Asian Journal of Biomedical and Pharmaceutical Sciences最新文献_第8页

Synthesis and Medicinal Significance of Chalcones- A Review 查尔酮的合成及药用意义综述

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-05-31 DOI: 10.15272/AJBPS.V6I56.814

Chavan Bb, Gadekar As, Mehta Pp, P. Vawhal, Kolsure Ak, Chabukswar Ar

{"title":"Synthesis and Medicinal Significance of Chalcones- A Review","authors":"Chavan Bb, Gadekar As, Mehta Pp, P. Vawhal, Kolsure Ak, Chabukswar Ar","doi":"10.15272/AJBPS.V6I56.814","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I56.814","url":null,"abstract":"Chalcone is an aromatic ketone that forms a central core for a variety of important biological compounds, which are collectively known as chalcones. They possess different activities like antibacterial, antifungal, anti-inflammatory and anti tumor etc depending on the substitution made on them. Chalcones are 1,3-diphenyl-2-propene-1-one, in which two aromatic rings are linked by a three carbon α, β-unsaturated carbonyl system.These are abundant in edible plants and are considered to be precursors of flavonoids and isoflavonoids. Chalcones possess conjugated double bonds and a completely delocalized Π-electron system on both benzene rings. Molecules possessing such system have relatively low redox potentials and have a greater probability of undergoing electron transfer reactions. The compounds with the backbone of chalcones have been reported to possess various biological activities such as antimicrobial, anti-inflammatory, analgesic, anti platelet, anti ulcerative, anti malarial, anticancer, antiviral, anti leishmanial, antioxidant, anti tubercular, anti hyperglycemic, immunomodulatory, inhibition of chemical mediators release, inhibition of leukotriene B4, inhibition of tyrosinase and inhibition of aldose reductase activities. The presence of a reactive alpha, beta -unsatutated keto function in chalcones is found to be responsible for their antimicrobial activity. In this paper through reviewing different biological significance of chalcones and their derivatives have been reported along with their chemistry and of synthesis. Synthetically or chemically chalcones are synthesized by two reactions: a) Aldol condensation and b) Claisen Schmidt condensation. But here is a focus on chalcones synthesized by Claisen Schmidt condensation which involves the condensation between an aromatic aldehyde or ketone with an aliphatic ketone or aldehyde catalysed by the presence of dilute alkali or acid to form alpha beta unsaturated compound.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"19 1","pages":"01-07"},"PeriodicalIF":0.0,"publicationDate":"2016-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85147817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Effect of Spirulina platensis as dietary Supplement on Some Biological Traits for Chickensunder Heat Stress Condition 饲粮中添加螺旋藻对热应激条件下鸡部分生物学性状的影响

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-05-31 DOI: 10.15272/AJBPS.V6I56.813

H. Zeweil, Abaza Im, S. Zahran, M. Ahmed, M. Haiam, Asmaa As

{"title":"Effect of Spirulina platensis as dietary Supplement on Some Biological Traits for Chickensunder Heat Stress Condition","authors":"H. Zeweil, Abaza Im, S. Zahran, M. Ahmed, M. Haiam, Asmaa As","doi":"10.15272/AJBPS.V6I56.813","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I56.813","url":null,"abstract":"This work was performed to investigate the effect of Spirulina platensis levels and vitamin E under heat stress on the performance, some physiological and blood biochemical constituents, antioxidant and immune responses traits of growing chickens. A total of 150 male Gimmizah local strain chicks (4 weeks of age) were randomly distributed among five treatment groups in battery brooder placed in a temperature-controlled room until 14 weeks of age. The first treatment was fed the basal diet only without any supplementation and kept in the first sector under optimum temperature 22-24oC and relative humidity (RH) 45-55 % (normal) used as negative control. Whereas, the other four treatments were kept in the last sector under chronic heat stress condition (38°C±1; 55-65 % RH) for three successive days a week from 11.00 am until 15.00 pm. The first heat stress group was fed the basal diet only without any supplementation and used as positive control (PC). Whereas in the other three treatments were fed the basal diet supplemented with Spirulina platensis at levels (0.5 and 1 g/kg diet) and vitamin E (75 mg/kg diet). The results indicated that different supplementations as Spirulina and VE decreased adverse effect of heat stress on growth performance and blood total protein, albumin, globulin, createinin, ALT, AST, total lipids, LDL, WBCs, RBCs, immunity of Chickens. In conclusion, addition of Spirulina platensis improved growth performance, immunity and can be decreased adverse effect stress on chickens under heat stress condition.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"43 1","pages":"08-12"},"PeriodicalIF":0.0,"publicationDate":"2016-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89634871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Assessment of Relationship between Streptococcus mutans, Dental Caries and TGF-β 变形链球菌、龋齿与TGF-β关系的研究

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-05-31 DOI: 10.15272/ajbps.v6i56.817

Hossein Eslami, A. Zarandi, F. Pouralibaba, Vahid Fakhrzadeh, Parisa Falsafi, Roya Rezaii Sepas

引用次数: 1

Assessment of First Trimester Vaginal Bleeding Using Ultrasound Sonography 孕早期阴道出血的超声评估

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-05-07 DOI: 10.15272/ajbps.v6i57.843

Kalyani Singh

{"title":"Assessment of First Trimester Vaginal Bleeding Using Ultrasound Sonography","authors":"Kalyani Singh","doi":"10.15272/ajbps.v6i57.843","DOIUrl":"https://doi.org/10.15272/ajbps.v6i57.843","url":null,"abstract":"Vaginal bleeding during the first trimester has been estimated to occur in 16% of all pregnant women, while the frequency of spontaneous abortion is traditionally estimated as 10-20%. The clinical approach though helpful is of limited value. Despite the latest technological developments and laboratory diagnosis the desired goal of early recognition is not achieved.The objective of the study to evaluate role of ultrasound in patients with first trimester vaginal bleeding. Hospital based study. A total of 100 cases presented with complaint of bleeding per vaginum during first trimester, were enrolled for study. Ultrasonographic examinations were done per abdominally by using ultrasound equipment.The data showed that it is the common problem in 20-30 age pregnant womens. In the present study various types of abortions constituted the commonest cause of first trimester bleeding. All cases the cases were diagnosed correctly on ultrasonography with 100% sensitivity and accuracy and managed appropriately. So ultrasound helped in establishing correct diagnosis timey and decides the line of management. Keywords: First trimester bleeding, Ultrasound examination, Clinical examination, Vaginal bleeding.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"120 1","pages":"54-56"},"PeriodicalIF":0.0,"publicationDate":"2016-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77305007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Goiter Prevalence in Children in North India Region 印度北部地区儿童甲状腺肿大患病率

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-05-03 DOI: 10.15272/AJBPS.V6I53.794

R. Kumari

引用次数: 2

Monitoring of Zinc in Liver Cirrhosis Patients 肝硬化患者锌的监测

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-05-03 DOI: 10.15272/AJBPS.V6I53.791

P. Ck, E. Jc

引用次数: 1

Eye Donation Awareness among the Students 学生的捐眼意识

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-05-03 DOI: 10.15272/AJBPS.V6I53.793

R. Kumari

引用次数: 8

Study of acute phase proteins in liver disease 肝病急性期蛋白的研究

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-05-03 DOI: 10.15272/AJBPS.V6I53.792

ey Cj, P. Ck

引用次数: 1

Profile of gross congenital malformations among live newborns and its associated risk factors from a tertiary care rural teaching institute. 农村三级保健教学机构新生儿先天性畸形概况及其相关危险因素

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-04-30 DOI: 10.15272/ajbps.v6i55.811

A. Marwah

{"title":"Profile of gross congenital malformations among live newborns and its associated risk factors from a tertiary care rural teaching institute.","authors":"A. Marwah","doi":"10.15272/ajbps.v6i55.811","DOIUrl":"https://doi.org/10.15272/ajbps.v6i55.811","url":null,"abstract":"Objective: To study the profile of gross congenital malformations among live newborns and its associated risk factors. Material and methods: All the babies born in this hospital (live births) during January 2014 to December 2014 formed the baseline population and those with congenital malformations were included in the study. Antenatal records were assessed and mothers were interviewed for socio-demographic variables. Study design: Cross- sectional, descriptive. Results: There were 6143 live births out of which 109 had gross congenital malformations giving an incidence of 1.7%. Central nervous system was most commonly affected (48%) followed by musculoskeletal (28%) and gastrointestinal system (13%). Incidence of congenital malformations was more among multipara females, preterm and low birth weight babies. Conclusion: A relative increase in the incidence of congenital malformations once again implies the importance of public health education and regular antenatal screening. We also, strongly recommend mandatory screening of all newborns by pediatrician after birth for timely detection and best possible treatment of these congenital malformations. Keywords: congenital malformation, newborn, live birth, antenatal, genetic.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"4 1","pages":"16-18"},"PeriodicalIF":0.0,"publicationDate":"2016-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78442707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Investigation on Learning and Memory Enhancing activity of Essential Oil inAlbizia julibrissin Flowers in Experimental Mice 合欢花挥发油对小鼠学习记忆增强作用的研究

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-04-25 DOI: 10.15272/AJBPS.V6I55.809

K. Dhanya, S. Satish, K. Hegde, A. Shabaraya

引用次数: 6