Autism Research and Treatment最新文献_第3页

Role of Inner Speech on Serial Recall in Children with ASD: A Pilot Study Using the Luria Hand Test. 内心言语对 ASD 儿童序列回忆的作用：使用卢里亚手试验进行的试点研究。

Autism Research and Treatment Pub Date : 2018-03-14 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6873412

Shota Mitsuhashi, Shogo Hirata, Hideyuki Okuzumi

引用次数: 0

A Study of the Correlation between VEP and Clinical Severity in Children with Autism Spectrum Disorder. 自闭症谱系障碍患儿VEP与临床严重程度的相关性研究

Autism Research and Treatment Pub Date : 2018-01-14 eCollection Date: 2018-01-01 DOI: 10.1155/2018/5093016

Winai Sayorwan, Nutthida Phianchana, Kannika Permpoonputtana, Vorasith Siripornpanich

{"title":"A Study of the Correlation between VEP and Clinical Severity in Children with Autism Spectrum Disorder.","authors":"Winai Sayorwan, Nutthida Phianchana, Kannika Permpoonputtana, Vorasith Siripornpanich","doi":"10.1155/2018/5093016","DOIUrl":"10.1155/2018/5093016","url":null,"abstract":"Visual evoked potential (VEP) is a technique used to assess the brain's electrical response to visual stimuli. The aims of this study were to examine neural transmission within the visual pathway through VEP testing in preschool children with autism spectrum disorder (ASD) and compare it to age-matched controls, as well as search for a correlation between the VEP parameters and the symptoms of ASD. Participants were composed of ASD children (9 males) and typically developing children (8 males and 4 females), aged between 3 and 5 years. Checkerboards were chosen as the pattern-reversal VEP. The clinical severity of ASD was assessed using the Autism Treatment Evaluation Checklist (ATEC) and the Vineland Adaptive Behavior Scales 2nd edition (VABS-II). Our findings demonstrated that children with ASD had significantly longer N145 latency compared to the controls. A longer N145 latency correlated with a higher score of ATEC within the sensory/cognitive awareness subdomain. In addition, a slower N145 response was also associated with a lower VABS-II score within the socialization domain. The correlation between longer VEP latency and abnormal behaviors in children with ASD suggests a delayed neural communication within other neural circuits, apart from the visual pathway. These lines of evidence support the possibility of using VEP, along with clinical parameters, for the assessment of ASD severity.","PeriodicalId":8659,"journal":{"name":"Autism Research and Treatment","volume":"2018 ","pages":"5093016"},"PeriodicalIF":0.0,"publicationDate":"2018-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/5093016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35940664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Initial Development of the Early Intensive Behavioral Intervention Parental Self-Efficacy Scale: A Pilot Study. 早期强化行为干预父母自我效能量表的初步开发:一项初步研究。

Autism Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-05-31 DOI: 10.1155/2017/9512180

Aaron Blocher-Rubin, Paige Krabill

{"title":"Initial Development of the Early Intensive Behavioral Intervention Parental Self-Efficacy Scale: A Pilot Study.","authors":"Aaron Blocher-Rubin, Paige Krabill","doi":"10.1155/2017/9512180","DOIUrl":"https://doi.org/10.1155/2017/9512180","url":null,"abstract":"Early Intensive Behavioral Intervention (EIBI) is an effective treatment for children with autism. However, it is known that some parents struggle to fully implement the program, and providers are not always able to identify the specifics of each family's individualized challenges. The purpose of this pilot study was to begin the process of developing a new instrument, the EIBI Parental Self-Efficacy (EPSE) Scale, to help providers better assess and assist parents in regard to EIBI implementation. The methodology included four phases: scale construction, expert review, pretest administration, and a large sample pilot study (N = 192). The final 29-item EPSE Scale contained strong reliability properties (Cronbach's alpha = .900). Factor analysis established five subscales: Family Well-Being, Preparing for Successful Sessions, Team Participation, Not Giving Up, and Working with your Child. Following this pilot study, future research is recommended to refine and validate the EPSE Scale as a useful clinical tool for EIBI providers.","PeriodicalId":8659,"journal":{"name":"Autism Research and Treatment","volume":"2017 ","pages":"9512180"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9512180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35114798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Longitudinal Study of Sensory Features in Children with Autism Spectrum Disorder. 自闭症谱系障碍儿童感觉特征的纵向研究。

Autism Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-08-27 DOI: 10.1155/2017/1934701

Lucia Perez Repetto, Emmanuelle Jasmin, Eric Fombonne, Erika Gisel, Mélanie Couture

{"title":"Longitudinal Study of Sensory Features in Children with Autism Spectrum Disorder.","authors":"Lucia Perez Repetto, Emmanuelle Jasmin, Eric Fombonne, Erika Gisel, Mélanie Couture","doi":"10.1155/2017/1934701","DOIUrl":"https://doi.org/10.1155/2017/1934701","url":null,"abstract":"Background: Between 45 and 95% of children with Autism Spectrum Disorder (ASD) present sensory features that affect their daily functioning. However, the data in the scientific literature are not conclusive regarding the evolution of sensory features in children with ASD. The main objective of this study was to analyze the sensory features of children within the age of 3-4 (T1) when they received their ASD diagnosis and two years later (T2) when they started school.Methods: We conducted a prospective cohort study to assess sensory features in 34 children with ASD over time. The data were collected using a standardized assessment tool, the Sensory Profile.Results: Our analyses show that sensory features in children with ASD are stable from the age of three to six years. The stability of sensory scores is independent of correction by covariates, such as cognitive level and autism severity scores.Conclusions: Children with ASD have sensory features that persist from the time of diagnosis at the age of 3 to 4 years to school age. This persistence of sensory features from an early age underscores the need to support these children and their parents. Sensory features should be detected early and managed to improve functional and psychosocial outcomes.","PeriodicalId":8659,"journal":{"name":"Autism Research and Treatment","volume":"2017 ","pages":"1934701"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1934701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35429323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Social Skills Intervention Participation and Associated Improvements in Executive Function Performance. 社会技能、干预、参与及相关执行功能表现的改善。

Autism Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-09-17 DOI: 10.1155/2017/5843851

Shawn E Christ, Janine P Stichter, Karen V O'Connor, Kimberly Bodner, Amanda J Moffitt, Melissa J Herzog

{"title":"Social Skills Intervention Participation and Associated Improvements in Executive Function Performance.","authors":"Shawn E Christ, Janine P Stichter, Karen V O'Connor, Kimberly Bodner, Amanda J Moffitt, Melissa J Herzog","doi":"10.1155/2017/5843851","DOIUrl":"https://doi.org/10.1155/2017/5843851","url":null,"abstract":"Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication. It has been postulated that such difficulties are related to disruptions in underlying cognitive processes such as executive function. The present study examined potential changes in executive function performance associated with participation in the Social Competence Intervention (SCI) program, a short-term intervention designed to improve social competence in adolescents with ASD. Laboratory behavioral performance measures were used to separately evaluate potential intervention-related changes in individual executive function component processes (i.e., working memory, inhibitory control, and cognitive flexibility) in a sample of 22 adolescents with ASD both before and after intervention. For comparison purposes, a demographically matched sample of 14 individuals without ASD was assessed at identical time intervals. Intervention-related improvements were observed on the working memory task, with gains evident in spatial working memory and, to a slightly lesser degree, verbal working memory. Significant improvements were also found for a working memory-related aspect of the task switching test (i.e., mixing costs). Taken together, these findings provide preliminary support for the hypothesis that participation in the SCI program is accompanied by changes in underlying neurocognitive processes such as working memory.","PeriodicalId":8659,"journal":{"name":"Autism Research and Treatment","volume":"2017 ","pages":"5843851"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/5843851","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35551157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Neuropsychological Characteristics of Children with Mixed Autism and ADHD. 混合型自闭症和多动症儿童的神经心理学特征。

Autism Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-07-25 DOI: 10.1155/2017/5781781

Costanza Colombi, Mohammad Ghaziuddin

引用次数: 0

Autistic Traits Affect P300 Response to Unexpected Events, regardless of Mental State Inferences. 自闭症特征影响P300对意外事件的反应，而不考虑心理状态推断。

Autism Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-06-04 DOI: 10.1155/2017/8195129

Mitsuhiko Ishikawa, Shoji Itakura, Hiroki C Tanabe

{"title":"Autistic Traits Affect P300 Response to Unexpected Events, regardless of Mental State Inferences.","authors":"Mitsuhiko Ishikawa, Shoji Itakura, Hiroki C Tanabe","doi":"10.1155/2017/8195129","DOIUrl":"https://doi.org/10.1155/2017/8195129","url":null,"abstract":"Limited use of contextual information has been suggested as a way of understanding cognition in people with autism spectrum disorder (ASD). However, it has also been argued that individuals with ASD may have difficulties inferring others' mental states. Here, we examined how individuals with different levels of autistic traits respond to contextual deviations by measuring event-related potentials that reflect context usage. The Autism Spectrum Quotient (AQ) was used to quantify autistic-like traits in 28 university students, and 19 participants were defined as Low or High AQ groups. To additionally examine inferences about mental state, two belief conditions (with or without false belief) were included. Participants read short stories in which the final sentence included either an expected or an unexpected word and rated the word's degree of deviation from expectation. P300 waveform analysis revealed that unexpected words were associated with larger P300 waveforms for the Low AQ group, but smaller P300 responses in the High AQ group. Additionally, AQ social skill subscores were positively correlated with evaluation times in the Unexpected condition, whether a character's belief was false or not. This suggests that autistic traits can affect responses to unexpected events, possibly because of decreased availability of context information.","PeriodicalId":8659,"journal":{"name":"Autism Research and Treatment","volume":"2017 ","pages":"8195129"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/8195129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35127604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Support Needs and Coping Strategies as Predictors of Stress Level among Mothers of Children with Autism Spectrum Disorder. 自闭症谱系障碍儿童母亲压力水平的预测因素--支持需求和应对策略。

Autism Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-12-25 DOI: 10.1155/2017/8685950

Sheri R Kiami, Shelley Goodgold

{"title":"Support Needs and Coping Strategies as Predictors of Stress Level among Mothers of Children with Autism Spectrum Disorder.","authors":"Sheri R Kiami, Shelley Goodgold","doi":"10.1155/2017/8685950","DOIUrl":"10.1155/2017/8685950","url":null,"abstract":"This study examined maternal stress, coping strategies, and support needs among mothers of children with Autism Spectrum Disorder (ASD). A convenience sample of 70 mothers completed the Parent Stress Index Short Form (PSI-SF), Coping Health Inventory for Parents (CHIP), and Modified Family Needs Questionnaire (FNQ). PSI-SF scores reflected clinically significant levels of stress for 77% of mothers, and mothers identified 62.4% of important needs as unmet. The five most frequently reported important unmet needs were (1) financial support; (2) break from responsibilities; (3) understanding of other after-school program children; (4) rest/sleep; (5) help remaining hopeful about the future. Most coping strategies (81%) were identified as helpful. Additionally, both coping strategies and support needs served as predictors for maternal stress. Maternal stress scores decreased by .402 points for each percent increase in helpful coping strategy, and stress scores increased by .529 points with each percent increase in unmet needs. Given large variation in questionnaire responses across participants and studies, utilization of user-friendly questionnaires, such as the PSI-SF, CHIP, and FNQ, is advocated to determine the evolving important needs unique to each family over the child's lifetime as well as guide prioritization of care, compilation of resources, and referrals for additional services.","PeriodicalId":8659,"journal":{"name":"Autism Research and Treatment","volume":"2017 ","pages":"8685950"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35825154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 2D : 4D Digit Ratio as a Biomarker for Autism Spectrum Disorder. 2D: 4D数字比作为自闭症谱系障碍的生物标志物。

Autism Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-07-19 DOI: 10.1155/2017/1048302

M Mackus, D de Kruijff, L S Otten, A D Kraneveld, J Garssen, J C Verster

{"title":"The 2D : 4D Digit Ratio as a Biomarker for Autism Spectrum Disorder.","authors":"M Mackus, D de Kruijff, L S Otten, A D Kraneveld, J Garssen, J C Verster","doi":"10.1155/2017/1048302","DOIUrl":"https://doi.org/10.1155/2017/1048302","url":null,"abstract":"It has been suggested that the second (2D, index finger) to fourth (4D, ring finger) digit ratio, 2D : 4D, may be a biomarker for the risk of developing autism. The aim of the current study was to determine the usefulness of the 2D : 4D digit ratio as biomarker for autistic traits. N = 401 healthy young volunteers participated in the study. For both hands, digit lengths were measured using digital Vernier calipers. In addition to demographics, the Autism Spectrum Quotient (AQ) questionnaire was completed, comprised of five subscales, assessing \"social insights and behavior,\" \"attention switching,\" \"communication,\" \"imagination,\" and \"attention to detail.\" Overall, no significant correlations were observed between the AQ total score, its subscales, and the 2D : 4D digit ratio. For women, the left hand 2D : 4D digit ratio correlated significantly with the subscale score \"communication\" (r = -0.142; p = 0.036). For men, a significant positive correlation was found between the left 2D : 4D digit ratio and the total AQ score (r = 0.157; p = 0.042) and AQ subscale \"attention switching\" (r = 0.182; p = 0.017). In conclusion, gender specific associations between the 2D : 4D digit ratio and specific autism traits were observed, which were stronger in men than in women. Future studies should be conducted in patients that are formally diagnosed with autism.","PeriodicalId":8659,"journal":{"name":"Autism Research and Treatment","volume":"2017 ","pages":"1048302"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1048302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35265181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Associations between Familial Rates of Psychiatric Disorders and De Novo Genetic Mutations in Autism. 自闭症患者精神疾病家族发病率与新生基因突变之间的关系。

Autism Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-11-08 DOI: 10.1155/2017/9371964

Kyleen Luhrs, Tracey Ward, Caitlin M Hudac, Jennifer Gerdts, Holly A F Stessman, Evan E Eichler, Raphael A Bernier

{"title":"Associations between Familial Rates of Psychiatric Disorders and De Novo Genetic Mutations in Autism.","authors":"Kyleen Luhrs, Tracey Ward, Caitlin M Hudac, Jennifer Gerdts, Holly A F Stessman, Evan E Eichler, Raphael A Bernier","doi":"10.1155/2017/9371964","DOIUrl":"https://doi.org/10.1155/2017/9371964","url":null,"abstract":"The purpose of this study was to examine the confluence of genetic and familial risk factors in children with Autism Spectrum Disorder (ASD) with distinct de novo genetic events. We hypothesized that gene-disrupting mutations would be associated with reduced rates of familial psychiatric disorders relative to structural mutations. Participants included families of children with ASD in four groups: de novo duplication copy number variations (DUP, n = 62), de novo deletion copy number variations (DEL, n = 74), de novo likely gene-disrupting mutations (LGDM, n = 267), and children without a known genetic etiology (NON, n = 2111). Familial rates of psychiatric disorders were calculated from semistructured interviews. Results indicated overall increased rates of psychiatric disorders in DUP families compared to DEL and LGDM families, specific to paternal psychiatric histories, and particularly evident for depressive disorders. Higher rates of depressive disorders in maternal psychiatric histories were observed overall compared to paternal histories and higher rates of anxiety disorders were observed in paternal histories for LGDM families compared to DUP families. These findings support the notion of an additive contribution of genetic etiology and familial factors are associated with ASD risk and highlight critical need for continued work targeting these relationships.","PeriodicalId":8659,"journal":{"name":"Autism Research and Treatment","volume":"2017 ","pages":"9371964"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9371964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35664807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5