental factors reveal a core role of maternal and infant nutritional deficiencies in term LBW in Ghana. The general prevalence of LBW in the Hospital facility was 6.2%. Conclusion: We conclude that poor maternal and infant nutrient supply is key factors in term LBW in Ghana. These factors are amenable to appropriate nutritional and educational interventions.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70310092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopmental Outcome in Neonates with Hypoglycaemia and AssociatedRisk Factors: A Follow up Study","authors":"Nitesh Melana, N. Ahmed, R. Soni, M. Goyal","doi":"10.4172/2376-127X.1000323","DOIUrl":"https://doi.org/10.4172/2376-127X.1000323","url":null,"abstract":"Introduction: Neonatal hypoglycemia is a common problem requiring medical attention in newborn and a leading cause of preventable brain damage, physical and mental handicap and early deaths among infants. Objective: To study the prevalence of neuro-developmental abnormalities and risk factors associated with poor outcome. Materials and methods: This was a prospective study on 39 neonates with hypoglycemia who were admitted to neonatal intensive care unit (NICU) from November 2015 to December 2016 and were fulfilling the inclusion criteria. Gestational age at birth, sex, birth weight, age of presentation, duration and severity of hypoglycaemia were noted in all neonates. Neuro-developmental assessment was done on follow up at 3 and 6 months by Denver developmental screening test 2 (DDST 2) method. Results: Out of 39 neonates, the prevalence of abnormal neurodevelopmental outcome according to DDST II method was 71.7% [n=28] at 3 months and 66.6% [n=26] at 6 months. Factors such as early onset, symptoms, longer duration of hypoglycemia, minimum blood glucose level, number of readings <25 mg/dl and maximum glucose infusion rate (GIR) were significantly associated with adverse outcome. Conclusion: Neonatal hypoglycemia is associated with long-term neurodevelopmental handicaps. Mental and psychomotor developmental indices of the children who suffered from hypoglycemia during new-born period are significantly low. Hence, early diagnosis and treatment of neonatal hypoglycemia is mandatory to prevent neurological sequelae.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-127X.1000323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48533819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zygosity Misclassification of Recent Young Twins by Maternal Reports in Japan","authors":"S. Ooki","doi":"10.4172/2376-127X.1000318","DOIUrl":"https://doi.org/10.4172/2376-127X.1000318","url":null,"abstract":"The problem of zygosity misclassification of twins has been paid little attention in Japan. By analyzing maternal reports collected using an internet questionnaire, the author found that around 30% of monozygotic twins were misclassified as dizygotic twins, mainly by obstetricians. On the other hand, the percentage of dizygotic twin pairs misclassified as monozygotic twins was lower. Misclassification was more frequently observed in cases of spontaneous pregnancy compared to iatrogenic pregnancy. The percentage of monozygotic twins misclassified as dizygotic is in very good accordance with that of monozygotic twins having two placentas. The reported number of placentas was very strongly associated with the reported zygosity. Thus, many monozygotic twins in Japan were still misclassified as dizygotic by obstetricians, presumably based solely on the placental findings.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-127X.1000318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48383417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Genomic Profile in Disseminated Peritoneal Leiomyomatosis: Three cases","authors":"Viviani, Cavillon, É. Boudier, Averous, S. Croce, N. Sananès, J. Baldauf, B. Langer, C. Akladios","doi":"10.4172/2376-127X.1000319","DOIUrl":"https://doi.org/10.4172/2376-127X.1000319","url":null,"abstract":"Disseminated peritoneal leiomyomatosis (DPL) is a rare disease entity belonging to the category of smooth muscle tumours of uncertain growth. It is characterized by proliferation of multiple smooth muscle nodules in the peritoneal cavity mimicking a malignant process such as peritoneal carcinomatosis but which when studied histologically proves to be of benign nature. Its origin is still unknown. Genomic analysis of DPL cases is of interest in order to understand its pathogenesis and subsequent course, but there are few extant studies. In this article we set out the genomic profiles, analysed by array-based comparative genomic hybridization (array-CGH), of peritoneal and uterine lesions in two cases of DPL detected after previous uterine morcellation for fibroids, as well as a \"sporadic\" case of DPL. Array-CGH findings revealed in all three cases a flat genomic profile. It is not possible to establish a genetic lineage between two lesions on the basis of the genomic profiles alone, owing to the absence of an unbalanced rearrangement. CGH is not conclusive enough in this type of disorder. Analysis of the exome could provide us with fresh information, not least about driving events in the cancerogenesis of these tumours.","PeriodicalId":87313,"journal":{"name":"Journal of pregnancy and child health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-127X.1000319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48914153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}