Asian Journal of Pharmaceutical Research and Health Care最新文献_第8页

Computational insights into the epilepsy-related phytoconstituents of Acacia farnesiana: In silico analysis, molecular modeling, and ADMET profiling 金合欢癫痫相关植物成分的计算分析:计算机分析、分子建模和ADMET分析

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-01-01 DOI: 10.4103/ajprhc.ajprhc_59_23

Payal Mittal, Shristi Gupta, GirishChandra Arya

{"title":"Computational insights into the epilepsy-related phytoconstituents of <i>Acacia farnesiana</i>: <i>In silico</i> analysis, molecular modeling, and ADMET profiling","authors":"Payal Mittal, Shristi Gupta, GirishChandra Arya","doi":"10.4103/ajprhc.ajprhc_59_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_59_23","url":null,"abstract":"Objective: This study aimed to evaluate the anticonvulsant potential of phytochemicals from Acacia farnesiana using molecular docking and compare their binding affinities with ethosuximide, a common anticonvulsant. Additionally, we conducted a comprehensive ADMET analysis of leucoxol, a promising phytochemical with strong docking scores against leucine-rich glioma-inactivated protein 1 (PDB ID-5Y30). Methods: Auto Dock Vina was employed for in silico analysis to predict binding affinities. Leucoxol exhibited significantly higher binding affinity (-7.9 kcal/mol) than ethosuximide (-4.9 kcal/mol), suggesting superior anticonvulsant potential. We thoroughly examined leucoxol’s ADMET profile to assess its pharmacokinetic and toxicological properties. Results: Comparative analysis indicated that leucoxol may be a more effective anticonvulsant with reduced toxicity compared to ethosuximide. It displayed strong binding and a favorable ADMET profile. Conclusion: Phytochemicals from Acacia farnesiana, especially leucoxol, exhibit promising binding affinities compared to ethosuximide, indicating their potential as anticonvulsant agents. Leucoxol, in particular, demonstrates strong anticonvulsant potential and a favorable ADMET profile, making it a candidate for further research as an anticonvulsant with reduced toxicity. However, additional experimental and clinical investigations are needed to confirm their efficacy and safety in treating convulsive disorders.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135106018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methotrexate-induced Neutropenia Methotrexate-induced嗜中性白血球减少症

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-01-01 DOI: 10.4103/ajprhc.ajprhc_15_23

KeshaAjaykumar Parmar, Maulin Mehta

引用次数: 0

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-01-01 DOI: 10.4103/ajprhc.ajprhc_89_22

A. Tom, J. Mandumpala, Aleena Manoj, Neha Maria Baby, S. Mathai, Siji Antony

{"title":"Drug-related Problems among Inpatients of General Medicine Department of a Tertiary Care Hospital in South India","authors":"A. Tom, J. Mandumpala, Aleena Manoj, Neha Maria Baby, S. Mathai, Siji Antony","doi":"10.4103/ajprhc.ajprhc_89_22","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_89_22","url":null,"abstract":"Background: Identification of drug-related problems (DRPs) is a medication management service that can add value to individual patient care. Determination of DRPs daily is a promising approach for optimizing treatment. Objective: The objective of this study was to analyze the incidence of DRPs identified along with the risk factors that contribute to its development. Setting: This study was conducted in a tertiary care hospital in Central Kerala, India. Methods: A cross-sectional study was conducted among 300 newly admitted patients to the general medicine department. Patient medical records were reviewed in 3 stages – medication reconciliation, medication order review, and discharge summary review, and DRPs were categorized based on the Pharmaceutical Care Network Europe V9.1. Patient characteristics such as age, gender, polypharmacy, comorbidities, nonadherence, and type of illness were recorded. Results: Out of 300 patients, 78.7% had DRPs. The incidence of DRPs was found to be 0.26 cases/people-months. Although age >60 years, gender, polypharmacy, nonadherence, comorbidities, and chronic ailments were risk factors for DRPs, only polypharmacy and comorbidities could be proven statistically. Conclusion: DRPs are an emerging issue within the confines of the health-care system and should be scrutinized to avoid negative outcomes. A stage-wise analysis of patients who are at risk will ensure better patient care.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"32 1","pages":"22 - 28"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85493514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management and outcomes of high-energy pilon fractures: A case of King Saud Medical City, KSA 高能量枕部骨折的治疗和结果:沙特国王医疗城一例

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-01-01 DOI: 10.4103/ajprhc.ajprhc_102_23

SaadeldinAhmed Idris, AhmedOnayzan Alshammari, AhmedMohammed Ahmed Abdalrahman, Hani Serhan, MajedMouaffek Majed Shogair, Hussain Alyassain, BashahMohammad Saleh Almustanir, HaniNouran Alharbi, Fahd Alshahrani, MashaelSultan Alsadoon, AbdulmohsinAdnan Alhabobi

{"title":"Management and outcomes of high-energy pilon fractures: A case of King Saud Medical City, KSA","authors":"SaadeldinAhmed Idris, AhmedOnayzan Alshammari, AhmedMohammed Ahmed Abdalrahman, Hani Serhan, MajedMouaffek Majed Shogair, Hussain Alyassain, BashahMohammad Saleh Almustanir, HaniNouran Alharbi, Fahd Alshahrani, MashaelSultan Alsadoon, AbdulmohsinAdnan Alhabobi","doi":"10.4103/ajprhc.ajprhc_102_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_102_23","url":null,"abstract":"Background: Despite being uncommon, pilon fractures are of interest to orthopedic surgeons because of the awkwardness of their treatment. Although various surgical techniques were used, poor outcomes are frequently encountered, and complications are highly prevalent. Objective: The objective of this study was to evaluate the clinical and radiographic outcomes of pilon fractures treated with a two-stage technique. Materials and Methods: The study included patients with tibial pilon fractures who had undergone two-stage procedures in King Saud Medical City (April 2017–March 2022). Fractures were categorized based on the Arbeitsgemeinschaftfur Osteosynthesefragen (AO) classification method. Outcomes were measured by the American Orthopedic Foot and Ankle Society (AOFAS) scoring system. Results: Twenty-one patients had tibial pilon fracture. Open fractures were seen in 23.8%, the majority was Gustilo type II in 60%. The mean follow-up was 24.7 months. The majority (47.6%) was AO type 43-B. Osteoarthritis was developed in 61.9%, and none mandates arthrodesis. Mean AOFAS was 86.91 points, it was excellent in 38.1%. Type 43 C fracture significantly had a poorer AOFAS score (P = 0.021). AOFAS score was significantly affected by fracture grade and association with fibular fracture, P = 0.025, and P = 0.019, respectively. Conclusion: Treatment for severe pilon fractures with a two-stage protocol yields favorable outcomes. Fewer soft-tissue complications and better articular reconstruction were the main benefits.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"157 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135104440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Properties of Methanolic and Acetone Extracts of Pictacia palaestina, Verbena triphylla and Nigella sativum 牡丹、马鞭草和黑草甲醇和丙酮提取物的抗氧化性能

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-01-01 DOI: 10.4103/ajprhc.ajprhc_61_23

NessrinGhazi Alabdallat, Hana Alanazi

{"title":"Antioxidant Properties of Methanolic and Acetone Extracts of Pictacia palaestina, Verbena triphylla and Nigella sativum","authors":"NessrinGhazi Alabdallat, Hana Alanazi","doi":"10.4103/ajprhc.ajprhc_61_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_61_23","url":null,"abstract":"Aims: The aim of the study was to estimate the antioxidant characteristics of methanolic and acetone extracts of Pistacia palaestina, Verbena triphylla, and Nigella sativa. Materials and Methods: The biochemical antioxidant assays that used were total phenols and flavonoids, total antioxidant capacity, ferric reducing power and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging. Results: The maximum antioxidant capacity and the ferric-reducing power of the examined plant extracts were shown in P. palaestina/methanol whereas N. sativa L./methanol was the lowest. The maximum scavenging activity of DPPH was shown in N. sativa L./acetone (IC50 = 2688 μg/ml), followed by, V. triphylla/acetone (IC50 = 573.5 μg/ml), N. sativa/methanol (IC50 = 437.7 μg/ml), V. triphylla/methanol (IC50 = 64 μg/ml), and P. palaestina methanol and acetone extracts (IC50 = 9.5 μ/g) being the lowest. Conclusion: The findings with methanol extract of P. palaestina methanol shown the highest antioxidant property which and can be due to the presence of high quantity of phenols and flavonoids in the methanol extract of this plant; moreover, N. sativa acetone extract has maximum DPPH-free radical scavenging activity. This may be because the acetone extract demonstrated capabilities to scavenge radicals remarkably for Nigella sativa L seeds.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135106008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of antimicrobial prophylaxis in surgical procedures in a tertiary care hospital in Southern India: A cross-sectional study 评估抗菌预防在外科手术在印度南部三级护理医院:一项横断面研究

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-01-01 DOI: 10.4103/ajprhc.ajprhc_98_23

Swathi Acharya, Ananyaa Agrawal

{"title":"Assessment of antimicrobial prophylaxis in surgical procedures in a tertiary care hospital in Southern India: A cross-sectional study","authors":"Swathi Acharya, Ananyaa Agrawal","doi":"10.4103/ajprhc.ajprhc_98_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_98_23","url":null,"abstract":"Context: Surgical site infections (SSIs) are the second-most common cause of health care-associated infections and are responsible for postoperative illness leading to increased morbidity and mortality. There are various preventive strategies against SSIs such as proper surgical technique, strict asepsis in the operating theater, control of infection within the hospital or general practice, and antibiotic prophylaxis. Widespread use of prophylactic antibiotics has the disadvantage of the emergence of multiresistant organisms. Thus, the implementation of proper surgical antimicrobial prophylaxis (SAP) practice is highly recommended to assess the pattern of SAP practiced in a tertiary care hospital in southern India. Subjects and Methods: A prospective, observational, cross-sectional study was conducted in a tertiary care hospital where data were collected from 175 inpatients admitted to the surgical ward. The pattern of SAP practice was analyzed using descriptive statistics. Results: The pattern of antibiotic prophylaxis revealed that the most commonly used agents were third-generation cephalosporins (57.71%), followed by broad-spectrum penicillins (18.86%), second-generation cephalosporins (13.71%), fluoroquinolones (4.57%), and antiamebic drugs (13.14%) mainly for gastrointestinal surgeries. Conclusions: Assessing the pattern of antimicrobial prophylaxis will help us to determine the appropriateness of the drugs prescribed with respect to the procedure and will help us to give feedback to the clinician and policymakers regarding the need for improvement in case of deviation in the practice compared to the guidelines given in the hospital antibiotic policy.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135106191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors of venous thromboembolism among COVID-19 patients COVID-19患者静脉血栓栓塞的影响因素

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-01-01 DOI: 10.4103/ajprhc.ajprhc_13_23

L. P. Low, F. Islahudin, S. Saffian

{"title":"Factors of venous thromboembolism among COVID-19 patients","authors":"L. P. Low, F. Islahudin, S. Saffian","doi":"10.4103/ajprhc.ajprhc_13_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_13_23","url":null,"abstract":"Context: Anticoagulants are used to prevent and treat venous thromboembolism (VTE), such as deep-vein thrombosis (DVT) and pulmonary embolism (PE) in COVID-19 for better outcomes. Aim: This study aims to explore clinical outcomes and factors affecting VTE among COVID-19 patients. Settings and Design: The study design involved a retrospective cohort study. Study Methods: Hospitalized COVID-19 patients in a tertiary hospital prescribed subcutaneous (SC) anticoagulants were included. Statistical Analysis Used: Multiple logistic regression was performed to determine factors affecting VTE among subjects. Results: A total of 450 patients were included. Types of anticoagulants include fondaparinux (n = 114, 38.1%), enoxaparin (n = 113, 37.8%), and heparin (n = 72, 24.1%). 423 (94.0%) patients were discharged well, 27 (6.0%) patients were admitted to the intensive care unit (ICU). The primary outcome was the prevalence of VTE, which occurred in 19.3% (n = 87) patients, with 80 (92.0%) reporting DVT and 7 (8.0%) reporting PE. The secondary outcome, which was the average length of hospital stay was 9.9 (±4.7) days. Factors of VTE occurrence were likely in patients not prescribed SC anticoagulants compared to those prescribed with SC anticoagulants (adjusted odds ratio [aOR] 54.330, 95% confidence interval [CI]: 7.086, 416.526), treatment with fondaparinux compared to heparin (aOR 2.502, 95% CI: 1.175, 5.327), and less likely in those discharged well compared to patients in the ICU (aOR 0.139, 95% CI: 0.053, 0.361). Conclusions: Careful monitoring is required to reduce VTE risk in COVID-19 patients.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"5 1","pages":"97 - 104"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74181666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between low back pain, pelvic floor dysfunction, and diastasis rectus abdominis in postnatal delivery women 产后妇女腰痛、盆底功能障碍和腹直肌转移之间的关系

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-01-01 DOI: 10.4103/ajprhc.ajprhc_102_22

Rishita Rai, Sudhakar Subramanian

{"title":"Association between low back pain, pelvic floor dysfunction, and diastasis rectus abdominis in postnatal delivery women","authors":"Rishita Rai, Sudhakar Subramanian","doi":"10.4103/ajprhc.ajprhc_102_22","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_102_22","url":null,"abstract":"Background: It is crucial to understand diastasis rectus abdominis (DRA) in postpartum women and how it affects them. DRA should be related to pelvic floor dysfunction (PFD) and low back pain (LBP). Prior researchers have contradictory findings in their studies. Objective: To estimate the prevalence of DRA and find the association between LBP, PFD, and DRA. Methodology: According to the eligibility criteria, 102 participants from Bengaluru were chosen for this study. The physical screening was performed to rule out DRA. Following informed consent, the participants have given the Oswestry Disability Index Questionnaire for LBP and Pelvic Floor Impact Questionnaire-7 for PFD. Subjects were divided into two classes: case and control. The data were analyzed using the Chi-square test and the Odds ratio using SPSS Software. Results: This analysis presents the findings of the prevalence of DRA and also the findings of rated LBP and PFD in both the groups. The degree of impact was determined to be P < 0.05. Conclusion: As an outcome, there is an association between LBP, PFD, and DRA.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"15 1","pages":"16 - 21"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87791877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ClinicoPathological Overview of Ovarian Tumors and Diagnostic Utility of Imprint Cytology 卵巢肿瘤的临床病理综述及印迹细胞学的诊断应用

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-01-01 DOI: 10.4103/ajprhc.ajprhc_85_22

N. Patel, Rupali R. Bavikar, Y. Ingale, Yesha Lad, Arpana A. Dharwadkar, V. Viswanathan

{"title":"ClinicoPathological Overview of Ovarian Tumors and Diagnostic Utility of Imprint Cytology","authors":"N. Patel, Rupali R. Bavikar, Y. Ingale, Yesha Lad, Arpana A. Dharwadkar, V. Viswanathan","doi":"10.4103/ajprhc.ajprhc_85_22","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_85_22","url":null,"abstract":"Introduction: For intra-operative diagnosis of ovarian tumors, imprint cytology is the method which gives result within 20 min. It does not affect the quality and utility of the specimen for histopathology. Despite advances in genetics and imaging, histopathological analysis remains the mainstay of ovarian tumor diagnosis. Aim: To describe incidence, age distribution, histological characteristics and whenever feasible, correlate the histopathological diagnosis of ovarian tumors with the imprint cytology technique. Materials and Methods: A total of 200 patients with ovarian tumors were included in this ambispective study from January 2017 to April 2022 at the Dr. D. Y. Patil Medical College, Hospital and Research Center, Pimpri. Results: One hundred and forty-eight (74%) of the 200 cases were benign, while 52 (26%) were malignant. The peak age incidence of benign tumors was in the second to fourth decades and malignant ovarian tumors was in fourth to sixth decades. Ovarian tumors involved the left ovary (n = 104, 52%) more than the right ovary (n = 90, 45%). Out of 200 cases, 130 cases (65%) were surface epithelial ovarian tumors, followed by 50 cases (25%) were germ cell tumors, followed by 14 cases (7%) were sex cord stromal tumors followed by 3 cases (3%) were secondary/metastatic tumors of ovary. Imprint cytology technique done on 148 cases (74%) showed 100% correlation with the histopathological diagnosis. Conclusion: Imprint cytology diagnosis correlated with the histopathological diagnosis of ovarian tumors.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"30 1","pages":"11 - 15"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79524469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal Mortality in Indonesia, Ask for Help 印度尼西亚的孕产妇死亡率，寻求帮助

IF 0.4

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2022-12-22 DOI: 10.55561/ajhr.v1i3.84

S. Sutrisno

引用次数: 0