Journal of cancer epidemiology and prevention最新文献

{"title":"Cross-issue synthesis: potential application to breast cancer, tamoxifen and genetic susceptibility.","authors":"R M Nixon,&nbsp;S W Duffy","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cross-design synthesis usually refers to the inclusion in a meta-analysis of studies addressing the same question but using different designs, for example, combining results from randomised trials with those from case-control studies. Here we describe a procedure for combining information from studies addressing different but clinically related questions, referred to, for brevity, as cross-issue synthesis.</p><p><strong>Methods: </strong>Surveys have measured the oestrogen receptor (ER) status of invasive breast cancer in women with mutations in the BRCA1 or BRCA2 gene. These mutations confer a substantially increased risk of breast cancer. These are also published randomised trials of tamoxifen administered for at least 3 years, either as an adjuvant therapy or for primary prevention, which record whether breast cancer recurred or occured respectively. These studies also give results by ER status. There are biological reasons to suppose that tamoxifen is more effective at preventing ER-positive cancers, and may have little or no effect at preventing ER-negative cancers. Women with BRCA mutations are more likely to develop ER-negative cancers. Combining meta analyses for these two types of studies supplies an estimate of the effectiveness of tamoxifen in preventing breast cancer in women with BRCA mutation. Hierarchical models were developed for this purpose. Estimation was by Markov chain Monte Carlo (MCMC).</p><p><strong>Results: </strong>A range of models were fitted by MCMC. Using these, the effect of tamoxifen on the relative risk of developing breast cancer in women with a mutation in the BRCA1 gene is estimated to be 0.90 95% confidence interval (CI) (0.52, 1.61), and for the BRCA2 gene 0.71 95% CI (0.45, 1.21).</p><p><strong>Discussion: </strong>This procedure can be generalised to combine information from two sets of studies addressing different, but clinically related questions.</p>","PeriodicalId":84981,"journal":{"name":"Journal of cancer epidemiology and prevention","volume":"7 4","pages":"205-12"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22471459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of control selection bias in a hospital-based case-control study of upper aero-digestive tract cancers.","authors":"Ines N Nishimoto,&nbsp;Javier Pintos,&nbsp;Nicolas F Schlecht,&nbsp;Humberto Torloni,&nbsp;André L Carvalho,&nbsp;Luiz P Kowalski,&nbsp;Eduardo L Franco","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Most of the evidence identifying determinants of UADT cancer risk comes from hospital-based case-control studies. However, such studies are thought to be influenced by selection bias given the extent of association of tobacco smoking and alcohol drinking with other diseases in the general population. We assessed the extent of selection bias due to inclusion of controls with tobacco or alcohol related diseases in a hospital-based case-control study of upper aero-digestive tract (UADT) cancers in Brazil.</p><p><strong>Methods: </strong>Risk factor information was obtained from 784 cases and 1568 non-cancer controls. Causes of hospitalization for controls were scored according to their likelihood of association with tobacco and alcohol. Odds ratios (OR) were calculated by conditional logistic regression with and without exclusion of controls with tobacco or alcohol related diseases.</p><p><strong>Results: </strong>The OR for smoking slightly increased after exclusion of controls with tobacco-related diseases, from 15.3 (95% confidence interval [CI]: 9.7, 24.2) among heaviest smokers (pack-years > 91) to 18.6 (95%CI: 11.4, 30.2). The OR for alcohol consumption remained unchanged after exclusion of controls with alcohol related diseases. Associations of low magnitude for some dietary variables (citric fruits, carotene-rich foods, spicy foods, maté tea) and wood stove use were not appreciably affected by the exclusion of controls.</p><p><strong>Conclusion: </strong>The bias introduced by controls with tobacco and alcohol related diseases is small, when these exposures are investigated as determinants, and almost negligible when considered as confounders of the association between other factors and UADT cancers.</p>","PeriodicalId":84981,"journal":{"name":"Journal of cancer epidemiology and prevention","volume":"7 3","pages":"131-41"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22314651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid increase in colorectal cancer rates in urban Shanghai, 1972-97, in relation to dietary changes.","authors":"Wei-Cheng You,&nbsp;Fan Jin,&nbsp;Susan Devesa,&nbsp;Gloria Gridley,&nbsp;Arthur Schatzkin,&nbsp;Gong Yang,&nbsp;Philip Rosenberg,&nbsp;Yong-Bing Xiang,&nbsp;Yan-Ren Hu,&nbsp;Qi Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In urban Shanghai, the largest industrial and commercial city in China, the age-adjusted (to world standard) incidence rates for colorectal cancer increased from 14.8 to 24.1 per 10(5) man-years and from 11.7 to 20.7 per 10(5) woman-years between 1972-73 and 1996-97. These changes were even more pronounced for colon cancer. The reasons for the rapid increases in cancer rates are not fully understood, but may involve dietary habits that have changed substantially overthe past two decades.</p><p><strong>Methods: </strong>Based on incidence data on 37000 colorectal cancers from 1972-1997 and dietary information during the past 20 years, an ecologic correlation analysis was performed.</p><p><strong>Results: </strong>Available data indicate that per capita food consumption in Shanghai of vegetable oil, poultry, eggs, and pork rose rapidly during the period 1978-97, whereas consumption of seafood, grain, and fresh vegetables changed little or showed little consistent trends. Statistically significant positive associations were observed between colon cancer rates and per capita consumption of vegetable oil, poultry, fresh eggs and pork.</p><p><strong>Discussion: </strong>These findings suggest that increases in dietary fat and certain protein consumption may play a role in the rising colon cancer rates in Shanghai.</p>","PeriodicalId":84981,"journal":{"name":"Journal of cancer epidemiology and prevention","volume":"7 3","pages":"143-6"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22314652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the sensitivity of a genetic test using gene-carrier probability estimates and its application in genetic counselling.","authors":"H Becher,&nbsp;J Chang-Claude","doi":"10.1080/14766650252962630","DOIUrl":"https://doi.org/10.1080/14766650252962630","url":null,"abstract":"<p><strong>Background: </strong>The estimation of the sensitivity of a genetic test is of practical importance. If a 'gold standard' (an exact test) is not available, an estimate of the probability of being a gene carrier may be useful for an individual. This information could be based on individual pedigree and family-history data, and a known genetic model for the disease of interest.</p><p><strong>Methods: </strong>We develop a maximum-likelihood estimate of the sensitivity of a genetic test that may be applied in a situation without a 'gold standard', in which an estimate of the probability of being a gene carrier for an individual is available.</p><p><strong>Results: </strong>A maximum-likelihood estimate for the sensitivity can be obtained through an iterative algorithm. We demonstrate the method using data from a project on familial breast cancer. We further present disease-risk estimates incorporating results from a genetic test with different values of sensitivity, and compare these with disease-risk estimates that are solely based on family-history data.</p><p><strong>Discussion: </strong>We provide a systematic methodology to obtain an estimate of sensitivity of a genetic test when only gene-carrier probability estimates from a genetic model are available. Given a negative result from a genetic test, predictions for lifetime and age-specific disease-risk, accounting for test sensitivity, can then be provided in genetic counselling.</p>","PeriodicalId":84981,"journal":{"name":"Journal of cancer epidemiology and prevention","volume":"7 1","pages":"13-9"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22056725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Countrywide estimation of the burden of injuries in Greece: a limited resources approach.","authors":"N Dessypris,&nbsp;E Petridou,&nbsp;Y Skalkidis,&nbsp;M Moustaki,&nbsp;A Koutselinis,&nbsp;D Trichopoulos","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>We have assessed the ability of the Emergency Department Injury Surveillance System (EDISS), a registration network operating with limited resources, to predict the burden and pattern of injuries in the whole Greece.</p><p><strong>Methods: </strong>We have compared hospitalizations calculated on the basis of EDISS with those routinely recorded by the National Statistical Service countrywide. EDISS relies on data collected in the Emergency Departments of four hospitals, two located in the Greater Athens area, and two district hospitals in the remaining Greece. EDISS data concern hospitalized and non-hospitalized patients of all ages, with all types of injuries irrespectively of their etiology or intent.</p><p><strong>Results: </strong>Over a three-year period 148 835 subjects with injuries were interviewed. Using sampling ratios of 2.2% for all injuries outside Greater Athens and for adults in Greater Athens but 28.9% for childhood injuries, the total annual number of injuries in Greece was estimated at 1.53 million (95% confidence interval: 1.48-1.57 million). Of those, about 18% concern children less than 15 years old. The difference between the EDISS estimated and the actually recorded hospitalized injuries was, in preliminary terms, acceptable.</p><p><strong>Discussion: </strong>Of the ten major categories of injuries, seven among children and five among adults have shown deviations of less than 20%. For the remaining categories deviations were larger but in only one instance did the difference exceed 50%. It is concluded, that for a small and relatively homogeneous country, like Greece, injury data provided by four large hospitals can generate reasonably reliable estimates for large categories of injuries.</p>","PeriodicalId":84981,"journal":{"name":"Journal of cancer epidemiology and prevention","volume":"7 3","pages":"123-9"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22314650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjusting for measurement error in the Cox proportional hazards regression model.","authors":"R Mallick,&nbsp;K Fung,&nbsp;D Krewski","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The Harvard Six Cities Study (Dockery et al.) was the first large-scale cohort study to demonstrate an association between long-term exposure to fine particulate matter less than 2.5 microns in aerodynamic diameter (PM2.5) and mortality in urban centres in the United States. Because of the pivotal role of this study in the establishment of the first U.S. national ambient air quality objective for PM2.5 in 1997 (Greenbaum et al.), the results of this study were subjected to an independent detailed re-analysis to test the robustness of the findings to alternative analytic methods (Krewski et al.), including an assessment of the effect of exposure measurement error on estimates of risk based on the Cox proportional hazards model. It is well-known that random measurement error leads to downward bias in estimates of risk, and overstatement of the precision of such estimates.</p><p><strong>Methods: </strong>Data from the Harvard Six Cities Study were used to evaluate the potential impact of measurement error on estimates of risk. After introducing a known amount of measurement error into the original data, estimates of risk were calculated using two methods for adjusting for measurement error: regression calibration (RCAL) and simulation extrapolation (SIMEX). With RCAL, the observed value of PM2.5 is replaced by its expected value with respect to the measurement error distribution. SIMEX adjusts for measurement error by adding progressively larger errors to the data and then extrapolating back to the case of no measurement error. Computer simulation was used to evaluate the accuracy and precision of both RCAL and SIMEX, and to assess the robustness of RCAL to mis-specification of the measurement error distribution.</p><p><strong>Results and conclusions: </strong>When the measurement error distribution was correctly specified, RCAL greatly reduced the downward bias in risk estimates induced by random measurement error, even when the degree of measurement error was relatively large. SIMEX, on the other hand, failed to adequately adjust for the effects of random measurement error in the Cox model, even in the presence of a moderate degree of measurement error. Although RCAL is thus preferable to SIMEX, RCAL was not robust against mis-specification of the measurement error distribution, seriously overestimating (underestimating) risk when the measurement error was overstated (understated).</p>","PeriodicalId":84981,"journal":{"name":"Journal of cancer epidemiology and prevention","volume":"7 4","pages":"155-64"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22471454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An evaluation of spatio-temporal models for the estimation of the mortality relative risk from breast cancer in Galicia, Spain.","authors":"M E López-Vizcaíno,&nbsp;C L Vidal-Rodeiro,&nbsp;M I Santiago-Pérez,&nbsp;E Vázquez-Fernández,&nbsp;X Hervada-Vidal","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Disease mapping is now a big focus of interest in the area of Public Health, and the geographical distribution of a disease has an important role in understanding its origin or its causes. The purpose of this work is to review and evaluate different techniques to map the mortality risk of a disease in small geographical areas.</p><p><strong>Methods: </strong>Three different methods have been studied. The first one is a classical approach consisting of mapping SMRs, which are maximum likelihood estimates of the relative risk under a Poisson model of death counts. In a second step we consider Poisson and negative binomial regression to fit the rates and finally we use a Bayesian approach that assumes a hierarchical model where the death counts follow a Poisson distribution conditioned by the prior information. These methods have been applied to the study of geographical variation in female breast cancer mortality from 1976 to 1999 in the districts of Galicia, Spain.</p><p><strong>Results: </strong>Mapping the SMRs using the first method has important drawbacks and there are difficulties to distinguish the mortality pattern. With the second method we achieved some improvements. The Bayesian methodology produces smoother maps with a clear mortality pattern.</p><p><strong>Discussion: </strong>These methods are powerful tools for identifying areas with elevated risk. The Bayesian methodology has many advantages over the other methods that had been analysed in this work.</p>","PeriodicalId":84981,"journal":{"name":"Journal of cancer epidemiology and prevention","volume":"7 4","pages":"181-93"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22471457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case-control study of occupation and breast-cancer risk in Connecticut.","authors":"T Zheng,&nbsp;T R Holford,&nbsp;S Taylor Mayne,&nbsp;J Luo,&nbsp;P Hansen Owens,&nbsp;S Hoar Zahm,&nbsp;B Zhang,&nbsp;Y Zhang,&nbsp;W Zhang,&nbsp;Y Jiang,&nbsp;P Boyle","doi":"10.1080/14766650252962621","DOIUrl":"https://doi.org/10.1080/14766650252962621","url":null,"abstract":"<p><strong>Background: </strong>Several occupations have recently been related to breast-cancer. The results, however, are inconsistent. We analyse data from a case-control study of breast cancer in Connecticut conducted in 1994-97 to further examine the potential relationship between occupation and breast-cancer risk.</p><p><strong>Methods: </strong>A total of 608 breast-cancer cases and 609 controls, 31-85 years old, were included in the study. Information regarding occupation and other breast-cancer risk-factors was obtained through in-person interviews by trained interviewers, using a standardised, structured questionnaire.</p><p><strong>Results: </strong>after adjustment for major breast-cancer risk-factors, a significantly increased risk of breast cancer was observed for teachers and librarians [odds ratio (OR), = 1.9, 95% confidence interval (CI) 1.3-2.7]. A significantly reduced risk, on the other hand, was observed for technicians and related supports (OR = 0.5, 95% CI 0.3-0.9). No other occupational groups showed a significant association with breast-cancer risk.</p><p><strong>Conclusions: </strong>The observed increase in breast-cancer risk among teachers and librarians is consistent with most earlier studies. It is currently unknown, however, what factors may explain the observed increase. Considering that teachers and librarians represent one of the largest single occupational groups among employed US women, further investigation of this association is warranted.</p>","PeriodicalId":84981,"journal":{"name":"Journal of cancer epidemiology and prevention","volume":"7 1","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22056665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social networks among older Australians: a validation of Glass's model.","authors":"Lynne C Giles,&nbsp;Patricia A Metcalf,&nbsp;Craig S Anderson,&nbsp;Gary R Andrews","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The purpose of the study was to validate a set of measures of social networks that will be useful in epidemiological studies of the health of older persons.</p><p><strong>Methods: </strong>Confirmatory factor analysis was used to test a multi-dimensional model of social networks. Data were drawn from The Australian Longitudinal Study of Ageing, conducted in the greater metropolitan area of Adelaide, South Australia. Participants were 1477 persons aged > or = 70 years who lived in the community or an institution and took part in the Australian Longitudinal Study of Ageing. Social networks with children, other relatives, friends and confidants were considered. Demographic indicators of gender, age group, income, education, marital status and place of residence were also measured, and social networks were compared for categories of these variables.</p><p><strong>Results: </strong>Networks with children, relatives, friends and confidants were substantiated in these analyses. Differences in networks between categories of the demographic variables were evident.</p><p><strong>Discussion: </strong>Adoption of the proposed measures will allow greater comparability between studies of older persons. This could lead to a better understanding of the effect of specific social networks upon health.</p>","PeriodicalId":84981,"journal":{"name":"Journal of cancer epidemiology and prevention","volume":"7 4","pages":"195-204"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22471458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UK dietary exposure to BSE in beef mechanically recovered meat: by birth cohort and gender.","authors":"J D Cooper,&nbsp;S M Bird","doi":"10.1080/147666502321082728","DOIUrl":"https://doi.org/10.1080/147666502321082728","url":null,"abstract":"<p><strong>Background: </strong>Meat recovered mechanically from bovine vertebral columns for use in burgers, sausages and other meat products may have been contaminated with bovine spongiform encephalopathy (BSE) from recovered spinal cord and dorsal root ganglia (DRG). We quantified UK exposure to BSE in beef mechanically recovered meat (MRM) by birth cohort (born pre-1940, in 1940-1969, post-1969), gender and calendar period (1980-1989, 1990-1996) because information on any two of BSE exposure intensity, vCJD incubation period and the new cases of vCJD tells us about the third.</p><p><strong>Methods: </strong>Synthesis of evidence on BSE epidemiology, MRM production, infectivity in spinal cord and DRG, and UK dietary consumption.</p><p><strong>Findings: </strong>Production of beef MRM peaked at 5000 tonnes in 1987, was nil in 1989 but recovered to 2000 tonnes in 1995 when it ceased altogether; reportedly 90% was used in burgers. Mean weight of spinal cord recovered per carcass was 3.3 g (95% credible interval 0.24-12.02 g) before the specified bovine offal (SBO) legislation and 1.5 g (0.02-8.30 g) after the legislation; whereas recovered weight of DRG (as infectious as spinal cord) was 27 g. Recovery of spinal cord from 1-year pre-clinical bovines peaked in 1988 at 238 g and of DRG in 1993 at 4250 g (medians). Median infectivity (5th and 95th percentiles) consumed in beef MRM was 33 250 (30 550-35 950), 65 600 (60 250-71 050) and 14 350 (13 150-15 600) bovine oral (Bo) ID50 units for the post-1969, 1940-1969 and pre-1940 birth cohorts in 1980-1989; and 44 250 (41 300-47 350), 39 600 (37 100-42,400) and 8750 (8100-9350) Bo ID50 units in 1990-1996. Males consumed almost 58% of infectivity in both periods. If the worst-case level of infectivity pertained, exposure, instead of halving in 1990-1996, would be sustained at around its 1980-1989 level for the two older birth cohorts and would have doubled in 1990-1996 for the post-1969 birth cohort.</p><p><strong>Interpretation: </strong>SBO legislation in 1989 contributed only a 6% reduction in the infectivity in beef MRM. Salient sensitivity issues are highlighted.</p>","PeriodicalId":84981,"journal":{"name":"Journal of cancer epidemiology and prevention","volume":"7 2","pages":"59-70"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22173598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}