Akanksha Singh, Meenu Verma, Vaishali Mishra, K. J. Singh, S. K. Tewari, Mahesh Pal
{"title":"Development of Phyto-cosmetic Herbal Sindoor from Rosa indica L. and Its Characterization","authors":"Akanksha Singh, Meenu Verma, Vaishali Mishra, K. J. Singh, S. K. Tewari, Mahesh Pal","doi":"10.9734/ajrimps/2023/v12i4233","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i4233","url":null,"abstract":"Aim: The objective of this research study was to develop a liquid herbal sindoor containing flower petal extract of Rosa indica L., and to evaluate the stability, antioxidant and antibacterial activities of the developed formulation.
 Place and Duration of Study: The formulation was prepared in the Phytochemistry Division of CSIR- National Botanical Research Institute. The duration of the study period was 90 days.
 Methodology: The crude ethanolic extract of R. indica flowers was incorporated into a base for the preparation of liquid herbal sindoor. The antioxidant activity of this herbal product was evaluated according to the DPPH radical scavenging method, and the stability study of the formulation was evaluated for 90 days. The antibacterial activity was performed on those strains of bacteria, which are responsible for several skin infections using Disc Diffusion Assay.The HPLC- DAD analysis identified the anthocyanins cyanidin 3,5-diglucoside and pelargonidin 3,5-diglucoside in R. indica, flower extract.
 Results and Discussion: The formulation showed antioxidant activity and its stability was assessed in terms of pH values and color stability of the flower extract. It was observed that both these properties did not show any significant changes.
 Conclusion: The prepared herbal liquid sindoor was found safe to use having a potential to substitute the toxic lead tetraoxide (Pb3O4) containing sindoor available in the market.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135803220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Review of the Epilepsy, Including Its Causes, Symptoms, Biomarkers, and Management","authors":"Yash Srivastav, Akhandnath Prajapati, Prachi Agrahari, Madhaw Kumar","doi":"10.9734/ajrimps/2023/v12i4232","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i4232","url":null,"abstract":"Epilepsy is a long-term medical disorder that frequently causes unpredictable, unprovoked repeated seizures that have an impact on both physical and mental abilities. It is among the most prevalent neurological conditions. Greek term epilambanein, which is the root of the English word epilepsy, means \"to be seized.\" Both the sickness and the one-time attack were meant by this. The word refers to the magical beliefs of the time, which led to the stigma associated with epilepsy because people with epilepsy were seen to be dirty or bad. A recent study found that nearly 90% of the 70 million epileptics worldwide live in developing countries. Genetic testing has expanded the possibility of figuring out the aetiology of different types of epilepsies. It needs some prior clinical application knowledge to complete this challenging endeavour. Genetic testing techniques include chromosome microarray analysis, karyotyping, single-gene testing, gene panel testing, whole exome sequencing, and whole genome sequencing. The allegedly first documented account of epilepsy, as it was then perceived and understood, may be found in one of the earliest Babylonian medical manuals, Sakikku (English translation: \"All Diseases\"), which dates from around 1050 BC. The pathogenesis, aetiology, treatment, biomarkers, and risk factors for epilepsy are reviewed in this review article.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134944370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of In-vitro Antimicrobial, Anti-arthritis and In-vivo Analgesic and Neuropharmacological Investigation of the Bark Extract of Solanum americanum Milli","authors":"Mariya Alam Ayshi, Tajmim Jahan Ritu","doi":"10.9734/ajrimps/2023/v12i4231","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i4231","url":null,"abstract":"Purpose: The objective of this study was to investigate the impact of methanol-prepared bark extract of Solanum americanum Milli. Bark on several in vitro activities, including antimicrobial and anti-arthritis effects. Additionally, the study aimed to assess the analgesic and neuropharmacological properties of the extracts in an animal model.
 Place and Duration of Study: The research study was carried out from March 2023 to July 2023 at the Bangladesh Council of Scientific and Industrial Research (BCSIR) and the Laboratory of Phytochemistry and Pharmacology, Department of Pharmacy, as well as the Laboratory of Microbiology at Stamford University Bangladesh, Dhaka.
 Methodology: The methodology involved various doses of methanolic bark extract of Solanum americanum Milli (MESAB), and employed techniques such as the Disk Diffusion Method for antimicrobial test and the Inhibition of Protein Denaturation Assay for anti-arthritic test. The analgesic efficacy was assessed by the hot plate test and administration of acetic acid induced writhing responses in Swiss albino mice. The mechanism test is conducted through the cyclic guanosine monophosphate (cGMP) test. The neuropharmacological inquiry included the measurement of locomotor activity through the utilization of open field and hole cross tests.
 Results: The Disk Diffusion Test of MESAB yielded findings indicating its antimicrobial properties against all strains used in this research. The findings from the study examining the anti-arthritis properties indicate that MESAB exhibits a significant efficacy of 94.59% in inhibiting arthritis at a concentration of 1000 µg/mL. This level of efficacy is comparable to that of diclofenac sodium, which also has a similar efficacy of 98.19% at the same concentration. The findings of the present study demonstrated that MESAB displayed analgesic properties in both analgesic models, suggesting the involvement of both central and peripheral pathways. Based on the results of the study, it was observed that the administration of MESAB at a dosage of 400 mg/kg had a significant analgesic effect. The application of MB before to treatment resulted in a further enhancement of this effect, leading to an increase in the percentage of inhibition from 66.75% to 79.70%, respectively. The consideration of the involvement of the GABA-benzodiazepine receptor in neuropharmacological activity holds significant importance. In the Open Field and Hole Cross Tests, it was shown that the extract exhibited significant result compared to Diazepam in terms of increasing motor coordination.
 Conclusion: In the future, plant-derived pharmacological compounds may offer potential benefits for various clinical disorders, such as neurodegenerative illnesses. These substances possess neuropharmacological properties, antibacterial effects, and anti-arthritic activity, which could potentially serve as alternatives to non-steroidal anti-inflammatory drugs (NSAIDs).","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136308890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panee Sirisa-Ard, Kiatisak Pholsonklam, Dinh Thi Xuyen, Dinh Thi Dieu Hang, Vu Dinh Chinh, Lê Thiên Kim, Zito Viegas, Da Cruz, Pacharamon Sorncharoen, Choosak Nithikathkul
{"title":"Chemical Composition, Antibacterial and Antioxidant Activities of Extracts from Dry Leaves and Ash-Dry Leaves of Luffa cylindrica (L.) Roem Cultivated in Vietnam","authors":"Panee Sirisa-Ard, Kiatisak Pholsonklam, Dinh Thi Xuyen, Dinh Thi Dieu Hang, Vu Dinh Chinh, Lê Thiên Kim, Zito Viegas, Da Cruz, Pacharamon Sorncharoen, Choosak Nithikathkul","doi":"10.9734/ajrimps/2023/v12i4230","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i4230","url":null,"abstract":"Luffa cylindrica (L.) Roem was traditionally used to treat stomachaches, as antihyperlipidemic and antioxidant, particularly for atherosclerosis therapy, as a suppository to cure constipation and spleenopathy, as an anthelmintic, carminative, emmenagogue, galactagogue, and as an antiseptic. Therefore, the aim of this study was to study the chemical composition, antibacterial and antioxidant properties of an extract from dry leaves (LuL) compared to ash-dry leaves (LuA) of Luffa cylindrica (L.) Roem.
 Our results showed the physical-chemical and phytochemical properties, antioxidant activity, antibacterial activity and the metal ion content of both extracts. The comparison between the extract from dry leaves (LuL) and ash-dry leaves (LuA) of Luffa cylindrica (L.) Roem, showed difference in quantitative phytochemical determination of cardiac glycosides, alkaloids, phenolics, flavonoids, and triterpenoids. This finding may be related to the LuA sample being burned out incompletely into ash. Furthermore, this study showed that the activity of extracts from dry leaves (LuL) and ash-dry leaves (LuA) contained both bacteriostatic and bactericidal effects. The antioxidant properties observed may be related to , the flavonoids content. The presence of metal ions in both extracts, which may contribute to the known wound healing effects, deserves further study.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135396523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multi-Detector Computed Tomography Angiographic Evaluation of Extremity Vascular Trauma: Case Series","authors":"Krishna Kumar M., Anil Kumar V., Arun R., S. V","doi":"10.9734/ajrimps/2023/v12i4229","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i4229","url":null,"abstract":"Objective: The purpose of this article is to review the multidetector computed tomography (MDCT) angiography within the evaluation of extremity trauma. Trauma could be a great public health dilemma in developing and developed countries and regularly involves teenagers. Among different kinds of trauma, vascular injuries of the extremities need special consideration because they’ll be threatening to limb and life. Vascular injury going to exsanguination and hemorrhagic shock is second to central nervous system injury; thus, imaging diagnosis is crucial for the trauma victim as early as possible from admission to the hospital. Although the speed of successful management of those injuries has been increased because of proper pre hospitalization, early referral of patients to specialized trauma centers, and proper surgical interventions, these injuries remain a challenging problem, especially in developing countries. \u0000Conclusion: With the rising trend of road traffic accidents and violence, vascular injuries have become a significant contributor of limb loss, with increased morbidity and mortality. MDCT Angiography has become the most non-invasive diagnostic imaging vascular triage tool applicable to all or any varieties of extremity trauma. Axial sections, multiplanar reconstructions and 3D volume-rendered images should aid within the detection and improve the interpretation of such vascular injuries, osseous and soft-tissue injuries which could be of immense help to the clinician planning surgical procedures. ","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"162 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86161969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on Chemical Constituents of Styrax dasyanthus Perk","authors":"Zhi-Qiang Zhang, Hai-Rong Zhong, Hong-Bo Jiang, Hai-Yan Xiang","doi":"10.9734/ajrimps/2023/v12i4228","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i4228","url":null,"abstract":"Objective: This study aimed to investigate the chemical components present in the ethyl acetate extract of Styrax dasyanthus leaves.\u0000Methods: Chemical components were isolated and purified using organic solvent decolorization, extraction, preparation of the liquid phase, silica gel column chromatography, and semi-preparative high-performance liquid chromatography. The structure identification of the isolated compounds was based on nuclear magnetic resonance (NMR) data and carbon spectrum matching analysis.\u0000Results: A total of six compounds were isolated from Styrax dasyanthus, which were identified as (-)-secoisolarciresinol (1), dibutylphthalate (2), dihydromyricetin (3), kaempferol-3-O-(beta)-D-glucopyranoside (4), kaempferol-3-rutinoside (3,4',5,7-tetrahydroxyflavone-3-rutinoside) (5), and (-)-secoisolariciresinol-4-O-(beta)-D-glucopyranoside (6).\u0000Conclusion: This study represents the first isolation of these six compounds from Styrax dasyanthus.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91143169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Common Perioperative Concerns in Pediatric Anesthesia: A Literature Review","authors":"Wael Waheed Mohamed","doi":"10.9734/ajrimps/2023/v12i4227","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i4227","url":null,"abstract":"There are several disorders that require children to be anesthetized. Sometimes, it is due to the non-cooperation of the children that requires them to be put under sedation for a procedure that is necessary for them, while at other times, it is because of any indicated surgical procedure that they have to go through, that they are put under anesthesia. However, unlike adults, children particularly the pediatric populations have particular demands and requirements that make them special candidates for receiving the required anesthesia. In children, nearly all parameters are different anatomically, physiologically, pharmacologically, and psychologically. \u0000According to some recent studies, it has also been noted that there are significant adverse events that are linked with the induction of anesthesia in the pediatric population, that are bound to arise if care is not taken during or after the anesthesia. These problems could arise in lieu of several factors such as the choice of anesthetic, the mode of anesthesia, airway management, and the reversal of anesthesia. In all cases, it is better to avoid the risk of complications and adverse events by making sure that only the most competent and expert of all staff are involved in the anesthesia team. With proper care and management of anesthesia, it is obvious that the risk of any critical events would be comparatively much less and that the children could be operated on easily. \u0000This review aims to deal with certain problems that arise in the background of anesthesia induction in the pediatric population. The age group that is referred to here belongs neonates to up to thirteen years of age. This review will explore the causes that result from the induction of anesthesia in such populations.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90495419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. A. Freitas, L. O. Onyemeh, P. O. Nneji, O. M. Ola, D. A. Faloye
{"title":"Evaluation of the Antidiabetic Potentials of Musa acuminata Leaves Crude Extract in Alloxan-Induced Wistar Rats","authors":"A. A. Freitas, L. O. Onyemeh, P. O. Nneji, O. M. Ola, D. A. Faloye","doi":"10.9734/ajrimps/2023/v12i4226","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i4226","url":null,"abstract":"Context: Musa acuminata is a plant of the tropical and subtropical regions. Over the past few decades, the health benefits of Musa acuminata have received much attention. All parts of the plant, including fruits, peel, pseudo stem, corm, flowers, leaves, sap, and roots, have found their use in treating many diseases in traditional medicine. \u0000Aim: This study was conducted to appraise the protective effect of Musa acuminata extract on alloxan-induced Diabetics Mellitus in wistar rats. \u0000Settings and Design: This investigation was carried out using 24 Wistar rats, both males and females. The experimental models were divided into six groups; 4 rats per group. \u0000Materials and Methods: The experimental models were divided into six groups; 4 rats per group. Alloxan was intraperitonially injected at a dose of 150 mg/kg body weight for day 1 across all groups except the positive control which is Group A together with oral administration of the aqueous extract of Musa acuminata (100 mg/kg, 200mg/kg and 300mg/kg body weight for the treatment group) and Group F was administered a standard drug. The animals were sacrificed on the 11th day under deep anesthesia with chloroform. The blood was collected by cardiac puncture and kidneys were collected for the histological profile. \u0000Statistical Analysis: Kidney oxidative stress marker Malondialdehyde (MDA) and antioxidant enzyme activities Creatinine and Urea, were determined. \u0000Results: The alloxan injection indicated an increase in Malondialdehyde (MDA), with a decrease in Urea and Creatinine when compared with the control. A remarkable decrease in antioxidant enzymes was also observed. Oxidant/antioxidant imbalance, alloxan-induced diabetic mellitus, and histological changes in the kidneys were reduced almost to normal by the administration of Musa acuminata. \u0000Conclusion: Based on the current findings, Musa acuminata leaves at low dose (100 mg/kg body weight) in the alloxan Induced Wistar rat has some anti diabetics potential than at 200 mg/kg body weight, 300 mg/kg body weight and standard drug (Metformin).","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79218424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pinkey Rawal, C. Ramesh, B. Sowmya, C. Ranjitha, L. Maria
{"title":"Study on of Ethanol and Aqueous Extracts of Embelia ribes for Anthelmintic Properties","authors":"Pinkey Rawal, C. Ramesh, B. Sowmya, C. Ranjitha, L. Maria","doi":"10.9734/ajrimps/2023/v12i4225","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i4225","url":null,"abstract":"Objectives: The present research study was conducted for the comparative evaluation of ethanol and aqueous extract of Embelia ribes for its in vitro anthelmintic properties. \u0000Methods: The authenticated leaves of plant Embelia ribes were dried and powdered. The powdered drug was defatted with petroleum ether and a part of marc leftover was subjected to ethanol extraction using Soxhlet apparatus. Another part was subjected aqueous extraction using chloroform water. The ethanol and aqueous extracts of Embelia ribes was subjected to preliminary phytochemical investigation. Both the extracts were evaluated for in vitro anthelmintic properties using earthworms. \u0000Results: The ethanol and aqueous extracts were revealed for the presence of alkaloids, glycosides, carbohydrates, flavonoids, tannins and phenols. The paralysis time and death time of worms were significantly reduced by the administration of ethanol and aqueous extracts of Embelia ribes. \u0000Conclusion: The result of the present investigation confirms the anthelmintic property of Embelia ribes.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75243592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. N. Y. Sandrine, Kavaye Kandeda Antoine, Bilanda Danielle Claude, Yonti Dzueffo Merveille, Atsamo Albert, O. P. Emmanuel, Djiogue Séfirin, D. Désiré, Kamtchouing Pierre, Ngo Bum Elisabeth
{"title":"Bridelia atroviridis (Phyllanthaceae) Aqueous Extract Attenuates Scopolamine-induced Amnesia and Depression in Rat: Role of Cholinergic, Monoaminergic, and Antioxidant Mechanisms","authors":"M. N. Y. Sandrine, Kavaye Kandeda Antoine, Bilanda Danielle Claude, Yonti Dzueffo Merveille, Atsamo Albert, O. P. Emmanuel, Djiogue Séfirin, D. Désiré, Kamtchouing Pierre, Ngo Bum Elisabeth","doi":"10.9734/ajrimps/2023/v12i3224","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i3224","url":null,"abstract":"Background: Anti-inflammatory and antioxidant activities are the main pathways of neuroprotective drugs. Bridelia atroviridis possesses those activities and is empirically used by Cameroonian traditional healers to alleviate memory and mood disorders. \u0000Objective: The purpose of this study is to evaluate the anti-amnesic and antidepressant effects of Bridelia atroviridis aqueous extract (EA). \u0000Methods: Scopolamine was used to induce amnesia and depression in rats. Administrated per os, three doses of EA, including 36, 72, and 144 mg/kg, were used. Behavioral disorders were evaluated through novel object recognition, the Morris water maze, forced swimming, and an open arena. The oxidative stress markers, like malondialdehyde, reduced glutathione, and nitrite levels in the brain, were measured. Neurometabolites, serotonin, and acetylcholine levels were determined. Hematoxylin-eosin paraffin-embedded histological sections were used to assess neuron viability in the cortex and the hippocampus. \u0000Results: Pre-treatments with EA attenuated the deleterious effects of scopolamine and improved brain biomarkers. Indeed, when compared to vehicle control, Bridelia atroviridis increased Ca2+, Mg2+, serotonin, and acetylcholine levels in the brain. Furthermore, the plant reduced significantly (p < 0.001) the recognition index in the novel object recognition test and increased (p < 0.001) the time spent in the target quadrant in the Morris water maze test. Besides, EA has scavenging activities and attenuates neuron death in the cortex and hippocampus. \u0000Conclusion: According to this study, the aqueous extract of B. atroviridis barks protects against scopolamine-induced memory loss and depressive disorders. The preventive activities of the plant involve cholinergic and monoaminergic pathways and antioxidant potential. \u0000Graphical Abstract: \u0000","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81069675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}