International journal of gastrointestinal cancer最新文献

{"title":"Acinar cell carcinoma of the pancreas.","authors":"Rachel Pimenta Riechelmann,&nbsp;Paulo Marcelo Hoff,&nbsp;Renato Alonso Moron,&nbsp;Luiz Heraldo da Câmera Lopes,&nbsp;Antonio Carlos Buzaid","doi":"10.1385/IJGC:34:2-3:067","DOIUrl":"https://doi.org/10.1385/IJGC:34:2-3:067","url":null,"abstract":"<p><p>Acinar cell carcinoma of the pancreas is a rare tumor for which the best chemotherapy regimen has not been clearly established. Here, we report on a female patient with an unusually long survival and a remarkable response to weekly paclitaxel. To our knowledge, this is the first time that paclitaxel has been associated with an objective response in this disease. The patient recurred after initial resection and failed multiple prior chemotherapeutic regimens. She received weekly paclitaxel at 80 mg/m2 and responded after eight doses, maintaining controlled disease for a total of 4 mo. We present her case in detail and review the available literature regarding this rare type of tumor.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"34 2-3","pages":"67-72"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:34:2-3:067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24678272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoma of the cystic duct remnant with direct colonic invasion.","authors":"Takehiro Noji,&nbsp;Satoshi Kondo,&nbsp;Satoshi Hirano,&nbsp;Yoshiyasu Ambo,&nbsp;Eichi Tanaka,&nbsp;Shyunichi Okushiba,&nbsp;Hiroyuki Katoh","doi":"10.1385/IJGC:34:2-3:117","DOIUrl":"https://doi.org/10.1385/IJGC:34:2-3:117","url":null,"abstract":"<p><p>Carcinoma of the cystic duct remnant is extremely rare, and only five cases have been reported previously in the English literature. We present another case of carcinoma of the cystic duct remnant and review the literature. A 62-yr-old woman was diagnosed as having hilar cholangiocarcinoma and transverse colon cancer. However, at laparotomy, the center of the tumor mass was in the cystic duct remnant with contiguous colonic invasion. The pathology of the surgical specimen confirmed carcinoma of the cystic duct remnant. The diagnosis of carcinoma of the cystic duct remnant was made using Ozden's new criteria.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"34 2-3","pages":"117-20"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:34:2-3:117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24676533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoma of the esophagus with mixed basaloid squamous and glandular differentiation: a distinct histological presentation.","authors":"Vishal Bhagat,&nbsp;Milind Javle,&nbsp;Joseph Geradts","doi":"10.1385/IJGC:34:2-3:139","DOIUrl":"https://doi.org/10.1385/IJGC:34:2-3:139","url":null,"abstract":"<p><p>Esophageal cancer is the third most common gastrointestinal cancer and ranks among the ten commonest cancers worldwide. Histologically, approx 60% of esophageal cancers are adenocarcinomas and 40% are squamous cell carcinomas (SCC). Other rare cancers of the esophagus include small-cell carcinomas, squamous cell carcinomas with sarcomatous features, adenoid cystic carcinomas, and mucoepidermoid carcinomas. Basaloid squamous cell carcinoma (BSCC) or basaloid squamous carcinoma (BSC) is a distinct clinicopathological entity, seen more frequently in elderly males. Stage at presentation is often advanced and regional adenopathy or distant metastases are not uncommon at presentation. We describe an unusual case report of esophageal BSCC with glandular differentiation. The clinical significance of glandular differentiation in this rare type of tumor is not known.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"34 2-3","pages":"139-42"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:34:2-3:139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24676537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local recurrence of rectal cancer after total mesorectal excision without preoperative radiotherapy.","authors":"Christiaan P van Lingen,&nbsp;Clark J Zeebregts,&nbsp;Jos J G M Gerritsen,&nbsp;H Jan Mulder,&nbsp;Walter J B Mastboom,&nbsp;Joost M Klaase","doi":"10.1385/IJGC:34:2-3:129","DOIUrl":"https://doi.org/10.1385/IJGC:34:2-3:129","url":null,"abstract":"<p><strong>Background: </strong>At this moment, it is still debatable whether all patients with mobile rectal cancer who undergo surgical removal of the tumor should be treated with preoperative radiotherapy, since it is likely that only certain patients will benefit from this strategy. In this study, patients with mobile rectal cancer were immediately operated upon and only those with positive nodes or with incomplete resection received adjuvant radiotherapy.</p><p><strong>Aims of the study: </strong>To investigate the local recurrence rate after the use of a selective policy of adjuvant radiotherapy and to determine risk factors for local recurrence.</p><p><strong>Methods: </strong>In a 5-yr-period, 178 patients with rectal cancer were referred to our institute. A total of 131 patients with mobile rectal cancer were treated with curative intent, which implied a microscopically radical resection and no signs of distant metastasis at operation. A retrospective analysis was undertaken to investigate the incidence of local recurrence in this curative group and to determine risk factors for local recurrence.</p><p><strong>Results: </strong>The postoperative mortality in the curative group was 5.3%. Local recurrences were observed in 6 patients (4.6%) after a median period of 25 mo (range 11-37); two of them also had distant metastases detected at the same time. The highest local recurrence rates were seen in men (5.3%), in distal rectal cancers (6.9%), and in the node-positive group (8.7%).</p><p><strong>Conclusion: </strong>A low local recurrence rate can be achieved after total mesorectal excision (TME) without preoperative radiotherapy. Our results suggest using preoperative radiotherapy only for those patients who are at a higher risk for local recurrence. Staging techniques for selection of these patients are at this moments till inappropriate.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"34 2-3","pages":"129-34"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:34:2-3:129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24676535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MAGE1 is expressed by a subset of pancreatic endocrine neoplasms and associated lymph node and liver metastases.","authors":"Donna E Hansel,&nbsp;Michael G House,&nbsp;Raheela Ashfaq,&nbsp;Ayman Rahman,&nbsp;Charles J Yeo,&nbsp;Anirban Maitra","doi":"10.1385/IJGC:33:2-3:141","DOIUrl":"https://doi.org/10.1385/IJGC:33:2-3:141","url":null,"abstract":"<p><strong>Background: </strong>MAGE1 was originally isolated from human melanoma cells as a target antigen for autologous cytotoxic T lymphocytes. Expression of MAGE1 has subsequently been identified in a number of neoplastic cell types, including testicular germ cell and breast cancer cells, which has led to the development of antitumor MAGE1 vaccines.</p><p><strong>Aim of the study: </strong>To determine if Mage-1 is expressed in pancreatic endocrine neoplasms (PENs) and PEN metastases.</p><p><strong>Methods: </strong>We utilized immunolabeling analysis for Mage-1 on 49 primary PENs, 11 liver metastases, and 6 lymph node metastases. A semiquantitative labeling index (LI) of 0 (no expression), 1, 2 (moderate expression), and 3 (intense expression, correlating with internal control markers) was used to determine relative amounts of MAGE1 expression in these lesions.</p><p><strong>Results: </strong>We have identified MAGE1 expression in a subset (42 of 49; 86%) of PENs. Normal pancreatic ducts, present in tissue adjacent to PENs, were utilized as a positive control for Mage-1 immunolabeling (index score 3); no other detectable labeling for Mage-1 was evident in normal pancreatic tissue. Primary PENs, with or without metastases (mean LI score 1.2 vs 1.0, respectively), did not demonstrate a significant difference in Mage-1 LI, although intratumoral heterogeneity was apparent in some, but not all, of these lesions. Lymph node metastases (mean score 2.0) demonstrated a significant increase in Mage-1 LI as compared to primary, non-metastatic lesions (p = 0.04984) and primary metastatic lesions (p = 0.02351). In contrast, six patients with a survival of less than one year demonstrated a low Mage-1 LI (mean score, 0.58).</p><p><strong>Conclusions: </strong>MAGE1 expression is present in a subset of primary PENs and in lymph node metastases, and may therefore serve as a useful marker and potential therapeutic target in PENs. Furthermore, the absence of Mage-1 expression in a subset of primary PENs may indicate a worsened prognosis.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"33 2-3","pages":"141-7"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:33:2-3:141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24159347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical evaluation of tissue-specific proteolytic enzymes in adenomas containing foci of early carcinoma: correlations with cathepsin D expression and other malignant features.","authors":"Toshiaki Kunimura,&nbsp;Tomoko Inagaki,&nbsp;Masahiro Wada,&nbsp;Jun Ushio,&nbsp;Kasumi Sato,&nbsp;Tetsuji Enosawa,&nbsp;Masanao Nakashima,&nbsp;Hirotaka Kato,&nbsp;Ryouji Hayashi,&nbsp;Kouji Saitou,&nbsp;Toshio Morohoshi","doi":"10.1385/IJGC:33:2-3:149","DOIUrl":"https://doi.org/10.1385/IJGC:33:2-3:149","url":null,"abstract":"<p><strong>Background: </strong>Cathepsin D (CD) is an aspartyl lysosomal protease, and the prognostic value of CD expression has been studied in a variety of tumors, however, its role in early adenocarcinomas remains unclear.</p><p><strong>Aim of the study: </strong>We evaluated the expression of CD in a series of colorectal adenomas with severe dysplasia containing foci of early carcinoma and compared the results to several histopathological and immunohistochemical features.</p><p><strong>Methods: </strong>Adenomas were obtained by endoscopic polypectomy from 33 patients. Twenty-four of the 33 adenomas contained well-differentiated adenocarcinomas and nine adenomas contained moderately differentiated adenocarcinomas.</p><p><strong>Results: </strong>Positive CD expressions were observed in 25% of well-differentiated adenocarcinomas and in 66.7% of moderately differentiated adenocarcinomas (p < 0.05). Of the 12 adenocarcinomas with positive CD expression, four had positive CD expression in their adenomas (p < 0.01), 6 showed positive Ki-67 expression in their adenomas (NS), and 10 had positive p53 expression in their adenomas (p < 0.05). No significant association was seen between the level of CD expression and adenoma size.</p><p><strong>Conclusions: </strong>The expression of CD in adenocarcinoma correlated significantly with differentiation, and with the levels of CD and p53 expression in the adenomas of the polyp.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"33 2-3","pages":"149-54"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:33:2-3:149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24159348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival after radical resection of advanced pancreatic cancer: a case report with special reference to CD8+ T-cell infiltration.","authors":"Motoki Abe,&nbsp;Satoshi Kondo,&nbsp;Satoshi Hirano,&nbsp;Yoshiyasu Ambo,&nbsp;Eiichi Tanaka,&nbsp;Toshiaki Morikawa,&nbsp;Shunichi Okushiba,&nbsp;Hiroyuki Katoh","doi":"10.1385/IJGC:33:2-3:107","DOIUrl":"https://doi.org/10.1385/IJGC:33:2-3:107","url":null,"abstract":"<p><p>A 65-yr-old man who underwent pancreaticoduodenectomy with portal vein resection for pancreatic cancer is alive 8 yr after surgery. Originally, computed tomography (CT) revealed an 8-cm tumor in the pancreatic head. The tumor had infiltrated the portal vein, but grew expansively, so there was neither biliary obstruction nor jaundice. Pancreaticoduodenectomy with resection of the portal vein was performed for pancreatic cancer. Many tumor-infiltrating lymphocytes were seen within cancer cell nests on routine histopathology. We performed immunostaining for CD8, and found that a large number of the lymphocytes were CD8+ T cells. The patient's prognosis was considered poor because the tumor was large and had infiltrated the portal vein. We suspect that long-term survival may be related to the response of CD8+ T cells to the cancer.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"33 2-3","pages":"107-10"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:33:2-3:107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24160428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity.","authors":"George N Tzanakakis,&nbsp;Andrew N Margioris,&nbsp;Aristidis M Tsatsakis,&nbsp;Michael P Vezeridis","doi":"10.1385/IJGC:34:1:27","DOIUrl":"https://doi.org/10.1385/IJGC:34:1:27","url":null,"abstract":"<p><strong>Background: </strong>Cathepsin B, a lysosomal cysteine protease, has a major role in the mechanisms of tumor metastasis. The aim of the present work was to examine the correlation between cathepsin B activity and the metastatic potential of human pancreatic cancer.</p><p><strong>Methods: </strong>The primary cell line COLO 357 and the derivative tumor cell lines FG, L3.1, L3.2, L3.3, L3.4, and L3.5, which are characterized by progressively increasing metastatic potential, were injected intrasplenically in the athymic mice. Cathepsin B activity, metastasis, and ultrastructural characteristics were assessed.</p><p><strong>Results: </strong>An increased number of liver tumor nodules was observed with each subsequent intrasplenic inoculation (p = 0.001), associated with lymph node, splenic, and pancreatic involvement. Cathepsin B activity progressively increased (p = 0.001) and was strongly positively correlated with the metastatic potential. However, no correlation was found between the metastatic potential and ultrastructural characteristics.</p><p><strong>Conclusions: </strong>These findings further support the central role of cathepsin B in metastasis in a combined in vitro/in vivo model.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"34 1","pages":"27-38"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:34:1:27","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24598809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased cumulative incidence of prostate malignancies in colorectal cancer patients.","authors":"Nuri Ozden,&nbsp;Murat Saruc,&nbsp;Lynette M Smith,&nbsp;Arthi Sanjeevi,&nbsp;Hemant K Roy","doi":"10.1385/IJGC:34:1:49","DOIUrl":"https://doi.org/10.1385/IJGC:34:1:49","url":null,"abstract":"<p><strong>Background: </strong>Identifying subjects at an increased risk of colorectal cancer (CRC) is of considerable importance in designing effective screening strategies. Malignancies that cosegregate with CRC provide important markers for higher-risk patients. CRC and prostate cancer share many similarities with regard to etiological factors. However, the previous reports on associations between these common malignancies are contradictory and confounded by a lack of rigorous controls.</p><p><strong>Aim of the study: </strong>The aim of this study was to further elucidate the relationship between CRC and prostate cancer.</p><p><strong>Methods: </strong>We performed a retrospective case-control study of subjects receiving medical care at the Omaha Veteran's Administration Medical Center between 1992 and 2002. Cases (patients with CRC) were obtained through the pathology records, whereas controls (patients with a negative colonoscopy during the same time period) were found through assessment of the endoscopy database. All subjects had the pathology database queried for other malignancies. The medical record also was assessed for confounding factors such as prostate cancer screening, radiation therapy status, and so on.</p><p><strong>Results: </strong>We identified 149 male patients with CRC cases and 186 controls (age-matched male patients with a negative colonoscopy). The 10-yr cumulative incidence of prostate cancer was 10.7% of the cases but only 3.8% of the controls (p = 0.016). There were no significant differences between cases and controls among 11 other primary malignancies evaluated. The association between CRC and prostate cancer was unrelated to characteristics such as location in the colon and differentiation. Furthermore, confounding factors including frequency of prostate cancer screening and radiation therapy status did not explain the cosegregation between CRC and prostate.</p><p><strong>Conclusion: </strong>This preliminary report suggests that there is an association between CRC and prostate cancer. If replicated in other populations, this may have important implications for cancer screening strategies.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"34 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:34:1:49","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24598811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appendicular metastasis from pancreatic adenocarcinoma.","authors":"Levent Filik,&nbsp;Sedef Ozdal-Kuran,&nbsp;Bahattin Cicek,&nbsp;Neslihan Zengin,&nbsp;Ozgur Ozyilkan,&nbsp;Burhan Sahin","doi":"10.1385/IJGC:34:1:55","DOIUrl":"https://doi.org/10.1385/IJGC:34:1:55","url":null,"abstract":"<p><p>We present a 78-yr-old man with appendicular metastases from pancreatic adenocarcinoma. Barium enema X-ray showed incomplete filling of a distended appendix in a patient with abdominal discomfort. Colonoscopic evaluation revealed firm nodules in appendicular orifice. Histopathological examination of the nodule in the appendix revealed a metastatic adenocarcinoma. Abdominal computed tomography showed a low-density mass in the body of the pancreas. Endoscopic ultrasonography disclosed a hypoechoic mass in the body of the pancreas. Appendicular metastasis is extremely rare. To our knowledge, this is the second case of adenocarcinoma of the pancreas metastatic to the appendix in English language literature. A brief review of relevant literature is presented.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"34 1","pages":"55-8"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:34:1:55","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24598812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}