Asian Journal of Biomedical and Pharmaceutical Sciences最新文献_第3页

Pros and Challenges to Pharmacists in Prescribing Practice. 药师在处方实践中的优势与挑战。

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2020-01-01 DOI: 10.35841/2249-622x.70.7832

Majid Khan

{"title":"Pros and Challenges to Pharmacists in Prescribing Practice.","authors":"Majid Khan","doi":"10.35841/2249-622x.70.7832","DOIUrl":"https://doi.org/10.35841/2249-622x.70.7832","url":null,"abstract":"Pharmacists are the hearts of health care team and independent prescribers in United Kingdom and other developed countries. Nowadays pharmacists oriented to patient care rather traditional mercantile products orientation. Clinical Pharmacy is the combined agreement between physician and pharmacist in which pharmacist prescribing and providing patient care. The health care team is fragile in the absence of pharmacist, literature supported prescription by pharmacists and the members include physicians, stakeholders and patients, but some physicians not supported them due to loss of dignity, deskilled junior physicians and some considered them deficient of well diagnostic skills. Provision of drug therapy without competent clinical pharmacist is impossible and incomplete. The implementation of pharmacists prescribing can effectively decrease burdens and workload from the shoulders of physicians to provide them time for complex diseases, facilitate pharmacists regarding jobs issues instead of five years degree of Doctor of Pharmacy, patient counseling and educations, reduction of polypharmacy and iatrogenic diseases as well as to stabilize the health care triangle.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"30 1","pages":"26-28"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74119738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of an Enzyme Linked Immunosorbent Assay (ELISA) for gentamicin quantification in dried blood spot samples 开发和验证酶联免疫吸附法(ELISA)定量庆大霉素在干血斑样品

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35841/2249-622x.66.18-1176

Teng Meng, Abdel Qader Al Bawab, A. Hawwa, J. McElnay

引用次数: 2

A pilot study to evaluate alternative approaches for treatment of urinary tract infections in dogs. 一项初步研究，评估治疗狗尿路感染的替代方法。

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35841/2249-622x.66.18-1172

E. Biasibetti, M. Capucchio, T. Cocca, MauroBigliati, N. Bruni, E. Martello

引用次数: 2

Preventive effects of soy lecithin in combination with flavonoids on stz induced Diabetes Mellitus in rats 大豆卵磷脂联合黄酮类化合物对stz诱导大鼠糖尿病的预防作用

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35841/2249-622X.67.19-253

Zade Kv, Gulkari Vd

{"title":"Preventive effects of soy lecithin in combination with flavonoids on stz induced Diabetes Mellitus in rats","authors":"Zade Kv, Gulkari Vd","doi":"10.35841/2249-622X.67.19-253","DOIUrl":"https://doi.org/10.35841/2249-622X.67.19-253","url":null,"abstract":"The present research work was design to investigate the anti-diabetic effect of Crude Soy lecithin (CSL) in combination with Flavonoids. Various dosed of CSL, quercetin and rutin were standardized and effective dose of CSL, quercetin and rutin was selected. Male Sprague Dawley rats weighing (200-225 g) were subjected to overnight fasting to induced diabetics by STZ (60 mg/kg i.p.) and blood sample was collected after 72 hrs to conform diabetics. Rats with blood glucose level ≥ 200 mg/dl were selected for further study. A dose of combination of CSL and quercetin with rutin p.o. was administered 60 min prior to blood sample withdrawal for estimation of glucose level. Positive control group were treated with STZ injected rats and negative control with metformin (100 mg/kg bw). Effect of CSL in combination with Flavonoids on Blood glucose level, Total Cholesterol level and Total Triglyceride level was evaluated. The results suggested treatment with CSL, quercetin and rutin were significantly decrease plasma glucose, cholesterol and triglyceride level in rats as compared to STZDiabetic rats. CSL show anti-diabetic effect alone and in combination with Flavonoids on STZ Induced Diabetes Mellitus (DM) in Rats.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"21 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91434638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of prescription patterns and drug use across the Kurdistan region. 库尔德斯坦地区处方模式和药物使用评估。

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35841/2249-622X.67.19-193

Rawaz D. Tawfeeq, Tarin Tahssen Obied, A. Ommar

{"title":"Assessment of prescription patterns and drug use across the Kurdistan region.","authors":"Rawaz D. Tawfeeq, Tarin Tahssen Obied, A. Ommar","doi":"10.35841/2249-622X.67.19-193","DOIUrl":"https://doi.org/10.35841/2249-622X.67.19-193","url":null,"abstract":"Errors in drug prescriptions are the most common preventable medication errors encountered in clinical practices worldwide. The aim of this research is to examine the pattern of prescriptions and drug use in the Kurdistan region and to determine whether the drug prescribing was based on rational therapeutic consideration. A cross sectional-observational study was conducted in the Kurdistan region of Iraq over a period of five months. A total of 1000 prescriptions were selected randomly from different pharmacies and data obtained from each prescription. In these prescriptions a total of 2878 medications were prescribed. The percentage of medications including antibiotics, supplement, non-steroidal antiinflammatory drugs and other painkillers 51.8%, 44.2%, 31.8%, and 21.8% per encounter respectively. The average number of drugs per prescription was 2.8. Drugs prescribed by generic name were 27% and more than 98 per cent of prescriptions were handwritten. The duration of therapy was mentioned in 56.5% of prescriptions. However, the dose and dosage form of medications were recorded 62% and 87.3% respectively. The percentage of prescriptions signed by the prescriber was 88.1%.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87340541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Docking study and result conclusion of heterocyclic derivatives having urea and acyl moiety. 脲酰基杂环衍生物的对接研究及结果结论。

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35841/2249-622X.67.19-082

Rakhi Mishra, A. Mazumder, R. Mazumder, Prem Shankar Mishra, Preeti Chaudhary

{"title":"Docking study and result conclusion of heterocyclic derivatives having urea and acyl moiety.","authors":"Rakhi Mishra, A. Mazumder, R. Mazumder, Prem Shankar Mishra, Preeti Chaudhary","doi":"10.35841/2249-622X.67.19-082","DOIUrl":"https://doi.org/10.35841/2249-622X.67.19-082","url":null,"abstract":"In the field of molecular modeling, Docking is a method which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex. Knowledge of the preferred orientation in turn may be used to predict the strength of association or binding affinity between two molecules. In this study a series of synthesized compounds were evaluated for focusing on binding modes, potential interactions and specific binding sites. Chemically compounds bear both the moiety acyl as well as urea and their interaction by using in silico study was investigated with beta tubulin protein that interferes with the tubulin-microtubule equilibrium, crucial for cellular mitosis. In silico studies revealed that synthesized and tested compounds show 1-7 no. of interactions with amino acids of tubulin protein. Docking study was done by using Autodock, it was found that among different synthesized compound some shows the highest and best scoring pose (lowest energy) which was -2.94 Kcal/mole between N (11) and Leucine (113) and -3.09 between N (11) and Alanine (149). Compounds with amino, hydroxy, methyl, methoxy, trimethoxy and dimethoxy substitution in derivatives of acyl urea gave an idea that urea and acyl when used in combination in different synthesized compounds show good antitumor activity.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85066712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Inhibitory Properties of Combined Ethanol Seed Extract of P. guineense and T. conophorum on -Glucosidase Enzyme 几内亚棘球菌与棘球菌混合乙醇种子提取物对-葡萄糖苷酶的抑制作用

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35841/2249-622X.67.19-256

A. Dokubo, Odinaka Em, C. Jao

{"title":"Inhibitory Properties of Combined Ethanol Seed Extract of P. guineense and T. conophorum on -Glucosidase Enzyme","authors":"A. Dokubo, Odinaka Em, C. Jao","doi":"10.35841/2249-622X.67.19-256","DOIUrl":"https://doi.org/10.35841/2249-622X.67.19-256","url":null,"abstract":"The study was aimed to evaluate the α-glucosidase inhibitory properties of combined ethanol seed extract of Piper guineense and Tetracarpidium conophorum (CEPGTC). In vitro inhibitory assay was conducted in accordance with standard methods. p-nitrophenyl--D-glucopyranoside (pNPG) was used as a substrate. Fixed amount of the enzyme was incubated with increasing concentrations of CEPGTC seed extract (20-100 μg/ml) at 37°C for 15 min. The continuous production of p-nitrophenol was determined by measuring the absorbances at 410 nm. Acarbose at varying concentration (20-100g/ml) was used as the positive control. The median Inhibitory Concentration (IC50) values were graphically determined as the half-maximal inhibitory from plots of percent inhibition against log inhibitor concentration and by non-linear regression analysis. The enzyme kinetics (pattern of Inhibition) was determined using the Michaelis Menten’s equation and Lineweaver-Burk plot. The result showed that there was inhibition in all concentrations evaluated. The IC50 values estimated were 2.9 μg/ml and 2.5 μg/ml for CEPGTC and acarbose respectively. However, The IC50 value for acarbose was significantly (p<0.05) different from CEPGTC which is an indication of acarbose as effective -glucosidase inhibitor thus, used as positive control. An enzyme kinetics studies from the Lineweaver-Burke plot showed that CEPGTC seed extract demonstrated an uncompetitive inhibition on α-glucosidase while acarbose exhibited non competive (mixed inhibition). The inhibitory response and mechanism of inhibition observed in this study showed that combined ethanol seed extract of Piper guineense and Tetracarpidium conophorum has the potential to reduce glucose turnover and improve Hyperglycemia.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89083047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE EFFECT OF SYNTHETIC CB2 RECEPTOR AGONIST (AM1241) ON CYTOKINE LEVELS IN OVALBUMIN-INDUCED ASTHMA IN RATS 合成cb2受体激动剂(am1241)对卵清蛋白诱导哮喘大鼠细胞因子水平的影响

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.4066/2249-622X-C1-017

A. Parlar

引用次数: 0

Job satisfaction of doctors working at Upazila Health Complexes in Barisal District. Barisal区Upazila保健中心医生的工作满意度。

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.35841/2249-622X.67.19-066

Md. Haroon Or Rashid, Mirajul Islam, A. Imtiaz, Hasina Mahmuda Ferdushi, A. Salahuddin, Monzur Hussain Chowdhury, Tufael

{"title":"Job satisfaction of doctors working at Upazila Health Complexes in Barisal District.","authors":"Md. Haroon Or Rashid, Mirajul Islam, A. Imtiaz, Hasina Mahmuda Ferdushi, A. Salahuddin, Monzur Hussain Chowdhury, Tufael","doi":"10.35841/2249-622X.67.19-066","DOIUrl":"https://doi.org/10.35841/2249-622X.67.19-066","url":null,"abstract":"Doctor's profession has long been among one of the most attractive professions in our society, but doctors are increasingly getting dissatisfied with their jobs. Job satisfaction is very important but very less studied issue. The aim of this study to assess the level of job satisfaction among doctors at selected Upazila Health Complexes in Barisal District. A descriptive cross sectional study was conducted among 59 doctors posted in 9 Upazila Health Complexes of Barisal district. Data was collected by using structured questionnaire consisting of 54 questions and JSS (Job Satisfaction Survey) scale, where higher values indicated higher level of satisfaction. The average scores of items were computed to construct factor scores for each individual. The total number of doctors included in this study was 59.78% were male. Majority (66.1%) had age ranged 25-35 years. Majority (86.4%) of doctors was married and almost 80% were Muslim. Most of the respondents (64.4%) had clinical experience of 0 to 5 years. The result displayed that 57.6% of doctors were dissatisfied, 27.1% were satisfied and 15.3% were ambivalent. Majority of the respondents were dissatisfied with salary, promotional scope allowances, night duty, working hours, accommodation facility and transport facility. Job satisfaction among doctors in this study was low. Responsible authority should take necessary action to improve job satisfaction.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89774831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

ADVANTAGES OF HANDS PRO INSTRUMENTAL MANIPULATION IN SPORT 在运动中，手的优势有利于器械操作

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2019-01-01 DOI: 10.4066/2249-622x-c1-016

Aldo Alexander Silva Garcia

引用次数: 0