Antiretroviral therapy initiation in France: adherence to national guidelines and outcome.

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-01-01 Epub Date: 2011-08-31 DOI:10.1177/1545109711418362

Vatthanaphone Latthaphasavang, Marie-Anne Bouldouyre, Anne Rachline, Diane Ponscarme, Willy Rozenbaum, Jean-Yves Mary, Constance Delaugerre, Jean-Michel Molina

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引用次数: 2

Abstract

Objectives and methods: Retrospective study of all patients who started antiretroviral therapy (ART) in 2007 in a single center in Paris, with baseline characteristics and 1-year outcome, to assess adherence to national guidelines.

Results: We analyzed 118 patients. Time of ART initiation was in agreement with the guidelines for only 64 (54.2%) patients. Fifty patients (42%) started ART with AIDS or a CD4 count <200 cells/mm(3). In all, 62 (52%) and 47 patients (40%) received a combination of 2 nucleoside analogues with efavirenz (EFV) and 1 ritonavir-boosted protease inhibitor (PI/r), respectively. Treatment regimens were in accordance with the guidelines for 114 patients (97%). At 1 year, 16 patients (13.5%) were lost to follow-up, only 5 (4.9%) experienced HIV disease progression or death, but 19 (18.6%) required hospitalization. Antiretroviral therapy was changed in 21 patients (21%). Ten patients (8.4%) experienced virologic failure.

Conclusion: Antiretroviral therapy was in agreement with guidelines for the choice of combination but was often initiated too late.

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法国开始抗逆转录病毒治疗:遵守国家指南和结果。

目的和方法:回顾性研究2007年在巴黎单一中心开始抗逆转录病毒治疗(ART)的所有患者，基线特征和1年结局，以评估对国家指南的依从性。结果:我们分析了118例患者。只有64例(54.2%)患者的ART起始时间与指南一致。50名患者(42%)在开始抗逆转录病毒治疗时伴有艾滋病或CD4计数。结论:抗逆转录病毒治疗符合联合用药指南的要求，但往往开始得太晚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)

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