Asian Journal of Biomedical and Pharmaceutical Sciences最新文献_第9页

Biochemical Composition and Preliminary Qualitative Analysis of Marine ClamGafrarium divaricatum (Gmelin) From Mumbai, West Coast of India 印度西海岸孟买海产异花螯虾(Gmelin)的生化组成及初步定性分析

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-04-25 DOI: 10.15272/AJBPS.V6I55.804

A. Eswar, K. Ramamoorthy, Z. Isha, S. Gokulakrishnan

{"title":"Biochemical Composition and Preliminary Qualitative Analysis of Marine ClamGafrarium divaricatum (Gmelin) From Mumbai, West Coast of India","authors":"A. Eswar, K. Ramamoorthy, Z. Isha, S. Gokulakrishnan","doi":"10.15272/AJBPS.V6I55.804","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I55.804","url":null,"abstract":"The present work investigates the potential use of the whole tissue of clam Gafrarium divaricatum (Gmelin) as a food source in a coastal region of India. In order to evaluate its food value, a detailed biochemical analysis of the whole tissue has been carried out. The results of biochemical analysis show very high protein content (26.32%), Carbohydrate (11.23%) and lipid (1.29%). The protein consists of 10 essential and 9 non essential amino acids which are as follows (Lysine 14.36%, Histidine 9.02, Methionine 8.92 %) and (Alanine 5.94%, Aspartic acid 4.98, Asparagine 3.79, Tyrosine 3.52 and Proline 3.21%) are the predominant essential amino and non essential amino acids. G. divaricatum consists of 6 different fatty acids out of which 2 are saturated fatty acids (SFA), one monounsaturated fatty acids (MUFA) and three polyunsaturated fatty acids (PUFA). SFA, MUFA and PUFA content was 27.18, 11.02, 12.47, 17.96, 11.38 and 11.38% respectively in fat (1.29 gm/100gm). In addition it contains Vitamins such as Vitamin A (112.3 IU), Vitamin C (24.11 mg/g), D (13.96 IU), B12 (1.98μg/g.), E (1.14 mg/g), K (0.59 mg/g) and B6 (0.31mg/g). Mineral composition of whole tissue showed presence of Calcium 312.74 mg/g, Sodium 89.93mg/g, Magnesium 61.11 mg/g, Potassium 21.38 mg/g as major and Copper 1.43, iron 1.37 and zinc 0.38 mg/g as minor quantity. The test for secondary metabolites shows the presence of alkaloids, phenolics, terpenes, carotenoids and steroids. This shows that the clam species is a good alternative food source to fish and can be very well exploited after its toxicity evaluation. The presence of secondary metabolites will have some medicinal values like hepatoprotective activity and anti oxidant activity which is currently under investigation.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"2 1 1","pages":"01-06"},"PeriodicalIF":0.0,"publicationDate":"2016-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78293821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antidepressant and Skeletal Muscle Relaxant Activity of Methanolic Extracts of Basella alba. L 白底藻甲醇提取物的抗抑郁和骨骼肌松弛活性。l

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-04-25 DOI: 10.15272/ajbps.v6i55.806

K. Nagamani, D. Kaur, G.Abhinayani, G. Goud

{"title":"Antidepressant and Skeletal Muscle Relaxant Activity of Methanolic Extracts of Basella alba. L","authors":"K. Nagamani, D. Kaur, G.Abhinayani, G. Goud","doi":"10.15272/ajbps.v6i55.806","DOIUrl":"https://doi.org/10.15272/ajbps.v6i55.806","url":null,"abstract":"Depression is considered as affective mood disorder which is characterized by change in mood, lack of confidence, etc. Depression is the most prevelant disorder and the symptoms associated with depression changes the neurotransmitter levels in brain such as norepinephrine, serotonin and dopamine. Muscle relaxant is a term usually used to refer to skeletal muscle relaxants (drugs), which act on the central nervous system (CNS) to relax muscles. These drugs are often prescribed to reduce pain and soreness associated with sprains, strains, or other types of muscle injury. Basella alba is the plant selected to use as a test drug in experimental animals. After selecting the plant, Leaves has been dried and powdered by using methanol and extracted by using soxhlet apparatus. Evaluation of anti depressant activity as well as skeletal muscle relaxant activity has been done to test the potency of the drug and to know its activity. After comparing the test drug with standard drug Diazepam results has shown that the extract has both anti depressant and skeletal muscle relaxant activities .Therefore, it is concluded that Basella alba extract has good anti depressant and skeletal muscle relaxant activity on mice.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"6 1","pages":"07-10"},"PeriodicalIF":0.0,"publicationDate":"2016-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74014021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Potential Investigation of Peceol for formulation of Ezetimibe self nano emulsifyingDrug Delivery Systems 山核桃油制备依折替米自纳米乳化给药体系的潜力研究

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-04-24 DOI: 10.15272/AJBPS.V6I54.803

P. Pp, K. Vaishali, Payghan Santosh

{"title":"Potential Investigation of Peceol for formulation of Ezetimibe self nano emulsifyingDrug Delivery Systems","authors":"P. Pp, K. Vaishali, Payghan Santosh","doi":"10.15272/AJBPS.V6I54.803","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I54.803","url":null,"abstract":"The present work was aimed at formulating and physicochemical characterization SNEDDS (self Nano emulsifying drug delivery system) of ezetimibe and evaluating its in vitro and in vivo potential. The solubility of both drugs was determined in excipient screening studies. Pseudoternary phase diagrams were used to evaluate the Nano emulsification existence area, composed of different surfactants, co surfactants, and oils at different surfactant to-cosurfactant (S/CoS) ratios, and the system exhibiting the largest percentage area of the self-Nano emulsifying region was selected and optimum oil ratio in the SNEDDS was selected by evaluating the clarity, precipitation and mean droplet size of the resultant Nanoemulsions. The release rate of ezetimibe was investigated using an in vitro dissolution test. In vitro dissolution studies showed that the SNEDDS composed of Peceol (20% wt/wt), Tween 80 (30% wt/wt), Ethanol (30% wt/wt), and ezetimibe (20% wt/wt) had higher initial dissolution rates for both drugs when compared with plain EZT. More importantly, EZT SNEDDS had a significantly increased dissolution profile in distilled water and pH 4.0 acetate buffer, implying enhanced bioavailability. The underlying mechanism of the loading capacity of EZT was elucidated by measurement of the zeta potential analysis. The results implied that EZT was located both in the Nanoemulsion core and the surfactant–cosurfactant layer. Comparative pharmacokinetic evaluation of EZT SNEDDS was investigated in terms of C max, tmax and AUC using rats. The SNEDDS formulation significantly increases pharmacokinetics parameter as compared with plain ezetimibe. The optimized formulation was then subjected to stability studies and was found to be stable over 6 months. Thus, the study confirmed that the SNEDDS formulation can be used as a possible alternative to traditional oral formulations of ezetimibe to improve its bioavailability","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"7 1","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"2016-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75432505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Complications of Peptic Ulcer Perforation: A Clinical Case Study 消化性溃疡穿孔并发症1例临床研究

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-04-07 DOI: 10.15272/ajbps.v6i57.841

Ashutosh Kumar Singh

引用次数: 1

Clinical Profile and Outcome of Chronic Pancreatitis in Children 儿童慢性胰腺炎的临床特点和预后

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-04-07 DOI: 10.15272/ajbps.v6i57.840

D. Singh

引用次数: 7

Clinico pathological Study of Cystic Swellings of Scrotum 阴囊囊性肿胀的临床病理研究

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-04-07 DOI: 10.15272/AJBPS.V6I57.839

A. Singh

引用次数: 3

A Study of Abdominal tuberculosis in North Indian Patients 北印度病人腹部结核的研究

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-04-07 DOI: 10.15272/AJBPS.V6I57.838

D. Singh

引用次数: 1

Phytochemical Qualitative Analysis and Total Tannin Content in the Aqueous Extract of Areca catechu Nut 槟榔水提物植物化学定性分析及总单宁含量

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-03-19 DOI: 10.15272/ajbps.v6i54.789

S. Balasubramanian, V. R. and

引用次数: 6

Assessment of Lipoproteins in Pregnancy Induced Hypertension 妊高征中脂蛋白的评估

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-03-19 DOI: 10.15272/AJBPS.V6I54.801

P. Ck, E. Jc

引用次数: 0

Protective effects of Nymphaea lotus Linn. (Nymphaeaceae) aqueous extract against chronicunpredictable mild stress induced testicular lipid peroxidation 睡莲的保护作用。水提物抗慢性不可预测轻度应激诱导睾丸脂质过氧化

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-03-19 DOI: 10.15272/AJBPS.V6I54.785

Mireille Km, P. Dd, Bilanda Danielle Claude, Yol, rine Mn, M. Marguerite, Ngoungoure Madeleine Chantal, N. Rodrigue, Agnes Oc, D. Théophile, Kamtchouing Pierre

{"title":"Protective effects of Nymphaea lotus Linn. (Nymphaeaceae) aqueous extract against chronicunpredictable mild stress induced testicular lipid peroxidation","authors":"Mireille Km, P. Dd, Bilanda Danielle Claude, Yol, rine Mn, M. Marguerite, Ngoungoure Madeleine Chantal, N. Rodrigue, Agnes Oc, D. Théophile, Kamtchouing Pierre","doi":"10.15272/AJBPS.V6I54.785","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I54.785","url":null,"abstract":"Stress has been associated with various diseases such as harms the heart system, nervous system, affect the level of hormone, but also morphology and function of testis. The purpose of the present study was to investigate protective properties of Nymphaea lotus (N. lotus), against deleterious effects induced by unpredictable chronic mild stress (CMS) on testes of albino male rats. Adult male Wistar rats were divided into five groups as one non-stressed group and four stressed groups (n = 5 in each group). The stressed groups were exposed to 14 days of CMS, receiving concomitantly and respectively, distilled water (10 mL/kg), Yohimbine (2 mg/kg) and N. lotus at the level of 75 and 200 mg/kg. The reproductive organs weight, oxidative stress markers, and histoarchitecture of the testis were examined. Exposition to CMS to the male rats caused no significant changes in the relative weight of testis, but affects its histoarchitecture, that is preserved in stressed rats treated with N. lotus. Further CMS significantly declined the amount of Nitrites (P<0.05), GSH (P<0.05) and SOD (P<0.001) levels and increase up to 16.25% the level of testicular lipid peroxidation when compared to unstressed rats. N. lotus at the both doses significantly reduced (P<0.001 for 75 mg/kg and P<0.01 for 200 mg/kg) MDA levels in comparison to stressed rats, suggesting an lipid peroxidation inhibitory effect of our plant. The unpredictable chronic mild stress paradigm used in our study enhanced oxidative stress in testis and causes histological damages that N. lotus treatment significantly minimize.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"4 1","pages":"01-06"},"PeriodicalIF":0.0,"publicationDate":"2016-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75200627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7