Journal of biomedical and allied research最新文献

{"title":"Type 1 and 2 Diabetes Mellitus and Oral Health","authors":"M. Goldberg","doi":"10.37191/mapsci-2582-4937-1(2)-008","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-1(2)-008","url":null,"abstract":"Diabetes is characterized by an elevated level of glucose in the blood.Type I diabetes mellitusresults from insulin deficiency. In contrast, type 2 diabetes results of insulin resistance.A third group recently identified confirmed that the secretory defects of gestational insulin are the consequence of abnormal glucose tolerance during pregnancy. Symptoms of diabetes include the classic triad [polyuria, polydipsia, polyphagia]. Long-term complications of diabetes include nephropathy and autoimmune cardiovascular illness dysfunctions. The symptoms of type 2 diabetes develop more slowly than type I diabetes. These patients may be obese. Adults develop micro- and macro- vascular conditions, producing irreversible damages to the eyes (retinopathy, cataracts), kidney (nephropathy), nervous system (neuropathy and parenthesis). Oral complications including candidiasis (fungal infection due to any type of Candida), dental caries, tooth loss, gingivitis, lichen planus, neurosensory disorders (burning mouth syndrome), periodontitis, salivary dysfunction, xerostomia, and taste impairment. Diabetes implicate greater prevalence of fissured tongue, irritation fibroma, traumaticulcers, and recurrent aphthous stomatitis. Hyperglycemia induces non-enzymatic elevated levels of glucose that stimulate interleukin-6 expression. Altogether these factors contribute to cardiovascular disease.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41762451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Assess Risk of Hypertension and its Potential Association with Coronary Diseases in Patients with High Pulse Wave Velocity","authors":"A. Nagay","doi":"10.37191/mapsci-2582-4937-1(2)-007","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-1(2)-007","url":null,"abstract":"Background and objectives: The work was initiated to assess risk of hypertension and its potential association with coronary diseases in patients with high pulse wave velocity. \u0000\u0000Materials and methods: The study included 150 patients with hypertension in average age of 60.8 ± 7.05 years. Genotyping of the SNP was performed by polymerase chain reaction, multiplex Real-Time PCR. Essential hypertension panel: 9 genes. Vascular stiffness was determined on a Sphygmocor apparatus. \u0000\u0000Result: In our study, the highest genetic risk was found 55%. We found the PWV tendency to increase towards high genetic risk of susceptibility to the hypertension (12± 1.5 and 11± 2.8: 10.7± 5.3). In patients with high genetic risk, the systolic pressure was found 17 mm Hg higher than the one in the low risk group. Three genes of salt sensitivity were found to make a 70% contribution to the risk above (ADD1 1378 G/T, GNB825 C/T, and CYP11B2 С344Т). According to our findings, the deleterious alleles, such as CYP11B2, GNB and NOS3, made more frequent contribution to the hypertension risk and blood vessel deterioration. We suppose that the frequent occurrence of NOS3 mutations was associated with the endothelial dysfunction, a triggering mechanism for the vessel deterioration.In our study, mutations in NOS3:-786_T>C, GNB: 825_C>T, AGTR2:1675G>A and AGT:704_T>C genes occurred most frequently in patients with high genetic risk.\u0000\u0000Conclusions: The above mutations are supposed to cause alterations in phenotypic expression in the cells of blood vessels in every other hypertensive person. The alterations make up 55% of the whole population of hypertensive persons. In other cases, factors of ecological effect of the environment, probably, left behind the genetic inheritance regardless of age and sex. To our mind, there are significant ethnic differences in ADD1, GNB and CYP11B2 genes. Mutation points in the genes were associated with dangerous prediction of the hypertension. These conclusions confirmed the concept of variability of the mutations associated with the etiology of salt gradient disorder, geographical latitude and race phenotype. Thus, the panel we use can be a suitable genetic marker to identify subjects with high risk of hypertension living in the hot climate and having associations with ischemic stroke, diabetes and heart failure.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46715665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Hypertrophy of the Inner Lip","authors":"M. Cutrone, E. Valerio, R. Grimalt","doi":"10.37191/mapsci-2582-4937-1(1)-005","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-1(1)-005","url":null,"abstract":"Variations on normality on the vulvar aspect have generated many difficulties among general pediatricians.The great amount of aesthetical perfection has led to an increasing number of adolescents seeking for vulvar correction. Here we describe a common alteration and provide some clues on the eventual surgical managing of the condition.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47738335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Internal Target Volume (ITV) Generated with Lung Optimization Treatment (LOT) and Maximum Intensity Projection (MIP) by 4-Dimensional CT scan in Radiosurgery Treatment of Early Lung Cancer","authors":"D. Dutta","doi":"10.37191/mapsci-2582-4937-1(1)-004","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-1(1)-004","url":null,"abstract":"Background: Comparison ofinternal target volume (ITV) generated with lung optimization treatment (LOT) and 4-dimenstional computed tomography (4D-CT) measured maximum intensity projection (MIP) methods in lung tumour treatment. \u0000\u0000Materials and Methods: 18 patients with lung cancer (n=8, stage T1A: 2, Stage T2: 6 pt, mean GTV 12.6 cc) and lung metastasis (n=10) accrued. 13/18 (72%) had right sided tumour, 12/18 (66%) had upper lobe tumour and 11 (61%) had 2-views on LOT. CT simulation (inhale and exhale phase) done for LOT based ITV generation (ITV-L). Same patient cohort underwent ITV generation with 4D-CT measured MIP methods (ITV-M). Comparison was done between the ITV in these two different methods. \u0000\u0000Results: Mean GTV was 12.6cc, ITV-L and ITV-M was 29.1 and 57.6 cc. Mean GTV, ITV-L and ITV-M in 1-view, 2-view, right lung, left lung, upper lobe, middle, lower lobe and primary lung cancer and lung metastasis were 3.2, 18.5,13.4, 10.7, 16.5, 6.3, 3.6, 25.5, 2.4 cc; 15.1, 38.1, 30.6, 25.1, 35.9, 19.7, 11.3, 49.9, 12.4 and 24.1, 79.1, 49.2, 79.8, 73.7, 34.1, 17.2, 106.4, 18.7 cc respectively. In 1-view and 2-view, ITV-L and ITV-M were 29.1, 57.6 (p-value: 0.001) and 38.1, 79.1 (p-value-0.009) respectively. Right lung tumour ITV-L and ITV-M were 30.6, 49.2 (p-value-0.001) and in left lung tumours 25.1 and 79.8 cc (p-value- 0.0.14) respectively. In upper, middle and lower lobe tumour, ITVs were 35.9, 73.7 (p-value-0.004); 19.7, 34.1 (p-value-0.474) and 11.3, 17.2 (p-value-0.001) respectively. In primary lung tumour and metastasis disease, ITVs were 49.9, 106.4 (p-value-0.071) and 12.4, 18.7 (p-value-0.001). Increase in mean ITV volume with MIP in all patient cohort was 49% [(ITV-M - ITV-L)x100 / ITV-M], in 1-view cohort 37%, 2-view 52%, right lung 38%, left lung 68.5%, upper lobe lung 51%, middle lobe 42%, lower lobe 34%, primary lung cancer 53% and metastatic lung cancer 34% respectively.\u0000\u0000Conclusions: MIP generated ITV volumes are significantly larger compared to LOT generated volume. ITV-M is larger in relation to lobes, side of tumour and type of tumour. There may be higher lung tissue necrosis when treated with ITV-M, as the 'high dose' volumes are more in this patient cohort.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41625960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Obsidian Impediment - Comedones","authors":"Anu Bajaj","doi":"10.37191/mapsci-2582-4937-1(1)-003","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-1(1)-003","url":null,"abstract":"Comedones appear as blackheads and whiteheads and implicate cutaneous zones with dense sebaceous follicles, particularly the face, upper chest or dorsal torso. Acne vulgaris is frequently enunciated with comedones. Hyper-proliferation and aberrant desquamation of ductal keratinocytes is enunciated which impedes sebum exudation within a pilo-sebaceous duct, thus engendering comedones. Also, a prototypicpilo-sebaceous duct unit metamorphoses into a comedone when progenitor component of the sebaceous glands differentiate into epithelial-like cells.“Micro-comedone theory” cogitates acne configuration as “comedogenesis” which is contingent to androgen secretion, hyper-proliferating keratinocytes with accumulation of keratin and sebum within the pilo-sebaceous unit. Hyperkeratinisation is also due to secretion of pro-inflammatory cytokines interleukin -1 alpha (IL-1α) produced as a result of cutaneous colonization of Propionibacterium acnes.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41349934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrophotometric Determination of Zolmitriptan in Pure Form and in Tablets Through Charge Transfer Complex Reaction","authors":"S. Ashour","doi":"10.37191/mapsci-2582-4937-1(1)-006","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-1(1)-006","url":null,"abstract":"Apert syndrome (AS) a type of acrocephalosyndactyly is a rare congenital disorder with autosomal dominant mode of transmission that consists of craniofacial synostosis, midfacial hypoplasia and bilateral limb syndactyly. Patients present in early childhood for multiple surgeries which make it imperative to know about various anaesthetic implications like difficult airway ventilation, airway hyper reactivity, associated congenital anomalies, increased airway secretions and deranged temperature thermoregulation associated with this syndrome. The patient should be thoroughly evaluated preoperatively and managed accordingly. We discuss the successful management of a three and a half years old male child two simple, rapid and selective colorimetric methods were developed for the determination of zolmitriptan (ZMT) in pure form and pharmaceutical preparations. These methods are based on the directly formation of charge-transfer complexes between ZMT and m-nitrophenol (MNP) in aqueous medium (ZMT: MNP, 1:1) and 2,4-dinitrophenol (DNP) in ethanol:water (80:20). The developed method involves formation of coloured complexes (1:1) of ZMT with MNP and DNP. The yellow formed complexes were quantitatively measured at 400 and 440 nm for ZMT-MNP and ZMT-DNP, respectively. Beer's law was obeyed in the concentration ranges of 3.0–260 μg/mL for MNP and 3.5–120 μg/mL for DNP. Limit of detection and limit of quantitation for MNP were calculated as 0.58 and 1.75 μg/mL, respectively, and for DNP were 0.32 and 0.97 μg/mL, respectively. The method was validated with respect to accuracy, robustness and selectivity. The proposed method has been successfully applied for the determination of ZMT in tablets.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47968499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Appendageal Wainscot- Dermoid Cyst","authors":"Anu Bajaj","doi":"10.37191/mapsci-2582-4937-1(1)-002","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-1(1)-002","url":null,"abstract":"Epidermoid and dermoid cystsare developmental cysts which ensue from displacement ofembryologic tissue or sites of fusion of embryonic elementsand weredescribed by Roser in 1859.Congenital dermoid cysts are described as a dys-embryogeniclesions arising from entrapped ectodermal tissueduringgestational midlinefusionoffirst or secondbranchial arch. Acquireddermoid cysts were designated as “Implantation cysts” in 1895by Sutton and can be engendered bysurgical procedures, as a variant of thyroglossal duct cyst oras traumatic manifestationdisplaying entrapped surface epithelium and implanted epithelial cells of deep connective tissue with subsequent differentiation and configuration of a cyst. Dermoid cysts are commonly asymptomatic and secondary infection ensures the emergence of clinical symptoms. Dermoid cysts are soft, nodular, sessile lesions with an absent pedicle and are discerned on commonly enunciated onfacial regions such as the upper lip, gingiva, palate, uvula or as intra-oral lesions, although no site is exempt.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41993073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Appraisal of a Research report of Student Perceptions and Understanding of Client-Therapist Interactions within the Inpatient Acute Care Environment: Qualitative Study","authors":"A. S. Rahman","doi":"10.37191/mapsci-2582-4937-1(1)-001","DOIUrl":"https://doi.org/10.37191/mapsci-2582-4937-1(1)-001","url":null,"abstract":"The aim of this appraisal was to assess the validity and reliability of this qualitative research report. In general, this qualitative research study shows its appropriateness and credibility. Data collection procedure was seemed unclear but sampling strategy and sample size, data collection time, study group and settings were clearly described. Inductive analytical process was applied during analysis of data. The researchers showed their understanding of data through description of coding and theme based charting. The authors used quotations from different participants to validate their transparency and trustworthiness. The reliability between the data presented and study findings were clearly examined. The summary findings and interpretations were clearly described and presented in qualitative research journal.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44583434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}