Asian Journal of Pharmaceutical Sciences最新文献_第8页

Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review 隐形眼镜作为眼科给药的新兴平台:系统综述

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-27 DOI: 10.1016/j.ajps.2023.100847

Hongyu Yang , Ming Zhao , Dandan Xing, Jian Zhang, Ting Fang, Faxing Zhang, Zhihao Nie, Yaming Liu, Lihua Yang, Ji Li, Dongkai Wang

{"title":"Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review","authors":"Hongyu Yang , Ming Zhao , Dandan Xing, Jian Zhang, Ting Fang, Faxing Zhang, Zhihao Nie, Yaming Liu, Lihua Yang, Ji Li, Dongkai Wang","doi":"10.1016/j.ajps.2023.100847","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100847","url":null,"abstract":"<div><p>The number of people with eye diseases has increased with the use of electronics. However, the bioavailability of eye drops remains low owing to the presence of the ocular barrier and other reasons. Although many drug delivery systems have been developed to overcome these problems, they have certain limitations. In recent years, the development of contact lenses that can deliver drugs for long periods with high bioavailability and without affecting vision has increased the interest in using contact lenses for drug delivery. Hence, a review of the current state of research on drug delivery contact lenses has become crucial. This article reviews the key physical and chemical properties of drug-laden contact lenses, development and classification of contact lenses, and features of the commonly used materials. A review of the methods commonly used in current research to create contact lenses has also been presented. An overview on how drug-laden contact lenses can overcome the problems of high burst and short release duration has been discussed. Overall, the review focuses on drug delivery methods using smart contact lenses, and predicts the future direction of research on contact lenses.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100847"},"PeriodicalIF":10.2,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment 通过siRNA疗法重塑肿瘤免疫微环境，实现精准癌症治疗

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100852

Lingxi Jiang , Yao Qi , Lei Yang , Yangbao Miao , Weiming Ren , Hongmei Liu , Yi Huang , Shan Huang , Shiyin Chen , Yi Shi , Lulu Cai

{"title":"Remodeling the tumor immune microenvironment via siRNA therapy for precision cancer treatment","authors":"Lingxi Jiang , Yao Qi , Lei Yang , Yangbao Miao , Weiming Ren , Hongmei Liu , Yi Huang , Shan Huang , Shiyin Chen , Yi Shi , Lulu Cai","doi":"10.1016/j.ajps.2023.100852","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100852","url":null,"abstract":"<div><p>How to effectively transform the pro-oncogenic tumor microenvironments (TME) surrounding a tumor into an anti-tumoral never fails to attract people to study. Small interfering RNA (siRNA) is considered one of the most noteworthy research directions that can regulate gene expression following a process known as RNA interference (RNAi). The research about siRNA delivery targeting tumor cells and TME has been on the rise in recent years. Using siRNA drugs to silence critical proteins in TME was one of the most efficient solutions. However, the manufacture of a siRNA delivery system faces three major obstacles, <em>i.e.</em>, appropriate cargo protection, accurately targeted delivery, and site-specific cargo release. In the following review, we summarized the pharmacological actions of siRNA drugs in remolding TME. In addition, the delivery strategies of siRNA drugs and combination therapy with siRNA drugs to remodel TME are thoroughly discussed. In the meanwhile, the most recent advancements in the development of all clinically investigated and commercialized siRNA delivery technologies are also presented. Ultimately, we propose that nanoparticle drug delivery siRNA may be the future research focus of oncogene therapy. This summary offers a thorough analysis and roadmap for general readers working in the field.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100852"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of virus-capsid mimicking biologic-shell based versus polymeric-shell nanoparticles for enhanced oral insulin delivery 模拟病毒衣壳的生物壳纳米颗粒与聚合物壳纳米颗粒增强口服胰岛素递送的比较

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100848

Zhixiang Cui , Shuman Cui , Lu Qin , Yalin An , Xin Zhang , Jian Guan , Tin Wui Wong , Shirui Mao

{"title":"Comparison of virus-capsid mimicking biologic-shell based versus polymeric-shell nanoparticles for enhanced oral insulin delivery","authors":"Zhixiang Cui , Shuman Cui , Lu Qin , Yalin An , Xin Zhang , Jian Guan , Tin Wui Wong , Shirui Mao","doi":"10.1016/j.ajps.2023.100848","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100848","url":null,"abstract":"<div><p>Virus-capsid mimicking mucus-permeable nanoparticles are promising oral insulin carriers which surmount intestinal mucus barrier. However, the impact of different virus-capsid mimicking structure remains unexplored. In this study, utilizing biotin grafted chitosan as the main skeleton, virus-mimicking nanoparticles endowed with biologic-shell (streptavidin coverage) and polymeric-shell (hyaluronic acid/alginate coating) were designed with insulin as a model drug by self-assembly processes. It was demonstrated that biologic-shell mimicking nanoparticles exhibited a higher intestinal trans-mucus (>80%, 10 min) and transmucosal penetration efficiency (1.6–2.2-fold improvement) than polymeric-shell counterparts. Uptake mechanism studies revealed caveolae-mediated endocytosis was responsible for the absorption of biologic-shell mimicking nanoparticles whereas polymeric-shell mimicking nanoparticles were characterized by clathrin-mediated pathway with anticipated lysosomal insulin digestion. Further, <em>in vivo</em> hypoglycemic study indicated that the improved effect of regulating blood sugar levels was virus-capsid structure dependent out of which biologic-shell mimicking nanoparticles presented the best performance (5.1%). Although the findings of this study are encouraging, much more work is required to meet the standards of clinical translation. Taken together, we highlight the external structural dependence of virus-capsid mimicking nanoparticles on the muco-penetrating and uptake mechanism of enterocytes that in turn affecting their <em>in vivo</em> absorption, which should be pondered when engineering virus-mimicking nanoparticles for oral insulin delivery.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100848"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano transdermal system combining mitochondria-targeting cerium oxide nanoparticles with all-trans retinoic acid for psoriasis 结合线粒体靶向氧化铈纳米颗粒与全反式维甲酸治疗银屑病的纳米透皮系统

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100846

Wei Wang , Xinyi Xu , Yanling Song , Lan Lan , Jun Wang , Xinchang Xu , Yongzhong Du

{"title":"Nano transdermal system combining mitochondria-targeting cerium oxide nanoparticles with all-trans retinoic acid for psoriasis","authors":"Wei Wang , Xinyi Xu , Yanling Song , Lan Lan , Jun Wang , Xinchang Xu , Yongzhong Du","doi":"10.1016/j.ajps.2023.100846","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100846","url":null,"abstract":"<div><p>Psoriasis is an inflammatory skin disease that is intricately linked to oxidative stress. Antioxidation and inhibition of abnormal proliferation of keratinocytes are pivotal strategies for psoriasis. Delivering drugs with these effects to the site of skin lesions is a challenge that needs to be solved. Herein, we reported a nanotransdermal delivery system composed of all-trans retinoic acid (TRA), triphenylphosphine (TPP)-modified cerium oxide (CeO<sub>2</sub>) nanoparticles, flexible nanoliposomes and gels (TCeO<sub>2</sub>-TRA-FNL-Gel). The results revealed that TCeO<sub>2</sub> synthesized by the anti-micelle method, with a size of approximately 5 nm, possessed excellent mitochondrial targeting ability and valence conversion capability related to scavenging reactive oxygen species (ROS). TCeO<sub>2</sub>-TRA-FNL prepared by the film dispersion method, with a size of approximately 70 nm, showed high drug encapsulation efficiency (>96%). TCeO<sub>2</sub>-TRA-FNL-Gel further showed sustained drug release behaviors, great transdermal permeation ability, and greater skin retention than the free TRA. The results of <em>in vitro</em> EGF-induced and H<sub>2</sub>O<sub>2</sub>-induced models suggested that TCeO<sub>2</sub>-TRA-FNL effectively reduced the level of inflammation and alleviated oxidative stress in HaCat cells. The results of <em>in vivo</em> imiquimod (IMQ)-induced model indicated that TCeO<sub>2</sub>-TRA-FNL-Gel could greatly alleviate the psoriasis symptoms. In summary, the transdermal drug delivery system designed in this study has shown excellent therapeutic effects on psoriasis and is prospective for the safe and accurate therapy of psoriasis.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100846"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic biomineralization nanoplatform-mediated differentiation therapy and phototherapy for cancer stem cell inhibition and antitumor immunity activation 仿生生物矿化纳米平台介导的分化和光疗对肿瘤干细胞抑制和抗肿瘤免疫激活的作用

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100851

Shan Gao, Meng Liu, Dongzhu Liu, Xinru Kong, Yuelin Fang, Yingying Li, Hang Wu, Jianbo Ji, Xiaoye Yang, Guangxi Zhai

{"title":"Biomimetic biomineralization nanoplatform-mediated differentiation therapy and phototherapy for cancer stem cell inhibition and antitumor immunity activation","authors":"Shan Gao, Meng Liu, Dongzhu Liu, Xinru Kong, Yuelin Fang, Yingying Li, Hang Wu, Jianbo Ji, Xiaoye Yang, Guangxi Zhai","doi":"10.1016/j.ajps.2023.100851","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100851","url":null,"abstract":"<div><p>Growing evidence suggests that the presence of cancer stem cells (CSCs) is a major challenge in current tumor treatments, especially the transition from non-CSCs to differentiation of CSCs for evading conventional therapies and driving metastasis. Here we propose a therapeutic strategy of synergistic differentiation therapy and phototherapy to induce differentiation of CSCs into mature tumor cells by differentiation inducers and synergistic elimination of them and normal cancer cells through phototherapy. In this work, we synthesized a biomimetic nanoplatform loaded with IR-780 and all-trans retinoic acid (ATRA) <em>via</em> biomineralization. This method can integrate aluminum ions into small-sized protein carriers to form nanoclusters, which undergo responsive degradation under acidic conditions and facilitate deep tumor penetration. With the help of CSC differentiation induced by ATRA, IR-780 inhibited the self-renewal of CSCs and cancer progression by generating hyperthermia and reactive oxygen species in a synergistic manner. Furthermore, ATRA can boost immunogenic cell death induced by phototherapy, thereby strongly causing a systemic anti-tumor immune response and efficiently eliminating CSCs and tumor cells. Taken together, this dual strategy represents a new paradigm of targeted eradication of CSCs and tumors by inducing CSC differentiation, improving photothermal therapy/photodynamic therapy and enhancing antitumor immunity.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100851"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-temperature photothermal-induced alkyl radical release facilitates dihydroartemisinin-triggered “valve-off” starvation therapy 低温光热诱导的烷基自由基释放促进了双氢青蒿素触发的“关阀”饥饿治疗

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100850

Xiaomin Su , Boshu Ouyang , Yao Liu , Yang Wang , Ruizhe Xu , Lili Niu , NanNan Li , Ce Xu , Zanya Sun , Huishu Guo , Zhiqing Pang , Xiangrong Yu

{"title":"Low-temperature photothermal-induced alkyl radical release facilitates dihydroartemisinin-triggered “valve-off” starvation therapy","authors":"Xiaomin Su , Boshu Ouyang , Yao Liu , Yang Wang , Ruizhe Xu , Lili Niu , NanNan Li , Ce Xu , Zanya Sun , Huishu Guo , Zhiqing Pang , Xiangrong Yu","doi":"10.1016/j.ajps.2023.100850","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100850","url":null,"abstract":"<div><p>The high nutrient and energy demand of tumor cells compared to normal cells to sustain rapid proliferation offer a potentially auspicious avenue for implementing starvation therapy. However, conventional starvation therapy, such as glucose exhaustion and vascular thrombosis, can lead to systemic toxicity and exacerbate tumor hypoxia. Herein, we developed a new “valve-off” starvation tactic, which was accomplished by closing the valve of glucose transporter protein 1 (GLUT1). Specifically, dihydroartemisinin (DHA), 2,20-azobis [2-(2-imidazolin-2-yl) propane] dihydrochloride (AI), and Ink were co-encapsulated in a sodium alginate (ALG) hydrogel. Upon irradiation with the 1064 nm laser, AI rapidly disintegrated into alkyl radicals (R<sup>•</sup>), which exacerbated the DHA-induced mitochondrial damage through the generation of reactive oxygen species and further reduced the synthesis of adenosine triphosphate (ATP). Simultaneously, the production of R<sup>•</sup> facilitated DHA-induced starvation therapy by suppressing GLUT1, which in turn reduced glucose uptake. Systematic <em>in vivo</em> and <em>in vitro</em> results suggested that this radical-enhanced “valve-off” strategy for inducing tumor cell starvation was effective in reducing glucose uptake and ATP levels. This integrated strategy induces tumor starvation with efficient tumor suppression, creating a new avenue for controlled, precise, and concerted tumor therapy.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100850"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted hyperalkalization with NaOH-loaded starch implants enhances doxorubicin efficacy in tumor treatment 用NaOH负载的淀粉植入物进行靶向超碱性化可增强阿霉素在肿瘤治疗中的疗效。

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100853

Changkyu Lee

{"title":"Targeted hyperalkalization with NaOH-loaded starch implants enhances doxorubicin efficacy in tumor treatment","authors":"Changkyu Lee","doi":"10.1016/j.ajps.2023.100853","DOIUrl":"10.1016/j.ajps.2023.100853","url":null,"abstract":"<div><p>High-alkali treatment using sodium hydroxide (NaOH) injection can be a therapeutic approach for killing tumor cells. Alkalization can damage cellular structures and lead to cell death. Increased alkalinity can also enhance the efficacy of certain chemotherapeutic drugs such as doxorubicin (DOX). In this study, NaOH-loaded starch implants (NST implants) were used to induce hyperalkalization (increase pH) in the tumor environment, thereby inducing necrosis and enhancing the effects of DOX. NaOH is a strongly alkaline substance that can increase the pH when injected into a tumor. However, the administration of NaOH can have toxic side effects because it increases the pH of the entire body, not just at the tumor site. To overcome this problem, we developed an injectable NST implant, in which NaOH can be delivered directly into the tumor. This study showed that NST implants could be easily administered intratumorally in mice bearing 4T1 tumors and that most of the NaOH released from the NST implants was delivered to the tumors. Although some NaOH from NST implants can be systemically absorbed, it is neutralized by the body's buffering effect, thereby reducing the risk of toxicity. This study also confirmed both <em>in vitro</em> and <em>in vivo</em> that DOX is more effective at killing 4T1 cells when alkalized. It has been shown that administration of DOX after injection of an NST implant can kill most tumors. Systemic absorption and side effects can be reduced using an NST implant to deliver NaOH to the tumor. In addition, alkalinization induced by NST implants not only exerts anticancer effects but can also enhance the effect of DOX in killing cancer cells. Therefore, the combination of NaOH-loaded starch implants and DOX treatment has the potential to be a novel therapy for tumors.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100853"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination therapy to overcome ferroptosis resistance by biomimetic self-assembly nano-prodrug 仿生自组装纳米前药联合治疗抗脱铁性

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100844

Yong Huang , Yi Lin , Bowen Li , Fu Zhang , Chenyue Zhan , Xin Xie , Zhuo Yao , Chongzhi Wu , Yuan Ping , Jianliang Shen

{"title":"Combination therapy to overcome ferroptosis resistance by biomimetic self-assembly nano-prodrug","authors":"Yong Huang , Yi Lin , Bowen Li , Fu Zhang , Chenyue Zhan , Xin Xie , Zhuo Yao , Chongzhi Wu , Yuan Ping , Jianliang Shen","doi":"10.1016/j.ajps.2023.100844","DOIUrl":"10.1016/j.ajps.2023.100844","url":null,"abstract":"<div><p>Ferroptosis has emerged as a potent form of no-apoptotic cell death that offers a promising alternative to avoid the chemoresistance of apoptotic pathways and serves as a vulnerability of cancer. Herein, we have constructed a biomimetic self-assembly nano-prodrug system that enables the co-delivery of gefitinib (Gefi), ferrocene (Fc) and dihydroartemisinin (DHA) for the combined therapy of both ferroptosis and apoptosis. In the tumor microenvironment, this nano-prodrug is able to disassemble and trigger drug release under high levels of GSH. Interestingly, the released DHA can downregulate GPX4 level for the enhancement of intracellular ferroptosis from Fc, further executing tumor cell death with concomitant chemotherapy by Gefi. More importantly, this nano-prodrug provides highly homologous targeting ability by coating related cell membranes and exhibits outstanding inhibition of tumor growth and metastasis, as well as no noticeable side-effects during treatments. This simple small molecular self-assembled nano-prodrug provides a new reasonably designed modality for ferroptosis-combined chemotherapy.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100844"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46255679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emerging potential of siRNA nanotherapeutics in treatment of arthritis siRNA纳米疗法在关节炎治疗中的新潜力

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100845

Anjali Kumari , Amanpreet Kaur , Geeta Aggarwal

{"title":"The emerging potential of siRNA nanotherapeutics in treatment of arthritis","authors":"Anjali Kumari , Amanpreet Kaur , Geeta Aggarwal","doi":"10.1016/j.ajps.2023.100845","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100845","url":null,"abstract":"<div><p>RNA interference (RNAi) using small interfering RNA (siRNA) has shown potential as a therapeutic option for the treatment of arthritis by silencing specific genes. However, siRNA delivery faces several challenges, including stability, targeting, off-target effects, endosomal escape, immune response activation, intravascular degradation, and renal clearance. A variety of nanotherapeutics like lipidic nanoparticles, liposomes, polymeric nanoparticles, and solid lipid nanoparticles have been developed to improve siRNA cellular uptake, protect it from degradation, and enhance its therapeutic efficacy. Researchers are also investigating chemical modifications and bioconjugation to reduce its immunogenicity. This review discusses the potential of siRNA nanotherapeutics as a therapeutic option for various immune-mediated diseases, including rheumatoid arthritis, osteoarthritis, etc. siRNA nanotherapeutics have shown an upsurge of interest and the future looks promising for such interdisciplinary approach-based modalities that combine the principles of molecular biology, nanotechnology, and formulation sciences.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100845"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49721380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The enantioselective enhancing effect and mechanistic insights of chiral enhancers in transdermal drug delivery 手性增强剂在经皮给药中的对映选择性增强作用及机理研究

IF 10.2 1区医学

Asian Journal of Pharmaceutical Sciences Pub Date : 2023-09-01 DOI: 10.1016/j.ajps.2023.100849

Yang Zhang , Chao Liu , Dongxiao E. , Wenxuan Jia , Peng Sun , Hui Li , Guojing Yu , Peng Quan , Mingzhe Liu , Liang Fang

{"title":"The enantioselective enhancing effect and mechanistic insights of chiral enhancers in transdermal drug delivery","authors":"Yang Zhang , Chao Liu , Dongxiao E. , Wenxuan Jia , Peng Sun , Hui Li , Guojing Yu , Peng Quan , Mingzhe Liu , Liang Fang","doi":"10.1016/j.ajps.2023.100849","DOIUrl":"https://doi.org/10.1016/j.ajps.2023.100849","url":null,"abstract":"<div><p>Overlook of chiral consideration in transdermal drug delivery increases administrated dose and risk of side effects, decreasing therapeutical effects. To improve the transdermal delivery efficiency of eutomer, this work focused on investigating the law and mechanism of enantioselective enhancing effects of chiral permeation enhancers on drug enantiomers. Chiral nonsteroidal anti-inflammatory drugs and terpene permeation enhancers were selected as model drug and enhancers. The results indicated that the L-isomer of permeation enhancers increased the skin absorption of S-enantiomer of drug and D-isomer improve the permeation of R-enantiomer, in which the enhancement effect (ER) of L-menthol on S-enantiomer (ER = 3.23) was higher than that on R-enantiomer (ER = 1.49). According to the pharmacokinetics results, L-menthol tended to enhance the permeation of S-enantiomer better than R-enantiomer (2.56 fold), and showed excellent <em>in vitro</em>/<em>in vivo</em> correlations. The mechanism study showed that L-isomer of permeation enhancers improved the permeation of S-enantiomer by increasing the retention, but the D-isomer by improving partition for better permeation. Enantioselective mechanism indicated that the weaker chiral H-bond interaction between drug-chiral enhancers was caused by the enantiomeric conformation. Additionally, stronger chiral enhancers-skin interaction between L-isomer and S-conformation of ceramide produced better enhancing effects. In conclusion, enantioselective interaction of chiral drug-chiral enhancers and chiral enhancers-chiral skin played a critical role in transdermal drug delivery, rational utilization of which contributed to improving the uptake of eutomer and inhibiting distomers to decrease a half of dose and side effects, increasing transdermal therapeutical efficiency.</p></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"18 5","pages":"Article 100849"},"PeriodicalIF":10.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0