Preventive effects of soy lecithin in combination with flavonoids on stz induced Diabetes Mellitus in rats

Asian Journal of Biomedical and Pharmaceutical Sciences Pub Date : 2019-01-01 DOI:10.35841/2249-622X.67.19-253

Zade Kv, Gulkari Vd

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Abstract

The present research work was design to investigate the anti-diabetic effect of Crude Soy lecithin (CSL) in combination with Flavonoids. Various dosed of CSL, quercetin and rutin were standardized and effective dose of CSL, quercetin and rutin was selected. Male Sprague Dawley rats weighing (200-225 g) were subjected to overnight fasting to induced diabetics by STZ (60 mg/kg i.p.) and blood sample was collected after 72 hrs to conform diabetics. Rats with blood glucose level ≥ 200 mg/dl were selected for further study. A dose of combination of CSL and quercetin with rutin p.o. was administered 60 min prior to blood sample withdrawal for estimation of glucose level. Positive control group were treated with STZ injected rats and negative control with metformin (100 mg/kg bw). Effect of CSL in combination with Flavonoids on Blood glucose level, Total Cholesterol level and Total Triglyceride level was evaluated. The results suggested treatment with CSL, quercetin and rutin were significantly decrease plasma glucose, cholesterol and triglyceride level in rats as compared to STZDiabetic rats. CSL show anti-diabetic effect alone and in combination with Flavonoids on STZ Induced Diabetes Mellitus (DM) in Rats.

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大豆卵磷脂联合黄酮类化合物对stz诱导大鼠糖尿病的预防作用

本研究旨在探讨粗大豆卵磷脂(CSL)与黄酮类化合物联合使用的抗糖尿病作用。对黄芪多糖、槲皮素和芦丁的不同剂量进行了标准化，选择了黄芪多糖、槲皮素和芦丁的有效剂量。将体重200 ~ 225 g的雄性斯普拉格·道利大鼠以STZ (60 mg/kg i.p)诱导糖尿病，禁食过夜，72h后采血确认糖尿病。选择血糖≥200 mg/dl的大鼠进行进一步研究。在取血前60分钟给予CSL、槲皮素和芦丁组合剂量，以估计血糖水平。阳性对照组大鼠注射STZ，阴性对照组大鼠注射二甲双胍(100 mg/kg bw)。观察CSL联合黄酮类化合物对血糖、总胆固醇和总甘油三酯水平的影响。结果表明，与stzdiabetes大鼠相比，CSL、槲皮素和芦丁治疗可显著降低大鼠血浆葡萄糖、胆固醇和甘油三酯水平。黄酮类化合物对STZ诱导的大鼠糖尿病(DM)有单用或联用的抗糖尿病作用。

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Asian Journal of Biomedical and Pharmaceutical Sciences

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