Infant feeding options, other nonchemoprophylactic factors, and mother-to-child transmission of HIV in Zambia.

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-03-23 DOI:10.1177/1545109710393308

Kwasi Torpey, Mushota Kabaso, Mark A Weaver, Prisca Kasonde, Victor Mukonka, Maximillian Bweupe, Jonathan Mukundu, Justin Mandala

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引用次数: 14

Abstract

Background: The role of antiretroviral drugs in the prevention of mother-to-child transmission (PMTCT) of HIV is well known. The objective of this study is to explore how nonchemoprophylactic factors, including infant feeding practices, mother's HIV status disclosure, mode and place of delivery, infant gender, and maternal age, are related to MTCT.

Methods: The study analyzed program data of DNA polymerase chain reaction (PCR) results from dried blood spot samples and selected client information from perinatally exposed infants aged 0 to 12 months.

Results: A total of 8237 samples were analyzed. In all, 84% of the mothers ever breast-fed their children. In instances where both mother and baby received intervention, the transmission rates of HIV were higher among those who are still breast-feeding after 6 to 12 months. Disclosure, location, and mode of delivery did not have an effect on the transmission rates of HIV when both mother and baby received prophylaxis.

Conclusion: Nonchemoprophylaxis factors, especially breast-feeding, play a key role in perinatal transmission of HIV.

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在赞比亚，婴儿喂养选择、其他非化学预防因素和艾滋病毒母婴传播。

背景:抗逆转录病毒药物在预防艾滋病毒母婴传播(PMTCT)中的作用众所周知。本研究的目的是探讨非化学预防因素，包括婴儿喂养习惯、母亲艾滋病毒状况披露、分娩方式和地点、婴儿性别和母亲年龄，与母婴传播的关系。方法:对0 ~ 12月龄围产期暴露婴儿的干血斑标本DNA聚合酶链反应(PCR)程序数据和部分客户资料进行分析。结果:共分析样本8237份。总的来说，84%的母亲曾经用母乳喂养过孩子。在母亲和婴儿都接受干预的情况下，艾滋病毒的传播率在6至12个月后仍在母乳喂养的妇女中较高。当母亲和婴儿都接受预防措施时，披露情况、地点和分娩方式对艾滋病毒传播率没有影响。结论:非化学预防因素，尤其是母乳喂养在HIV围生期传播中起关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)

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