Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)最新文献

Greater acceptance of routine HIV testing (opt-out) by patients attending an infectious disease unit in Spain. 在西班牙，在传染病科就诊的病人更接受常规艾滋病毒检测(选择退出)。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-11-01 Epub Date: 2012-09-10 DOI: 10.1177/1545109712456879

Francisco Jover-Diaz, Jose-Maria Cuadrado, Mariano Matarranz, Elena Calabuig

{"title":"Greater acceptance of routine HIV testing (opt-out) by patients attending an infectious disease unit in Spain.","authors":"Francisco Jover-Diaz, Jose-Maria Cuadrado, Mariano Matarranz, Elena Calabuig","doi":"10.1177/1545109712456879","DOIUrl":"https://doi.org/10.1177/1545109712456879","url":null,"abstract":"Objective: Our objective was to determine attitudes and opinions of patients seen in our ID Unit on conducting HIV testing universally. Methods: The survey was conducted in patients between 18 and 65 years without known HIV infection. Requested information about the test was previous embodiment, reasons for rejection, opinion on the universal realization, benefits and/or drawbacks, possible test performance, and availability of results “test negative stigma.” Results: We surveyed 91 patients (54.9% males). Surprisingly, up to 18.7% of patients mistakenly believed that HIV testing is routinely performed without consent. A great majority (98.9%) felt that universal performance on the test would benefit mainly in early diagnosing and/or preventing transmission. Patients younger than 42 years were significantly more prone to doing the test as a routine procedure. Only 4 (4.4%) patients did not participate because they believed they were “not infected.” A vast majority (80.5%) of respondents would prefer to have results within the first 24 hours. In addition, 20.7% would have a problem with confidentiality if HIV serology testing was done. Conclusions: In summary, the vast majority (95.6%) of the surveyed patients had a fair opinion about universal HIV testing. Only 4 patients (4.4%) would not consent to HIV testing (because of low-risk perception). Availability of rapid HIV tests can facilitate fast result delivery, facilitating linkage to care. Considering favorable patients' opinion, recent opt-out screening recommendations, highest HIV prevalence in admitted patients, and cost-effectiveness, studies favor universal HIV testing.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 6","pages":"341-4"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109712456879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30894715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Choosing sides: HIV health care practices among shared populations of HIV-positive Latinos living near the US-Mexico border. 选择立场:居住在美墨边境附近的艾滋病毒阳性拉丁裔共同人口中的艾滋病毒卫生保健实践。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-11-01 Epub Date: 2012-08-27 DOI: 10.1177/1545109712453854

Argentina E Servin, Fátima A Muñoz, Steffanie A Strathdee, Justine Kozo, María Luisa Zúñiga

{"title":"Choosing sides: HIV health care practices among shared populations of HIV-positive Latinos living near the US-Mexico border.","authors":"Argentina E Servin, Fátima A Muñoz, Steffanie A Strathdee, Justine Kozo, María Luisa Zúñiga","doi":"10.1177/1545109712453854","DOIUrl":"https://doi.org/10.1177/1545109712453854","url":null,"abstract":"Background: We compared HIV-positive patients receiving care in the border cities of San Diego, United States, with Tijuana, Mexico.Methods: Participants were HIV-positive Latinos (n = 233) receiving antiretroviral therapy (ART) from San Diego-Tijuana clinics (2009-2010). Logistic regression identified correlates of receiving HIV care in San Diego versus Tijuana.Results: Those with their most recent HIV visit in San Diego (59%) were more likely to be older, have at least a high school education, and were less likely to have been deported than those with last visits in Tijuana. Despite reporting better patient-provider relationships and less HIV-related stigma than those with visits in Tijuana, San Diego patients were twice as likely to make unsupervised changes in their ART regimen.Conclusions: We observed poorer relative adherence among HIV-positive Latinos receiving care in San Diego, despite reports of good clinical relationships. Further study is needed to ascertain underlying reasons to avoid ART-related resistance.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 6","pages":"348-55"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109712453854","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30866119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Cryptococcal antigen screening and preemptive therapy in patients initiating antiretroviral therapy in resource-limited settings: a proposed algorithm for clinical implementation. 在资源有限的情况下，对开始抗逆转录病毒治疗的患者进行隐球菌抗原筛查和先发制人治疗:一种用于临床实施的拟议算法。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-11-01 Epub Date: 2012-09-26 DOI: 10.1177/1545109712459077

Joseph N Jarvis, Nelesh Govender, Tom Chiller, Benjamin J Park, Nicky Longley, Graeme Meintjes, Linda-Gail Bekker, Robin Wood, Stephen D Lawn, Thomas S Harrison

{"title":"Cryptococcal antigen screening and preemptive therapy in patients initiating antiretroviral therapy in resource-limited settings: a proposed algorithm for clinical implementation.","authors":"Joseph N Jarvis, Nelesh Govender, Tom Chiller, Benjamin J Park, Nicky Longley, Graeme Meintjes, Linda-Gail Bekker, Robin Wood, Stephen D Lawn, Thomas S Harrison","doi":"10.1177/1545109712459077","DOIUrl":"https://doi.org/10.1177/1545109712459077","url":null,"abstract":"HIV-associated cryptococcal meningitis (CM) is estimated to cause over half a million deaths annually in Africa. Many of these deaths are preventable. Screening patients for subclinical cryptococcal infection at the time of entry into antiretroviral therapy programs using cryptococcal antigen (CRAG) immunoassays is highly effective in identifying patients at risk of developing CM, allowing these patients to then be targeted with \"preemptive\" therapy to prevent the development of severe disease. Such CRAG screening programs are currently being implemented in a number of countries; however, a strong evidence base and clear guidance on how to manage patients with subclinical cryptococcal infection identified by screening are lacking. We review the available evidence and propose a treatment algorithm for the management of patients with asymptomatic cryptococcal antigenemia.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 6","pages":"374-9"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109712459077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30936872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

Clinical characteristics of HIV-infected patients who survive after the diagnosis of HIV infection for more than 10 years in a resource-limited setting. 在资源有限的环境中，诊断为HIV感染后存活超过10年的HIV感染患者的临床特征

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-11-01 Epub Date: 2012-06-28 DOI: 10.1177/1545109712449191

Sasisopin Kiertiburanakul, Pawinee Luengroongroj, Somnuek Sungkanuparph

{"title":"Clinical characteristics of HIV-infected patients who survive after the diagnosis of HIV infection for more than 10 years in a resource-limited setting.","authors":"Sasisopin Kiertiburanakul, Pawinee Luengroongroj, Somnuek Sungkanuparph","doi":"10.1177/1545109712449191","DOIUrl":"https://doi.org/10.1177/1545109712449191","url":null,"abstract":"A retrospective cohort study was conducted and 129 patients with a diagnosis of HIV infection for more than 10 years were identified. Half the patients were men and mean (standard deviation, SD) age at HIV diagnosis was 33.2 (9.2) years. One third had a diagnosis of AIDS at cohort entry with median (interquartile range, IQR) CD4 counts of 259 (112-430) cells/mm(3). All received antiretroviral therapy with median (IQR) current CD4 counts of 502 (363-607) cells/mm(3) and 95% had HIV RNA <50 copies/mL. For adverse events, 28% experienced drug resistance, 27% experienced hospitalization, 59% had dyslipidemia, 35% had creatinine >1.0 mg/dL, and 5% had glucose >126 mg/dL. In conclusion, immunological and virological responses can be achieved among patients with a diagnosis of HIV infection for more than 10 years even in a resource-limited setting. Adverse events are common. Preparation for monitoring and management of these adverse events is a crucial part of successful long-term HIV care.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 6","pages":"361-5"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109712449191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30727100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Factors associated with false-positive results from fingerstick OraQuick ADVANCE rapid HIV 1/2 antibody test. 手指戳OraQuick ADVANCE快速HIV 1/2抗体检测假阳性结果的相关因素

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-11-01 Epub Date: 2012-09-26 DOI: 10.1177/1545109712454194

Samara B Rifkin, Lauren E Owens, Jeffrey L Greenwald

{"title":"Factors associated with false-positive results from fingerstick OraQuick ADVANCE rapid HIV 1/2 antibody test.","authors":"Samara B Rifkin, Lauren E Owens, Jeffrey L Greenwald","doi":"10.1177/1545109712454194","DOIUrl":"https://doi.org/10.1177/1545109712454194","url":null,"abstract":"Objective: Identify factors associated with false-positive rapid HIV antibody tests.Design: This retrospective cohort study with nested case-controls involved patients tested for HIV by Boston Medical Center (BMC) affiliates.Methods: Cases had a reactive fingerstick OraQuick ADVANCE rapid HIV 1/2 antibody test and a negative Western blot. Controls had nonreactive rapid tests. We compared the prevalence of HIV risk factors between cases and the total nonreactive population and the prevalence of other clinical factors between cases and controls.Results: Of the 15 094 tests, 14 937 (98.9%) were negative and 11 (0.07%) were false positives (specificity of 99.9%). Cases were more likely to have had an HIV-infected sex partner and to be tested at certain sites compared to true negatives. More cases than controls had O-negative blood type.Conclusion: O-negative blood type and sex with an HIV-infected person may increase false-positive HIV fingerstick results. More targeted studies should examine these risk factors.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 6","pages":"356-60"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109712454194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30935160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Demographic predictors of HIV serostatus among HIV counseling and testing clients in rural Nigeria. 尼日利亚农村艾滋病毒咨询和检测客户中艾滋病毒血清状况的人口统计学预测因素。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-11-01 Epub Date: 2012-08-08 DOI: 10.1177/1545109712454193

Oluyemisi A Akinwande, Prince U Ele, Usman I Gebi, Donald O Igboelina, Patrick S Dakum, Michael L Alkan

{"title":"Demographic predictors of HIV serostatus among HIV counseling and testing clients in rural Nigeria.","authors":"Oluyemisi A Akinwande, Prince U Ele, Usman I Gebi, Donald O Igboelina, Patrick S Dakum, Michael L Alkan","doi":"10.1177/1545109712454193","DOIUrl":"https://doi.org/10.1177/1545109712454193","url":null,"abstract":"Nnewi is a rural Nigerian town with a human immunodeficiency virus (HIV) counseling and testing center which tests about 120 clients/d. The objective of this study is to determine the factors predicting positive HIV status at Nnewi. Review of records was done with age, gender, marital status, and occupation as variables. Logistic regression analysis was used to identify factors linked to a positive HIV test. Overall HIV prevalence was 31.14%. Drivers and married clients had a high risk of being HIV+ (odds ratio [OR], 3.59; 95% confidence interval [CI], 2.17-5.96 and OR, 2.78; 95% CI, 2.42-3.19). Housewives were 2 times more likely to be positive (OR, 2.11; 95% CI, 1.35-3.29). After adjustment, females had 22% higher risk (OR, 1.22; 95% CI, 1.03-1.45) with the highest chance found in married females (OR, 6.70; 95% CI, 4.45-10.09). The study succeeded in panning out an unexpected risk group: married women. Drivers have been known to be a risk group. Preventive methods must be tailored to and acceptable by each risk group.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 6","pages":"366-8"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109712454193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30820988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thalidomide-associated thrombosis in the treatment of HIV-associated severe aphthous disease: a case report and review of the literature. 沙利度胺相关血栓在治疗hiv相关严重口疮疾病中的应用:一例报告和文献综述。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-11-01 Epub Date: 2012-08-27 DOI: 10.1177/1545109712455460

Aimee C Hodowanec, Alice Han, David E Barker, Paul G Rubinstein, Blake Max

{"title":"Thalidomide-associated thrombosis in the treatment of HIV-associated severe aphthous disease: a case report and review of the literature.","authors":"Aimee C Hodowanec, Alice Han, David E Barker, Paul G Rubinstein, Blake Max","doi":"10.1177/1545109712455460","DOIUrl":"https://doi.org/10.1177/1545109712455460","url":null,"abstract":"Venous thrombosis is a well-described complication of thalidomide therapy in patients with multiple myeloma (MM). However, an association between thalidomide use and thrombosis in HIV-positive patients has not been previously described. We present the case of a 48-year-old HIV-positive man who developed a deep venous thrombosis while on thalidomide for the treatment of severe aphthous ulcers. We review the management of severe aphthous disease and the potential adverse effects of thalidomide therapy. We examine the association between thalidomide and thrombosis in patients with MM and discuss how the same relationship may or may not exist in HIV-positive patients. Although the strength of the association between thalidomide use and thrombosis in HIV-positive patients being treated for aphthous disease remains unclear, HIV providers should be aware of the potential risk of thrombosis in all patients receiving thalidomide.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 6","pages":"345-7"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109712455460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30866118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Once-daily nevirapine XR: a brief overview of the safety and efficacy of a new formulation. 每日一次奈韦拉平XR:一种新制剂的安全性和有效性的简要概述。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-11-01 Epub Date: 2012-08-27 DOI: 10.1177/1545109712456427

Laveeza Bhatti, Jay Gladstein

{"title":"Once-daily nevirapine XR: a brief overview of the safety and efficacy of a new formulation.","authors":"Laveeza Bhatti, Jay Gladstein","doi":"10.1177/1545109712456427","DOIUrl":"https://doi.org/10.1177/1545109712456427","url":null,"abstract":"Nevirapine (NVP) was the first nonnucleoside reverse transcriptase inhibitor (NNRTI) approved by the US Food and Drug Administration (FDA) in 1996, for the treatment of HIV infection. Current treatment guidelines include NVP as a component of a recommended alternative NNRTI regimen, which may be the preferred regimen for patients with established cardiovascular risk factors since NVP has minimal untoward effects on serum lipids. Two randomized and controlled clinical trials established the noninferior virologic efficacy of twice-daily NVP versus ritonavir-boosted atazanavir (ATV/r), a protease inhibitor with limited effects on serum lipids, each drug on a background regimen of once-daily (QD) tenofovir (TDF)/emtricitabine (FTC). An extended-release (XR) formulation of NVP was developed since QD dosing and reduced pill burdens have been shown to improve regimen adherence. This formulation (Viramune XR 400 mg) was recently FDA approved based on the results of 2 randomized, controlled clinical trials. The XR formulation will provide additional treatment options for patients who may benefit from NVP-based regimens.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 6","pages":"369-73"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109712456427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30866122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evaluation of a multimodal, distance learning HIV management course for clinical care providers in India. 对印度临床护理提供者多模式远程学习艾滋病毒管理课程的评价。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-09-01 Epub Date: 2012-07-16 DOI: 10.1177/1545109712451330

Larry William Chang, Dileep B Kadam, Shashi Sangle, Shivakumar Narayanan, Rohidas T Borse, Jane McKenzie-White, Craig W Bowen, Stephen D Sisson, Robert C Bollinger

{"title":"Evaluation of a multimodal, distance learning HIV management course for clinical care providers in India.","authors":"Larry William Chang, Dileep B Kadam, Shashi Sangle, Shivakumar Narayanan, Rohidas T Borse, Jane McKenzie-White, Craig W Bowen, Stephen D Sisson, Robert C Bollinger","doi":"10.1177/1545109712451330","DOIUrl":"https://doi.org/10.1177/1545109712451330","url":null,"abstract":"Distance learning is an important tool for training HIV health workers. However, there is limited evidence on design and evaluation of distance learning HIV curricula and tools. We therefore designed, implemented, and evaluated a distance learning course on HIV management for clinical care providers in India. After course completion, participant scores rose significantly from a pretest (78.4% mean correct) compared with the posttest (87.5%, P < .001). After course completion, participants were more likely to be confident in starting an initial antiretroviral (ARV) regimen, understanding ARV toxicities, encouraging patient adherence, diagnosing immune reconstitution syndrome, and monitoring patients on ARV medications (P ≤ .05). All participants (100%) strongly agreed/agreed that they would recommend this course to others, and most of them (96%) strongly agreed/agreed that they would take a course in this format again. A pragmatic approach to HIV curriculum development and evaluation resulted in reliable learning outcomes, as well as learner satisfaction and improvement in knowledge.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 5","pages":"277-82"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109712451330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30766531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Vitamin D insufficiency and deficiency among HIV-1-infected patients in a tropical setting. 热带地区hiv -1感染患者的维生素D不足和缺乏

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-09-01 Epub Date: 2012-01-13 DOI: 10.1177/1545109711432142

Surasak Wiboonchutikul, Somnuek Sungkanuparph, Sasisopin Kiertiburanakul, La-or Chailurkit, Angkana Charoenyingwattana, Wittaya Wangsomboonsiri, Wasun Chantratita, Boonsong Ongphiphadhanakul

{"title":"Vitamin D insufficiency and deficiency among HIV-1-infected patients in a tropical setting.","authors":"Surasak Wiboonchutikul, Somnuek Sungkanuparph, Sasisopin Kiertiburanakul, La-or Chailurkit, Angkana Charoenyingwattana, Wittaya Wangsomboonsiri, Wasun Chantratita, Boonsong Ongphiphadhanakul","doi":"10.1177/1545109711432142","DOIUrl":"https://doi.org/10.1177/1545109711432142","url":null,"abstract":"Vitamin D plays role in bone health and the regulation of the immune system. A cross-sectional study of serum 25-hydroxyvitamin D (25[OH]D) levels was conducted among HIV-1-infected Thai patients to determine the prevalence and associated factors of low vitamin D levels (25[OH]D <30 ng/mL) in tropical setting. 25-Hydroxyvitamin D was measured by liquid chromatography/tandem mass spectrometry. Of 178 patients, 58% received antiretroviral therapy at median (interquartile range [IQR]) duration of 7.4 (5.9-8.5) years. The prevalence of 25(OH)D deficiency (<20 ng/mL) and insufficiency (20-29.9 ng/mL) was 26.8% and 44.9%, respectively. Multivariate analysis showed that receiving efavirenz (EFV) was significantly associated with low vitamin D status (odds ratio = 3.60; 95% confidence interval, 1.06-12.15, P <.05). The mean (±standard deviation) level of 25(OH)D in patients receiving and not receiving EFV was 22.9 (6.6) and 28.6 (10.7) ng/mL, respectively, (P <.05). Low vitamin D status is common and needs to be assessed among HIV-infected patients including tropical residents especially when EFV is used.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 5","pages":"305-10"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711432142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30387744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17