Lab on a Chip最新文献_第9页

Generation, control, and application of stable bubbles in a hypersonic acoustic system† 高超声速声学系统中稳定气泡的产生、控制和应用

IF 6.1 2区工程技术

Lab on a Chip Pub Date : 2024-08-14 DOI: 10.1039/D4LC00591K

Xiaotian Shen, Xianwu Ke, Tiechuan Li, Chongling Sun and Xuexin Duan

{"title":"Generation, control, and application of stable bubbles in a hypersonic acoustic system†","authors":"Xiaotian Shen, Xianwu Ke, Tiechuan Li, Chongling Sun and Xuexin Duan","doi":"10.1039/D4LC00591K","DOIUrl":"10.1039/D4LC00591K","url":null,"abstract":"Bubble-based microfluidics has been applied in many fields. However, there remains a need for a facile and flexible method for stable bubble generation and control in a microchannel. This paper reports a hypersonic acoustic system that can generate and release functional stable bubbles in a microchannel in an on-demand manner. It was found that the hypersonic frequency in this system played a vital role in the generation and control of bubbles. Specifically, a nanostructurally enhanced acoustic resonator was used to generate highly localized ultrahigh-frequency acoustic waves that ensured the feasibility and rapidity of bubble generation. Simultaneously, the acoustothermal effect of hypersound was harnessed to effectuate precise control over the bubble size. In addition, high-throughput droplet splitting was performed to confirm the stability of bubbles and their functionality in micromanipulation. The results showed that a mother droplet could be split controllably into a desired number of daughter droplets with specific volume ratios. In summary, the hypersonic acoustic system was demonstrated to be capable of on-demand-generation of stable bubbles in a microfluidic context and thus may extend the bubble-based applications.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141980752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel thermoplastic microvalves based on an elastomeric cyclic olefin copolymer† 基于弹性环状烯烃共聚物的新型热塑性微阀

IF 6.1 2区工程技术

Lab on a Chip Pub Date : 2024-08-13 DOI: 10.1039/D4LC00501E

Katie Childers, Ian M. Freed, Mateusz L. Hupert, Benjamin Shaw, Noah Larsen, Paul Herring, Jeanne H. Norton, Farhad Shiri, Judy Vun, Keith J. August, Małgorzata A. Witek and Steven A. Soper

{"title":"Novel thermoplastic microvalves based on an elastomeric cyclic olefin copolymer†","authors":"Katie Childers, Ian M. Freed, Mateusz L. Hupert, Benjamin Shaw, Noah Larsen, Paul Herring, Jeanne H. Norton, Farhad Shiri, Judy Vun, Keith J. August, Małgorzata A. Witek and Steven A. Soper","doi":"10.1039/D4LC00501E","DOIUrl":"10.1039/D4LC00501E","url":null,"abstract":"Microfluidic systems combine multiple processing steps and components to perform complex assays in an autonomous fashion. To enable the integration of several bio-analytical processing steps into a single system, valving is used as a component that directs fluids and controls introduction of sample and reagents. While elastomer polydimethylsiloxane has been the material of choice for valving, it does not scale well to accommodate disposable integrated systems where inexpensive and fast production is needed. As an alternative to polydimethylsiloxane, we introduce a membrane made of thermoplastic elastomeric cyclic olefin copolymer (eCOC), that displays unique attributes for the fabrication of reliable valving. The eCOC membrane can be extruded or injection molded to allow for high scale production of inexpensive valves. Normally hydrophobic, eCOC can be activated with UV/ozone to produce a stable hydrophilic monolayer. Valves are assembled following in situ UV/ozone activation of eCOC membrane and thermoplastic valve seat and bonded by lamination at room temperature. eCOC formed strong bonding with polycarbonate (PC) and polyethylene terephthalate glycol (PETG) able to hold high fluidic pressures of 75 kPa and 350 kPa, respectively. We characterized the eCOC valves with mechanical and pneumatic actuation and found the valves could be reproducibly actuated >50 times without failure. Finally, an integrated system with eCOC valves was employed to detect minimal residual disease (MRD) from a blood sample of a pediatric acute lymphoblastic leukemia (ALL) patient. The two module integrated system evaluated MRD by affinity-selecting CD19(+) cells and enumerating leukemia cells via immunophenotyping with ALL-specific markers.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/lc/d4lc00501e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selectively cross-linked hydrogel-based cocktail drug delivery micro-chip for colon cancer combinatorial drug screening using AI-CSR platform for precision medicine† 基于选择性交联水凝胶的结肠癌鸡尾酒给药微芯片利用人工智能-CSR 平台进行精准医疗的组合药物筛选

IF 6.1 2区工程技术

Lab on a Chip Pub Date : 2024-08-13 DOI: 10.1039/D4LC00520A

Kiran Kaladharan, Chih-Hsuan Ouyang, Hsin-Yu Yang and Fan-Gang Tseng

{"title":"Selectively cross-linked hydrogel-based cocktail drug delivery micro-chip for colon cancer combinatorial drug screening using AI-CSR platform for precision medicine†","authors":"Kiran Kaladharan, Chih-Hsuan Ouyang, Hsin-Yu Yang and Fan-Gang Tseng","doi":"10.1039/D4LC00520A","DOIUrl":"10.1039/D4LC00520A","url":null,"abstract":"Cancer, ranked as the second leading cause of global mortality with a prevalence of 1 in 6 deaths, necessitates innovative approaches for effective treatment. Combinatorial drug therapy for cancer treatment targets several key pathways simultaneously and potentially enhances anti-cancer efficacy without intolerable side effects. However, it demands precise and accurate control of drug-dose combinations and their release. In this study, we demonstrated a selectively cross-linked hydrogel-based platform that can quantify and release drugs simultaneously for in-parallel cocktail drug screening. PDMS was used as the flow channel substrate and the poly (ethylene glycol) diacrylate (PEGDA) hydrogel array was formed by UV exposure using the photomask. Employing our platform, cocktails of anticancer drugs are precisely loaded and simultaneously released in-parallel into HCT-116 colon cancer cells, facilitating combinatorial drug screening. The integration of an artificial intelligence-based complex system response (AI-CSR) platform successfully identifies optimal drug-dose combinations from a pool of ten approved drugs. Notably, our cocktail drug chip demonstrates exceptional efficiency, screening 155 drug-dose combinations within a brief two and a half hours, a marked improvement over traditional methods. Furthermore, the device exhibits low drug consumption, requiring a mere 1 μL per patch of chip. Thus, our developed PDMS drug-loaded hydrogel platform presents a novel and expedited approach to quantifying drug concentrations, promising to be a faster, efficient and more precise approach for conducting cocktail drug screening experiments.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flow tweezing of anisotropic magnetic microrobots in a dynamic magnetic trap for active retention and localized flow sensing 在动态磁性捕获器中对各向异性磁性微型机器人进行流动镊取，以实现主动保持和局部流动传感。

IF 6.1 2区工程技术

Lab on a Chip Pub Date : 2024-08-09 DOI: 10.1039/D4LC00474D

Yuan Liu, Quanliang Cao, Haifeng Xu and Gungun Lin

{"title":"Flow tweezing of anisotropic magnetic microrobots in a dynamic magnetic trap for active retention and localized flow sensing","authors":"Yuan Liu, Quanliang Cao, Haifeng Xu and Gungun Lin","doi":"10.1039/D4LC00474D","DOIUrl":"10.1039/D4LC00474D","url":null,"abstract":"Controlled manipulation of microscale robotic devices in complex fluidic networks is critical for various applications in biomedical endovascular sensing, lab-on-chip biochemical assays, and environmental monitoring. However, achieving controlled transport and active retention of microscale robots with flow sensing capability has proven to be challenging. Here, we report the dynamic tweezing of an anisotropic magnetic microrobot in a rotating magnetic trap for active retention and localized flow sensing under confined fluidic conditions. We reveal a series of unconventional motion modes and the dynamics of the microrobot transporting in a confined fluidic flow, which manifest themselves as transitions from on-trap centre rolling to large-area revolution and off-trap centre rolling with varying rotating frequencies. By retaining the robot within the magnetic trap and its motion modulated by the field frequency, the off-centre rolling of the microrobot endows it with crucial localized flow sensing capabilities, including flow rate and flow direction determination. The magnetic microrobot serves as a mobile platform for measuring the flow profile along a curved channel, mimicking a blood vessel. Our findings unlock a new strategy to determine the local magnetic tweezing force profile and flow conditions in arbitrary flow channels, revealing strong potential for microfluidics, chemical reactors, and in vivo endovascular flow measurement.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programming hierarchical anisotropy in microactuators for multimodal actuation† 在微型致动器中编程分层各向异性，以实现多模态致动。

IF 6.1 2区工程技术

Lab on a Chip Pub Date : 2024-08-08 DOI: 10.1039/D4LC00369A

Shiyu Wang, Shucong Li, Wenchang Zhao, Ying Zhou, Liqiu Wang, Joanna Aizenberg and Pingan Zhu

{"title":"Programming hierarchical anisotropy in microactuators for multimodal actuation†","authors":"Shiyu Wang, Shucong Li, Wenchang Zhao, Ying Zhou, Liqiu Wang, Joanna Aizenberg and Pingan Zhu","doi":"10.1039/D4LC00369A","DOIUrl":"10.1039/D4LC00369A","url":null,"abstract":"Microactuators, capable of executing tasks typically repetitive, hazardous, or impossible for humans, hold great promise across fields such as precision medicine, environmental remediation, and swarm intelligence. However, intricate motions of microactuators normally require high complexity in design, making it increasingly challenging to realize at small scales using existing fabrication techniques. Taking inspiration from the hierarchical-anisotropy principle found in nature, we program liquid crystalline elastomer (LCE) microactuators with multimodal actuation tailored to their molecular, shape, and architectural anisotropies at (sub)nanometer, micrometer, and (sub)millimeter scales, respectively. Our strategy enables diverse deformations with individual LCE microstructures, including expanding, contracting, twisting, bending, and unwinding, as well as re-programmable shape transformations of assembled LCE architectures with negative Poisson's ratios, locally adjustable actuation, and changing from two-dimensional (2D) to three-dimensional (3D) structures. Furthermore, we design tetrahedral microactuators with well-controlled mobility and precise manipulation of both solids and liquids in various environments. This study provides a paradigm shift in the development of microactuators, unlocking a vast array of complexities achievable through manipulation at each hierarchical level of anisotropy.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SUPERCELLS: a novel microfluidic reactor architecture for ultra-fast sequential delivery of chemical reagents† 超级电池：用于超快顺序输送化学试剂的新型微流控反应器结构

IF 6.1 2区工程技术

Lab on a Chip Pub Date : 2024-08-08 DOI: 10.1039/D4LC00534A

Naghmeh Fatemi, Ahmed Taher, Jelle Fondu, Lei Zhang, Tinne De Moor, Kherim Willems, Olivier Henry, Peter Peumans and Tim Stakenborg

{"title":"SUPERCELLS: a novel microfluidic reactor architecture for ultra-fast sequential delivery of chemical reagents†","authors":"Naghmeh Fatemi, Ahmed Taher, Jelle Fondu, Lei Zhang, Tinne De Moor, Kherim Willems, Olivier Henry, Peter Peumans and Tim Stakenborg","doi":"10.1039/D4LC00534A","DOIUrl":"10.1039/D4LC00534A","url":null,"abstract":"Applications such as nucleic acid synthesis or next-generation sequencing involve repeated fluidic cycles with the same set of reagents. The large dead volumes present in external valves and pumps with relatively long supply lines mandate the inclusion of extensive rinsing steps in current protocols, resulting in the consumption of significant quantities of reagents. To allow for fast rinsing, to reduce reagent consumption, and to ensure high reagent purity, we propose a fluidic concept based on a hierarchical branching structure. The working principle comprises a 3D fluidic network of supply lines – one line per reagent – that ensures reagents to be provided up to the entrance of every single reaction cavity, called supercells. Because all reagents are always present inside or at the inlet of a supercell, the principle allows for very rapid reagent switching, while a continuous flow avoids cross contamination. Selection of a specific reagent to enter the supercells is controlled by adjusting the pressure over different supply lines. As the pressure is regulated by a single, external controller per reagent, no integrated valves are needed. The very small distances to the reaction cavities also results in the use of minimal reagent volumes and, hence, largely reduces operational costs. We demonstrated the working principle of this concept and show an average switching time of 0.23 ± 0.09 s for the current design at a flow rate of 10 nL s−1. We used a 10 × 10 matrix of supercells to validate the fluidic concept to be scalable towards a large number of reaction sites. In summary, we believe the presented fluidic 3D hierarchical concept allows designing flow cells that enable highly parallel, more cost-efficient, and faster work flows for applications requiring many reagent cycles.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlling bacterial growth and inactivation using thin film-based surface acoustic waves† 利用基于薄膜的表面声波控制细菌生长和灭活

IF 6.1 2区工程技术

Lab on a Chip Pub Date : 2024-08-08 DOI: 10.1039/D4LC00285G

Hui Ling Ong, Bruna Martins Dell' Agnese, Yunhong Jiang, Yihao Guo, Jian Zhou, Jikai Zhang, Jingting Luo, Ran Tao, Meng Zhang, Lynn G. Dover, Darren Smith, Kunyapat Thummavichai, Yogendra Kumar Mishra, Qiang Wu and Yong-Qing Fu

{"title":"Controlling bacterial growth and inactivation using thin film-based surface acoustic waves†","authors":"Hui Ling Ong, Bruna Martins Dell' Agnese, Yunhong Jiang, Yihao Guo, Jian Zhou, Jikai Zhang, Jingting Luo, Ran Tao, Meng Zhang, Lynn G. Dover, Darren Smith, Kunyapat Thummavichai, Yogendra Kumar Mishra, Qiang Wu and Yong-Qing Fu","doi":"10.1039/D4LC00285G","DOIUrl":"10.1039/D4LC00285G","url":null,"abstract":"Formation of bacterial films on structural surfaces often leads to severe contamination of medical devices, hospital equipment, implant materials, etc., and antimicrobial resistance of microorganisms has indeed become a global health issue. Therefore, effective therapies for controlling infectious and pathogenic bacteria are urgently needed. Being a promising active method for this purpose, surface acoustic waves (SAWs) have merits such as nanoscale earthquake-like vibration/agitation/radiation, acoustic streaming induced circulations, and localised acoustic heating effect in liquids. However, only a few studies have explored controlling bacterial growth and inactivation behaviour using SAWs. In this study, we proposed utilising piezoelectric thin film-based SAW devices on a silicon substrate for controlling bacterial growth and inactivation with and without using ZnO micro/nanostructures. Effects of SAW powers on bacterial growth for two types of bacteria, i.e., E. coli and S. aureus, were evaluated. Varied concentrations of ZnO tetrapods were also added into the bacterial culture to study their effects and the combined antimicrobial effects along with SAW agitation. Our results showed that when the SAW power was below a threshold (e.g., about 2.55 W in this study), the bacterial growth was apparently enhanced, whereas the further increase of SAW power to a high power caused inactivation of bacteria. Combination of thin film SAWs with ZnO tetrapods led to significantly decreased growth or inactivation for both E. coli and S. aureus, revealing their effectiveness for antimicrobial treatment. Mechanisms and effects of SAW interactions with bacterial solutions and ZnO tetrapods have been systematically discussed.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/lc/d4lc00285g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single and few cell analysis for correlative light microscopy, metabolomics, and targeted proteomics† 用于相关光学显微镜、代谢组学和靶向蛋白质组学的单细胞和少细胞分析

IF 6.1 2区工程技术

Lab on a Chip Pub Date : 2024-08-08 DOI: 10.1039/D4LC00269E

Luca Rima, Christian Berchtold, Stefan Arnold, Andri Fränkl, Rosmarie Sütterlin, Gregor Dernick, Götz Schlotterbeck and Thomas Braun

{"title":"Single and few cell analysis for correlative light microscopy, metabolomics, and targeted proteomics†","authors":"Luca Rima, Christian Berchtold, Stefan Arnold, Andri Fränkl, Rosmarie Sütterlin, Gregor Dernick, Götz Schlotterbeck and Thomas Braun","doi":"10.1039/D4LC00269E","DOIUrl":"10.1039/D4LC00269E","url":null,"abstract":"The interactions of proteins, membranes, nucleic acid, and metabolites shape a cell's phenotype. These interactions are stochastic, and each cell develops differently, making it difficult to synchronize cell populations. Consequently, studying biological processes at the single- or few-cell level is often necessary to avoid signal dilution below the detection limit or averaging over many cells. We have developed a method to study metabolites and proteins from a small number of or even a single adherent eukaryotic cell. Initially, cells are lysed by short electroporation and aspirated with a microcapillary under a fluorescent microscope. The lysate is placed on a carrier slide for further analysis using liquid-chromatography mass spectrometry (LC-MS) and/or reverse-phase protein (RPPA) approach. This method allows for a correlative measurement of (i) cellular structures and metabolites and (ii) cellular structures and proteins on the single-cell level. The correlative measurement of cellular structure by light-microscopy, metabolites by LC-MS, and targeted protein detection by RPPA was possible on the few-cell level. We discuss the method, potential applications, limitations, and future improvements.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/lc/d4lc00269e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A micro-scale humanized ventilator-on-a-chip to examine the injurious effects of mechanical ventilation† 用于研究机械通气损伤效应的微尺度人源化芯片呼吸机

IF 6.1 2区工程技术

Lab on a Chip Pub Date : 2024-08-07 DOI: 10.1039/D4LC00143E

Basia Gabela-Zuniga, Vasudha C. Shukla, Christopher Bobba, Natalia Higuita-Castro, Heather M. Powell, Joshua A. Englert and Samir N. Ghadiali

{"title":"A micro-scale humanized ventilator-on-a-chip to examine the injurious effects of mechanical ventilation†","authors":"Basia Gabela-Zuniga, Vasudha C. Shukla, Christopher Bobba, Natalia Higuita-Castro, Heather M. Powell, Joshua A. Englert and Samir N. Ghadiali","doi":"10.1039/D4LC00143E","DOIUrl":"10.1039/D4LC00143E","url":null,"abstract":"Patients with compromised respiratory function frequently require mechanical ventilation to survive. Unfortunately, non-uniform ventilation of injured lungs generates complex mechanical forces that lead to ventilator induced lung injury (VILI). Although investigators have developed lung-on-a-chip systems to simulate normal respiration, modeling the complex mechanics of VILI as well as the subsequent recovery phase is a challenge. Here we present a novel humanized in vitro ventilator-on-a-chip (VOC) model of the lung microenvironment that simulates the different types of injurious forces generated in the lung during mechanical ventilation. We used transepithelial/endothelial electrical impedance measurements to investigate how individual and simultaneous application of mechanical forces alters real-time changes in barrier integrity during and after injury. We find that compressive stress (i.e. barotrauma) does not significantly alter barrier integrity while over-distention (20% cyclic radial strain, volutrauma) results in decreased barrier integrity that quickly recovers upon removal of mechanical stress. Conversely, surface tension forces generated during airway reopening (atelectrauma), result in a rapid loss of barrier integrity with a delayed recovery relative to volutrauma. Simultaneous application of cyclic stretching (volutrauma) and airway reopening (atelectrauma), indicates that the surface tension forces associated with reopening fluid-occluded lung regions are the primary driver of barrier disruption. Thus, our novel VOC system can monitor the effects of different types of injurious forces on barrier disruption and recovery in real-time and can be used to interogate the biomechanical mechanisms of VILI.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/lc/d4lc00143e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lab-on-PCB solid propellant microthruster with multi-mode thrust capabilities 具有多模式推力能力的实验室用 PCB 固体推进剂微型推进器。

IF 6.1 2区工程技术

Lab on a Chip Pub Date : 2024-08-07 DOI: 10.1039/D4LC00516C

Jeongrak Lee, Seonghyeon Kim, Hanseong Jo and Anna Lee

{"title":"Lab-on-PCB solid propellant microthruster with multi-mode thrust capabilities","authors":"Jeongrak Lee, Seonghyeon Kim, Hanseong Jo and Anna Lee","doi":"10.1039/D4LC00516C","DOIUrl":"10.1039/D4LC00516C","url":null,"abstract":"In the realm of nano/microsatellite clustering, the demand for microthrusters is steadily growing. Solid propellant microthrusters, recognized for their lightweight build and structural simplicity, carry significant commercial promise. However, existing solid propellant microthrusters manufactured using MEMS technology encounter notable issues such as inconsistent thrust generation positions, limited thrust profiles, and issues related to productivity, scalability, and durability. In this study, we propose a novel shared-chamber solid-propellant microthruster design that consistently produces thrust at a designated position and accommodates multiple thrust modes. The components and fabrication of this thruster were developed using lab-on-printed-circuit-board (PCB) technology and PCB surface mount technology, showcasing enhanced structural stability, scalability, and potential for mass production. Our ignition and combustion experiments confirmed the repeatability of the unit operation, a fundamental feature of this innovative microthruster. Furthermore, we successfully implemented and evaluated the power mode for increased thrust and the continuous mode for prolonged operational duration. Integrating the lab-on-PCB-based shared-chamber solid propellant microthruster with propulsion and electronic control systems holds promising potential for future satellite missions.","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0