Asian Spine Journal最新文献

{"title":"Response to the letter to the editor: Efficacy of gabapentin and pregabalin for the treatment of neurogenic claudication in lumbar spinal stenosis: a double-blind randomized placebo-controlled trial.","authors":"Chatupon Chotigavanichaya, Korawish Mekariya, Borriwat Santipas, Sirichai Wilartratsami, Ekkapoj Korwutthikulrangsri, Monchai Ruangchainikom, Panya Luksanapruksa","doi":"10.31616/asj.2026.0088.r2","DOIUrl":"10.31616/asj.2026.0088.r2","url":null,"abstract":"","PeriodicalId":8555,"journal":{"name":"Asian Spine Journal","volume":"20 3","pages":"625-626"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter to the editor: Methodological considerations on \"Comparison of dexmedetomidine and morphine versus plain ropivacaine 0.2% for myofascial infiltration in thoracolumbar spinal fusion: a double-blind randomized trial\".","authors":"Sandeep Dey, Stuti Bhamri, Ankita Jaiswal, Kanika Gupta, Mukesh Mohan Gupta, Ashutosh Kumar","doi":"10.31616/asj.2026.0125.r2","DOIUrl":"10.31616/asj.2026.0125.r2","url":null,"abstract":"","PeriodicalId":8555,"journal":{"name":"Asian Spine Journal","volume":"20 3","pages":"620-621"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of glucagon-like peptide-1 agonist therapy with postsurgical outcomes following multilevel correction for adult spinal deformity: a propensity score-matched analysis.","authors":"Cassandra D'Amico, Benjamin Jacques, Robert Ferdon, Jason Silvestre, Stephen Lewis, Christopher Nielsen, John Glaser, Charles Reitman, James Lawrence, Robert Ravinsky","doi":"10.31616/asj.2025.0407","DOIUrl":"10.31616/asj.2025.0407","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Purpose: </strong>This study aimed to examine outcomes in patients with adult spinal deformity (ASD) undergoing deformity correction with and without glucagon-like peptide-1 receptor agonist (GLP-1A) therapy.</p><p><strong>Overview of literature: </strong>GLP-1As, widely used in diabetes management, have recently been linked to reduced postoperative complications. However, their role in spinal surgery remains underexplored.</p><p><strong>Methods: </strong>This multicenter, retrospective cohort study was conducted using the TriNetX Global Collaborative Database (2005-2025) utilizing Current Procedural Terminology and International Classification of Diseases, 10th Revision, codes for patients undergoing spinal deformity correction because of ASD. Patients prescribed GLP-1As within 1 year of surgery were 1:1 propensity-score matched with those who were not using GLP-1As. The cohort was matched according to patient demographics and comorbidities. Surgical outcomes between groups were analyzed at 1- and 2-year intervals. Significance was defined as p <0.05.</p><p><strong>Results: </strong>At 1 and 2 years following surgery, patients taking GLP-1As exhibited significantly lower odds of pseudoarthrosis, hardware failures, wound dehiscence, infections, thromboembolic events, readmissions, and mortality.</p><p><strong>Conclusions: </strong>The findings reveal a significant reduction in the rates of pseudoarthrosis, hardware failure, readmission, and mortality in patients treated with GLP-1As. These results align with the recent literature, pointing to a potential complementary therapy in ASD management. Further studies characterizing the mechanism by which GLP-1As affect postoperative spinal physiology are warranted to assess their utility in optimizing patient outcomes.</p>","PeriodicalId":8555,"journal":{"name":"Asian Spine Journal","volume":" ","pages":"442-454"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intradiscal mesenchymal stem cell therapy for degenerative disc disease: a systematic review and meta-analysis of randomized trials.","authors":"Ahmad Jabir Rahyussalim, Satria Wisnu Murti, Rudi Thenggono, Faiza Al Khalifa Calista","doi":"10.31616/asj.2025.0354","DOIUrl":"10.31616/asj.2025.0354","url":null,"abstract":"<p><strong>Study design: </strong>Systematic review and meta-analysis.</p><p><strong>Purpose: </strong>To investigate the efficacy and safety of intradiscal mesenchymal stem cell (MSC) injection for patients with degenerative disc disease (DDD).</p><p><strong>Overview of literature: </strong>DDD is a common cause of chronic low-back pain (CLBP). Studies have shown that MSC therapy may have the potential to reverse the degenerative process. However, the evidence remains inconclusive.</p><p><strong>Methods: </strong>A comprehensive search of Europe PMC, Cochrane Library, Scopus, and Medline was conducted up to April 30, 2025, using relevant keywords. Randomized controlled trials (RCTs) comparing intradiscal MSC injections with sham/placebo in patients with DDD were included. Random-effects models were used to calculate the odds ratios and mean differences (MDs).</p><p><strong>Results: </strong>Seven RCTs were included. MSC injection was associated with significantly greater reductions in Visual Analog Scale pain scores (MD, 6.67; 95% confidence interval [CI], -9.31 to -4.02; p<0.00001, I2=29%) and Oswestry Disability Index (ODI) (MD, -4.05%; 95% CI, -5.24 to -2.87; p<0.00001, I2=32%) compared with sham/placebo. The magnitude of improvement increased with longer followup. No significant differences were observed between groups in treatment-emergent adverse events (AEs), serious AEs, treatment discontinuation due to AEs, or mortality.</p><p><strong>Conclusions: </strong>Intradiscal MSC injection appears to be a safe and effective therapy, offering modest improvements in pain and function for patients with CLBP due to DDD who do not respond to conservative treatments.</p>","PeriodicalId":8555,"journal":{"name":"Asian Spine Journal","volume":" ","pages":"541-557"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of biportal versus uniportal endoscopic decompression for the treatment of lumbar degenerative disease: a systematic review and meta‑analysis.","authors":"Alexander Yu, Mark Kurapatti, Ryan Hoang, James Hong, Nancy Shrestha, Ryan Stadler, Peter Campbell, Junho Song, Joshua Lee, Samuel K Cho","doi":"10.31616/asj.2025.0104","DOIUrl":"10.31616/asj.2025.0104","url":null,"abstract":"<p><strong>Study design: </strong>Systematic review and meta-analysis.</p><p><strong>Purpose: </strong>To perform a comprehensive meta-analysis comparing clinical outcomes of uniportal versus biportal endoscopic spine surgery across decompression procedures in patients with lumbar degenerative disease (LDD).</p><p><strong>Overview of literature: </strong>Uniportal endoscopic spine surgery has been a widely adopted minimally invasive technique, whereas biportal endoscopy has recently emerged as a promising alternative with potential advantages in surgical outcomes.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of comparative studies was conducted in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. PubMed, Embase, and Scopus databases were searched to identify relevant studies. Eleven studies encompassing 374 uniportal and 368 biportal patients were included. Outcomes analyzed were Oswestry Disability Index (ODI), Visual Analog Scale (VAS) scores for back and leg pain, complication rates, operative time, and length of hospital stay.</p><p><strong>Results: </strong>Biportal endoscopic surgery was associated with a significantly lower ODI at 1-3 months and at final follow-up compared with uniportal surgery. However, uniportal discectomy demonstrated significantly shorter operative time and length of hospital stay than biportal discectomy. No significant differences were observed between approaches in terms of VAS scores, complication rates, or ODI at other time points.</p><p><strong>Conclusions: </strong>Both uniportal and biportal endoscopic spine surgeries yield comparable postoperative outcomes in LDD. Although biportal surgery showed a modest advantage in ODI improvement, it did not reach the minimal clinically important difference. Uniportal surgery demonstrated greater efficiency in terms of operative time and recovery, particularly for discectomy procedures.</p>","PeriodicalId":8555,"journal":{"name":"Asian Spine Journal","volume":" ","pages":"558-571"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Methodological considerations on \"Comparison of dexmedetomidine and morphine versus plain ropivacaine 0.2% for myofascial infiltration in thoracolumbar spinal fusion: a double-blind randomized trial\".","authors":"Jiayi Yu","doi":"10.31616/asj.2026.0125.r1","DOIUrl":"10.31616/asj.2026.0125.r1","url":null,"abstract":"","PeriodicalId":8555,"journal":{"name":"Asian Spine Journal","volume":"20 3","pages":"619-620"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between gut microbiota and spinal canal stenosis: a bidirectional Mendelian randomization and hub gene study across East Asian and European populations.","authors":"Weihang Zhu, Lei Li, Yida Wang, Yongbin Wang, Zihan Cui, Tianrui Wang, Lu Zhang, Chao Wang","doi":"10.31616/asj.2025.0235","DOIUrl":"10.31616/asj.2025.0235","url":null,"abstract":"<p><strong>Study design: </strong>Mendelian randomization (MR) and gene-level analysis.</p><p><strong>Purpose: </strong>To investigate the relationship between gut microbiota (GM) and spinal canal stenosis (SCS).</p><p><strong>Overview of literature: </strong>To date, no studies have demonstrated the relationship between GM and SCS or explored its racial differences.</p><p><strong>Methods: </strong>This study utilized summary data from publicly available, large-scale genome-wide association studies to investigate the causal relationship between GM and SCS in interracial, European, and East Asian populations using a bidirectional two-sample MR approach. Reverse MR analysis was conducted to estimate the effect of SCS on GM taxa with significant associations. Additionally, genelevel analyses-including Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and protein-protein interaction network analysis-were performed to elucidate key biological processes and hub genes involved in both GM and SCS.</p><p><strong>Results: </strong>In the interracial population, five bacterial taxa were identified as risk factors and four as protective factors for SCS. Among Europeans, three bacterial taxa were associated with increased risk and three with reduced risk. In the East Asian population, seven bacterial taxa demonstrated protective effects, while one taxon was associated with increased risk. Sensitivity analyses revealed no evidence of heterogeneity or horizontal pleiotropy. Cross-comparisons indicated significant differences in GM profiles between European and East Asian populations. Gene-level analysis identified key GO terms, enriched KEGG pathways, and hub genes potentially mediating the relationship between GM and SCS.</p><p><strong>Conclusion: </strong>This study identified a potential causal relationship between GM and SCS, highlighting distinct microbial and genetic mechanisms in European and East Asian populations. The findings provide novel insights into the pathogenesis, prevention, and treatment of SCS. Gene-level analyses suggest potential molecular pathways underlying the GM-SCS association, providing a foundation for future mechanistic research.</p>","PeriodicalId":8555,"journal":{"name":"Asian Spine Journal","volume":" ","pages":"419-430"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical study of diaphragmatic crura and segmental vessels for lumbar spinal surgery.","authors":"Hiroo Shiraga, Nobuyuki Suzuki, Kenji Kato, Kiyoshi Yagi, Yuji Joyo, Sanshiro Yasuma, Chiho Minamitani, Yuko Waguri-Nagaya, Kenichi Yoshimura, Hideki Murakami","doi":"10.31616/asj.2025.0294","DOIUrl":"10.31616/asj.2025.0294","url":null,"abstract":"<p><strong>Study design: </strong>Observational cadaveric anatomical study.</p><p><strong>Purpose: </strong>To investigate the anatomical relationship between the segmental vessels and the diaphragmatic crus, aiming to reduce the risk of segmental vessel injury.</p><p><strong>Overview of literature: </strong>Total en bloc spondylectomy and lateral lumbar interbody fusion are advanced surgical procedures associated with segmental vessel injury. Previous research suggests these injuries may arise from anatomical variations where segmental vessels intersect intervertebral discs. At upper lumbar levels, the diaphragmatic crus lies adjacent to the vertebral bodies, and its relationship with segmental vessels may increase vascular risk. Although this proximity has been noted, no study has specifically examined the detailed anatomy of the crus in relation to segmental vessels. Clarifying this relationship is critical for surgical planning and safety.</p><p><strong>Methods: </strong>Fifteen Thiel-embalmed human cadavers (three males, 12 females; mean age 90.1 years) were dissected. Segmental arteries and veins from L1 to L5 and both crura were identified and measured. Crus origin, width, and distance from the vertebral midline were assessed. Data were analyzed using paired t-tests and Wilcoxon signed-rank tests.</p><p><strong>Results: </strong>The right crus was broader, originated more caudally, and was positioned closer to the vertebral midline along the ventral surface of the vertebral body than the left crus, especially at L1-L3. Segmental arteries and the left segmental vein coursed between the crus and vertebral bodies, whereas the right segmental vein consistently passed ventral to the crus.</p><p><strong>Conclusions: </strong>The diaphragmatic crus shows laterality in origin, width, and position, with distinct relationships to segmental vessels. Recognizing these anatomical features may help surgeons minimize vascular injury and improve safety during lumbar spinal surgery.</p>","PeriodicalId":8555,"journal":{"name":"Asian Spine Journal","volume":" ","pages":"411-418"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145548019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Efficacy of gabapentin and pregabalin for the treatment of neurogenic claudication in lumbar spinal stenosis: a double-blind randomized placebo-controlled trial.","authors":"Abins T K, Ravi Gaur, Nagma Sheenam, Arindam Ghosh","doi":"10.31616/asj.2026.0088.r1","DOIUrl":"10.31616/asj.2026.0088.r1","url":null,"abstract":"","PeriodicalId":8555,"journal":{"name":"Asian Spine Journal","volume":"20 3","pages":"623-624"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior epidural fat as a diagnostic marker on magnetic resonance imaging for differentiating isthmic and degenerative lumbar spondylolisthesis: a retrospective study.","authors":"Kunkun Sheng, Renjie Peng, Shengjun Qian, Lei Yu, Zhan Wang","doi":"10.31616/asj.2025.0338","DOIUrl":"10.31616/asj.2025.0338","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective study.</p><p><strong>Purpose: </strong>To investigate the diagnostic utility of anterior epidural fat (EF) for distinguishing isthmic from degenerative lumbar spondylolisthesis.</p><p><strong>Overview of literature: </strong>Isthmic and degenerative lumbar spondylolisthesis must be distinguished accurately for appropriate clinical decision making. However, magnetic resonance imaging (MRI) often fails to detect pars defects; thus, additional imaging markers are needed.</p><p><strong>Methods: </strong>We retrospectively analyzed lumbar spondylolisthesis in 274 patients, of whom 129 had isthmic disease and 145 had degenerative disease. We assessed the presence and structure of anterior EF on midsagittal MRI, calculated diagnostic performance metrics, and used multivariable logistic regression to identify independent predictors of isthmic spondylolisthesis.</p><p><strong>Results: </strong>Anterior EF was observed in 95.3% of isthmic cases and 28.3% of degenerative cases (p <0.001). As a diagnostic marker, anterior EF had 95.3% sensitivity and 71.7% specificity, and the area under the receiver operating characteristic curve indicated excellent discriminative ability. Morphologically, acute triangular anterior EF was significantly more common in patients with isthmic disease (75.2%) than in those with degenerative disease (17.2%). Multivariable analysis confirmed anterior EF as a strong independent predictor (odds ratio, 38.730; p <0.001).</p><p><strong>Conclusions: </strong>Anterior EF is an MRI feature that is highly sensitive and moderately specific for identifying isthmic spondylolisthesis. Its presence and characteristic acute triangular structure are valuable ancillary signs that are useful in early, noninvasive diagnosis.</p>","PeriodicalId":8555,"journal":{"name":"Asian Spine Journal","volume":" ","pages":"506-514"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}