Asian Journal of Chemistry最新文献_第8页

Harnessing Agricultural Byproducts: Rice Husk-Derived Adsorbents for Heavy Metal Remediation in Water 利用农业副产品：稻壳衍生吸附剂对水中重金属的修复作用

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.30883

Ari Hardianto, Winni Sahara Ramadhani, Ivani Nurjannah, Lucy Adinisa, Anni Anggraeni, Solihudin, Husain Akbar Sumeru, Fajriana Shafira Nurrusyda, U. Pratomo, H. Bahti, Toto Subroto

引用次数: 0

Facile and Eco-Friendly Synthesis of Silver Nanoparticles using Semecarpus anacardium and their Antibacterial and Anticancer Activity 利用无患子简便、环保地合成银纳米粒子及其抗菌和抗癌活性

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.31030

Koteswara Rao Pagolu, G.V. Gaurav, Ch. Shivanarayana, D. A. Rao

{"title":"Facile and Eco-Friendly Synthesis of Silver Nanoparticles using Semecarpus anacardium and their Antibacterial and Anticancer Activity","authors":"Koteswara Rao Pagolu, G.V. Gaurav, Ch. Shivanarayana, D. A. Rao","doi":"10.14233/ajchem.2024.31030","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31030","url":null,"abstract":"Plant extracts are utilized to synthesize nanoparticles containing bioactive compounds that can effectively decrease metal toxicity. In present study, the aqueous extracts of Semecarpus anacardium leaves and stems were used to reduce silver nitrate and synthesize silver nanoparticles (AgNPs), which have potent antibacterial and anticancer effects. The physico-chemical methods such as XRD, UV-Vis, Fourier transform IR and SEM were used to characterize the biogenci silver nanoparticles. These methods validated the synthesis of AgNPs with smaller size and homogeneously sphere-shaped AgNPs (10-50 nm) after incubation with S. anacardium leaf and stem extract. Stem extract derived AgNPs showed the significant cancer fighting abilities in the human breast (MDA-MB-231) and prostate adenocarcinoma (PC-3) cells compared to that of derived AgNPs. Stem extract derived AgNPs exhibits the significant antibacterial activity against E. coli and B. subtilis with respect to the gentamycin. Additionally, the study demonstrated that green synthetic AgNPs may be investigated for use as a treatment against bacterial infections.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140420125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graft Copolymerization of Acrylonitrile onto Banana Cellulose Fiber 将丙烯腈接枝共聚到香蕉纤维素纤维上

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.31072

S. Kusumadevi, N. Nanjundaswamy, L. R. Shivakumara, T.N. Seshan, T. Demappa

{"title":"Graft Copolymerization of Acrylonitrile onto Banana Cellulose Fiber","authors":"S. Kusumadevi, N. Nanjundaswamy, L. R. Shivakumara, T.N. Seshan, T. Demappa","doi":"10.14233/ajchem.2024.31072","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31072","url":null,"abstract":"The graft co-polymerization of acrylonitrile monomer (AN) onto banana cellulose fiber (BCF) was carried out using ceric ammonium nitrate (CAN)/oxalic acid (OA) as redox pair in the aqueous nitric acid medium at 90 ºC. The effect of different reaction conditions on the grafting has been studied by determining the grafting parameters, i.e. concentration of acrylonitrile, ceric ammonium nitrate, oxalic acid, nitric acid, reaction time and temperature were carefully optimized to achieve the highest rate of grafting polymerization (RG), highest percent grafting yield (%GY) and grafting efficiency (%GE). All the reagents enhanced the RG%, GY% and %GE, with an increase of concentration up to a certain extent and then found to decline, except for the concentration of nitric acid. The grafting parameters were also increased with time/duration and temperature. The water retention value (WRV) of the grafted co-polymer was also measured. Activation parameters such as energy of activation (Ea), enthalpy change (ΔH), entropy change (ΔS) and free energy change (ΔG) can also be reported by using the Arrhenius plot. The evidence of grafting can also be predicted by the FTIR spectral analysis, moreover, the organic reaction mechanism has been proposed.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"24 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ERGO-based Bimetallic Nanocomposite as Novel Sensing Material for the Assay of 4-Nitrophenol in Water Samples 基于 ERGO 的双金属纳米复合材料是检测水样中 4-硝基苯酚的新型传感材料

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.31124

K. G. B. Kumari, T. Reddy, Akkaraboyina Lakshmi Lavanya, T. Satyadev

{"title":"ERGO-based Bimetallic Nanocomposite as Novel Sensing Material for the Assay of 4-Nitrophenol in Water Samples","authors":"K. G. B. Kumari, T. Reddy, Akkaraboyina Lakshmi Lavanya, T. Satyadev","doi":"10.14233/ajchem.2024.31124","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31124","url":null,"abstract":"A new approach for detecting and quantifying p-nitrophenol, a major environmental pollutant, is the focus of this work, which involves the electrochemical fabrication of a bimetallic alloy of ruthenium and nickel on an ergo-based pencil graphite electrode. The characterization of the fabricated composite involves techniques such as X-ray diffraction, scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). The composite was observed to form clusters with a size of 4.30 nm. The electrooxidation of p-nitrophenol on the Ru@Ni/ERGO/PGE electrode was investigated using chronoamperometric studies. The results indicate a satisfactory linear relationship between para-nitrophenol concentration within the range of 2.5 to 50 µM. Significantly, the proposed method demonstrates a low detection limit of 0.36 µM and a limit of quantification of 1.1 × 10-6 M. The nanocomposite electrode exhibits favourable outcomes in terms of selectivity, sensitivity and repeatability for an electrochemical sensor material. Stability testing conducted over five weeks further supports the reliability of the electrode. The capability of sensor is validated in real samples including soil and water. This study introduces a promising electrochemical sensor material in the composite electrode making it more effective in detecting p-nitrophenol.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"373 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Thiazole Schiff Base Analogs 噻唑席夫碱类似物的合成、表征、分子对接研究和生物学评价

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.31077

Muhammad Zoadur Rahman, Md. Din Islam, Md. Aminul Haque, Mohammad Mostafizur Rahman, Emdad Hossain, R. Sutradhar

引用次数: 0

In silico Toxicity Assessment and Quantification of Potential Genotoxic Impurity in Olmesartan Medoxomil Drug Substance using GC-MS/MS 利用 GC-MS/MS 对奥美沙坦酯药物中潜在的基因毒性杂质进行硅学毒性评估和定量

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.30736

R. P. Patha, Karunakar Dasa, R. Bhoomireddy, Srinivas R Thumu, Ravi Kiran Panchakarla, Manidhar Syam Kumar Buddha

{"title":"In silico Toxicity Assessment and Quantification of Potential Genotoxic Impurity in Olmesartan Medoxomil Drug Substance using GC-MS/MS","authors":"R. P. Patha, Karunakar Dasa, R. Bhoomireddy, Srinivas R Thumu, Ravi Kiran Panchakarla, Manidhar Syam Kumar Buddha","doi":"10.14233/ajchem.2024.30736","DOIUrl":"https://doi.org/10.14233/ajchem.2024.30736","url":null,"abstract":"This study was designed to assess the in silico toxicity of 4-chloromethyl-5-methyl-1,3-dioxol-2-one (4-CMMD) in olmesartan medoxomil (OLM) using sophisticated advanced analytical GC-MS/MS method. The developed GC-MS/MS method is more sensitive as well as selective, for trace level analysis of genotoxic impurity 4-chloromethyl-5-methyl-1,3-dioxol-2-one (4-CMMD) in olmesartan medoxomil (OLM). In silico genotoxicity of 4-CMMD have been confimed by ICH M7 guidelines and tested to be “POSITIVE” in both knowledge and statistical based approaches. The conditions of gas chromatographic separation and mass spectrometry were optimized on stationary phase DB-35MS, helium carrier gas as at a flow rate of 1.5 mL/min. Quantification was performed in multiple reaction monitoring (MRM) mode. The absence of interference at the retention time of 4-CMMD indicates that the newly developed approach is very specific and selective for accurately measuring trace levels of impurities. Additionally, this method provided linear results which were validated by linearity solutions, with concentrations ranging from 3.74 to 45.12 ppm and an observed coefficient of regression of 0.9981. Sensitivity results shows this method is more sensitive detection limit (DL) achieved at 1.23 ppm and quantification limit (QL) achieved at 3.74 ppm. The developed method is precise and accurate according to the precision results, which show RSD values < 10% and recovery > 90%, both of which are within acceptable standards. The solution stability of the samples was assessed at both room temperature and refrigerated settings, and it was found to be stable for a period of 48 h. As a result, this method has been employed for the intented purpose of quantifying 4-CMMD at the trace levels in testing laboratories, pharmaceutical analytical laboratories, and quality control laboratories.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"37 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140420569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Series of Indole and Azaindole Derivatives with Oxo-dihydropyridines: Synthesis, Characterization and Cytotoxicity Studies against Breast Malignant Cell Lines 吲哚和氮杂吲哚与氧化二氢吡啶的新系列衍生物：针对乳腺恶性细胞系的合成、表征和细胞毒性研究

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.30317

A. Madugula, K. Jagadeesh, D.B.N. Suresh Varma, K. G. Kadiyala, S. Pedada, Rama Swamy Guttula, U. Nagababu, Gururaja Rangaiah

引用次数: 0

Synthesis, Antimicrobial Activities and Molecular Docking Studies of New N-Acylated Derivatives of 5-(2-Phenyl-1,8-naphthyridin-3-yl)-1,3,4-oxadiazol-2-amine 5-(2-苯基-1,8-萘啶-3-基)-1,3,4-恶二唑-2-胺的新型 N-酰化衍生物的合成、抗菌活性和分子对接研究

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.30953

Kadeer Md, Ramesh Domala

{"title":"Synthesis, Antimicrobial Activities and Molecular Docking Studies of New N-Acylated Derivatives of 5-(2-Phenyl-1,8-naphthyridin-3-yl)-1,3,4-oxadiazol-2-amine","authors":"Kadeer Md, Ramesh Domala","doi":"10.14233/ajchem.2024.30953","DOIUrl":"https://doi.org/10.14233/ajchem.2024.30953","url":null,"abstract":"Present study establishes a novel synthetic route of N-acetylated derivatives of 5-(2-phenyl-1,8-naphthyridine-3-yl)-1,3,4-oxadiazole-2-amine (6a-j), which was achieved in four steps with good yields. 2-Amino nicotinaldehyde and ethyl 3-oxo-3-phenylpropanoate on refluxing with triethylamine in ethanol undergoes Friedlander synthesis to furnish ethyl 2-phenyl-1,8-naphthyridine-3-carboxylate, which further converted into 2-phenyl-1,8-naphthyridine-3-carbohydrazide by reacting with hydrazine hydrate upon reflux, followed by cyclization with cyanogen bromide in the presence of water and 1,4-dioxane with sodium bicarbonate to afford 5-(2-phenyl-1,8-naphthyridin-3-yl)-1,3,4-oxadiazol-2-amine (5). Compound 5 was acetylated using numerous symmetrical anhydrides to synthesize novel N-acetylated derivatives (6a-j). The IR, 1H, 13C NMR and mass spectral analysis were used to characterize the structure of synthetic compounds. The synthesized compounds were evaluated for their antimicrobial efficiency against bacteria (S. aureus and E. coli) using ampicillin as a standard reference and against fungi (C. albicans) using fluconazole as a standard reference. Compound 6e exhibited good antibacterial properties while compounds 6c and 6e had shown high antifungal activity, whereas remaining compounds shown moderate to weaker antimicrobial activity. The synthesized derivatives verified their docking strength against Mtb MurB (PDB ID: 5JZX) and showed significant docking activity, however, compound 6f (-10.98 kcal/mol) and compound 6b (-10.52 kcal/mol) had a strong binding affinity compared to the other synthesized compounds.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"74 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Thieno[2,3-d]pyrimidin-4-ol Tethered with 1,2,3-Triazole Derivatives and Their Antimicrobial Activity 噻吩并[2,3-d]嘧啶-4-醇与 1,2,3-三唑衍生物的合成和表征及其抗菌活性

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.31022

Amit D. Khakhariya, Nikhil P. Savaniya, K. Ladva

引用次数: 0

A Useful Method for in situ Indirect Radiolabeling of Carbonyl-Containing Biomolecules 对含羰基的生物大分子进行原位间接放射性标记的有效方法

Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.31197

Barakat M. Shabsoug, Ned D. Heindel

引用次数: 0