Ayu最新文献

{"title":"A compendious review of <i>Chitraka Haritaki Avaleha</i> - A polyherbal <i>Ayurveda</i> formulation for bronchial asthma.","authors":"Sagar Mahendrabhai Bhinde,&nbsp;Sonam Sagar Bhinde,&nbsp;Virendra K Kori,&nbsp;Kalpana S Patel","doi":"10.4103/ayu.AYU_340_20","DOIUrl":"https://doi.org/10.4103/ayu.AYU_340_20","url":null,"abstract":"<p><strong>Introduction: </strong><i>Avaleha</i> (confection) is an unique dosage form of Ayurvedic pharmaceutics, which is frequently prescribed in various disorders and especially in respiratory disorders. <i>Chitraka</i> <i>Haritaki</i> <i>Avaleha</i> (CHA) is one such formulation being used extensively by <i>Ayurveda</i> physicians for bronchial asthma, despite its classical use in various other disorders too. CHA was first time described by Vrindamadhava in the 9^th century and had been amended for many times till today. Because of its demand, many pharmaceutical companies are also manufacturing it, and is freely available in the market.</p><p><strong>Aim: </strong>The aim is to screen and compile references pertaining to composition, method of preparation, therapeutic uses, organoleptic, and physico-chemical parameters of CHA from different classics and original research articles.</p><p><strong>Materials and methods: </strong>Description of CHA was extensively reviewed from Vrindamadhava, Chakradatta, Vangasena, Gadanigraha, Yogatarangini, Bhaishjya Ratnavali and Yogaratnakara. Synonyms, <i>Rasapanchaka</i> (<i>Ayurveda</i> principles of drug action), and <i>Dosha</i> <i>Karma</i> (therapeutic attributes) of ingredients were compiled from Bhavaprakasha Nighantu. Organoleptic and physicochemical parameters were compiled from original research articles, searched from PubMed, Google Scholar, and Research Gate.</p><p><strong>Results: </strong>Variations in formulation name, ingredients, method of preparation, therapeutic indications and <i>Anupana</i> (adjuvant) was observed in the classical texts. Value of water-soluble extracts and pH of analytical study was found different than <i>Ayurveda</i> Pharmacopeia of India standards.</p><p><strong>Conclusion: </strong>Screening through various texts revealed that CHA has been mentioned in seven classical treatises and two gazetted texts with amendments which indicate its high demand and clinical efficacy in bronchial asthma along with other diseases. Disparity found in analytical parameters indicates the need of standardization of pharmaceutical process.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"41 1","pages":"12-18"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c0/a2/AYU-41-12.PMC8415241.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39450950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of nutritional value and antioxidant activity of root and leaf of <i>Samarakhai</i> (<i>Byttneria herbacea</i> Roxb.): An extra pharmacopoeial herb.","authors":"Tarun Sharma,&nbsp;Rabinarayan Acharya","doi":"10.4103/ayu.AYU_270_18","DOIUrl":"https://doi.org/10.4103/ayu.AYU_270_18","url":null,"abstract":"<p><strong>Background: </strong><i>Samarakhai</i> (<i>Byttneria</i> <i>herbacea</i> Roxb.), family Sterculiaceae, is one of the reputed folklore medicinal herbs, found in many parts of India. Although consumed as a vegetable since long time, its root and leaves are not yet reported for its nutritive value and antioxidant activities.</p><p><strong>Aim: </strong>The aim of this study was to evaluate nutritional value and antioxidant potential of root and leaf of <i>B</i>. <i>herbacea</i> Roxb.</p><p><strong>Materials and methods: </strong>Nutritional parameters such as carbohydrate, fat, protein, energy value, calcium, iron, zinc, manganese, phosphorus and vitamin C were evaluated. Antioxidant activity was evaluated through three test methods, i.e., 1,1-diphenyl-2-picrylhydrazyl, ferric-reducing antioxidant power (FRAP) and phosphomolybdenum assay.</p><p><strong>Results: </strong><i>B</i>. <i>herbacea</i> roots and leaves showed the presence of total carbohydrate 46.39 g/100 g and 40.12 g/100 g, total fat 0.63 g/100 g and 1.20 g/100 g, true protein 11.46 g/100 g and 10.49 g/100 g, energy content 237.07 kcal/100 g and 213.24 kcal/100 g, iron 821.10 ppm and 889.64 ppm, zinc 9.2 ppm and 47.98 ppm, manganese 329.86 ppm and 474.59 ppm, phosphorus 0.40 ppm and 0.10 ppm and calcium 4856.84 ppm and 14964.49 ppm, respectively. The half-maximal inhibitory concentration values of the methanol extract of root, leaf and ascorbic acid were found to be 217.25 µg/ml, 131.42 µg/ml and 178.88 µg/ml, respectively. In FRAP assay, antioxidant activity of methanol extract of leaf (129.15 µM) was found to be more than root (73.13 µM).</p><p><strong>Conclusion: </strong><i>B</i>. <i>herbacea</i> root contains high amount of true protein, carbohydrate and energy value, while micronutrients such as iron, zinc, manganese and calcium are more in its leaf. Both roots and leaves exhibited potent antioxidant activity where the leaves possess more values than the roots.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"41 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/03/fd/AYU-41-29.PMC8415235.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39473810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of <i>Chlorophytum borivilianum</i> Sant. F against gamma radiation-induced testicular injuries in Swiss albino mice.","authors":"Ruchi Vyas,&nbsp;Garima Sharma,&nbsp;Devki Sain,&nbsp;Rashmi Sisodia","doi":"10.4103/ayu.AYU_82_20","DOIUrl":"https://doi.org/10.4103/ayu.AYU_82_20","url":null,"abstract":"<p><strong>Background: </strong>Radiation therapy is considered as an important tool in cancer treatment. Despite its impressive role in treating cancer, severe side effects in organs have been reported. To address these therapeutic side effects, several combination methods have been identified to minimize adverse effects caused by radiation therapy.</p><p><strong>Aims and objectives: </strong>Based on higher radioactive sensitivity of testicular tissues, administration of <i>Chlorophytum</i> <i>borivilianum</i> (CB) Sant. F extracts was evaluated for its protective effects against radiation in testis.</p><p><strong>Materials and methods: </strong>Two forms of CB extracts (CB alone and CB-silver nanoparticles [AgNPs]) were administered at a dose of 50 mg/kg body weight in Swiss albino male mice for 7 consecutive days. Following 6 Gy gamma radiation, animals were observed for 30 days in four phases. Sperm counts, body weight, testicular weight and stereological and histological evaluation of testis were evaluated.</p><p><strong>Results: </strong>Following irradiation, a significant decline in body weight (<i>P</i> = 0.008) and testicular weight (<i>P</i> = 0.001) was noted when compared with control. Ununiformed type A and B spermatogonia, partially filled tubules, inter-tubular vacuoles, and disrupted epithelium were the main types of damages caused by irradiation. Reorganization and resumption of histological features emerged from the 15^th day postirradiation in CB extract (CBE)-treated animals.</p><p><strong>Conclusion: </strong>Testicular response was observed against radiation in animals treated with CB extracts, while CB-AgNPs indicated better toleration when compared to CB extract alone.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"41 1","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/7e/AYU-41-45.PMC8415242.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39473812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of <i>Triphala Ghrita</i> and <i>Goghrita Manda Tarpana</i> in the management of <i>Shushkakshipaka</i> w.s.r. to dry eye syndrome: An open labelled randomized comparative clinical trial.","authors":"Gangadhar M Timmapur,&nbsp;Shamsa Fiaz","doi":"10.4103/ayu.AYU_108_18","DOIUrl":"https://doi.org/10.4103/ayu.AYU_108_18","url":null,"abstract":"<p><strong>Background: </strong><i>Shalakya Tantra</i> is one of the eight branches of Ayurveda, which also includes ophthalmology. <i>Shushkakshipaka</i> (dry eye syndrome) is one of the diseases, involving all parts of eye (<i>Sarvagata Netra Roga</i>) characterized by <i>Gharsha</i> (gritty feeling), <i>Toda</i> (pricking type of pain), <i>Kunita</i> (photophobia), <i>Avila Darshana</i> (blurred vision), <i>Daha</i> (burning sensation) and <i>Raktaraji</i> (congestion in the eye). All these symptoms are similar to the symptoms of dry eye syndrome.</p><p><strong>Aims and objective: </strong>The objective of the present study was to evaluate and compare the effect of <i>Triphala Ghrita</i> and <i>Goghrita Manda</i> (supernant liquid part of cow ghee) <i>Tarpana</i> (therapeutic procedure done on the eye) in the management of <i>Shushkakshipaka</i>.</p><p><strong>Materials and methods: </strong>Thirty patients fulfilling the inclusion criteria of <i>Shushkakshipaka</i> were selected from the outpatient department and inpatient department of <i>Shalakya Tantra</i>, Sri Dharmasthala Manjunatheshwara College of Ayurveda, Hassan. Clinical signs and symptoms were given suitable scores according to their severity, and assessment was based on the relief in these symptoms after the treatment. Patients of dry eye syndrome were allocated alternatively in two groups for <i>Tarpana</i>, namely <i>Triphala Ghrita</i> <i>Tarpana</i> (TGT) group and <i>Goghrita Manda Tarpana</i> (GMT) group and <i>Tarpana</i> was given for 7 consecutive days in afternoon with follow up after 15 days for 2 months.</p><p><strong>Results: </strong>Moderate relief (50%-75% relief) was seen in 73.3% of the patients in both the groups, while marked relief (>75% but <100% relief) was seen in 26.7 patients in both the groups. Relief in symptoms like <i>Gharsha</i> (74%), <i>Avila Darshana</i> (65%), <i>Upadeha</i> (80%), <i>Daha</i> (72%), <i>Kunita</i> (78%), <i>Toda</i> (59%) and <i>Raktaraji</i> (83%) was obtained.</p><p><strong>Conclusion: </strong>The effect of <i>Goghrita Manda Tarpana</i> (GMT) on <i>Garsha, Toda</i> and <i>Daha</i> was better in immediately after treatment than <i>Triphala Ghrita</i> <i>Tarpana</i> (TGT).</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"41 1","pages":"52-57"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/2f/AYU-41-52.PMC8415239.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39474271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Panchakarma</i> in autoimmune pancreatitis: A single-case study.","authors":"Rajkala P Patil,&nbsp;Panchakshari D Patil,&nbsp;Anup B Thakar","doi":"10.4103/ayu.AYU_15_20","DOIUrl":"https://doi.org/10.4103/ayu.AYU_15_20","url":null,"abstract":"Autoimmune pancreatitis (AIP) is the pancreatic manifestation of a systemic fibro-inflammatory disorder. AIP is a unique form of pancreatitis in which autoimmune mechanisms are suspected to be involved in the pathogenesis. AIP is a rare disorder, its exact cause is unknown, but it is thought to be caused by the body's immune system attacking the pancreas and it responds to steroid therapy only. In Ayurveda, although there is no synonym for AIP, but has a resemblance in clinical features of Grahani Dosha (derangement of duodenum and intestine). The cause of Grahani Dosha is Mandagni (hypofunctioning of Agni) and Panchakarma therapy increases Agni. As per Charaka Samhita, treatment for Grahani Dosha amongst the Panchakarma therapy is Virechana (therapeutic purgation) and Basti (medicated enema). The present case report is of a 30-year-old female, diagnosed as case of AIP with multisystem involvement with increased level of immunoglobulin G (IgG), glycosylated heamoglobin (HbA1c), cholesterol, triglycerides, low-density lipoprotein (LDL) and body mass index (BMI). The patient was on anticholinergic agents, antacids, levothyroxine, multivitamin along with iron and antihistamine drugs since 1 year, but with not much relief. Patient was treated with classical Virechana and Madhutailika Basti. It was observed after the completion of therapy, that there was decrease in IgG, HbA1c, S. cholesterol, S. triglyceride, low density lipoprotein (LDL) and body mass index (BMI). This shows that Virechana and Basti play a significant role in patient with AIP associated with other disorders.","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"40 4","pages":"242-246"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/07/AYU-40-242.PMC8078606.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38872387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of herbal medicines for potential allopathic antidiabetic adulterants: An analytical study.","authors":"Girish Pamidimarri,&nbsp;Jayanthi Mathaiyan,&nbsp;S Manikandan,&nbsp;S Rajan,&nbsp;Gitanjali Batmanabane","doi":"10.4103/ayu.AYU_227_19","DOIUrl":"https://doi.org/10.4103/ayu.AYU_227_19","url":null,"abstract":"<p><strong>Background: </strong>There are several reports worldwide on adulteration of herbal medicines (HMs) with allopathic drugs. In India, only a few studies have reported adulteration of HMs with antidiabetics and there are no systematic studies.</p><p><strong>Aims: </strong>To develop a rapid and validated method for detection of allopathic antidiabetic adulterants and to explore the extent of adulteration in HMs sold in South India.</p><p><strong>Materials and methods: </strong>Standards and solvents were purchased from Sigma-Aldrich. Different brands of antidiabetic HM samples with manufacturing licenses were procured from dispensaries. Spiked drug free psyllium husk as solid and flask seed oil as liquid herbal matrices were used for method development. The spiked matrices with different concentrations were extracted with methanol and subjected to centrifugation. The supernatant was collected and analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Isocratic elution was carried on a C18 column with 0.1% (v/v) formic acid:methanol (3:7, v/v) as a mobile phase. All drugs were monitored for two ion products in positive electrospray ionization mode using multiple reaction monitoring scans.</p><p><strong>Results: </strong>The retention time was 9 min. Limit of detection is 10 Pictograms (pg) for all analytes except for metformin, which was 370 pg. Recoveries of analytes range from 96% to 117%. Forty different brands of antidiabetic HMs were analyzed. Adulterant peaks were not observed in the mass chromatograms of HMs.</p><p><strong>Conclusions: </strong>A single-run method was developed by LC-MS/MS for the detection of proposed antidiabetics in HMs from licensed manufacturing units and online sold HMs across herbal dispensaries in Puducherry union territory, India. None of the HMs was found to be adulterated with proposed allopathic antidiabetic adulterants.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"40 4","pages":"262-272"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/ae/AYU-40-262.PMC8078608.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38938184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis of the effect of the intervention of <i>Arogya Kashayam</i> in COVID-19 positive cases in Madhya Pradesh.","authors":"Umesh Shukla,&nbsp;Sanjay Srivastava,&nbsp;Pankaj Gupta,&nbsp;Nitin Ujjaliya","doi":"10.4103/ayu.ayu_365_20","DOIUrl":"https://doi.org/10.4103/ayu.ayu_365_20","url":null,"abstract":"<p><strong>Introduction: </strong>Coronavirus disease (COVID-19) is a newly identified strain of corona virus that causes illness ranging from the clinical features similar to the common cold to a fatal condition due to severe respiratory failure. According to the WHO, there have been more than 26.3 million confirmed COVID-19 cases in more than 190 countries to date. In light of the outbreak, various treatment modalities have been considered, including traditional medicine, which has been widely used in the pandemic of severe acute respiratory syndrome (SARS) and H₁N₁ influenza. Ayurveda contributes a measurable ratio in the world's traditional practices. As per the guideline of directorate of AYUSH, Government of Madhya Pradesh, cases of COVID-19 were intervened with <i>Arogya</i> <i>Kashayam</i> (AK-20), a decoction prepared from the herbs at 88 COVID Care Centers (CCC) across the state.</p><p><strong>Aim: </strong>To evaluate retrospectively, the effect of the intervention of AK-20 in COVID-19 positive cases as stand alone or in combination with hydroxychloroquine (HCQ) administered at CCC in Madhya Pradesh.</p><p><strong>Materials and methods: </strong>It is a retrospective study with 4432 COVID-19 reverse transcription-polymerase chain reaction (RTPCR) tested positive cases including 2750 males and 1682 females between 5 and 80 years of age. All the cases were intervened with AK-20 as stand alone or in combination with HCQ. Moreover, these patients were also given Zinc and Vitamin C simultaneously. The intervention of AK-20 was made through the district level government AYUSH machinery, and the related data were collected in specially designed case report form. The data were analyzed retrospectively, and outcomes included the RTPCR testing or asymptomatic discharge from the CCC as per the prevailing ICMR guidelines.</p><p><strong>Results: </strong>The present study reveals that out of 4432 COVID-19 RTPCR-positive cases, 2817 (63.56%) received HCQ with AK-20 and 1615 cases (36.43%) received AK-20 as a stand alone treatment. Among the cases that received HCQ and AK-20, 2681 cases (94.17%) recovered completely in an average of 6.8 days and among those who were on standalone AK-20, 1502 cases (93.00%) recovered completely in the same average days. The Chi-square test showed that both the groups were equally effective (<i>P</i> < 0.01; <i>F</i> = 0.3764).</p><p><strong>Conclusion: </strong>The retrospective analysis showed that the treatment practices of AK-20 standalone or in combination with HCQ applied in COVID-19 positive cases at CCC in Madhya Pradesh were effective against SARS coronavirus 2 disease. A significant number of cases was tested negative or asymptomatically discharged from both the groups of interventions. Moreover, AK-20 alone has shown statistically equal results to that when used in combination with HCQ therapy.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"40 4","pages":"209-215"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/c8/AYU-40-209.PMC8078609.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38872383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality publications in Ayurveda: Need of the hour.","authors":"Mandip Goyal","doi":"10.4103/ayu.ayu_375_20","DOIUrl":"https://doi.org/10.4103/ayu.ayu_375_20","url":null,"abstract":"","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"40 4","pages":"207-208"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/06/AYU-40-207.PMC8078604.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38872382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of <i>Rituharitaki</i> (seasonal adjuvant of <i>Haritaki</i>) on disorders of <i>Varsha Ritu</i> (monsoon) w.s.r. to quality of life: An open labelled randomized controlled clinical trial.","authors":"A V Smitha, K V Dilipkumar","doi":"10.4103/ayu.AYU_243_18","DOIUrl":"10.4103/ayu.AYU_243_18","url":null,"abstract":"<p><strong>Background: </strong>Monsoon epidemics are always a serious concern in the public health sector. Administration of <i>Haritaki</i> with suitable vehicle as per season (<i>Rituharitaki</i>) is a simple, cost-effective preventive measure which can be used for such conditions.</p><p><strong>Aims and objectives: </strong>Study objectives were to assess the effect of <i>Rituharitaki</i> in preventing the diseases in <i>Varsha Ritu</i> (monsoon) and its effect on the WHO quality of life BREF (QOL BREF), total leukocyte count (TLC), differential count (DC) and erythrocyte sedimentation rate (ESR) in healthy volunteers.</p><p><strong>Materials and methods: </strong>From 82 participants, based on inclusion criteria, 60 participants were selected and randomly allocated into trial and control group of 30 each using a computer generated random number table. Intervention given was <i>Rituharitaki</i> (<i>Terminalia chebula</i> Retz) in tablet form-3 tablets of 1g each and Saindhava (rock salt) 1g with lukewarm water at 6.30 am on empty stomach to the participants of trial group for 60 days in <i>Varsha</i> <i>Ritu</i> in Kerala and were observed during this period.</p><p><strong>Results: </strong>The results were analyzed using Chi-square test and paired <i>t</i>-test. Significant results were obtained in the trial group in reducing the severity and frequency of common cold (p < 0.001), cough (p < 0.05), and fever (p < 0.001). In the WHO QOL BREF domain 1 & 4 showed significant result in the trial group (p < 0.05). Among the haematological parameters - total leukocyte count (TLC), eosinophil count and erythrocyte sedimentation rate (ESR) were statistically significant reduced (p < 0.05) in the trial group.</p><p><strong>Conclusion: </strong><i>Rituharitaki</i> is found to be effective in reducing severity and frequency of diseases in <i>Varsha Ritu</i> and had effect on quality of life of patients.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"40 4","pages":"223-229"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/6a/AYU-40-223.PMC8078607.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38872385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An experimental study to evaluate the effect of <i>Nitya Sevaniya</i> (daily consumable) and <i>Nitya Asevaniya</i> (daily non-consumable) food items on albino rats.","authors":"Saylee Deshmukh,&nbsp;Mahesh Vyas,&nbsp;Mukesh Kumar B Nariya","doi":"10.4103/ayu.AYU_288_18","DOIUrl":"https://doi.org/10.4103/ayu.AYU_288_18","url":null,"abstract":"<p><strong>Background: </strong>As per Ayurveda, <i>Nitya</i> <i>Sevaniya</i> (NS) food items are recommended for daily intake while <i>Nitya</i> <i>Asevaniya</i> (NAS) food items should be avoided for daily intake due to their systemic wholesome and unwholesome effects after consumption, respectively.</p><p><strong>Aim and objectives: </strong>The present study was conducted to perform <i>in vivo</i> safety evaluation of selected <i>Nitya</i> <i>Sevaniya</i> and <i>Nitya</i> <i>Asevaniya</i> food items.</p><p><strong>Materials and methods: </strong>Thirty rats were randomly divided into five groups-each containing six Charle's Foster strain albino rats. Group 1 served as standard diet group, groups 2 and 3 served as test drug received groups namely NS50 and NS100, in which 50% and 100% mixture of <i>Nitya</i> <i>Sevaniya</i> food was administered, respectively. Group 4 and 5 as test drug received groups <i>Nitya</i> <i>Asevaniya</i> 50 (NAS50) and <i>Nitya</i> <i>Asevaniya</i> 100 (NAS100), in which 50% and 100% <i>Nitya</i> <i>Asevaniya</i> food mixtures was administered, respectively. The test diet was administered orally in the form of freshly prepared pellet twice a day <i>ad</i> <i>libitum</i> for 90 days. Parameters studied were gross behavior, body and organ weight, food and water intake, fecal and urine output, hematological and biochemical parameters, electrocardiogram and histology of various organs.</p><p><strong>Results: </strong>In the NAS100 group, a significant change was observed in 20 of 47 parameters in view of pathological aspect. Among them, three parameters, i.e., platelet count, serum glutamic-oxaloacetic transaminase (SGOT) and indirect bilirubin were above normal limits, while other parameters were within the normal limits. No significant change was observed in any of the parameters in the NS50 and NS100 group after 90 days of administration as compared with the control group.</p><p><strong>Conclusion: </strong>Considering findings of this study, it is concluded that selected NS food items are safe while consumption of only selected <i>Nitya</i> <i>Asevaniya</i> food items (when administered in 100% dose) for 90 days have the potential of inflammatory changes in the liver, spleen; fat deposition in kidney and impairment of cardiac and renal functions.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":"40 4","pages":"247-255"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/90/AYU-40-247.PMC8078600.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38938182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}