{"title":"Metabolomics approaches for early cancer diagnosis: a review","authors":"","doi":"10.35495/ajab.2020.12.566","DOIUrl":"https://doi.org/10.35495/ajab.2020.12.566","url":null,"abstract":"Cancer remains a major burden on global public health with high mortality rates worldwide. Current diagnosis can detect cancer in late stages when therapy options become limited. Early diagnosis is broadly recognized as the key to a better treatment to save lives. The metabolomics approach provides a better understanding of the different types of cancer. They offer promising and potential interventions in biomarkers discovery which eventually will be better suited for individualized medicine. It elucidates endpoint products for other omic processes while significantly improving the understanding of pathogenesis and mechanisms yet to be discovered. Metabolomics offers a less-invasive, cost-effective for predicting, screening, diagnosis, prognosis, and monitoring therapeutic responses of the disease. There are two methods to study the metabolism and metabolites: targeted and untargeted. The workflow of these approaches requires different analytical platforms, such as Nuclear Magnetic Resonance spectroscopy (NMR), Mass Spectrometry (MS), and different bioinformatic tools. This review provides a systematic summary of metabolomics methods in identifying metabolic biomarkers of cancers (colorectal, prostate, breast, bladder, pancreas, lung, and buccal cancers). In addition, the current review will try to shed light on DNA lesions as a potential metabolic biomarker for cancer.","PeriodicalId":8506,"journal":{"name":"Asian Journal of Agriculture and Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41836231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nutritional and physical requirements for mycelial growth and fruiting body production of six strains of Pleurotus djamor from Luzon Island, Philippines","authors":"","doi":"10.35495/ajab.2021.05.233","DOIUrl":"https://doi.org/10.35495/ajab.2021.05.233","url":null,"abstract":",","PeriodicalId":8506,"journal":{"name":"Asian Journal of Agriculture and Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46809253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Malik, Sawera Nayyab, M. R. Mirza, S. Muzammil, Javaria Saleem Cheema, Komal Imran, Kanwal Nisar, S. Hayat, M. Javed
{"title":"Growth performance of major carps during exposure of zinc and bioaccumulation in fish body organs","authors":"I. Malik, Sawera Nayyab, M. R. Mirza, S. Muzammil, Javaria Saleem Cheema, Komal Imran, Kanwal Nisar, S. Hayat, M. Javed","doi":"10.35495/ajab.2021.02.092","DOIUrl":"https://doi.org/10.35495/ajab.2021.02.092","url":null,"abstract":"Growth is an index of metals influence on a fish. This investigation aimed to determine growth responses of major carps viz. Catla catla, Labeo rohita and Cirrhina mrigala during exposure to sublethal concentration to zinc. The variations among fish age, species, treatment (zinc) of growth parameters viz. weight increment, fork lengths, and condition factor were statistically significant at P<0.01. The control fish age group 90,120,150 and 180 day showed better feed conversion ratio 0.234, 0.168, 0.132 and 0.29 as compared to that of zinc exposed fish which showed range 0.01 to 0.23. Three fish species showed significantly higher amount of zinc in liver than other organs. Labeo rohita showed significantly higher trend for zinc accumulation in body organs than as compared to Cirrhina mrigala and Catla catla. Among body organs; skin, muscle, scales displayed significantly lesser trend for zinc accumulation. It is concluded that metal intoxication significantly reduced the growth of all three fish species and may also show good indicator of metals present in surrounding environment.","PeriodicalId":8506,"journal":{"name":"Asian Journal of Agriculture and Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45849229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md. Hafiz All Amin, S. Sumi, W. Jutidamrongphan, K. Techato
{"title":"Economic potentiality of Colocasia esculenta L. under multipurpose tree-based agroforestry systems","authors":"Md. Hafiz All Amin, S. Sumi, W. Jutidamrongphan, K. Techato","doi":"10.35495/ajab.2021.01.059","DOIUrl":"https://doi.org/10.35495/ajab.2021.01.059","url":null,"abstract":"Taro (Colocasia esculenta L. cv. Latiraj) is a vegetable for many people in tropical and sub-tropical countries in the world. Because of large quantities of vitamins and minerals, it has considerable value in the food market. As the Taro has raised market demand, it needs to increase production as much as possible. Agroforestry would be a possible production approach for Taro as it can be practised in a partially shaded conditions. The research aimed to evaluate the performance of Taro under woody perennials of Melia azedarach, Leucaena leucocephala, Albizia lebbeck and sole crop cultivation to get potential production and high financial return. This experiment was followed a single factor Randomized Complete Block Design (RCBD) with three replications. The treatments were (1) sole cropping of Latiraj, (2) Latiraj-Melia azedarach, (3) Latiraj-Albizia lebbeck and (4) Latiraj-Leucaena leucocephala. The results showed the maximum number of stolon per plant (29.50) found in LatirajAlbizia lebbeck and noted the minimum number of stolon (19.17) was in LatirajLeucaena leucocephala. Also, the highest stolon length (60.85 cm) and girth (3.33 cm) were observed in Latiraj-Albizia lebbeck and Latiraj-Melia azedarach, respectively. Moreover, the highest stolon yield (10.08 ton/ha) was obtained from Latiraj-Albizia lebbeck compared to (9.85 ton/ha) Latiraj sole cropping. The maximum benefit-cost ratio (4.78) was recorded in the Latiraj-Albizia lebbeck, 24% higher than (3.62) Latiraj sole cropping for economic performance. Finally, it was found that the Taro cv. Latiraj cultivation under Albizia lebbeck as an agroforestry practice would be a sustainable strategy to maximize the production, touching financial benefit and ensuring the proper utilization of vacant woodlots space.","PeriodicalId":8506,"journal":{"name":"Asian Journal of Agriculture and Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43950300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Van-Thanh Vo, T. Duong, Nhat-Anh-Thu Mai, Huyen Nguyen Thi Thuong
{"title":"Assessment of lead toxicity in red tilapia Oreochromis sp. through hematological parameters","authors":"Van-Thanh Vo, T. Duong, Nhat-Anh-Thu Mai, Huyen Nguyen Thi Thuong","doi":"10.35495/ajab.2021.01.016","DOIUrl":"https://doi.org/10.35495/ajab.2021.01.016","url":null,"abstract":"Fish is one of the reliable biomonitoring used to assess the levels of heavy metal pollution in the aquatic environment. Analyzing the biological parameters of fish provides a predictable transformation of the underwater ecosystem and the current state of nursery water. Blood directly or indirectly reacts to changes in the environment, objectively reflects the physiological state and allows predicting the direction of adaptive responses in the body. According to the blood indicators and proper generalization of the blood system, we can estimate the physiological and pathological processes inside the body. This study aimed to estimate the effects of lead on hematological parameters in red tilapia. Fish were investigated for the effects of the lead after one week. Fish blood is taken from the tail vein by suction injection. Hematological parameters were determined by standard methods. The number of WBC is counted indirectly through blood smears stained Giemsa. The result of the study shows when the concentration of lead for infection increase from 0mgL -1 (control) to 0.5mgL -1 , 1.0mgL -1 and 1.5mgL -1 , there is a decrease in the hematocrit, hemoglobin, RBC and increases of the mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, WBC. RBC and WBC have observed the shape. Blood cells of red tilapia Oriochromis sp. living in a lead polluted environment can be affected and result in many different values of hematological parameters. This is an adaptive reaction of the body in response to harmful factors at the cellular level.","PeriodicalId":8506,"journal":{"name":"Asian Journal of Agriculture and Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49420303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wardah Wardah, Finalah Nurhayati, Mery Maria Magdalena, N. Fazilah, T. Sopandi
{"title":"Growth and biochemical composition of Spirulina platensis dry biomass in diluted monosodium glutamate waste waters","authors":"Wardah Wardah, Finalah Nurhayati, Mery Maria Magdalena, N. Fazilah, T. Sopandi","doi":"10.35495/ajab.2021.05.220","DOIUrl":"https://doi.org/10.35495/ajab.2021.05.220","url":null,"abstract":"The use of low-cost culture media is important for the development of large-scale Spirulina platensis production. This study aims to investigate the effects of using diluted monosodium glutamate wastewater (MSGW) as a culture medium on the growth and biochemical composition of S. platensis dry biomass. Nitrogen and phosphorus uptake by S. platensis from MSGW media was also investigated in this study. Four concentrations of MSGW have been used in this study, namely 1.5, 2.5, 3.5 and 4.5 mL/L and Walne medium was used as a control. All media were adjusted at pH 9 and S. platensis culture was carried out for 14 day at 36.0C, 77% relative humidity, 5000 lux light intensity and aeration rate at 0.7 L/min. The results of this study have indicated that the growth, protein, lipids, carbohydrates and chlorophyll of S. platensis biomass at 2.5 mL/L MSGW concentrations were not significantly different from Walne medium, but were significantly different from 1.5, 3.5 and 4.5 mL/L MSGW concentrations. The present study have also shown those nitrogen and phosphorus uptakes by S. platensis from 2.5 mL/L MSGW concentration was not significantly different from Walne medium, but were significantly different from 1.5, 3.5 and 4.5 mL/L MSGW concentrations. The present study concluded that S. platensis can be cultivated in MSGW as a medium with an optimum concentration of 2.5 mL/L. This finding will serve as a basic reference for future studies to utilize MSGW for microalgae culture media.","PeriodicalId":8506,"journal":{"name":"Asian Journal of Agriculture and Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48219325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nimarsha Sonali Kamaradiwela Arachchige, B. Jayawardena
{"title":"Chemical composition and anti-diabetic activities in two novel accessions of Cinnamon (Cinnamomum zeylanicum) leaves grown in Sri Lanka","authors":"Nimarsha Sonali Kamaradiwela Arachchige, B. Jayawardena","doi":"10.35495/ajab.2021.03.138","DOIUrl":"https://doi.org/10.35495/ajab.2021.03.138","url":null,"abstract":"Diabetes Mellitus is a major health concern in many countries. Although there are many synthetic drugs to manage diabetes, most of them are associated with many side effects. Hence there is attention to the use of natural herbs with fewer side effects as an alternative. In this study the hypoglycemic properties, biological activities and chemical composition of leaves of two new Cinnamomum zeylanicum accessions (Sri Wijaya and Sri Gemunu) were investigated using spectrometric techniques. Ethanolic extracts of the two accessions were tested for alpha-amylase inhibitory activity (IC50 of Sri Gemunu 0.0565 ± 0.0013 mg/mL, IC50 of Sri Wijaya 0.1136 ± 0.0011 mg/mL), alpha-glucosidase inhibitory activity (IC50 of Sri Gemunu 0.0347 ± 0.0002 mg/mL, IC50 of Sri Wijaya 0.0884 ± 0.0002 mg/mL), total phenolic content (20.60 ± 0.01 mg Gallic acid equivalents.gof Sri Gemunu, 6.07 ± 0.01 mg Gallic acid equivalents.g of Sri Wijaya), total flavonoid content (72.02 ± 0.02 mg quercetin equivalents.gof Sri Gemunu, 23.59 ± 0.02 mg quercetin equivalents.g of Sri Wijaya), total proanthocyanidin content (0.60 ± 0.05 g catechin equivalents.gof Sri Gemunu, 0.15 ± 0.05 g catechin equivalents.g of Sri Wijaya) and DPPH radical scavenging activity (IC50-58.18 ± 2.53 μg/mL of Sri Wijaya, IC50-69.60 ± 5.48 μg/mL of Sri Gemunu). GC-MS analysis and HPLC analysis indicated that both accessions were rich in eugenol and cinnamaldehyde. According to the results of this study, the ethanolic extract of Sri Gemunu Cinnamomum zeylanicum accession leaves displayed better anti-diabetic properties than the leaves of Sri Wijaya.","PeriodicalId":8506,"journal":{"name":"Asian Journal of Agriculture and Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46603425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of spatial variation on the physicochemical properties and mineral\u0000content of stingless bee honey (Heterotrigona itama) in Terengganu,\u0000Malaysia","authors":"","doi":"10.35495/ajab.2021.04.176","DOIUrl":"https://doi.org/10.35495/ajab.2021.04.176","url":null,"abstract":"The growing interest in the usage of stingless bee honey as a functional food proceeds from its composition, which has been associated with bio-medicinal properties. However, the composition of honey is dependent on the types and origin of bees’ foods, which are flower nectar and plant honeydew. Thus, this study was done to investigate the influence of spatial variation on the physicochemical and mineral content of stingless bee honey in Terengganu, Malaysia. Honeys produced by Heterotrigona itama were collected from five different locations around Terengganu, Malaysia that are surrounded by different plant diversity. The physicochemical properties, antioxidant activity, total phenolic compounds, total flavonoid compounds, and minerals of stingless bee honey were evaluated. Results obtained show that the pH of honey at all locations differed significantly, ranging from 3.30 to 3.54. The sweetness of honey varied between locations, from 69.30 to 75.76 °Brix. The moisture content of honey ranged from 27.28 to 33.13% and the electrical conductivity from 0.65 to 1.46 mScm -1 , which differed significantly among the five selected locations. The parameters for colour, L* (lightness of the sample), a* (the colour scale from red to green) and b* (the colour scale from yellow to blue) values ranged from 25.02 to 52.55, - 0.12 to 7.42, and 10.36 to 14.88, respectively. The total flavonoid content of honey ranged from 1.41 to 6.64 mg CE/g, while total phenolic content gave a value of 3.94 to 10.54 mg GAE/g. The antioxidant activity of honey gave a value ranging from 71.14 to 85.27%. The location of hives had a significant influence on the amount of minerals in stingless bee honey. It can be concluded that the physicochemical properties and mineral content of honey produced by H. itama were different between locations due to the variation of plant diversity at respective locations. The data obtained provides information on the effect of spatial biodiversity variation on the quality of stingless bee honey in selected locations in Terengganu, Malaysia.","PeriodicalId":8506,"journal":{"name":"Asian Journal of Agriculture and Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69848040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}