Australasian Journal of Dermatology最新文献

{"title":"Clinical Features and Risks of Congenital Melanocytic Naevi: A Retrospective Analysis of Patients at the Queensland Children's Hospital","authors":"Yolanka Lobo,&nbsp;Jessica Zhuang,&nbsp;Hannah Gribbin,&nbsp;William Felipe Pinzon Perez,&nbsp;H. Peter Soyer,&nbsp;Laura Wheller","doi":"10.1111/ajd.14418","DOIUrl":"10.1111/ajd.14418","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background/Objectives</h3>\u0000 \u0000 <p>Congenital melanocytic naevi (CMN) are a risk factor for melanoma. Melanoma risk is dependent on the congenital phenotype. Our primary aims were to assess the clinical characteristics of CMN that indicate a high risk of neurocutaneous melanosis (NCM) and melanoma in an Australian paediatric population group; to identify patient characteristics and clinical features of CMN that trigger further investigations; and to determine the rate of malignancy and other complications for CMN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively reviewed the electronic medical records of all patients under 18 years who were diagnosed with CMN at the Queensland Children's Hospital between 2014 and 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighty-eight patients (38 males and 50 females) were included in the analysis. Eighteen patients (20%) had a biopsy to rule out malignancy. Central nervous system magnetic resonance imaging (MRI) was performed in 16 patients (18%). Five patients (5.7%) experienced complications, of which three had NCM and two had transient neurological symptoms with normal MRI. No cases of melanoma, non-melanoma tumours or deaths were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CMN size, location over the posterior midline axis and multiple numbers of CMN were found to be significantly associated with the development of complications. CMN size, CMN site, presence of satellite naevi and location over the posterior midline axis were all significantly associated with the likelihood of an MRI or biopsy being performed. Large-scale studies, such as a population-based registry, are recommended to accurately assess the true lifetime risk of complications and associated risk factors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 2","pages":"61-68"},"PeriodicalIF":2.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of a fledgling public dermatology clinic in rural Australia","authors":"Grace Xiaoying Li BSc (Med) Hons,&nbsp;Xin Lin Wong BMed, MD MMed (Clin Epi),&nbsp;Deshan Frank Sebaratnam MBBS (Hons), MMed (Clin Epi), FRCP (London), FACD","doi":"10.1111/ajd.14399","DOIUrl":"10.1111/ajd.14399","url":null,"abstract":"<p>There is paucity of research available regarding the epidemiological characteristics of patients attending dermatology outpatient services in rural Australia. We performed a retrospective cohort study of patients attending a public dermatology clinic established at Dubbo Base Hospital in rural New South Wales. The broad range of dermatological presentations encountered, coupled with the brisk uptake of services by remote patients, highlights the ongoing need for specialist dermatology services in underserved rural communities.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 2","pages":"93-96"},"PeriodicalIF":2.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Erysipelas: An Important Buttock Dermatosis, in Hindsight","authors":"Serene Chan,&nbsp;Lachlan Byth","doi":"10.1111/ajd.14414","DOIUrl":"10.1111/ajd.14414","url":null,"abstract":"&lt;p&gt;Erysipelas is a superficial bacterial infection of the dermis, typically caused by beta-haemolytic streptococci including &lt;i&gt;Streptococcus pyogenes&lt;/i&gt; (group A), &lt;i&gt;S. agalactiae&lt;/i&gt; (group B) and &lt;i&gt;S. dysgalactiae&lt;/i&gt; (group C/G). The typical site is the lower leg, with the face, arm or surgical wounds affected in a minority of cases. Gluteal erysipelas is uncommon and can be multiply recurrent [&lt;span&gt;1&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;An 89-year-old woman presented to hospital with an acute painful eruption on the buttocks which began 48 h prior. The patient had experienced five similar episodes in the same distribution over the past 12 months, each of which had resolved with oral clindamycin over 1–2 weeks. The past medical history included recurrent urinary tract infections and stress incontinence. There was no history of trauma or immobility.&lt;/p&gt;&lt;p&gt;Examination revealed well-demarcated, warm, indurated, blanchable plaques on the bilateral buttocks, with an irregular border and peripheral papules. Superficial linear erosions were present on the medial buttocks (Figure 1). The patient was afebrile and there was no inguinal lymphadenopathy. The differential diagnosis included erysipelas, giant cellulitis-like Sweet syndrome, leukaemia cutis, Wells syndrome, panniculitis (including cold panniculitis, factitial panniculitis or paraffinoma), interstitial granulomatous dermatitis, urticaria and irritant contact dermatitis.&lt;/p&gt;&lt;p&gt;Skin biopsy showed papillary dermal oedema and a mixed perivascular and interstitial inflammatory infiltrate, including neutrophils undergoing karyorrhexis (Figure 2). The white cell count was 5.2 × 10&lt;sup&gt;9&lt;/sup&gt;/L (4.0–10.0), CRP 119 mg/L (&lt; 5) and blood cultures negative. Swabs from the erosion showed growth of group C/G streptococcus, sensitive to penicillin. The eruption resolved with intravenous cefazolin followed by oral cefalexin for a total of 14 days. Prophylactic penicillin V 500 mg twice daily was commenced at follow-up, and the patient was referred for consideration of low-dose topical oestrogen for genitourinary syndrome of menopause.&lt;/p&gt;&lt;p&gt;Gluteal erysipelas accounts for fewer than 1% of cases of erysipelas. Besides streptococci, &lt;i&gt;Staphylococcus aureus&lt;/i&gt; and Gram-negative bacteria are occasionally responsible. The classical presentation is a circumscribed, fiery-red plaque in a butterfly-like distribution over the buttocks. Lesions pass through violaceous and bruise-like stages as they resolve with antibiotic therapy. Predisposing factors are divided into local (lymphoedema, immobility, trauma, surgery, vaginal or anorectal streptococcal colonisation) and systemic (immunosuppression, obesity, metabolic syndrome, alcohol use disorder) [&lt;span&gt;2-4&lt;/span&gt;]. Group B and C/G streptococci have a predilection for the buttocks, with most cases occurring in females, and vaginal colonisation may be the common factor [&lt;span&gt;2&lt;/span&gt;]. Multiple recurrences occur in one-third of patients, with cumulative lymphatic injury, impaire","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 2","pages":"e65-e66"},"PeriodicalIF":2.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Lichen Sclerosus in Phimosis: Insights From a Multidisciplinary Retrospective Study","authors":"Stefano Bighetti,&nbsp;Stefano Mancon,&nbsp;Nazareno Suardi,&nbsp;Piergiacomo Calzavara-Pinton,&nbsp;Vincenzo Maione,&nbsp;Mariachiara Arisi,&nbsp;Giovanni Lughezzani,&nbsp;Nicola Zerbinati,&nbsp;Iacopo Ghini,&nbsp;Luca Bettolini","doi":"10.1111/ajd.14417","DOIUrl":"10.1111/ajd.14417","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to evaluate the prevalence of lichen sclerosus (LS) in male patients undergoing circumcision for phimosis, emphasising the significance of a multidisciplinary approach in the early diagnosis and management of this condition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis was performed on 841 male patients who underwent circumcision at a high-volume medical centre between 2001 and 2023. Data were collected on clinical diagnoses made by both dermatologists and urologists, along with the corresponding histological findings. Logistic regression models were utilised to assess diagnostic accuracy and the relationship between clinical suspicion and histological confirmation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Histological confirmation of LS was identified in 30.6% of the cases. Dermatologists demonstrated a diagnostic accuracy of 81.8%, whereas urologists showed an accuracy of 46.1%. The evaluations conducted by dermatologists exhibited a significant correlation with histological confirmation of LS (odds ratio 4.81; 95% confidence interval: 1.96–11.80; <i>p</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study elucidates the differences in diagnostic accuracy between dermatologists and urologists in identifying LS in patients undergoing circumcision for phimosis, highlighting the necessity of a multidisciplinary approach to improve the diagnostic process. Furthermore, the epidemiological data obtained from this research offer valuable insights into the prevalence of LS and the associated diagnostic challenges within a substantial patient cohort.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 2","pages":"e39-e42"},"PeriodicalIF":2.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopy of Primary Cutaneous B-Cell Lymphoma: A Systematic Review","authors":"Ioannis-Alexios Koumprentziotis,&nbsp;Efthymia Asimakopoulou,&nbsp;Konstantinos Liopyris,&nbsp;Alexander Stratigos,&nbsp;Vasiliki Nikolaou","doi":"10.1111/ajd.14416","DOIUrl":"10.1111/ajd.14416","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 2","pages":"e52-e59"},"PeriodicalIF":2.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of a Case of Scleromyxedema With Intravenous Immunoglobulin and Thalidomide and a Two-and-a-Half-Year Follow-Up","authors":"Deepak Kumar Sahu,&nbsp;Biswanath Behera,&nbsp;Siddhartha Dash,&nbsp;Pavithra Ayyanar,&nbsp;Priyanka Sangwan","doi":"10.1111/ajd.14413","DOIUrl":"10.1111/ajd.14413","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 2","pages":"e62-e64"},"PeriodicalIF":2.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of a Real-Time PCR Assay for the Detection of Dermatophytosis by Sampling With an Adhesive Tape Technique","authors":"Sophie Walter,&nbsp;Dedee F. Murrell,&nbsp;Ryanbi Pratama,&nbsp;Alice E. Kizny Gordon,&nbsp;Christopher J. McIver","doi":"10.1111/ajd.14415","DOIUrl":"10.1111/ajd.14415","url":null,"abstract":"&lt;p&gt;Dermatophytosis is a very common fungal infection [&lt;span&gt;1&lt;/span&gt;]. Prompt and accurate diagnosis utilising newer technologies [&lt;span&gt;2, 3&lt;/span&gt;] may facilitate early commencement of suitable treatment. We previously reported the development and validation of a real-time polymerase chain reaction (RT-PCR) assay targeting the chitin-synthase 1 gene (CHS-1) specific for common dermatophytes, including species of the &lt;i&gt;Microsporum&lt;/i&gt;, &lt;i&gt;Epidermophyton&lt;/i&gt; and &lt;i&gt;Trichophyton&lt;/i&gt; genera [&lt;span&gt;4&lt;/span&gt;]. Since implementation, this assay has been efficacious in screening clinical samples for dermatophytes and for early detection (i.e., &lt; 6 weeks) in filamentous cultures. However, the assay was limited in its ability to detect &lt;i&gt;Microsporum canis&lt;/i&gt; due to the inefficient binding of the primers and probe used in the PCR assay [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Also developed was an adhesive tape sampling technique to facilitate the collection of genomic material for the RT-PCR assay and circumvent practical issues that can be associated with traditional use of scalpel blades and clippers (e.g., operator injury, patient antipathy to ‘sharps’, suitability of the infected site) [&lt;span&gt;5&lt;/span&gt;]. Adhesive tape strips have been used in dermatology research as a minimally invasive technique for epidermal transcriptomics and proteomics, particularly in atopic dermatitis [&lt;span&gt;6-9&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In our initial study of 16 patients, the RT-PCR results for the adhesive tape impressions correlated with those obtained by microscopy and culture [&lt;span&gt;4&lt;/span&gt;]. Here, we report an assessment of the utility of the RT-PCR assay for detection of dermatophyte CHS-1 gene on adhesive tape impressions of lesions undertaken from April 2018 to February 2024 (approximately 5.8 years). Impressions were taken from 308 lesions located on a variety of specified anatomical sites (274 lesions) and unspecified sites (34 lesions) in patients attending dermatology clinics at a tertiary teaching hospital and an academic private practice in Australia (Appendix S1). Using fungal culture results as the reference standard, the sensitivity and specificity were calculated for RT-PCR assay alone, microscopic detection of fungal elements alone, and when both methods were used (Table 1).&lt;/p&gt;&lt;p&gt;Fifty-two dermatophyte strains were cultured from 308 samples (16.9%). The most common strain cultured was &lt;i&gt;Trichophyton rubrum&lt;/i&gt; (&lt;i&gt;n&lt;/i&gt; = 25), followed by &lt;i&gt;Trichophyton tonsurans&lt;/i&gt; (&lt;i&gt;n&lt;/i&gt; = 11), &lt;i&gt;Trichophyton&lt;/i&gt; sp. (&lt;i&gt;n&lt;/i&gt; = 8), &lt;i&gt;Trichophyton mentagrophytes&lt;/i&gt; (&lt;i&gt;n&lt;/i&gt; = 5), &lt;i&gt;Microsporum canis&lt;/i&gt; (&lt;i&gt;n&lt;/i&gt; = 2) and &lt;i&gt;Epidermophyton floccosum&lt;/i&gt; (&lt;i&gt;n&lt;/i&gt; = 1). Among the dermatophytes isolated, 46 of 52 (88.5%) were RT-PCR positive (Appendix S1). The remaining six RT-PCR negative isolates included &lt;i&gt;Trichophyton rubrum&lt;/i&gt; (&lt;i&gt;n&lt;/i&gt; = 2), &lt;i&gt;Trichophyton tonsurans&lt;/i&gt; (&lt;i&gt;n&lt;/i&gt; = 1), &lt;i&gt;Trichophyton&lt;/i&gt; sp. (&lt;i&gt;n&lt;/i&gt; = 1) and &lt;i&gt;Microsporum canis&lt;/i&gt; (&lt;i&gt;n&lt;/i&gt; = 2). As men","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 2","pages":"e60-e61"},"PeriodicalIF":2.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14415","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing the Use of Shave Biopsy for Lesions Suspicious of Melanoma in Australia: An Exploratory Mixed-Methods Study","authors":"Daniel Lindsay,&nbsp;Louisa G. Collins,&nbsp;Catherine M. Olsen,&nbsp;Nirmala Pandeya,&nbsp;David C. Whiteman,&nbsp;Luke Bookallil,&nbsp;Andrea McMurtrie,&nbsp;Lena von Schuckmann","doi":"10.1111/ajd.14411","DOIUrl":"10.1111/ajd.14411","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Recent Australian trends indicate that shave biopsies for diagnosing lesions suspicious of melanoma are increasing, yet reasons for this remain relatively unknown. We sought to understand which factors influence Australian clinicians' use of shave biopsy for managing thin lesions suspicious of melanoma in sites of low cosmetic sensitivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used a convergent, exploratory mixed-methods design, with a cross-sectional online survey (<i>n</i> = 59) and semi-structured qualitative interviews (<i>n</i> = 15). We recruited clinicians working in skin cancer medicine across Australia, mostly general practitioners (&gt; 80%) with some dermatologists (<i>n</i> = 7 survey and <i>n</i> = 1 interview participant). Survey participants indicated how frequently they used shave biopsies and rated the importance of factors when considering the use of a shave biopsy. Interview participants elaborated on the motivating factors for using different biopsy techniques. Qualitative data were professionally transcribed and analysed with content analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Most survey participants (95%) reported that identifying fewer signs of locally advanced melanoma was ‘very important’ for using shave biopsy. Fifty per cent of survey participants also reported that faster procedure speed and greater convenience were ‘very important’ reasons for using shave biopsy. Procedure speed was particularly important for using shave biopsy among clinicians self-identifying as time-poor. Interview participants noted (a) the risk of transecting the lesion base or (b) incomplete lesion removal from shave biopsies as reasons against their use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The relative speed and convenience of shave biopsies in clinical practice are strong motivators for their use. Further evidence on patient outcomes with widespread use of shave biopsy is required to inform clinical guidelines.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 1","pages":"e1-e9"},"PeriodicalIF":2.2,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy and Safety of Non-Biologic and Biologic Treatments in Palmoplantar Pustular Psoriasis and Palmoplantar Pustulosis: A Systematic Review and Network Meta-Analysis","authors":"Khalid M. Alshareef,&nbsp;Amal H. Abualola,&nbsp;Esraa A. Shaheen,&nbsp;Abdulaziz A. Aljuaid,&nbsp;Faisl Alshibi,&nbsp;Renad Kalantan,&nbsp;Bader Bashrahil,&nbsp;Dhaifallah H. Alghowairi,&nbsp;Awadh M. Alamri","doi":"10.1111/ajd.14410","DOIUrl":"10.1111/ajd.14410","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Palmoplantar pustular psoriasis (PPPP), or palmoplantar pustulosis (PPP), is a type of psoriasis that affects the skin on the palms and soles. It is characterised by dermatosis and small sterile pustules and is considered a significant burden on patients' quality of life, as there is currently no gold standard treatment or cure. This network meta-analysis (NMA) compares the efficacy and safety of biologic and non-biologic medications for PPPP and PPP. Medline, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched. The efficacy and safety of all medications were assessed through a frequentist NMA using a random-effects model. Treatments were ranked using the net rank function, yielding P scores. Fourteen RCTs with 1056 participants were included. Guselkumab 100 mg was the most effective for improving PPPGA scores (<i>p</i> = 0.72, RR = 1.31, CI: 0.31–5.57). Guselkumab 100 mg was ranked the highest for achieving PPPASI-75 (RR = 5.4, CI: 1.26–23.2, <i>p</i> = 0.023). Oral cyclosporine 1 mg/kg/day was ranked the highest for PPPASI-50 (RR = 2.10, CI: 0.65–6.82). Etretinate 1 mg/kg/day had the highest rate of adverse events (RR = 1.78, CI: 0.92–3.44). Secukinumab 300 mg was associated with the highest rate of serious adverse events (RR = 1.58, CI: 0.21–12.02). Based on the P-scores from our NMA, guselkumab 100 mg was the most effective for PPPGA improvement, guselkumab 100 mg for PPPASI-75, oral cyclosporine 1 mg/kg/day for PPPASI-50, etretinate 1 mg/kg/day had the most adverse events, and secukinumab 300 mg was associated with the highest rate of serious adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>PROSPERO registration number: CRD42023460842</p>\u0000 </section>\u0000 </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 2","pages":"53-60"},"PeriodicalIF":2.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Predictors of Biological Therapy Intensification in Moderate-To-Severe Hidradenitis Suppurativa: A Multicentre Study","authors":"Francisco Javier Melgosa Ramos,&nbsp;Ramón García Ruiz,&nbsp;Antonio Martorell","doi":"10.1111/ajd.14412","DOIUrl":"10.1111/ajd.14412","url":null,"abstract":"<div>\u0000 \u0000 <p>Moderate-to-severe hidradenitis suppurativa (HS) is a debilitating disease that often requires biological therapy. Despite the effectiveness of approved doses, some patients experience partial or loss of response over time, leading to the need for dose intensification. This retrospective multicentre study aimed to identify predictors of biological therapy intensification in HS patients. The results showed that prior use of biological treatments and biosimilar adalimumab were significant predictors of intensification, suggesting closer monitoring may be needed for certain patient profiles to optimise treatment outcomes.</p>\u0000 </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 2","pages":"e35-e38"},"PeriodicalIF":2.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}