Asian Journal of Pharmaceutical Sciences最新文献

{"title":"Ginseng-derived exosome-like nanovesicles protect against liver fibrosis by regulating TIMP2 pathways and gut dysbiosis","authors":"Ji-Su Kim ,&nbsp;Yejin Sim ,&nbsp;Dong-ha Kim ,&nbsp;Jae-Hee Kwon ,&nbsp;Sang-Hoon Lee ,&nbsp;Wiramon Rungratanawanich ,&nbsp;Jihoon Kim ,&nbsp;JinSun Jung ,&nbsp;Yong Yook Lee ,&nbsp;Sun Hee Hyun ,&nbsp;Seung-Ho Lee ,&nbsp;Hyo-Jung Kwon ,&nbsp;Byoung-Joon Song ,&nbsp;Kwang-Won Seo ,&nbsp;Do-Kyun Kim ,&nbsp;Young-Eun Cho","doi":"10.1016/j.ajps.2025.101105","DOIUrl":"10.1016/j.ajps.2025.101105","url":null,"abstract":"<div><div>Metabolic dysfunction-associated fatty liver disease (MASLD) and alcohol-associated liver disease (ALD) are prevalent chronic liver diseases that can progress to steatohepatitis, fibrosis, cirrhosis, and ultimately liver failure. Here, we demonstrated that oral administration of GNVs provided substantial protection against liver injury and fibrosis in MASLD and ALD mouse models. In a Western-style high-fat diet-induced MASLD model and a chronic binge alcohol-induced ALD model, GNVs treatment significantly reduced gut leakiness by restoring intestinal junctional complex proteins and rebalancing the gut microbiome. GNVs attenuated hepatic lipid accumulation, oxidative stress and fibrogenic markers. GNV treatment downregulated the fibrosis-associated tissue inhibitor of metalloproteinase-2 (TIMP2) pathway in hepatic stellate cells, which is linked to enhanced matrix degradation and reduced fibrogenesis. GNVs prevent MASLD- and ALD-associated gut barrier dysfunction and liver fibrosis through modulation of the gut–liver axis and the TIMP2 pathway. Edible GNVs represent a novel, multifaceted therapeutic strategy for managing chronic liver diseases.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 6","pages":"Article 101105"},"PeriodicalIF":11.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145691625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial polysaccharide-binding protein mediates co-assembly of nanodrug and probiotics against drug-resistant infectious enteritis","authors":"Ying Sun,&nbsp;Jiayue Yang,&nbsp;Zirun Zhao,&nbsp;Suke Liu,&nbsp;Mingchun Li,&nbsp;Qilin Yu","doi":"10.1016/j.ajps.2025.101094","DOIUrl":"10.1016/j.ajps.2025.101094","url":null,"abstract":"<div><div>Intestinal drug-resistant pathogens, e.g., <em>Salmonella</em> enterica subsp. <em>enterica</em> serovar Typhimurium (<em>S</em>. Tm) and enteropathogenic <em>Escherichia coli (E. coli)</em>, frequently cause life-threatening infectious enteritis. Probiotic-based therapy is a promising way to eliminate drug-resistant pathogens for treatment of infectious enteritis, but its colonizing and therapeutic efficacy after oral administration are limited. Here, we developed a facile therapeutic agent to treat infectious enteritis by co-assembly of the peptide nanodrug melittin-loaded MSN grafted by polysaccharide-binding protein (MMPB) with the famous probiotic bacteria <em>Lactobacillus plantarum</em> (Lac) and <em>Bifidobacterium animalis</em> subsp. <em>lactis</em> (Bif). The nanodrug was composed of the antimicrobial peptide melittin and mesoporous silica nanoparticles exposing the artificial polysaccharide-binding protein. Owing to presence of the artificial protein on the MMPB surface, the nanodrug strongly bound and cross-linked the probiotic cells, forming the Lac+Bif+MMPB co-assembly. During co-incubation with the kanamycin-resistant <em>E. coli</em> strain (<em>Ecka</em>), the co-assembly strongly reduced the viability of <em>Ecka</em>, leading to the increase in the ratio of probiotic to <em>Ecka</em> from 1.6 to 9.2. After oral administration of the co-assembly to the mice pre-colonized by <em>Ecka</em>, Lac+Bif+MMPB almost eliminated the kanamycin-resistant gene in the intestine, and led to 2–3-fold higher levels of the probiotic cells than the nanodrug MMPB or the combined probiotics Lac+Bif. More importantly, in the mice suffering from enteritis caused by drug-resistant <em>S</em>. Tm, the co-assembly remarkably recovered the mouse body weight, reduced intestine colonization of <em>S</em>. Tm cells, and decreased the levels of pro-inflammatory cytokines in both serum and colons. This study realized the synthetic biology technique-mediated abiotic/biotic co-assembly for efficient treating infectious enteritis induced by drug-resistant pathogens.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 6","pages":"Article 101094"},"PeriodicalIF":11.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145691626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic continuum soft robot-driven precise delivery of prodrug nanoassemblies for gastric cancer chemo-immunotherapy","authors":"Yuequan Wang ,&nbsp;Hao Ye ,&nbsp;Denis von Arx ,&nbsp;Yukang Li ,&nbsp;Yifan Wang ,&nbsp;Alexandre Mesot ,&nbsp;Carlos Franco ,&nbsp;Xiang-Zhong Chen ,&nbsp;Yuting Wang ,&nbsp;Shenwu Zhang ,&nbsp;Salvador Pané ,&nbsp;Meng Niu ,&nbsp;Bradley J. Nelson ,&nbsp;Cong Luo","doi":"10.1016/j.ajps.2025.101103","DOIUrl":"10.1016/j.ajps.2025.101103","url":null,"abstract":"<div><div>Local precise drug delivery is conducive to improving therapeutic efficacy and minimizing off-target toxicity. Current local delivery approaches are focused mostly on superficial or postoperative tumor lesions, due to the challenges posed by the inaccessibility of deep-seated tumors. Herein, we report a magnetic continuum soft robot capable of non-invasive and site-specific delivery of prodrug nanoassemblies-loaded hydrogel. The nanoassemblies are co-assembled from redox-responsive docetaxel prodrug and oxaliplatin prodrug, and subsequently embedded into a hydrogel matrix. The hydrogel precursor and crosslinker are synchronously delivered using the soft robot under magnetic guidance and <em>in situ</em> crosslinked at the gastric cancer lesions, forming a drug depot for sustained release and long-lasting treatment. As the hydrogel gradually degrades, the nanoassemblies are internalized by tumor cells. The redox response ability enables them to be selectively activated within tumor cells to trigger the release of docetaxel and oxaliplatin, exerting a synergistic anti-tumor effect. We find that the combination effectively induces immunogenic cell death of gastric tumor, enhancing antitumor immune responses. This strategy offers an intelligent and controllable integration platform for precise drug delivery and combined chemo-immunotherapy.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 6","pages":"Article 101103"},"PeriodicalIF":11.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia-responsive hybrid nanoparticles loaded with fingolimod and colistin against multidrug-resistant Klebsiella pneumoniae with mature biofilm","authors":"Mengting Liu ,&nbsp;Xinrui Liu ,&nbsp;Tengli Zhang ,&nbsp;Yuanqiang Wang ,&nbsp;Hong Yao ,&nbsp;Xiwang Liu ,&nbsp;Zhiguo Fang ,&nbsp;Yinglan Yu ,&nbsp;Lei Luo","doi":"10.1016/j.ajps.2025.101107","DOIUrl":"10.1016/j.ajps.2025.101107","url":null,"abstract":"<div><div>Multidrug-resistant <em>Klebsiella pneumoniae</em> (MDR-<em>KP</em>) is characterized by high mortality and risk of nosocomial transmission, and biofilm constitutes the primary challenge in the treatment of its implant-associated and refractory pulmonary infections. Notably, the hypoxic microenvironment and the physical barrier of biofilm leading to the increased tolerance of the bacteria to antibiotics. Herein, a hypoxia-responsive hybrid nanoparticle (CHLip@FLD/COL) loaded separately with anti-biofilm candidate fingolimod (FLD) and antibiotic colistin (COL) is achieved targeting antibacterial efficacy against MDR-<em>KP in vitro</em> and <em>in vivo</em>. CHLip@FLD/COL is composed of hybridizing hypoxia-responsive lipids (HLipid) and lipid A targeting materials DSPE-mPEG-COL. HLipid is synthesized by hexadecanedioic acid esterified with nitroimidazole, while DSPE-mPEG is coupling with vector COL via amide reaction. The relative level of extracellular polymeric substances and the NIR-IIb sO₂ images of the infection site are used as indicators to establish mature biofilm models. CHLip@FLD/COL readily releases FLD and COL in hypoxic conditions, and its MIC against MDR-<em>KP</em> is only one-sixteenth of that when COL is used alone <em>in vitro</em>. The nanoparticle exhibits bacterial targeting ability and antibacterial effect in the pulmonary infection and biofilm infection mice models. Bacterial loads eliminated by 4 Log₁₀ CFU and 2 Log₁₀ CFU, respectively. The strategy provides a valuable reference for the treatment of refractory infections caused by MDR-<em>KP</em>.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 6","pages":"Article 101107"},"PeriodicalIF":11.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145691630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penetrative biomimetic nanovehicle boosts immunotherapy in triple-negative breast cancer via SOS1 blockade","authors":"Jiaxin Zhang ,&nbsp;Peng Xian ,&nbsp;Chao Wang ,&nbsp;Xier Pan ,&nbsp;Yaoyao Du ,&nbsp;Yunrong Nan ,&nbsp;Qing Pu ,&nbsp;Linghui Zou ,&nbsp;Donovan Green ,&nbsp;Shuting Ni ,&nbsp;Kaili Hu","doi":"10.1016/j.ajps.2025.101064","DOIUrl":"10.1016/j.ajps.2025.101064","url":null,"abstract":"<div><div>Immunotherapy of triple-negative breast cancer (TNBC) is significantly hindered by the immunosuppressive tumor microenvironment (TME). Notably, tumor-associated macrophages (TAMs), which constitute the predominant infiltrating immune cell type in TNBC, represent a critical target for “turning off” immunosuppressive TME. Despite numerous ongoing clinical trials, current strategies exhibit limited efficacy in overcoming immunosuppressive TME. Interestingly, regulation of son of sevenless 1 (SOS1), which is overexpressed in TNBC patients, shows promising potential for TAM repolarization. Herein, we developed a biomimetic liposomal platform (CCM/Cil-lipo@TD), which integrates cilengitide (Cil)-functionalized breast cancer cell membranes (CCM) to co-deliver tetrandrine (TET) and low-dose docetaxel (DTX) for TNBC therapy. This system synergistically enhanced immunotherapy by coupling SOS1 blockade-driven TAM repolarization with immune cell death (ICD)-mediated dendritic cell (DC) maturation, thereby reshaping the highly immunosuppressive TME in TNBC. Critically, the low-density Cil-anchored, CCM-fused liposomes overcome the penetration limitations inherent to conventional CCM-based delivery systems, achieving deep intratumoral accumulation of therapeutic payloads. Mechanistically, the CCM/Cil-lipo@TD ensured that TET-mediated SOS1 inhibition in tumor cells efficiently polarized TAM2 (protumor) toward TAM1 (antitumor). Furthermore, SOS1 blockade synergized with low-dose DTX-induced ICD to remodel TME, as evidenced by sustained cytotoxic T-cell infiltration and suppression of regulatory T cells. The CCM/Cil-lipo@TD exerted superior tumor inhibition (82.9 %) in 4T1 orthotopic models and effectively inhibited postoperative local recurrence and distant metastasis. Taken together, the Cil-engineered, cell membrane-anchoring CCM/Cil-lipo@TD provides a promising approach for TNBC immunotherapy.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 5","pages":"Article 101064"},"PeriodicalIF":11.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A self-assembled nano-spray formulation for synergistic therapy of anti-inflammation and skin repair","authors":"Qi Pan ,&nbsp;Shiwei Zhang ,&nbsp;Xiaojie Yan ,&nbsp;Jiajing Guo ,&nbsp;Bowen Li ,&nbsp;Yuan Ping","doi":"10.1016/j.ajps.2025.101067","DOIUrl":"10.1016/j.ajps.2025.101067","url":null,"abstract":"<div><div>Inflammatory skin disorders (ISDs), characterized by severe inflammation and impaired skin barrier functions, often requires persistent treatment due to chronic and relapsing natures. To address these issues, we developed a small-molecular self-assembled nanodrug (ECN) that is composed of natural epigallocatechin-3-gallate (EGCG) self-assembled with tripeptide collagen (CTP). By formulating a transdermal enhancer (cationic dendrimer) with ECN, the resulted dendrimers/ECN nanocomplex (DECN) can effectively penetrate into the skin layer, resulting in effective anti-inflammatory response and repair of skin-barrier functions. In animal models of ISDs, including atopic dermatitis (AD) and psoriasis, DECN showed remarkable skin penetration, with high level of drug deposition in the epidermal-dermal layer. By using a commercially available spray pump, DECN nanoparticles can be further translated into a spray formulation, which contributes to alleviating visible symptoms, skin lesions, and inflammatory progression of psoriasis and AD. This all-in-one spray nano-formulation offers an effective, safe, and convenient way for ISDs treatment.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 5","pages":"Article 101067"},"PeriodicalIF":11.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced strategies of covalent organic framework nanomedicines in targeting and overcoming biological barriers","authors":"Lei Zhong ,&nbsp;Jinpeng Liu ,&nbsp;Yingming Xiao ,&nbsp;Zhenyu Song ,&nbsp;Li Chen ,&nbsp;Ge Li ,&nbsp;Yi Wu","doi":"10.1016/j.ajps.2025.101066","DOIUrl":"10.1016/j.ajps.2025.101066","url":null,"abstract":"<div><div>Covalent organic frameworks (COFs) are crystalline and porous materials formed from periodically organized organic molecules bonded covalently to create highly stable architectures. Their mechanical properties can be precisely adjusted through structural modifications, making COFs exceptionally suitable for applications in cancer treatment and drug delivery. This review summarizes strategies for controlling the mechanical properties of COFs, including adjustments in structural dimensions, pore sizes and host-guest interactions. The remarkable advancements in drug delivery, cancer therapy, photodynamic therapy and photothermal therapy achieved through COFs with tunable mechanical properties are then discussed. By providing deeper insights into the biomedical applications of COF systems, this review aims to foster interdisciplinary research combining nanomedicine and COF materials. Additionally, the review explores recent studies and discoveries on COFs' potential as innovative drug carriers capable of biological overcoming barriers such as the blood-brain barrier, nasal mucosa, cutaneous layers and oral mucosa. Greater insight into both the limitations and potential of COFs could pave the way for developing more effective and targeted strategies within this challenging field.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 5","pages":"Article 101066"},"PeriodicalIF":11.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An erythrocyte membrane-fused plant-derived nanoparticles as a gene therapy vehicle for the treatment of CI/R injury","authors":"Shiyi Li ,&nbsp;Anni Wang ,&nbsp;Ru Zhang ,&nbsp;Miaomiao Zhang ,&nbsp;Pengcheng Guo ,&nbsp;Bixue Chen ,&nbsp;Yangke Yuan ,&nbsp;He Wang ,&nbsp;Jianxin Wang","doi":"10.1016/j.ajps.2025.101089","DOIUrl":"10.1016/j.ajps.2025.101089","url":null,"abstract":"<div><div>Ischemic stroke is currently the second leading cause of death worldwide, and insufficient endogenous neurogenesis is the greatest cause of post-stroke disability. MicroRNAs have been proven to hold therapeutic potential, unfortunately, they have a low stability that hinders their clinical usage. Our earlier work revealed that Panax notoginseng derived exosome like nanoparticles, namely PDNs have potential to bypass BBB and reduce the cerebral ischemia/reperfusion (CI/R) damage. In this study, we employed microRNA-124 as a model therapeutic gene, utilizing its engineered variant Agomir-124 (Ago124) to optimize loading efficiency. The therapeutic effects of Ago124@R-PDN were further assessed in several sets of experiments. Pharmacokinetic study showed that erythrocyte membrane extended the half-life of PDNs from 7 min to 11.3 h, and the loading efficiency of Ago124 reached 40 %. In an <em>in vitro</em> oxygen-glucose deprivation/reperfusion (OGD/R) model, Ago124@R-PDN enhanced IL-10 production in microglia by 67 % (<em>vs</em> 11.7 % with free Ago124), and promoted Tuj1⁺ neuronal differentiation by 2.23-fold compared with vehicle. Also, Ago124@R-PDN brought gene cargo into the brain, alleviated infarct volume, and improved functional behaviors in model mice. At last, we demonstrated that surface glycosyl of PDN facilitated its brain-entering ability by being recognized by sodium-glucose linked transporter-1 protein. In conclusion, our erythrocyte fused PDNs offer a promising strategy for delivering biomacromolecule to treat brain diseases.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 5","pages":"Article 101089"},"PeriodicalIF":11.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celastrol-loaded metal-phenolic nanozymes integrated microneedles with ROS scavenging and anti-inflammatory activities for psoriasis treatment","authors":"Li Qin ,&nbsp;Haozheng Jiao ,&nbsp;Yu Wang ,&nbsp;Lvyao Yang ,&nbsp;Xianbao Shi ,&nbsp;Peng Zhang","doi":"10.1016/j.ajps.2025.101062","DOIUrl":"10.1016/j.ajps.2025.101062","url":null,"abstract":"<div><div>Psoriasis is a chronic inflammatory skin disease, which seriously affects the physical and mental health of patients. The progression of psoriasis is influenced by the excessive production of reactive oxygen species (ROS) and inflammatory responses. In this paper, novel celastrol (Ce)-loaded metal-phenolic nanozymes (tannic acid-Fe³⁺) (TA-Fe) integrated microneedles (Ce@TA-Fe/MNs) were constructed to achieve the combined oxidative stress alleviation and anti-inflammatory therapy of psoriasis. Molecular dynamics simulations and structural characterization confirmed the successful fabrication of nanozymes. The Ce@TA-Fe/MNs system, characterized by its rapid dissolution kinetics and superior mechanical strength, enabled minimally invasive skin penetration for efficient nanozymes delivery. Nanozymes possessed superoxide dismutase and catalase mimetic enzyme activities, effectively eliminating excessive ROS in psoriatic skin lesions. Additionally, the release of Ce from Ce@TA-Fe provided strong antioxidant and anti-inflammatory effects. Based on these characteristics, Ce@TA-Fe/MNs could effectively alleviate the symptoms in psoriasis mice models. These findings demonstrated that the integration of Ce-equipped nanozymes within MNs holds great promise as a therapeutic strategy for the clinical management of psoriasis.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 5","pages":"Article 101062"},"PeriodicalIF":11.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles in cancer immunotherapy: Therapeutic, challenges and clinical progress","authors":"Hamed Manoochehri ,&nbsp;Anita S. La'ah ,&nbsp;Ali Babaeizad ,&nbsp;Mohsen Sheykhhasan ,&nbsp;Mohadeseh Rostamipoor ,&nbsp;Mahdiyeh Abbaspoor ,&nbsp;Fariba Nikravesh ,&nbsp;Samira Mozaffari Khosravi ,&nbsp;Hanie Mahaki ,&nbsp;Hamid Tanzadehpanah ,&nbsp;Piao Yang","doi":"10.1016/j.ajps.2025.101065","DOIUrl":"10.1016/j.ajps.2025.101065","url":null,"abstract":"<div><div>Cancer is a major global concern due to its high mortality rate. Tumor immunotherapy has revolutionized cancer treatment. However, low response rates and immune-related complications remain challenges. Extracellular vesicles (EVs), including exosomes, have emerged as promising therapeutic tools for various pathological conditions, especially cancer. Evidence indicates that changes in the quantity and composition of EVs can influence the immunosuppressive tumor microenvironment, potentially affecting the effectiveness of immunotherapy. Exploiting EVs for immune sensitization has generated significant clinical interest. This review provides an in-depth understanding of the origin of EVs, their therapeutic applications (such as drug delivery nanoplatforms and cancer immunotherapies, including vaccines), diagnostic potential as tumor biomarkers, ongoing EV-based clinical trials, and the challenges encountered in EV-based cancer immunotherapy.</div></div>","PeriodicalId":8539,"journal":{"name":"Asian Journal of Pharmaceutical Sciences","volume":"20 5","pages":"Article 101065"},"PeriodicalIF":11.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}