Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)最新文献_第6页

Sex and race effects on risk for selected outcomes among elderly HIV-infected patients. 性别和种族对老年艾滋病毒感染患者某些结局风险的影响

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-04-25 DOI: 10.1177/1545109711404947

Maria Frontini, Jigar Chotalia, Lauren Spizale, Wilfred Onya, Marco Ruiz, Rebecca A Clark

引用次数: 7

Impact of a psychoeducative intervention on adherence to HAART among low-literacy patients in a resource-limited setting: the case of an Arab country--Morocco. 在资源有限的情况下，心理教育干预对低识字率患者坚持HAART治疗的影响:以阿拉伯国家摩洛哥为例

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-04-18 DOI: 10.1177/1545109710397891

Imane Khachani, Hicham Harmouche, Wafa Ammouri, Fatima Rhoufrani, Latifa Zerouali, Redouane Abouqal, Zoubida Tazi-Mezalek, Mohamed Adnaoui, Mohamed Aouni, Abdelaziz Maouni

{"title":"Impact of a psychoeducative intervention on adherence to HAART among low-literacy patients in a resource-limited setting: the case of an Arab country--Morocco.","authors":"Imane Khachani, Hicham Harmouche, Wafa Ammouri, Fatima Rhoufrani, Latifa Zerouali, Redouane Abouqal, Zoubida Tazi-Mezalek, Mohamed Adnaoui, Mohamed Aouni, Abdelaziz Maouni","doi":"10.1177/1545109710397891","DOIUrl":"https://doi.org/10.1177/1545109710397891","url":null,"abstract":"Research has demonstrated that strict adherence is necessary to maximize highly active antiretroviral therapy (HAART) benefits. This is particularly challenging for low-literacy populations in resource-limited settings like Morocco and motivated the implementation of a psychoeducative program for patients under HAART at Rabat University Hospital. The study aimed at assessing the program's impact on adherence to antiretroviral medication, knowledge of HIV/AIDS and HAART, quality of life, and biological parameters. It included patients under treatment for at least 2 months that benefited from 3 to 5 educational and psychological support sessions. Data were collected at baseline, 3 and 6 months. In all, 50 patients were included. The mean age was 38 years; 52% were illiterate and 62% unemployed. Adherence scores were high at baseline (98%) and showed no significant change throughout the study. Knowledge of HAART and HIV/AIDS, and quality of life improved significantly both at months 3 and 6. Significant increase for CD4 count rates and decrease for viral load rates were also reported. The program had no significant impact on adherence but substantively developed patients' knowledge of HIV/AIDS and HAART and improved their quality of life.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 1","pages":"47-56"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109710397891","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29822900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Prevalence of asymptomatic bacterial sexually transmitted infections in hospitalized HIV patients in Baltimore City. 巴尔的摩市住院HIV患者无症状细菌性传播感染的流行情况

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-08-29 DOI: 10.1177/1545109711418509

Aimee Hodowanec, Seema Nayak, Manhattan Charurat, Leroy Vaughan, Mettassebia Kanno, Lori Fantry

{"title":"Prevalence of asymptomatic bacterial sexually transmitted infections in hospitalized HIV patients in Baltimore City.","authors":"Aimee Hodowanec, Seema Nayak, Manhattan Charurat, Leroy Vaughan, Mettassebia Kanno, Lori Fantry","doi":"10.1177/1545109711418509","DOIUrl":"https://doi.org/10.1177/1545109711418509","url":null,"abstract":"Sexually transmitted infections (STIs) are known to promote the transmission of HIV. Diagnosing these infections can identify patients engaging in high-risk behaviors and provides an opportunity for intervention and education. The Centers for Disease Control and Prevention (CDC) recommends STI screening as part of routine HIV care. Ninety HIV-infected inpatients admitted to the University of Maryland Hospital were screened for gonorrhea, chlamydia, and syphilis. None of the nucleic acid amplification probes were positive for gonorrhea, and 1 was positive for chlamydia. A total of 8 rapid plasma reagin (RPR) tests were positive, 2 of which are believed to be associated with new infection or treatment failure. Rapid plasma reagin positivity was found to be associated with men who have sex with men (MSM), low CD4 count, and high HIV viral load. Routine inpatient screening for asymptomatic STIs in HIV-infected patients may be beneficial, particularly patients not engaged in routine outpatient care.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 1","pages":"16-9"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711418509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30108018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-09-20 DOI: 10.1177/1545109711420875

Victoire de Lastours, Juliette Pavie, Constance Delaugerre, Jean-Michel Molina

{"title":"AIDS-related Kaposi's sarcoma can occur during peginterferon-α and ribavirin therapy for chronic hepatitis C infection.","authors":"Victoire de Lastours, Juliette Pavie, Constance Delaugerre, Jean-Michel Molina","doi":"10.1177/1545109711420875","DOIUrl":"https://doi.org/10.1177/1545109711420875","url":null,"abstract":"Introduction: Before the arrival of highly active antiretroviral therapy (HAART), interferon α has been used successfully to treat AIDS-related Kaposi's sarcoma (KS). Peginterferon-α (pegIFN-α) may still be used successfully in refractory KS.Case: Peginterferon-α and ribavirin (RBV) were initiated to treat hepatitis C virus (HCV) infection in an HIV-infected patient with high CD4 counts having discontinued antiretroviral therapy (ART). He developed disseminated KS 6 months after HCV treatment began. Beginning of ART, discontinuation of pegIFN/RBV, and 2 cycles of doxorubicine were necessary to treat KS.Discussion: Despite its activity on KS, thanks to its antiviral and antiangiogenic properties, PegIFN was unable to prevent the occurrence of severe KS. The absence of ART, despite high CD4 counts, and interferon-induced lymphopenia probably triggered the occurrence of KS in this patient.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 1","pages":"9-11"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711420875","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30154580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poorer ART outcomes with increasing age at a large public sector HIV clinic in Johannesburg, South Africa. 在南非约翰内斯堡的一家大型公共艾滋病诊所，随着年龄的增长，抗逆转录病毒治疗的效果越来越差。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-09-27 DOI: 10.1177/1545109711421641

Mhairi Maskew, Alana T Brennan, A Patrick MacPhail, Ian M Sanne, Matthew P Fox

{"title":"Poorer ART outcomes with increasing age at a large public sector HIV clinic in Johannesburg, South Africa.","authors":"Mhairi Maskew, Alana T Brennan, A Patrick MacPhail, Ian M Sanne, Matthew P Fox","doi":"10.1177/1545109711421641","DOIUrl":"10.1177/1545109711421641","url":null,"abstract":"Background: As the current HIV-positive population ages, the absolute number of patients >50 years on treatment is increasing.Methods: We analyze the differences in treatment outcomes by age category (18-29, 30-39, 40-49, 50-59, and ≥ 60) among 9139 HIV-positive adults initiating ART in South Africa.Results: The adjusted hazard ratios (HRs) for all-cause mortality increased with increasing age, with the strongest association in the first 12 months of follow-up among patients 50 to 59 years (HR 1.67; 95% confidence interval [CI]: 1.24-2.23) versus those <30 years. However, patients 50 to 59 years were less likely to be lost during 24 months on antiretroviral therapy ([ART] HR 0.75; 95% CI: 0.59-0.94) versus patients <30 years. By 6 and 12 months on treatment, older patients were less likely to increase their CD4 count by ≥ 50 cells/mm(3).Conclusion: Although older patients are at higher risk of mortality and have poorer immunological responses than their younger counterparts, they are more likely to adhere to care and treatment in the first 24 months on ART.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 1","pages":"57-65"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30169477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension is common among HIV-infected persons, but not associated with HAART. 高血压在艾滋病毒感染者中很常见，但与HAART疗法无关。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-08-29 DOI: 10.1177/1545109711418361

Sheila Medina-Torne, Anuradha Ganesan, Irma Barahona, Nancy F Crum-Cianflone

{"title":"Hypertension is common among HIV-infected persons, but not associated with HAART.","authors":"Sheila Medina-Torne, Anuradha Ganesan, Irma Barahona, Nancy F Crum-Cianflone","doi":"10.1177/1545109711418361","DOIUrl":"https://doi.org/10.1177/1545109711418361","url":null,"abstract":"Background: With improved survival after the introduction of highly active antiretroviral therapy (HAART), non-AIDS-related morbidity and mortality have come to the forefront in the management of HIV patients. HAART has been linked to the development of several risk factors for cardiovascular disease including insulin resistance and hyperlipidemia, but its influence on hypertension requires further study.Methods: We performed a cross-sectional study of HIV-infected persons at two large HIV clinics to evaluate the prevalence and factors associated with hypertension. Hypertension was defined by at least two blood pressure measurements >140/90 mmHg or the use of an antihypertensive medication. Statistical analyses included multivariate logistic regression models.Results: We studied 707 HIV-infected adults with a median age of 41 years (IQR 36-46), 92% were male, 49% were Caucasian, and 72% were receiving HAART. The overall prevalence of hypertension was 31% and was similar among those receiving and not receiving HAART (32% vs. 29%, p = 0.47). Factors associated with hypertension in the multivariate model included increasing age, longer duration of HIV, higher body mass index, and diabetes, with a trend for African American ethnicity.Conclusions: Hypertension is common among HIV-infected persons and is associated with established risk factors, but not with HAART use. Given the high prevalence of hypertension and its association with duration of HIV infection, other factors such as virally-mediated endothelial changes or immune activation may play a role. Further investigations are needed.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 1","pages":"20-5"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711418361","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29963296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 100

Antiretroviral therapy initiation in France: adherence to national guidelines and outcome. 法国开始抗逆转录病毒治疗:遵守国家指南和结果。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-08-31 DOI: 10.1177/1545109711418362

Vatthanaphone Latthaphasavang, Marie-Anne Bouldouyre, Anne Rachline, Diane Ponscarme, Willy Rozenbaum, Jean-Yves Mary, Constance Delaugerre, Jean-Michel Molina

{"title":"Antiretroviral therapy initiation in France: adherence to national guidelines and outcome.","authors":"Vatthanaphone Latthaphasavang, Marie-Anne Bouldouyre, Anne Rachline, Diane Ponscarme, Willy Rozenbaum, Jean-Yves Mary, Constance Delaugerre, Jean-Michel Molina","doi":"10.1177/1545109711418362","DOIUrl":"https://doi.org/10.1177/1545109711418362","url":null,"abstract":"Objectives and methods: Retrospective study of all patients who started antiretroviral therapy (ART) in 2007 in a single center in Paris, with baseline characteristics and 1-year outcome, to assess adherence to national guidelines.Results: We analyzed 118 patients. Time of ART initiation was in agreement with the guidelines for only 64 (54.2%) patients. Fifty patients (42%) started ART with AIDS or a CD4 count <200 cells/mm(3). In all, 62 (52%) and 47 patients (40%) received a combination of 2 nucleoside analogues with efavirenz (EFV) and 1 ritonavir-boosted protease inhibitor (PI/r), respectively. Treatment regimens were in accordance with the guidelines for 114 patients (97%). At 1 year, 16 patients (13.5%) were lost to follow-up, only 5 (4.9%) experienced HIV disease progression or death, but 19 (18.6%) required hospitalization. Antiretroviral therapy was changed in 21 patients (21%). Ten patients (8.4%) experienced virologic failure.Conclusion: Antiretroviral therapy was in agreement with guidelines for the choice of combination but was often initiated too late.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 1","pages":"40-6"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711418362","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30110685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Adherence and preexisting major protease inhibitor resistance mutations are associated with virologic failure of a dual-class antiretroviral regimen with inhibitors of HIV-1 viral protease and integrase. 依从性和先前存在的主要蛋白酶抑制剂耐药突变与HIV-1病毒蛋白酶和整合酶抑制剂双类抗逆转录病毒治疗方案的病毒学失败有关。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-10-04 DOI: 10.1177/1545109711422124

Edward M Gardner, Andre G Melendez, Maria Astiz, Kimberly Bray

{"title":"Adherence and preexisting major protease inhibitor resistance mutations are associated with virologic failure of a dual-class antiretroviral regimen with inhibitors of HIV-1 viral protease and integrase.","authors":"Edward M Gardner, Andre G Melendez, Maria Astiz, Kimberly Bray","doi":"10.1177/1545109711422124","DOIUrl":"https://doi.org/10.1177/1545109711422124","url":null,"abstract":"Objectives: Novel treatment strategies are needed for treatment-experienced HIV-infected individuals. We retrospectively evaluated virologic outcomes on a dual-class, protease inhibitor (PI) plus raltegravir, antiretroviral (ARV) regimen.Methods: Virologic success was defined by a plasma HIV-RNA level ≤200 copies/mL. Adherence was measured using pharmacy refill data. The association between adherence and virologic failure was assessed using bivariate logistic regression.Results: In 39 individuals, median prior antiretroviral therapy (ART) exposure was 11 years. Of 39 individuals, 36 (92%) achieved an HIV-RNA ≤200 copies/mL. After a median follow-up of 328 days (interquartile range [IQR] 190-737 days), 74% maintained an HIV-RNA <200 copies/mL but only 44% had <50 copies/mL. Median adherence was 96.4% (IQR 83.3%-100%). For every 10% decrease in adherence, the odds of virologic failure increased by 90% (odds ratio [OR] = 1.9, 95% confidence interval [CI] 1.1-3.3). In all, 4 individuals had ≥2 preexisting major PI resistance mutations and all 4 had virologic failure.Conclusions: Most treatment-experienced individuals achieved virologic suppression on a dual-class regimen of a PI plus raltegravir. Success was limited by poor medication adherence and preexisting major PI resistance mutations.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 1","pages":"34-9"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711422124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30186904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Infant feeding options, other nonchemoprophylactic factors, and mother-to-child transmission of HIV in Zambia. 在赞比亚，婴儿喂养选择、其他非化学预防因素和艾滋病毒母婴传播。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-03-23 DOI: 10.1177/1545109710393308

Kwasi Torpey, Mushota Kabaso, Mark A Weaver, Prisca Kasonde, Victor Mukonka, Maximillian Bweupe, Jonathan Mukundu, Justin Mandala

{"title":"Infant feeding options, other nonchemoprophylactic factors, and mother-to-child transmission of HIV in Zambia.","authors":"Kwasi Torpey, Mushota Kabaso, Mark A Weaver, Prisca Kasonde, Victor Mukonka, Maximillian Bweupe, Jonathan Mukundu, Justin Mandala","doi":"10.1177/1545109710393308","DOIUrl":"https://doi.org/10.1177/1545109710393308","url":null,"abstract":"Background: The role of antiretroviral drugs in the prevention of mother-to-child transmission (PMTCT) of HIV is well known. The objective of this study is to explore how nonchemoprophylactic factors, including infant feeding practices, mother's HIV status disclosure, mode and place of delivery, infant gender, and maternal age, are related to MTCT.Methods: The study analyzed program data of DNA polymerase chain reaction (PCR) results from dried blood spot samples and selected client information from perinatally exposed infants aged 0 to 12 months.Results: A total of 8237 samples were analyzed. In all, 84% of the mothers ever breast-fed their children. In instances where both mother and baby received intervention, the transmission rates of HIV were higher among those who are still breast-feeding after 6 to 12 months. Disclosure, location, and mode of delivery did not have an effect on the transmission rates of HIV when both mother and baby received prophylaxis.Conclusion: Nonchemoprophylaxis factors, especially breast-feeding, play a key role in perinatal transmission of HIV.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 1","pages":"26-33"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109710393308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29763258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Alcohol, drugs, sexual behavior, and HIV in Trinidad and Tobago--the way forward. 特立尼达和多巴哥的酒精、毒品、性行为和艾滋病毒——前进的道路。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-08-04 DOI: 10.1177/1545109711416245

Sandra D Reid, Robert M Malow, Rhonda Rosenberg

引用次数: 16