Methotrexate-induced嗜中性白血球减少症

IF 0.2 Q4 PHARMACOLOGY & PHARMACY

Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-01-01 DOI:10.4103/ajprhc.ajprhc_15_23

KeshaAjaykumar Parmar, Maulin Mehta

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引用次数: 0

摘要

各种恶性肿瘤、自身免疫性疾病如类风湿关节炎(RA)和选择性流产通常使用甲氨蝶呤(MTX)治疗，这是一种叶酸拮抗剂。虽然有许多MTX常见的副作用，如恶心、呕吐和口腔炎的报道，但文献中很少发现MTX引起中性粒细胞减少的病例。我们有一例中性粒细胞减少症，患者服用甲氨蝶呤片剂治疗RA。对该病例进行了研究，对报告的药物不良反应进行的因果关系评估表明，根据世卫组织- umc的因果关系分类，该病例属于“可能”类别。

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Methotrexate-induced Neutropenia

Various malignancies, autoimmune disorders such as rheumatoid arthritis (RA), and elective abortions commonly use methotrexate (MTX) for their treatment, which is a folate antagonist. Although many cases of the common side effects of MTX such as nausea, vomiting, and stomatitis have been reported, very few cases of MTX-induced neutropenia have been found in the literature. We have taken a case of neutropenia that developed after the patient took tablet MTX for RA. The case was studied and the causality assessment of the reported adverse drug reaction showed it to be in the category of “probable” according to the WHO-UMC causality categories.

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来源期刊

Asian Journal of Pharmaceutical Research and Health Care PHARMACOLOGY & PHARMACY-

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