Bacteriophage最新文献_第10页

Bacteriophages for managing Shigella in various clinical and non-clinical settings. 在各种临床和非临床环境中用于控制志贺氏菌的噬菌体。

Bacteriophage Pub Date : 2013-01-01 Epub Date: 2013-05-21 DOI: 10.4161/bact.25098

Lawrence D Goodridge

引用次数: 24

Biochemical insights into the function of phage G1 gp67 in Staphylococcus aureus. 金黄色葡萄球菌噬菌体G1 gp67功能的生化分析。

Bacteriophage Pub Date : 2013-01-01 DOI: 10.4161/bact.24767

Joseph Osmundson, Seth A Darst

引用次数: 6

Phage-host interactions during pseudolysogeny: Lessons from the Pid/dgo interaction. 假溶解过程中噬菌体与宿主的相互作用：Pid/dgo 相互作用的启示。

Bacteriophage Pub Date : 2013-01-01 Epub Date: 2013-05-21 DOI: 10.4161/bact.25029

William Cenens, Angella Makumi, Mehari Tesfazgi Mebrhatu, Rob Lavigne, Abram Aertsen

引用次数: 0

Lytic bacteriophages reduce Escherichia coli O157: H7 on fresh cut lettuce introduced through cross-contamination. 溶菌噬菌体可减少通过交叉污染引入的新鲜生菜上的大肠杆菌 O157: H7。

Bacteriophage Pub Date : 2013-01-01 DOI: 10.4161/bact.24323

Sean Ferguson, Cheryl Roberts, Eric Handy, Manan Sharma

{"title":"Lytic bacteriophages reduce Escherichia coli O157: H7 on fresh cut lettuce introduced through cross-contamination.","authors":"Sean Ferguson, Cheryl Roberts, Eric Handy, Manan Sharma","doi":"10.4161/bact.24323","DOIUrl":"10.4161/bact.24323","url":null,"abstract":"The role of lytic bacteriophages in preventing cross contamination of produce has not been evaluated. A cocktail of three lytic phages specific for E. coli O157:H7 (EcoShield™) or a control (phosphate buffered saline, PBS) was applied to lettuce by either; (1) immersion of lettuce in 500 ml of EcoShield™ 8.3 log PFU/ml or 9.8 log PFU/ml for up to 2 min before inoculation with E. coli O157:H7; (2) spray-application of EcoShield™ (9.3 log PFU/ml) to lettuce after inoculation with E. coli O157:H7 (4.10 CFU/cm2) following exposure to 50 μg/ml chlorine for 30 sec. After immersion studies, lettuce was spot-inoculated with E. coli O157:H7 (2.38 CFU/cm2). Phage-treated, inoculated lettuce pieces were stored at 4°C for and analyzed for E. coli O157:H7 populations for up to 7 d. Immersion of lettuce in 9.8 log PFU/ml EcoShield™ for 2 min significantly (p < 0.05) reduced E. coli O157:H7 populations after 24 h when stored at 4°C compared with controls. Immersion of lettuce in suspensions containing high concentrations of EcoShield™ (9.8 log PFU/ml) resulted in the deposition of high concentrations (7.8 log log PFU/cm2) of bacteriophages on the surface of fresh cut lettuce, potentially contributing to the efficacy of the lytic phages on lettuce. Spraying phages on to inoculated fresh cut lettuce after being washed in hypochlorite solution was significantly more effective in reducing E. coli O157:H7 populations (2.22 log CFU/cm2) on day 0 compared with control treatments (4.10 log CFU/cm2). Both immersion and spray treatments provided protection from E. coli O157:H7 contamination on lettuce, but spray application of lytic bacteriophages to lettuce was more effective in immediately reducing E. coli O157:H7 populations fresh cut lettuce.","PeriodicalId":8686,"journal":{"name":"Bacteriophage","volume":"3 1","pages":"e24323"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/25/bact-3-e24323.PMC3694057.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31192110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phage therapy: Should bacterial resistance to phages be a concern, even in the long run? 噬菌体治疗:即使从长远来看，细菌对噬菌体的耐药性是否值得关注?

Bacteriophage Pub Date : 2013-01-01 DOI: 10.4161/bact.24219

Anni-Maria Ormälä, Matti Jalasvuori

引用次数: 60

Dualities in the analysis of phage DNA packaging motors. 噬菌体DNA包装马达分析中的二元性。

Bacteriophage Pub Date : 2012-10-01 DOI: 10.4161/bact.23829

Philip Serwer, Wen Jiang

引用次数: 18

The moron comes of age. 傻瓜成年了。

Bacteriophage Pub Date : 2012-10-01 DOI: 10.4161/bact.23146

Nichole Cumby, Alan R Davidson, Karen L Maxwell

引用次数: 61

On the interactions between virulent bacteriophages and bacteria in the gut. 肠道内强毒噬菌体与细菌相互作用的研究。

Bacteriophage Pub Date : 2012-10-01 DOI: 10.4161/bact.23557

Damien Maura, Laurent Debarbieux

引用次数: 26

Viral molecular mimicry circumvents abortive infection and suppresses bacterial suicide to make hosts permissive for replication. 病毒分子模仿避免了流产感染，抑制了细菌自杀，使宿主允许复制。

Bacteriophage Pub Date : 2012-10-01 DOI: 10.4161/bact.23830

Tim R Blower, Francesca L Short, Peter C Fineran, George P C Salmond

{"title":"Viral molecular mimicry circumvents abortive infection and suppresses bacterial suicide to make hosts permissive for replication.","authors":"Tim R Blower, Francesca L Short, Peter C Fineran, George P C Salmond","doi":"10.4161/bact.23830","DOIUrl":"https://doi.org/10.4161/bact.23830","url":null,"abstract":"The global interplay between bacteria and bacteriophages has generated many macromolecules useful in biotechnology, through the co-evolutionary see-saw of bacterial defense and viral counter-attack measures. Bacteria can protect themselves using abortive infection systems, which induce altruistic suicide in an infected cell and therefore protect the clonal population at the expense of the infected individual. Our recent paper describes how bacteriophage ΦTE successfully subverted the activity of a plasmid-borne abortive infection system. ΦTE evolved mimics of the small RNA antitoxin that naturally inhibits the active toxin component of this anti-viral mechanism. These mutant phages further manipulated the behavior of the host population, through transduction of the plasmid encoding the abortive infection system. Transductants thereby became enslaved by the abortive infection system, committing suicide in response to infection by the original phage population. In effect, the new host was infected by an \"addictive altruism,\" to the advantage of the resistant bacteriophage.","PeriodicalId":8686,"journal":{"name":"Bacteriophage","volume":"2 4","pages":"234-238"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/bact.23830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31484893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Soil-based systemic delivery and phyllosphere in vivo propagation of bacteriophages: Two possible strategies for improving bacteriophage persistence for plant disease control. 噬菌体的土壤系统输送和叶球体内繁殖：提高噬菌体持久性以控制植物病害的两种可能策略。

Bacteriophage Pub Date : 2012-10-01 DOI: 10.4161/bact.23530

Fanny B Iriarte, Aleksa Obradović, Mine H Wernsing, Lee E Jackson, Botond Balogh, Jason A Hong, M Timur Momol, Jeffrey B Jones, Gary E Vallad

{"title":"Soil-based systemic delivery and phyllosphere in vivo propagation of bacteriophages: Two possible strategies for improving bacteriophage persistence for plant disease control.","authors":"Fanny B Iriarte, Aleksa Obradović, Mine H Wernsing, Lee E Jackson, Botond Balogh, Jason A Hong, M Timur Momol, Jeffrey B Jones, Gary E Vallad","doi":"10.4161/bact.23530","DOIUrl":"10.4161/bact.23530","url":null,"abstract":"Soil-based root applications and attenuated bacterial strains were evaluated as means to enhance bacteriophage persistence on plants for bacterial disease control. In addition, the systemic nature of phage applied to tomato roots was also evaluated. Several experiments were conducted applying either single phages or phage mixtures specific for Ralstonia solanacearum, Xanthomonas perforans or X. euvesicatoria to soil surrounding tomato plants and measuring the persistence and translocation of the phages over time. In general, all phages persisted in the roots of treated plants and were detected in stems and leaves; although phage level varied and persistence in stems and leaves was at a much lower level compared with persistence in roots. Bacterial wilt control was typically best if the phage or phage mixtures were applied to the soil surrounding tomatoes at the time of inoculation, less effective if applied 3 days before inoculation, and ineffective if applied 3 days after inoculation. The use of an attenuated X. perforans strain was also evaluated to improve the persistence of phage populations on tomato leaf surfaces. In greenhouse and field experiments, foliar applications of an attenuated mutant X. perforans 91-118:∆OPGH strain prior to phage applications significantly improved phage persistence on tomato foliage compared with untreated tomato foliage. Both the soil-based bacteriophage delivery and the use of attenuated bacterial strains improved bacteriophage persistence on respective root and foliar tissues, with evidence of translocation with soil-based bacteriophage applications. Both strategies could lead to improved control of bacterial pathogens on plants.","PeriodicalId":8686,"journal":{"name":"Bacteriophage","volume":" ","pages":"215-224"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/1e/bact-2-215.PMC3594209.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40227571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0