Asian Journal of Biomedical and Pharmaceutical Sciences最新文献_第7页

Bacteriological Profile of Post-Operative Wound Infection 术后伤口感染的细菌学分析

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-08-03 DOI: 10.15272/AJBPS.V6I53.797

S. Roy

引用次数: 6

Alteration In in -Vitro Infectivity of Leishmania donovani ExposedTo Gamma Radiation γ辐射对多诺瓦利什曼原虫体外感染性的影响

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-07-27 DOI: 10.15272/AJBPS.V6I58.834

S. Manna

{"title":"Alteration In in -Vitro Infectivity of Leishmania donovani ExposedTo Gamma Radiation","authors":"S. Manna","doi":"10.15272/AJBPS.V6I58.834","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I58.834","url":null,"abstract":"At particular doses of gamma radiation from Co60 source suppresses the intracellular parasitism, a fact which raises the question of whether the phenomenon may find practical applications in the outcome of infectious diseases. In this study, stationary phase of promastigotes exposed to radiation doses in the range 10-20 krad (standard dose) resulted in significant parasitization of mononuclear phagocytic system in vitro. However, promastigotes irradiated with 20krad consistently resulted in higher parasitization and optimum infection after acquiring the shape of amastigote- like organism than those exposed to either higher or lower radiation doses. It was observed that 10 krad was necessary to immobilize immediately the organisms, whereas only 30 krad rendered them noninfective and 40-50 krad made promastigotes unable to recognize the binding ligand for attachment to macrophage cell. In comparison to the irradiated parasite, the rate of phagocytosis of 20 krad irradiated cells, were higher while considering the percentage of infected macrophages, the mean number of engulfed parasites by each macrophage cells and the statistics of the two. The rate of infected cells was approximately 8% greater in 20 krad irradiated cells than nonirradiated cells.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"1090 1","pages":"27-30"},"PeriodicalIF":0.0,"publicationDate":"2016-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76708328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solubility Enhancement of Poorly Water Soluble Drug Zaltoprofen by Mixed Hydrotropy Approach 混合疏水法增强难水溶性药物扎尔托洛芬的溶解度

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-06-28 DOI: 10.15272/ajbps.v6i57.836

Kate Ba, Phulzalke Sb, Deshmukh Mt

{"title":"Solubility Enhancement of Poorly Water Soluble Drug Zaltoprofen by Mixed Hydrotropy Approach","authors":"Kate Ba, Phulzalke Sb, Deshmukh Mt","doi":"10.15272/ajbps.v6i57.836","DOIUrl":"https://doi.org/10.15272/ajbps.v6i57.836","url":null,"abstract":"The present study is probably the earliest attempt to enhance Solubility of Zaltoprofen by using mixed hydrotropy and mixed solvency approaches. Zaltoprofen is selected as model drug because it is practically insoluble in water hence there is need to increase the solubility for better absorption and improved therapeutic efficacy. In the preformulation study physical compatibility of the drug-excipient was screened and compatibility was observed between Zaltoprofen and selected solubilizers. In the drug solubilizers interference study no interference was observed in UV spectrophometric analysis of Zaltoprofen in presence of employed solubilizers. Aqueous solubility of Zaltoprofen was found 0.028 mg/ml. The solubilizers sodium acetate, sodium benzoate and sodium salicylate, ethanol, PEG 600, piperazine anhydrous, were selected for solubilization studies on the basis of solubility enhancement ratio. The solubility enhancement ratio in sodium citrate, citric acid, urea, PEG 6000, PEG 4000, PEG 200, PEG 400, propylene glycol and glycerin were found to be less as compare to selected solubilizers. The solubility determination of drug in hydrotropic solutions was carried out at room temperature and solubilizing power of different hydrotropes could be ranked as: Piperazine anhydrous > sodium salicylate > sodium benzoate > sodium acetate > PEG 600. From the equilibrium solubility curves of Zaltoprofen in solubilisers it was concluded that increase in the solubility was nonlinear function with respect to the hydrotrope concentration. Keywords: Mixed hydrotropy, Zaltoprofen, solubility, selective COX2 inhibitor","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"27 1","pages":"32-39"},"PeriodicalIF":0.0,"publicationDate":"2016-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84483295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Are partial PPAR gamma agonists a rational therapeutic strategy for preventing abnormalities of the diabetic kidney 部分PPAR γ激动剂是预防糖尿病肾脏异常的合理治疗策略吗

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-06-28 DOI: 10.15272/AJBPS.V6I57.822

V. Sharma

{"title":"Are partial PPAR gamma agonists a rational therapeutic strategy for preventing abnormalities of the diabetic kidney","authors":"V. Sharma","doi":"10.15272/AJBPS.V6I57.822","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I57.822","url":null,"abstract":"Diabetes mellitus is probably the single most important metabolic disease and is widely recognized as one of the leading causes of death and disability. Up to a third of people with diabetes mellitus suffer end-stage renal failure due to diabetic nephropathy. Diabetic nephropathy strategies to delay progression of diabetic nephropathy- including glycemic and blood pressure control, modification of the rennin-angiotensin system and management of lipid levels with statins-have been effective, but development of new strategies is essential if the ever-increasing burden of this disease is to be minimized. Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone receptor superfamily of ligand- activated transcription factors. PPAR-γ is the key regulator of lipid metabolism and energy balance implicated in the development of insulin resistance. The identification of putative natural and synthetic ligands and activators of PPAR-γ has helped to unravel the molecular basis of its function, including molecular details regarding ligand binding, conformational changes of the receptor and cofactor binding leading to the emergence of the concept of selective PPAR-γ modulators .No satisfactory therapeutic option is currently available to treat patients with nephropathy except for fewer agents like angiotensin converting enzyme inhibitors, angiotensin AT1 receptor blockers and few antioxidants, which have been shown to improve the function of diabetic kidney to some extent. Thus, tremendous efforts are being made to explore promising therapeutic interventions to treat diabetic nephropathy. This review discussed various presently employed and recently developed pharmacological interventions to treat diabetic nephropathy and to improve the function of diabetic kidney. In addition, the recently identiﬁed potential target sites involved in the pathogenesis of diabetic nephropathy have been delineated.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"26 1","pages":"01-03"},"PeriodicalIF":0.0,"publicationDate":"2016-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84144545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Linezolid in Human Plasma Using Turbulent Flow Online Extractionand Tandem Mass Spectrometry 紊流在线萃取-串联质谱法测定人血浆中的利奈唑胺

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-06-28 DOI: 10.15272/AJBPS.V6I57.824

Valli Kumari Rv, Venkateswar Rp

{"title":"Determination of Linezolid in Human Plasma Using Turbulent Flow Online Extractionand Tandem Mass Spectrometry","authors":"Valli Kumari Rv, Venkateswar Rp","doi":"10.15272/AJBPS.V6I57.824","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I57.824","url":null,"abstract":"A rapid and sensitive HTLC-ESI-MS/MS method was developed for the determination of Linezolid in human plasma using an internal standard (cetirizine hydrochloride) with an advanced online sample preparation. This HTLC technique reduces the time required for sample cleanup since sample extraction and analysis are performed. A 10μl of prepared sample is directly injected into the HTLC-MS/MS system where analyte was retained on the extraction column (Cyclone P 50 × 0.5mm, 50μm) and washed away the waste with the help of extraction solvent. Then the analyte was eluted from the extraction column and transferred to the analytical column (Zorbex XDB C18 50 × 2.1mm, 5μm) using mobile phase of the mixture of 0.5% formic acid, 10mM ammonium formate and acetonitrile. The eluted analyte was then detected on mass spectrometer with ESI ion source and a positive selective reaction monitoring mode (SRM). The SRM transitions were m/z 383.20 → 337.20 for Linezolid and m/z 389.10 → 201.01 for internal standard. The developed method was validated as per USFDA guidelines. The method was linear over the concentration range of 0.409 – 20.310 ng/ml. The within batch and between batch accuracy for the three concentrations (LQC, MQC and HQC) were ranged from 98 -110.6% and 98 .6 – 108.3% respectively. The % RSD for all the QC samples was ranged from 3.0 – 8.1%. The percentage recovery of linezolid in HQC (16ng/ml), MQC (13ng/ml) and LQC (1,1ng/ml) was 60.3, 73 and 86.45% respectively. Stability studies were also performed and the results were within the acceptance range. This method was applied to the measurement of linezolid in human plasma and pharmacokinetic study.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"66 3 1","pages":"09-16"},"PeriodicalIF":0.0,"publicationDate":"2016-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77435746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Relationship between Early Childhood Oral Health Impact Scale and Preschools?Fear and Behavior during Dental Treatment 幼儿口腔健康影响量表与学前教育的关系?牙科治疗期间的恐惧和行为

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-06-28 DOI: 10.15272/AJBPS.V6I57.829

A. Vafaei, E. Najafpour, M. Derafshi, Zar

{"title":"Relationship between Early Childhood Oral Health Impact Scale and Preschools?Fear and Behavior during Dental Treatment","authors":"A. Vafaei, E. Najafpour, M. Derafshi, Zar","doi":"10.15272/AJBPS.V6I57.829","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I57.829","url":null,"abstract":"This study aimed to investigate the relationship between Early Childhood Oral Health Impact Scale (ECOHIS) and preschoolers’ fear and behavior during dental treatment. This cross-sectional study was conducted on 385 children aged 3 to 6 attending the pediatric dentistry department of Tabriz Faculty of Dentistry in their first dental appointment. Oral health related quality of life was measured with ECOHIS questionnaire and dental fear using Children’s Fear Survey Schedule (CFSS-DS) questionnaire. Frankle’s behavioral scale was also used for the evaluation of behavioral status. Data were analyzed by SPSS version13.0. ECOHIS score was correlated with CFSS-DS score (P<0.01) and Frakle’s behavioral scale. There was an association between ECOHIS and CFSS-DS score (B =0.198), and ECOHIS and behavioral status (B=-0.193). According to the results, the poorest oral health related quality of life was associated with high levels of dental anxiety and behavioral disorders. According to the results, there was an association between early childhood oral health related quality of life and the level of dental fear and behavioral status.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"1 1","pages":"17-21"},"PeriodicalIF":0.0,"publicationDate":"2016-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79931284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulation Development and Evaluation of Orodispersible Tablets of Quetiapine Fumarate by Sublimation Method 升华法制备富马酸喹硫平多孔分散片的配方及评价

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-06-28 DOI: 10.15272/AJBPS.V6I57.835

M. Bagade, Shete Rv, S. B. Phulzalke, B. Kate

{"title":"Formulation Development and Evaluation of Orodispersible Tablets of Quetiapine Fumarate by Sublimation Method","authors":"M. Bagade, Shete Rv, S. B. Phulzalke, B. Kate","doi":"10.15272/AJBPS.V6I57.835","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I57.835","url":null,"abstract":"The objective of present study was to formulate directly compressible orodispersible tablets of quetiapine fumarate by sublimation method with a view to enhance patient compliance. A full 32 factorial design was used to investigate the effect of two variables viz., concentration of Indion 414 and camphor. Indion 414 (3-5 % w/w) was used as superdisintegrant and camphor (5-15 % w/w) as subliming agent. The tablets were evaluated for thickness, weight variation, hardness, friability, content uniformity, wetting time, porosity, in vitro disintegration time and in vitro drug release. In vitro dissolution profile revealed faster and maximum drug from formulation F3. SEM study show formation of pores on tablet surface after sublimation of the sublimating agent, thus providing a sufficiently porous structure. This permitted the selection of a batch of tablets with desired disintegration time and improved dissolution rate after oral administration. The F3 batch containing the Indion 414 (5%) and Camphor (5%) w/w of total formulation weight had shown good the disintegration time of 18.66 seconds and with improved dissolution rate and desirable friability. Further studies will be required to evaluate the performance of dosage form in vivo and In Vitro In vivo Correlation. Keywords : Orodispersible tablet, factorial design, Indion 414, sublimation, quetiapine fumarate","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"96 1","pages":"22-31"},"PeriodicalIF":0.0,"publicationDate":"2016-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76863101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Chemical component and acute toxicity study of Erythrococca anomala (Euphorbiaceae) 异常红球菌(Euphorbiaceae)化学成分及急性毒性研究

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-06-28 DOI: 10.15272/ajbps.v6i57.819

Patrice Bilé Aka Miezan, T. Okpekon, F. Yapi, N. Bony, G. Gbassi, J. Assi

{"title":"Chemical component and acute toxicity study of Erythrococca anomala (Euphorbiaceae)","authors":"Patrice Bilé Aka Miezan, T. Okpekon, F. Yapi, N. Bony, G. Gbassi, J. Assi","doi":"10.15272/ajbps.v6i57.819","DOIUrl":"https://doi.org/10.15272/ajbps.v6i57.819","url":null,"abstract":"Erythrococca anomala (Juss. ex. Poir) Pain (Euphorbiaceae) is a medicinal plant widely used in sub-saharan Africa. It is popular against certain diseases such as malaria, arthritis, rheumatism and toothache. However, there are no data on its phytochemical and biological profile, hence the importance of this study is to search for chemical groups of this plant and to determine the toxicological parameters that justify its use in the traditional medicine. Standard characterization methods and thin layer chromatography (TLC) were used for the phytochemical screening. The acute toxicity study of Erythrococca anomala was performed according to the guideline OECD 423 using Wistar rats. Phytochemical screening revealed the presence of polyphenols, alkaloids, catechol tannins, saponins, leucoanthocyanins, flavonoids, polyterpenes and sterols which could justify the biological and pharmacological properties of this herb. The acute toxicity study of the extracts, administered intraperitoneally in Wistar rats, was used to determine the 50% lethal dose (LD 50 ) value to be 741.31 mg/kg of body weight (BW), 100% lethal dose (DL 100 ) corresponding to 2000 mg/kg BW and maximum tolerated dose (MTD) to 700 mg/kg BW. These toxicological data allow us to qualify Erythrococca anomala at very low toxic hence its importance in the traditional use against malaria and multifaceted pain.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"66 1","pages":"04-08"},"PeriodicalIF":0.0,"publicationDate":"2016-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91093934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Abortifacient Effect of Amaranthus viridis L. Aqueous Root Extract on Albino Rats 苋菜根水提物对白化大鼠的流产作用

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-05-31 DOI: 10.15272/AJBPS.V6I56.805

U. Kanerkar, P. Bhogaonkar, N. Indurwade

引用次数: 2

Thyroid Dysfunction in Central Referral Hospital, Sikkim 锡金中央转诊医院的甲状腺功能障碍

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2016-05-31 DOI: 10.15272/AJBPS.V6I56.808

S. Bhutia, K. Bhutia, T. A. Singh

引用次数: 4