Australasian Journal of Dermatology最新文献

{"title":"From Monotherapy to Adjunctive Therapies: Application of Dermocosmetics in Acne Management Across Australia and New Zealand.","authors":"Ryan De Cruz, Rebecca Nguyen, Peggy Chen, Delphine Kerob, Kurt Gebauer, Anneliese Willems, Philip Tong, Michael Lee","doi":"10.1111/ajd.14447","DOIUrl":"https://doi.org/10.1111/ajd.14447","url":null,"abstract":"<p><p>Acne vulgaris is a globally prevalent dermatological disease, with its severity ranging from mild to severe. While moderate to severe acne often requires topical or systemic pharmaceutical therapy, mild to moderate acne may be managed with dermocosmetics, which are over-the-counter skincare agents with active ingredients that target acne pathophysiology. Dermocosmetics can also be effective as adjunct therapy for the management of more severe acne. For example, they can be used to complement the mode of action of pharmaceuticals or to mitigate side effects and improve treatment compliance. This review discusses the roles of commonly available dermocosmetics in the context of both mild and severe acne management protocols.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Compound Heterozygous Mutations in ILNEB Syndrome","authors":"Hannah Wu,&nbsp;Khiem A. Tran,&nbsp;Lauren Gawey,&nbsp;Madison Stokes,&nbsp;Joshua Hekmatjah,&nbsp;Jay Kincannon","doi":"10.1111/ajd.14443","DOIUrl":"10.1111/ajd.14443","url":null,"abstract":"<div>\u0000 \u0000 <p>Interstitial Lung, Nephrotic Syndrome and Epidermolysis Bullosa (ILNEB) is a rare autosomal recessive genetic syndrome caused by mutations in <i>ITGA3</i>. This gene encodes the three subunit of integrin 3β1, which plays an important role in the structure and function of keratinocytes. We analysed compound heterozygous mutations in a patient, observing clinical features that mirrored some but not all previously reported ILNEB cases. These findings suggested that the mutations in this patient shared a common loss-of-function mechanism. This case expands the current understanding of the genotype–phenotype correlations in ILNEB.</p>\u0000 </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 3","pages":"e167-e170"},"PeriodicalIF":2.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmental Congenital Vascular Anomaly With Atrophy, Ulceration and Scarring With Complications in Pregnancy","authors":"Anne R. Halbert,&nbsp;AmyLeigh Hall,&nbsp;Cathryn Poulton","doi":"10.1111/ajd.14441","DOIUrl":"10.1111/ajd.14441","url":null,"abstract":"<p>A 33-year-old woman with a segmental non-involuting congenital vascular anomaly of the left neck developed pain and ulceration in pregnancy and left-sided Horner's syndrome after delivery. Mutational analysis of affected tissue showed a missense mutation in <i>GNA11</i> (Glu209) and a second mutation in <i>PIK3CA</i>. Sirolimus therapy resulted in healing of the ulceration and resolution of the Horner's syndrome.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 3","pages":"e160-e162"},"PeriodicalIF":2.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#Acne: A Thematic Qualitative Analysis of Acne Content on TikTok","authors":"Laxmi Iyengar,&nbsp;Susan Saldanha,&nbsp;Alvin H. Chong","doi":"10.1111/ajd.14433","DOIUrl":"10.1111/ajd.14433","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>TikTok has accrued over 3 million posts and 129 billion views under #acne, establishing itself as a popular platform amongst adolescents to access health information. We conducted an in-depth thematic analysis of acne videos on TikTok to determine how adolescents engage with acne content.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The top 150 consecutive videos under #acne on TikTok were subjected to rigorous qualitative analysis by experienced researchers (Laxmi Iyengar, Susan Saldanha) until data saturation was reached, guided by SRQR (Standards for Reporting Qualitative Research) guidelines. Five themes were identified:(1) Pimple popping, (2) Acne education, (3) ‘Acne transformation’ depicting treatment success stories, (4) Acne positivity, normalising acne and (5) Acne reality, capturing the lived experience of acne.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, the top 150 videos under #acne accumulated almost 2 billion views and 102 million followers. The majority of acne content was uploaded by females (125/150; 84%). Medically trained clinicians represented only 11% of the content (17/150). Pimple-popping videos attracted the most significant viewership (804 million views; 44%; 17% of content) despite having a lower proportion of content than acne education videos, uploaded by patients and clinicians (324 million views; 34% of content). These videos included dietary hacks, miracle cures and narratives that antagonised the medical treatments. Acne reality videos demonstrating the mental health burden of acne were the least popular amongst TikTok viewers (79 million views; 4% of content).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Thematic qualitative research of acne on TikTok bridges the gap between clinical expertise and the lived experiences of those navigating acne in the digital age. Based on the results of the study, strategies are proposed for dermatologists to engage in the TikTok platform on the topic of acne, including medicolegal precautions. Given the lack of content credibility on social media, this research urges dermatologists to redefine healthy skin care practices based on evidence-based principles.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 3","pages":"127-134"},"PeriodicalIF":2.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Benign Adnexal Tumours With Mohs Micrographic Surgery: An Australian Retrospective Analysis","authors":"Alain Tran,&nbsp;Lucinda Liu,&nbsp;Anjana Prabu,&nbsp;Sonya Odhavji,&nbsp;Tim Rutherford","doi":"10.1111/ajd.14442","DOIUrl":"10.1111/ajd.14442","url":null,"abstract":"<div>\u0000 \u0000 <p>Benign adnexal tumours are characterised by slow growth; however, they can cause significant patient morbidity due to their predilection for the face and potential for disfigurement. We present a series of cases treated with Mohs micrographic surgery to reinforce the existing data that these tumours can be sub-clinically extensive and draw attention to their ability to invade both widely and deeply.</p>\u0000 </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 3","pages":"e163-e166"},"PeriodicalIF":2.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143498112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Sweet's Syndrome Presenting With Tongue Ulcerations","authors":"Olga Pawlik,&nbsp;Timothy Cowan,&nbsp;Andrew Miller","doi":"10.1111/ajd.14422","DOIUrl":"10.1111/ajd.14422","url":null,"abstract":"<p>We describe the case of an 87-year-old woman who developed Sweet's syndrome with atypical mucosal involvement following a post-operative wound infection. The disease manifestations included two large, ulcerated plaques on both sides of the tongue as well as cutaneous lesions. Her lesions resolved promptly with oral prednisolone.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 2","pages":"e43-e45"},"PeriodicalIF":2.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143498084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric Hypotrichosis: A Clinical and Algorithmic Approach to Diagnosis","authors":"Neda So,&nbsp;Leona Yip,&nbsp;David Orchard","doi":"10.1111/ajd.14429","DOIUrl":"10.1111/ajd.14429","url":null,"abstract":"<p>Paediatric hypotrichosis is the clinical feature of paucity of hair arising congenitally or in early life with the presentation being that of the child whose hair is growing insufficiently. It is a hallmark finding of a diverse group of genodermatoses and sporadic disorders, presenting as either an isolated symptom or in association with syndromic features. Hypotrichoses are rare, with numerous possible differentials requiring a thorough clinical assessment, additional investigations for hair shaft abnormalities and occasionally genetic counselling to reach a diagnosis. We propose a clinical algorithm for the investigation and diagnosis of paediatric hypotrichosis, designed to aid the clinician by utilising key clinical findings in conjunction with the forced hair pull test and trichoscopy to differentiate groups of hair shaft and hair loss disorders. We also discuss in further detail the pathogenesis, phenotypical features and microscopy findings of various types of hypotrichosis.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 3","pages":"e109-e119"},"PeriodicalIF":2.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajd.14429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Cardiovascular Outcomes in the Psoriasis Cohort. Psoriasis and Cardiovascular Disease-Clinician Knowledge, Practice and Perceptions.","authors":"Annika Smith, Belinda Lai, Sarah Zaman, Peter Wong, Fiona Foo, Katy J L Bell, Pablo Fernandez-Penas, Clara K Chow","doi":"10.1111/ajd.14436","DOIUrl":"https://doi.org/10.1111/ajd.14436","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is a risk factor for cardiovascular disease (CVD). This risk is independent and incremental to traditional cardiovascular (CV) risk factors, but clinician and patient perspectives on this risk are unclear. This study aims to assess the knowledge, perceptions, and practice of clinicians and patients with respect to psoriasis and CVD.</p><p><strong>Methods: </strong>This cross-sectional study consisted of a self-administered questionnaire capturing demographic characteristics, knowledge of the association between psoriasis and CVD, and perspectives on CV screening and management. This was distributed to members of relevant Australasian Speciality Medical Colleges, speciality societies, and psoriasis patients in public and private clinic settings. Survey data were assessed using descriptive statistics. Logistic regression was used to investigate the relationship between categorical variables and the outcome variable, for example, to determine factors predictive of clinician knowledge and perceptions. For all analyses, a p-value of less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>A total of 298 clinicians (dermatologists (86), rheumatologists (56), cardiologists (53), general practitioners (103)) and 102 patients with psoriasis were surveyed. Regarding clinician knowledge of the association between psoriasis and CVD, dermatologists and rheumatologists indicated knowledge of this association (98.8%) (85/96) and 91.1% (51/56) respectively, while only 54.7% (29/53) of cardiologists and 29.1% (30/103) of GPs indicated knowledge of this association. Only 23.5% (24/102) of patients surveyed indicated knowledge of this association. Clinicians with a higher proportion of their caseload including psoriasis patients were significantly more likely to be aware of the association between psoriasis and CVD (OR 3.05 [1.64, 5.68]; p < 0.001). Most clinicians nominated GPs as best placed to facilitate CV risk factor screening and management (dermatologists 80.2% (69/86); rheumatologists 83.9% (47/56); cardiologists 75.5% (40/53); GPs 88.3% (91/103)). Patients preferred specialist input and multidisciplinary care for CVD risk management; 34.3% (35/102) nominated a cardiologist as the preferred clinician, and 23.5% (24/102) indicated preference for a multidisciplinary team.</p><p><strong>Limitations: </strong>The possibility of sampling and response bias, inherent in the study design, is acknowledged; however, responses are likely representative of clinician and patient sentiments on this issue and in keeping with similar study findings.</p><p><strong>Conclusion: </strong>Clinician and patient knowledge of the relationship between psoriasis and CVD needs to be improved. The establishment of a national consensus approach to address this gap in clinical care is needed.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution of Severe Hidradenitis Suppurativa Following Kidney Transplantation","authors":"Kerem Balan,&nbsp;Neslihan Akdogan,&nbsp;Guldehan Haberal,&nbsp;Seref Rahmi Yılmaz","doi":"10.1111/ajd.14437","DOIUrl":"10.1111/ajd.14437","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 3","pages":"178-179"},"PeriodicalIF":2.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pellagra and Scurvy in a Patient With Relapsed Schizophrenia","authors":"Vanessa Tran,&nbsp;Andrew Awad,&nbsp;Laura Scardamaglia,&nbsp;Gayle Ross","doi":"10.1111/ajd.14438","DOIUrl":"10.1111/ajd.14438","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 3","pages":"180-182"},"PeriodicalIF":2.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}