Asian Journal of Research in Medical and Pharmaceutical Sciences最新文献

{"title":"Effect of Co-administration of Vitamin A and Artesunate in Malaria-Infected Albino Mice","authors":"Onyemeh L. O., Freitas A. A., Olaide Z., Okoye A. C., Faloye D. A., Muoneke J. N.","doi":"10.9734/ajrimps/2023/v12i3223","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i3223","url":null,"abstract":"Malaria is a potentially fatal illness that results from infection by parasitic protozoa, which spread to humans via the bites of mosquitoes that have already been infected with the parasite. This research examines the impact of the simultaneous administration of Vitamin A and Artesunate on Plasmodium berghei-infected albino mice. A cohort of sixteen (16) albino mice, with a mean weight of 28g and indeterminate gender, were subjected to P. berghei inoculation. The mice were separated into four groups, each consisting of four animals. Artesunate was administered to Group A, distilled water was administered to Group B, Group C received antioxidant treatment in the form of vitamin A, and Group D was subjected to a combination treatment of Artesunate and Vitamin A. The study monitored the parasitemia level, hematocrit (PVC), percentage mortality rate, and change in body weight following the administration of various treatments, including an antimalarial drug (Artesunate), distilled water, Vitamin A, and a combination therapy of both Artesunate and Vitamin A. The co-administration of vitamin A and Artesunate may decrease the effectiveness of Artesunate in treating malaria infection. The research illustrates the intricate relationship between Artesunate and antioxidant (vitamin A) in mice infected with malaria. The efficacy of Artesunate in clearing the parasite was demonstrated by the reduction of Parasitaemia levels from +2(++) on the 5th day to +3 (+++) on the 7th day, followed by a decrease to +2(++) on the 9th day, and ultimately to +1(+) Parasitaemia on the 10th day. The co-administration of Vitamin A and Artesunate resulted in a reduction of the latter's efficacy in treating malaria, particularly in cases where the parasitemia level was at +3(+++) on the 5th, seventh, and 11th days and +2(++) on the ninth day. This procedure suggests that Vitamin A acted as an antagonist to the antimalarial effects of Artesunate. \u0000Furthermore, the mortality rate was 50%, and the PCV was reduced compared to Group A. Artesunate, a pro-oxidant that generates free oxygen radicals that act against the parasite. However, the presence of antioxidants like Vitamin A potentially counteracted the effects of pro-oxidants, indicating some form of pharmacological antagonism. The research findings indicate that the co-administration of vitamin A and Artesunate may reduce therapeutic effectiveness. Clinical interventions are recommended to be implemented to regulate the simultaneous administration of Artesunate and Vitamin A, as this may impact the therapeutic objective of malaria treatment.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72763806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Journey from Clinical Pharmacist to a Diabetic Foot Wound Care Pharmacist from India: An Experience from Amit Jain’s Institute of Diabetic Foot","authors":"H. C. Apoorva","doi":"10.9734/ajrimps/2023/v12i3222","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i3222","url":null,"abstract":"Diabetes is a growing problem and so are its complications with diabetic foot being one of the commonest known complications. Diabetic foot is often associated with amputation that increases the morbidity and mortality. Often, multidisciplinary management consisting of prevention, education, examination, treatment etc and multidisciplinary team approach can provide favorable outcomes. One of the members among this multidisciplinary team has been a pharmacist in few of the expert diabetic foot Centre’s around the world. It is observed that, though spoken of their role in clinical practice, either such roles are limited or undervalued. Further, there are sparse publications that provides a clear-cut role, training, responsibility, and their experience in a diabetic foot team. This article provides an essential insight on the journey of one of the first diabetic foot wound care Pharmacist from India.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75421059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anabolic Androgenic Steroids from Underground Market: drug Quality and Implications for Research","authors":"L. Câmara","doi":"10.9734/ajrimps/2023/v12i3221","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i3221","url":null,"abstract":"Currently, a large portion of users of anabolic androgenic steroids purchase these drugs from non-legal sources, the so-called underground market. Studies involving drugs seizures from the underground market, and their respective product chemical analysis, indicated that the adulteration rate can vary between 18 and 86%, plus a potential serious contamination by heavy metals or microorganisms. Inadvertent abuse of underground market products can put users' health at additional risk, leading to more serious side effects or unknown adverse events. The poor quality of these products may also jeopardize proper verification of causality in case report studies or case series.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88997854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Precision Medicine Approaches for Type 2 Diabetes Management: A Comprehensive Review","authors":"E. Milla-Amekor, E. Ewusie","doi":"10.9734/ajrimps/2023/v12i3220","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i3220","url":null,"abstract":"Projections indicate that, approximately 700 million people will be living with diabetes by 2050, a figure that has doubled in the previous twenty years. The rising cost of type 2 diabetes care might be reduced and existing treatment gaps could be closed with the help of precision medicine. Taking into consideration each individual unique genetic, environmental, and behavioral characteristic, precision medicine is a new approach to treatment. The primary goal of precision medication is to accurately foresee how a patient will respond to treatment. It may be used as a prophylactic strategy for the whole population because of how broadly it applies. Medication, weight reduction, regular exercise, and a nutritious diet all work together to prevent type 2 diabetes. Optimizing metabolic control is one way in which this kind of diabetes therapy has a probability to reduce death rates and improve standard of life. Inadequate funding for translational health research, incompatible data formats, a lack of system interoperability, a lack of decision-making support systems, and a lack of IT infrastructure support are just some of the obstacles to the widespread utilization of precision medicine technologies in clinical practice. Forecast translation of scientific results into practical applications may be aided by the creation of a worldwide clinical studies group dedicated to raising public understanding and appreciation of the great advantages of precision medicine in treating diabetes.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89624917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicological Effect of Green Tea (Camelia sinensis) on Haematological Parameters in Wistar Rats","authors":"Faith Onyedikachi Ogar, O. A. Georgewill, V. T. Ibubeleye","doi":"10.9734/ajrimps/2023/v12i3219","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i3219","url":null,"abstract":"Introduction: Green tea, derived from the leaves of Camellia sinensis, has gained significant attention due to its potential health benefits. It contains various bioactive compounds, such as polyphenols, flavonoids, and catechins, which have antioxidant, anti-inflammatory, and anticancer properties. Despite its widespread consumption and positive reputation, limited information is available regarding the potential toxicological effects of green tea. In this study, the toxicological impact of green tea extract on haematological parameters was investigated using Wistar rats as an animal model. \u0000Method:  Forty-eight adult male rats were randomly divided into four groups (n=12 per group). The control group received a vehicle solution, while the treatment groups were orally administered different doses of green tea extract (low dose: 100 mg/kg, moderate dose: 200 mg/kg, high dose: 400 mg/kg) once daily for 28 consecutive days. Haematological analysis was performed at baseline (day 0) and on days 7, 14, 21, and 28 of the study. Blood samples were collected from the retro-orbital plexus under light isoflurane anaesthesia, and various haematological parameters were assessed using automated Hematology analyzers. \u0000Results: The results of the haematological analysis showed that the administration of green tea extract did not significantly affect haemoglobin levels, packed cell volume, red blood cell count, eosinophil count, lymphocyte count, and neutrophil count compared to the control group throughout the study period. However, the white blood cell (WBC) count and its differential count exhibited some variations among the treatment groups. The low and moderate doses of green tea extract resulted in a slight increase in the WBC count compared to the control group, although the difference was not statistically significant. On the other hand, the high dose of green tea extract led to a slight decrease in the WBC count compared to the control group. Regarding platelet count, the low and moderate doses of green tea extract resulted in a significant increase compared to the control group. In contrast, the high dose of green tea extract caused a significant decrease in platelet count. \u0000Conclusions: Based on the findings of this study, it can be concluded that the administration of green tea extract did not have significant adverse effects on the assessed haematological parameters in Wistar rats, except for some minor variations in the WBC count and platelet count at higher doses. These results suggest that green tea consumption may not cause significant haematological toxicity in rats. However, further studies are warranted to evaluate the long-term effects and safety of green tea consumption in humans.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79924936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Perception of Herbal Medicine Use among Patients with Chronic Diseases in a Nigerian Teaching Hospital","authors":"S. C. Okenwa, Samuel Chijioke Ofili, Chika Augusta Ekweozor, Ebere Onyishi, I. Eze, Chiamaka Rita Odor, C. Iyi, Boniface Ebuka Samuel, Somtochukwu Maria-regina Nwajiobi, Nwachukwu Emmanuel Chijiekwu, W. J. Igbokwe, E. Asogwa, Stephanie Emmanuel, Precious Njoku","doi":"10.9734/ajrimps/2023/v12i3218","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i3218","url":null,"abstract":"Background: Man's quest to manage illness over many years has led to the development of complementary and alternative medicine (CAM). There are many types of CAM, and the most utilized is herbal medicine. The relevance of herbal medicine has increased over the years due to the surge in health demands and other factors that influence the management of diseases. Hence, this study was conducted to ascertain the frequency and pattern of herbal medicine use among patients diagnosed with chronic diseases in the University of Nigeria Teaching Hospital, its predictors, magnitude, and perception. \u0000Methodology: This was a cross-sectional descriptive study conducted among adult patients (n = 319) diagnosed with various chronic diseases, such as Diabetes Mellitus, Hypertension, Glaucoma, cancer, etc., from October 2022 to November 2022, at the University of Nigeria Teaching Hospital, Enugu, Nigeria. Questionnaires were administered through face-to-face interviews with patients. \u0000Results: A total of 319 patients were included in this study. The gender distribution is 139 males and 180 females. The rate of herbal medicine use was 65.2%. Herbal medicine use among the female gender was higher, but there was no relationship between gender and herbal medicine use (P = 0.842). Of participants using herbal medicine, 46.1% used it for treating their health condition, 30.4% used herbal medicine to improve well-being, and 10.3% for preventing diseases. Their perception of herbal medicine uses as compared to conventional synthetic medicine based on modifications of some issues found from literature reviews that militate against the use of herbal medicine such as dose (15% strongly agreed, 20.1% agreed, 23.2% neutral, 18.8% disagreed and 22.9% strongly disagreed) etc. \u0000Short Conclusion: The study discovered that patients in Nigeria with chronic conditions frequently use herbal medicines. Age, gender, marital status, occupation, education, monthly income, religion, health insurance, the timing of sickness diagnosis, the number of medications prescribed, and multiple chronic conditions were all linked to the usage of herbal medicines.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"363 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82991564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasofacial Morphometry of Ekpeye Tribe in Rivers State, Nigeria","authors":"Boma Uriah Erekosima, Didia Monday Kinikanwo, U. Oparaodu, V. Ikenga, George Samuel","doi":"10.9734/ajrimps/2023/v12i3217","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i3217","url":null,"abstract":"Background: Nasofacial Anthropometry is concerned with the measurements of the proportions, size and shape of the human nose and face [1]. This study was aimed at investigating the nasofacial dimensions in Ekpeye tribe in Rivers state. \u0000Methods: Nasofacial parameters of 362 adults were measured using vernier calliper. The nasal length was measured as the distance between the nasion and the nasopinale; nasal width was measured as the distance between ala to ala. The morphological facial length was measured as the distance from the nasion to gnathion and morphological facial width was measured as the distance between right and left zygomatic arches. \u0000Results: Data obtained was analyzed using SPSS version 26.0 and Microsoft Excel 2013. The mean nasal index for the males was 95.03±17.31 while females presented with 91.04±10.39, this is statistically significant. The mean facial index for the males was 101.72±59.52 while females presented with 93.18±12.65. \u0000Conclusion: In this study, it was observed that the Ekpeye people have platyrrhine type of nose and Hyperleptoprosopic category of face. Hence the data in this study has provided anthropometric data for the Ekpeye people, which will be beneficial in forensic science and nasofacial reconstructive surgeries.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80824415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory and Antimicrobial Potential of Three Natural Polyketides Isolated from Endophytic Fungus Phomopsis sp CAM212 against to Dysenteric Causing Pathogens","authors":"Marie Louise Medoua, Sylvain Nsangou Pechangou, B. E. Enang II, Assam Assam Jean Paul, E. Njoya, F. N. Njayou, P. Moundipa","doi":"10.9734/ajrimps/2023/v12i3216","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i3216","url":null,"abstract":"Aims: The present work aimed to evaluate the anti-amoebic, antibacterial, and anti-inflammatory potential of three natural polyketides from Phomopsis sp. CAM212. \u0000Study Design: Clinical isolates of E.histolytica, E.coli ATCC25922 strain, primary peritoneal mouse macrophages and three polyketides were used. \u0000Places and Duration of Study: Laboratory of Pharmacology and Toxicology, Laboratory of Medical Microbiology, Faculty of Science, University of Yaounde 1 between May and December 2022. \u0000Methodology: During this work, we evaluated the ability of three natural polyketides from Phomopsis sp to inhibit the growth of germs responsible for amoebic and bacillary dysentery. First, the anti-amoebic activity was carried out on clinical isolates of E. histolytica in polyxenic culture. Subsequently, we evaluated the antibacterial potential on a strain of E. coli ATCC25922. Finally, the anti-inflammatory potentials were evaluated on a primary culture of SC activated macrophages through inhibition of nitric oxide (NO) production, activation of phosphatase alcaline (ALP) and inhibition of 5-lipoxygenase (5-LOX). \u0000Results: It emerges from this work that among compounds, phomopsinin B, presented the highest anti-amoebic potential (84.4 % inhibition after 72h) and the highest antibacterial potential (MIC=12.5µg/mL and MBC/MIC=2). Phomopsini A and phomopsini A acetate showed moderate anti amoebic and antibacterial potentials. However, all these activities remain lower than that of metronidazole and ciprofloxacin (90% of amoebic inhibition after 72h; MIC=0.72µg/mL and MBC/MIC=4). Subsequently, all tested compounds were nontoxic on primary macrophages. Phomopsinin B exhibited a great anti-inflammatory potential through the inhibition of NO production (IC50=1.72±0.91µg/mL); inihibition of 5-LOX activity (IC50=36.97±7.12µg/mL) and activation of ALP activity (IC50=0.13±0.01µg/mL) as compared to Baicalin the standard. The anti-inflammatory potential of phomopsinin A and phomopsinin A acetate were lower compared to baicalin. \u0000Conclusion: Ultimately, among compounds tested, phomopsinin B exhibited the best anti-amoebic, antibacterial and ant-inflammatory potential similar to the respective standards within the limits of the tests carried out.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"158 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76816942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transurethral Monopolar Resection of the Prostate: Experience of Amirou Boubacar Hospital in Niamey, Niger","authors":"Bori Moussa, A. Josué, Soumana Amadou, Dambaki Mamane Salissou, Kaka Mamane Salissou","doi":"10.9734/ajrimps/2023/v12i3215","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i3215","url":null,"abstract":"Introduction: Benign prostatic hypertrophy (BPH) is a very common urological pathology and occurs in men in their fifties. The clinical manifestation is manifested by symptoms of the lower urinary tract such as dysuria and pollakiuria. Surgical management has been revolutionized by the advent of trans-urethral resection of the prostate (TURP), which is a reference treatment. \u0000Objective: The objective of this work was to evaluate the results of the first cases of transurethral resection of the prostate at Amirou Boubacar hospital in Niamey. \u0000Patients and Methods: This was a descriptive study conducted at Amirou Boubacar Hospital in Niamey over the period from December 5, 2021 to June 5, 2022 and involved patients admitted to the urology department of Amirou Boubacar Hospital in Niamey. The variables studied were: age, profession, level of education, marital status, clinical and therapeutic aspect. The data was collected on an individual collection form from hospital records. To analyze the data, spss version 20 software was useful and allowed us to obtain our results. \u0000Results: During our study period we had 28 cases of TURP out of a prevalence of 9.20% of all emergencies. The most represented age group is that of 60 – 69 years with 60.72%. Farmers represented (71.43%), civil servants (21.43%). Shopkeepers (7.14%). From a clinical point of view, all our patients consulted for dysuria and pollakiuria, an average IPSS score (International Prostate Symptom Score) of 22.33. The average total PSA (Prostate Specific Antigen) was 3 ng / ml, an average prostate volume of 45.20 g. The average duration of intervention was 41 min. a catheterization of 48 hours, as a complication we note 3.57% a type of severe hyponatremia \u0000Conclusion: Benign prostatic hypertrophy is a frequent pathology in urology whose surgical management has been revolutionized by TURP (Transurethral Resection of the Prostate) being the gold standard. This shortens the hospitalization period with a good improvement in the patient's quality of life and micturition.","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73063525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose and Time Dependent Protective Effects of Apocyanin and Curcumin Against Diclofenac-Induced Cardiotoxicity in Male Rats","authors":"F. N. Okwakpam, Felix I. Igwe, S. Omeodu, M. Monanu","doi":"10.9734/ajrimps/2023/v12i2214","DOIUrl":"https://doi.org/10.9734/ajrimps/2023/v12i2214","url":null,"abstract":"This study explored the protective potential of apocyanin and curcumin in diclofenac-induced cardiotoxicity utilizing cardiac enzymes, pro-inflammatory markers, and along with histopathological endpoints. A total of 123 male Wistar rats were used for the study. 43 rats were used for the determination of the median lethal dose (LD50) of apocyanin and curcumin while 80 rats were randomly divided into 8 groups of 10 rats each. Group 1(control) received distilled water while others received orally, per mg/kg body weight of treatments as follows: group 2(1000, apocyanin, group 3(1000, curcumin), group 4(10, diclofenac), group 5(500, apocyanin and 10, diclofenac), group 6(1000, apocyanin and 10, diclofenac), group 7(500, curcumin and 10, diclofenac) and group 8(1000, curcumin and 10, diclofenac). The treatments were administered daily for 14 and 28 days. LD50 up to 5000mg/kg body weight of apocyanin and curcumin did not show any fatality in animals. Administration of diclofenac significantly (p < 0.05) elevated the activities of creatinine kinase-MB, lactate dehydrogenase, levels of troponin-T, and tumor necrosis factor. There was no alteration in the activities of Interleukin- 1β. The histological results also showed cardiac insults such as cardiac muscle having severe fibro collagenous stroma, reduced myocytes density, and thick wall blood vessels. However, pretreatment with 500 and 1000 mg/kg body weight of apocyanin or curcumin attenuated all biochemical alterations and histological lesions induced by diclofenac in a dose-dependent manner.  Pretreatments with apocyanin and curcumin inhibitors of NADPH oxidases 2weres effective in ameliorating diclofenac-induced cardiotoxicity suppressing inflammation and restoring normal histological architecture, thus, highlighting the therapeutic potentials of apocyanin and curcumin in the management of diclofenac-mediated cardiotoxicity. ","PeriodicalId":8536,"journal":{"name":"Asian Journal of Research in Medical and Pharmaceutical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75022050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}