Asian Journal of Chemistry最新文献

筛选
英文 中文
Catalytic Reduction of Aromatic Nitro Compounds in Aqueous Media using Silver Nanoparticles Embedded-Preyssler Functionalized Cellulose Biocomposite as a Green and Recoverable Catalyst 使用银纳米粒子嵌入-Preyssler 功能化纤维素生物复合材料作为绿色可回收催化剂催化还原水介质中的芳香族硝基化合物
Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.30931
A. Nazari, Majid M. Heravi, Mansoureh Daraie
{"title":"Catalytic Reduction of Aromatic Nitro Compounds in Aqueous Media using Silver Nanoparticles Embedded-Preyssler Functionalized Cellulose Biocomposite as a Green and Recoverable Catalyst","authors":"A. Nazari, Majid M. Heravi, Mansoureh Daraie","doi":"10.14233/ajchem.2024.30931","DOIUrl":"https://doi.org/10.14233/ajchem.2024.30931","url":null,"abstract":"Reduction reactions of aromatic nitro compounds to amines with high conversion and chemoselectivity have been achieved using a combination of catalytic quantities of silver nanoparticles embedded Preyssler-cellulose biocomposite (PC/AgNPs) with NaBH4 under mild conditions and in an aqueous medium. The stabilization of silver nanoparticles on the surface of the Preyssler-functionalized cellulose biocomposite with more accessible active sites may be reliable for increased catalytic hydrogenation.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"259 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physico-chemical Properties and Biological Activity of Honey from Two Districts of Tien Giang Province, Vietnam 越南前江省两个地区蜂蜜的理化性质和生物活性
Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.31217
Huynh Cang Mai, Thuong Nhan Phu Nguyen, Ngoc Lan Thi Nguyen, Ngoc Diep Thi Duong, Bao Viet Nguyen, Dinh Huong Tran, Thanh Tra Thi Tran, Minh Hoang Le, Tai Huan Phan
{"title":"Physico-chemical Properties and Biological Activity of Honey from Two Districts of Tien Giang Province, Vietnam","authors":"Huynh Cang Mai, Thuong Nhan Phu Nguyen, Ngoc Lan Thi Nguyen, Ngoc Diep Thi Duong, Bao Viet Nguyen, Dinh Huong Tran, Thanh Tra Thi Tran, Minh Hoang Le, Tai Huan Phan","doi":"10.14233/ajchem.2024.31217","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31217","url":null,"abstract":"This study was conducted to determine the physico-chemical properties and biological activity of honey collected from the Tan Phu Dong and Cai Be districts of Tien Giang province, Vietnam. The results showed that the 19% and 20% moisture content honey from Tan Phu Dong district had viscosities of 1075 Cp and 1013.33 Cp, insoluble solid contents of 0.12% and 0.09%, acidities of 32.49 mg/1000 g and 30.49 mg/1000 g, diastase index of 4.5 Schade and 4.09 Schade, free reducing sugar content of 65% and 67%, HMF contents of 0.98 mg/100 g and 0.86 mg/100 g and antioxidant activity of 0.47 and 0.52 mg vitamin C equiv./mg dry wt, respectively. The honey from Cai Be district with 22% moisture content, viscosities, insoluble solid content, acidity, diastase index, free reducing sugar, HMF content and DPPH antioxidant activity displayed as 619 Cp, 0.119%, 46.41 mg/1000 g, 5 Schade, 60.28%, 0.38 mg/100 g and 0.45 mg vitamin C equiv./mg dry wt, respectively.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"31 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Docking Studies, Synthesis, SAR and Anti-TB Activity of Glycinamido Analogues 甘氨酰基类似物的对接研究、合成、SAR 和抗结核活性
Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.30798
B. N. Vaidehi, Hymavathi Veeravarapu, Murali Krishna Kumar Muthyala
{"title":"Docking Studies, Synthesis, SAR and Anti-TB Activity of Glycinamido Analogues","authors":"B. N. Vaidehi, Hymavathi Veeravarapu, Murali Krishna Kumar Muthyala","doi":"10.14233/ajchem.2024.30798","DOIUrl":"https://doi.org/10.14233/ajchem.2024.30798","url":null,"abstract":"Mycolic acid is a crucial component of the Mycobacterium tuberculosis cell wall and mycolic acid methyltransferases (MAMTs) are essential for mycolic acids to mature. In the present study, an inhouse library of 330 ligands was designed taking glycinamido moiety as scaffold. Virtual screening was carried out with this library of compounds against MmaA1 as the target protein. About 55 hits were identified through docking, ADMET studies and these molecules were synthesized by the Schotten-Baumann reaction followed by a nucleophilic substitution reaction. All the compounds were subjected to in vitro anti-Tb screening by microplate alamar blue assay (MABA). The Mdb1, Mdb4 & Meb1 exhibited excellent activity against M. tuberculosis H37Rv bacilli strain with an MIC of 1.56 µg/mL. The SAR studies shows that the aryl ring attached directly to the nitrogen atom as present in 2(-N-substituted glycinamido) derivatives is essential for the compound to exhibit potent anti-TB activity.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"94 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable Synthesis of Porous Biomass-Derived Carbon from Tecoma capensis for High Performance Supercapacitors: Characterization and Electrochemical Evaluation 用于高性能超级电容器的 Tecoma capensis 多孔生物质衍生碳的可持续合成:表征和电化学评估
Asian Journal of Chemistry Pub Date : 2024-02-28 DOI: 10.14233/ajchem.2024.31041
S. Tharani, A. Prithiba
{"title":"Sustainable Synthesis of Porous Biomass-Derived Carbon from Tecoma capensis for High Performance Supercapacitors: Characterization and Electrochemical Evaluation","authors":"S. Tharani, A. Prithiba","doi":"10.14233/ajchem.2024.31041","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31041","url":null,"abstract":"Biowaste carbon products possess interesting physico-chemical properties and are cost-effective due to their remarkable characteristics. Biomass carbon derived from Tecoma capensis (TCL) was processed using pyrolysis at a controlled temperature in an eco-friendly, innovative and sustainable way to develop biomass-derived carbon material. The aim of this study is to demonstrate the facile synthesis of porous carbon compounds from biowaste and evaluate their use in supercapacitors. Various analytical methods, such as structural analysis, morphological studies and electrochemical studies, have been employed to characterize the carbon material generated from biomass. Electrochemical performance evaluation was conducted through cyclic voltammetry and galvanostatic charge-discharge studies utilizing 1 M H2SO4 and 1 M KOH aqueous electrolyte, which exhibited a specific capacitance of 238 F g-1. The outcomes of the studies suggested that the eco-friendly, straightforward process can be utilized to prepare biomass carbon for the electrochemical energy storage applications in an efficient and sustainable manner.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"12 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photocatalytic Degradation of Toxic Textile Dyes by Biosynthesized Silver Nanoparticles Synthesized from Strobilanthes hamiltoniana Leaf Extract 用 Strobilanthes hamiltoniana 叶提取物合成的生物合成银纳米粒子光催化降解有毒纺织染料
Asian Journal of Chemistry Pub Date : 2024-01-31 DOI: 10.14233/ajchem.2024.31064
J. Gangwar, K. S. Joseph
{"title":"Photocatalytic Degradation of Toxic Textile Dyes by Biosynthesized Silver Nanoparticles Synthesized from Strobilanthes hamiltoniana Leaf Extract","authors":"J. Gangwar, K. S. Joseph","doi":"10.14233/ajchem.2024.31064","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31064","url":null,"abstract":"Biocompatible nanoparticle synthesis from Strobilanthes hamiltoniana leaf extracts is an ecologically friendly, cost-effective and long-lasting technique for wastewater treatment, particularly for textile dye degradation. S. hamiltoniana mediated silver nanoparticles (SH-Ag NPs) showed a maximum absorbance of 432 nm. Based on the FESEM analysis, the SH-Ag NPs were usually spherical with an average diameter of nm. The FTIR analyses revealed the significance of functional groups in the formation of SH-Ag NPs. Degradation and rate of degradation for textile dyes after 320 min, SH-Ag NPs displayed 88.4%, 79.49%, 0.0059 min-1 and 0.00495 min-1 for reactive blue 220 (RB-220) and reactive blue 222A (RB-222A) dyes. The phytotoxicity study of SH-Ag NPs treated dye solutions demonstrated a significant decrease in inhibitory efficiency when compared to dye effluents. The biosynthesized SH-Ag NPs could represent a viable catalyst alternative for treating textile dye degradation both before and after it enters aquatic environments.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140477454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Some Novel Chalcone Derivatives containing 5-Chloro Thiophene in a Base Structure: Synthesis, Characterization, in silico Study and Biological Evaluation 一些含有 5-氯噻吩基结构的新型查耳酮衍生物:合成、表征、硅学研究和生物学评估
Asian Journal of Chemistry Pub Date : 2024-01-31 DOI: 10.14233/ajchem.2024.31013
Viralkumar A. Doshi, Yogesh S. Patel
{"title":"Some Novel Chalcone Derivatives containing 5-Chloro Thiophene in a Base Structure: Synthesis, Characterization, in silico Study and Biological Evaluation","authors":"Viralkumar A. Doshi, Yogesh S. Patel","doi":"10.14233/ajchem.2024.31013","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31013","url":null,"abstract":"A novel series of chalcone derivatives (4a-o) of N-(4-acetylphenyl)-5-chlorothiophene-2-carboxamide was synthesized by coupling it with different substituted aromatic aldehydes. Synthesized chalcones were characterized by IR, NMR and mass spectra. They were screened in vitro antibacterial activity against four bacterial cultures and antifungal activity against three fungal cultures by using broth-dilution method. The significant antibacterial activity with ≤ 50 μg/mL has been displayed by compounds 4b and 4n against E. coli (MTCC 443), compounds 4b, 4e, 4i, 4n and 4o against P. aeruginosa (MTCC 1688), compounds 4c and 4n against S. aureus (MTCC 96). In silico investigation was also carried out to predict pharmacokinetic properties (ADME) of synthesized chalcone derivatives.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"621 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140472470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Characterization, DFT Studies, Biological Investigation and Molecular Modelling of Novel 1-(5-(1H-imidazol-1-yl)-3-methyl-1-phenyl-1H-pyrazol-4-yl)- 3-amino-2-cyano-N-phenyl-1H-benzo[f]chromene-5-carboxamide Derivatives 新型 1-(5-(1H-咪唑-1-基)-3-甲基-1-苯基-1H-吡唑-4-基)-3-氨基-2-氰基-N-苯基-1H-苯并[f]色烯-5-甲酰胺衍生物的合成、表征、DFT 研究、生物学研究和分子建模
Asian Journal of Chemistry Pub Date : 2024-01-31 DOI: 10.14233/ajchem.2024.30936
Rajat Patel, P. Sharma, Rohit R. Koshti, Akshay Vyas, C. Sangani
{"title":"Synthesis, Characterization, DFT Studies, Biological Investigation and Molecular Modelling of Novel 1-(5-(1H-imidazol-1-yl)-3-methyl-1-phenyl-1H-pyrazol-4-yl)- 3-amino-2-cyano-N-phenyl-1H-benzo[f]chromene-5-carboxamide Derivatives","authors":"Rajat Patel, P. Sharma, Rohit R. Koshti, Akshay Vyas, C. Sangani","doi":"10.14233/ajchem.2024.30936","DOIUrl":"https://doi.org/10.14233/ajchem.2024.30936","url":null,"abstract":"In this work, a new series of imidazole-pyrazole-benzo[f]chromene hybrids were designed and synthesized by a base-catalyzed cyclo-condensation through a one-pot multicomponent reaction. All compounds were tested for in vitro antimicrobial and anticancer activities. Enzyme inhibitory activities of all compounds were carried out against FabH and EGFR. The majority of synthesized  compounds displayed promising antimicrobial as well as anticancer activity against used strains and cancer cell lines respectively. The  compounds were also tested for in vitro anticancer activities against two cancer cell lines A549 and Hep G2. Compound 7f (IC50 = 0.62  µM) against EGFR and (IC50 = 1.31 µM) against A549 kinase displayed the most potent inhibitory activity as compared to another  member of the series. In the molecular modelling study, compound 7e was bound into the active pocket of EGFR with one pi-pi  interaction and one hydrogen bond having minimum binding energy ∆Gb = −7.6894 kcal/mol. Moreover, FabH molecule 7d was found  to be binding in the active pocket with a minimum binding energy of −8.9117 kcal/mol. ","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"184 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140478399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and Characterization of Activated Carbon from Lepironia articulata (Retz.) Domin Waste as an Adsorbent for Methylene Blue Dye Removal from Wastewater 从 Lepironia articulata (Retz.) Domin 废弃物中提取活性炭作为吸附剂用于去除废水中的亚甲基蓝染料的制备与表征
Asian Journal of Chemistry Pub Date : 2024-01-31 DOI: 10.14233/ajchem.2024.28325
Wilawan Dawmanee, Somporn Ruang-On, P. Nuengmatcha
{"title":"Preparation and Characterization of Activated Carbon from Lepironia articulata (Retz.) Domin Waste as an Adsorbent for Methylene Blue Dye Removal from Wastewater","authors":"Wilawan Dawmanee, Somporn Ruang-On, P. Nuengmatcha","doi":"10.14233/ajchem.2024.28325","DOIUrl":"https://doi.org/10.14233/ajchem.2024.28325","url":null,"abstract":"In this study, the optimum conditions for using activated carbon from Lepironia articulata (Retz.) Domin waste as an adsorbent were determined to remove dye pollutants from wastewater. The characteristics of the obtained activated carbon were assessed by performing energy dispersive X-ray (EDX), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopic (FTIR) techniques. The best optimum conditions for removing dye pollutants from wastewater were obtained at 30 mg/L methylene blue dye, 0.02 g of adsorbent and a contact time of 90 min. The maximum adsorption capacity of the activated carbon was 69.44 mg/g and the percentage removal achieved was more than 90%. The methylene blue dye adsorption data of the adsorbent were fitted to the Langmuir isotherm model. The prepared adsorbent was also applied for the removal of different colour dyes from real wastewater  samples and found that the percentage removal was 71.3%, 62.7%, 66.3%, 68.4% and 72.0% for dark blue dye, red dye, pink dye, sky  blue dye and yellow dye, respectively. These results indicated that the obtained activated carbon is highly effective and suitable  adsorbent for removing different types of colour dyes and toxic organic substances from the wastewater. ","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"398 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140472856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impurity Profiling and a Stability Indicating Advanced Liquid Chromatographic Method Development and Validation for the Estimation of Related Impurities of Anagrelide 用于估算阿那格雷相关杂质的杂质谱分析和稳定性指示高级液相色谱法的开发与验证
Asian Journal of Chemistry Pub Date : 2024-01-31 DOI: 10.14233/ajchem.2024.30785
Pavani Peddi, P. Prasada Rao, Ch. Pavan Kumar, N. Usha Rani, S. Tulasi
{"title":"Impurity Profiling and a Stability Indicating Advanced Liquid Chromatographic Method Development and Validation for the Estimation of Related Impurities of Anagrelide","authors":"Pavani Peddi, P. Prasada Rao, Ch. Pavan Kumar, N. Usha Rani, S. Tulasi","doi":"10.14233/ajchem.2024.30785","DOIUrl":"https://doi.org/10.14233/ajchem.2024.30785","url":null,"abstract":"A novel, streamlined and highly selective isocratic liquid chromatographic method has been developed for the quantification of impurities present in anagrelide. Exceptional resolution between anagrelide and its impurities was accomplished utilizing a Waters  Nova Pack C18 column (250 mm × 4.6 mm, 4 µm), employing a phosphate buffer with a pH of 4.4 as mobile phase A and a blend of  acetonitrile and methanol with buffer in a 30:40:30 v/v/v ratio as mobile phase B. The column oven was maintained at 35 ºC and the  mobile phase flowed at a constant rate of 1.0 mL/min, while detection was set at 254 nm. Rigorous validation was conducted to assess  accuracy, precision, specificity, linearity and sensitivity. Validation studies have unequivocally established the HPLC method’s precision,  specificity, rapidity, reliability and reproducibility. Linearity was ascertained for both anagrelide and its impurities, exceeding an R2 value of 0.95. The limits of detection (LOD) and limit of quantitation (LOQ) were determined to be more than sufficient for precise  estimation. This method was validated in accordance with the stringent ICH guidelines. The relative standard deviation (RSD) for intra- day and inter-day precision remained consistently below 5%. Percentage recovery demonstrated excellent agreement, affirming the  simplicity, specificity, precision and enhanced accuracy of method for determining related substances in pharmaceutical substances  and various anagrelide-containing dosage forms. ","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140478019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Antimicrobial Activity and Molecular Docking of Some Novel 2-Aryl-4H-[1,3]-thiazolo[4,5-b]indoles 一些新型 2-芳基-4H-[1,3]-噻唑并[4,5-b]吲哚的合成、抗菌活性和分子对接
Asian Journal of Chemistry Pub Date : 2024-01-31 DOI: 10.14233/ajchem.2024.30986
Bhargavi Posinasetty, R. K. Kumarachari, Prashanti Chitrapu, Jyothirmayee Devineni, S. Dharmalingam, Chilamakuru Naresh Babu, Jayendra Kumar
{"title":"Synthesis, Antimicrobial Activity and Molecular Docking of Some Novel 2-Aryl-4H-[1,3]-thiazolo[4,5-b]indoles","authors":"Bhargavi Posinasetty, R. K. Kumarachari, Prashanti Chitrapu, Jyothirmayee Devineni, S. Dharmalingam, Chilamakuru Naresh Babu, Jayendra Kumar","doi":"10.14233/ajchem.2024.30986","DOIUrl":"https://doi.org/10.14233/ajchem.2024.30986","url":null,"abstract":"In present study, six novel 2-aryl-4H-[1,3]-thiazolo[4,5-b]indoles (4a-f) were synthesized by integrating thiazole and indole motifs through a three-component one-pot condensation involving isatin, ammonium thiocyanate and arylaldehydes. Structural confirmation  was achieved using IR, 1H NMR and mass spectrometric techniques. Molecular targets, bioactivity scores, drug-likeness, anti- tuberculosis and antibacterial properties and toxicity were all predicted using various computational techniques. To calculate binding  affinities to Mycobacterium tuberculosis enoyl-ACP reductase and Escherichia coli Topoisomerase IV, in vitro bioactivity studies were  performed and Schrödinger docking simulations were performed. Anti-tubercular efficacy was evaluated using the MABA method,  while antibacterial effectiveness against both Gram-positive and Gram-negative bacteria was assessed through the agar plate method.  The results highlight the potential of these heterocyclic molecular hybrids, positioning them as promising candidates for further lead  optimization in the development of more potent and safer pharmaceutical agents. ","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"429 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140478338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信