International journal of gastrointestinal cancer最新文献

{"title":"The European organization for research and treatment of cancer quality of life questionnaire: implications for prognosis in pancreatic cancer.","authors":"Digant Gupta,&nbsp;Christopher G Lis,&nbsp;James F Grutsch","doi":"10.1007/s12029-007-0001-9","DOIUrl":"https://doi.org/10.1007/s12029-007-0001-9","url":null,"abstract":"<p><strong>Background: </strong>The goal of this study was to evaluate the association between patient quality of life (QoL) and survival in pancreatic cancer patients undergoing care in a community hospital comprehensive cancer center.</p><p><strong>Patients and methods: </strong>A consecutive case series of 55 histologically confirmed pancreatic cancer treated at Cancer Treatment Centers of America® at Midwestern Regional Medical Center was studied between 04/01 and 11/04. The EORTC QLQ-C30 was utilized to assess patient QoL. Kaplan-Meier method was used to calculate survival. Log-rank test was used to study the equality of survival distributions. Multivariate Cox regression analyses were then performed to evaluate the joint prognostic significance of those QoL and clinical factors that were shown to be prognostic upon univariate analyses.</p><p><strong>Results: </strong>Of the 55 patients, 28 were newly diagnosed and 27 had prior treatment history. The median age was 55 years (range 33-74 years). Majority (34) had stage IV disease at diagnosis. The QLQ-C30 parameters to show statistically significant associations with survival were physical, role, and emotional functioning scales and fatigue, appetite loss, constipation, and diarrhea symptom scales.</p><p><strong>Conclusions: </strong>We found that patient QoL, as measured by the QLQ-C30 physical functioning scale, provides useful prognostic information, independent of multiple cancer symptoms, in patients with pancreatic cancer. While these findings require further investigation in large patient cohorts, they may have important implications for patient stratification in clinical trials, as well as aid in clinical decision making.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"37 2-3","pages":"65-73"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12029-007-0001-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27009119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated splenic metastasis from colorectal mucinous carcinoma.","authors":"Singh Avninder,&nbsp;Amar Bhatnagar,&nbsp;Usha Agrawal,&nbsp;Sunita Saxena","doi":"10.1007/s12029-007-0007-3","DOIUrl":"https://doi.org/10.1007/s12029-007-0007-3","url":null,"abstract":"<p><p>Metastatic tumors of the spleen are rare and occur in the presence of disseminated visceral metastasis. Isolated splenic metastases from colorectal carcinoma are rare and only 19 cases have been reported in English literature. We report a case of isolated splenic metastasis in a 52-year-old man, occurring 9 years after the primary colorectal mucinous carcinoma was treated by anterior resection. The patient underwent splenectomy along with adjuvant chemotherapy and is alive and asymptomatic at 22 months follow-up.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"37 2-3","pages":"98-101"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12029-007-0007-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27009125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway.","authors":"Dora M Lam-Himlin,&nbsp;Jason A Daniels,&nbsp;Mariana F Gayyed,&nbsp;Jixin Dong,&nbsp;Anirban Maitra,&nbsp;Duojia Pan,&nbsp;Elizabeth A Montgomery,&nbsp;Robert A Anders","doi":"10.1007/s12029-007-0010-8","DOIUrl":"https://doi.org/10.1007/s12029-007-0010-8","url":null,"abstract":"<p><strong>Background: </strong>The Hippo (Hpo) pathway is highly conserved in humans and was originally uncovered in Drosophila as a potent regulator of inhibiting cell growth and promoting apoptosis. The Hippo pathway consists of a tumor suppressor kinase cascade that negatively regulates growth and results in inactivation of a transcriptional co-activator, Yorkie (yki). The human ortholog of Yki, the yes-associated protein (YAP), has a 31% sequence identity and similar biologic activity. The potential role of YAP in tumorigenesis was also reported in a murine genetic screen which identified a genomic amplification of YAP in hepatocellular carcinoma.</p><p><strong>Aim: </strong>Given this pathway's critical control of cell growth, survival, proliferation, and amplification in malignancy, we wanted to explore the possible role of the Hippo pathway in human esophageal and gastric tumorigenesis.</p><p><strong>Method: </strong>The expression of YAP was evaluated with immunolabeling of esophageal and gastric tissue microarrays from 169 patients, with nondysplastic, dysplastic, and malignant foci represented. Cytoplasmic and nuclear staining were scored as 0 = none, 1 < 10%, 2 = 10-50%, and 3 > 50% for the nonneoplastic, dysplastic, and malignant epithelium. Multiple scores were averaged for each patient. Expression of YAP could be seen in the proliferating compartments of nonneoplastic tissue.</p><p><strong>Results: </strong>Compared to nonneoplastic epithelium, there was a significant increase in YAP cytoplasmic and nuclear localization in high-grade dysplastic epithelium and adenocarcinoma of the esophagus. There was also a significant increase in YAP cytoplasmic and nuclear staining of gastric carcinoma and metastatic gastric disease compared to nonneoplastic gastric tissue.</p><p><strong>Conclusions: </strong>YAP expression in the cytoplasm and nucleus is significantly increased in high-grade dysplasia and adenocarcinoma of the esophagus as well as gastric adenocarcinoma and metastatic gastric disease, suggesting a role for this recently uncovered pathway in esophageal and gastric epithelial tumorigenesis.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"37 4","pages":"103-9"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12029-007-0010-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27206370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rodent endosonography to monitor esophageal cancer.","authors":"Navtej S Buttar,&nbsp;Maurits J Wiersema,&nbsp;Kenneth K Wang,&nbsp;Cathrine J DeMars,&nbsp;Ganapathy A Prasad,&nbsp;Lori S Lutzke","doi":"10.1007/s12029-007-0006-4","DOIUrl":"https://doi.org/10.1007/s12029-007-0006-4","url":null,"abstract":"<p><p>Animal models of luminal cancers are important to understand and assess chemopreventive and chemotherapeutic interventions. However, the ability to assess tumor growth and response without animal sacrifice is limited. We assessed the ability of luminal sonography to assess the presence of tumor and its size in a surgical esophagojejunostomy model of esophageal cancer. Luminal sonography had a sensitivity of 88%, specificity of 100%, and accuracy of 93% in identifying the esophageal cancers. The tumor dimensions on luminal sonography were within 11% of autopsy measurements. Minimal tumor dimension was 2 mm and maximum 6.2 mm. The procedure was feasible without technical difficulty. In conclusion, rodent endosonography is a useful technique that can accurately determine the presence of tumors as well as their dimensions.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"37 2-3","pages":"84-90"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12029-007-0006-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27009122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resection of small bowel adenocarcinoma liver metastasis combined with neoadjuvant and adjuvant chemotherapy results in extended disease-free period--a case report.","authors":"Tatjana Eigenbrod,&nbsp;Frank Kullmann,&nbsp;Frank Klebl","doi":"10.1007/s12029-007-0005-5","DOIUrl":"https://doi.org/10.1007/s12029-007-0005-5","url":null,"abstract":"<p><p>Small bowel adenocarcinoma (SBA) is a very rare tumor entity but occurs in up to 5% of patients suffering from familiar adenomatous polyposis (FAP). Because of nonspecific symptoms, diagnosis is usually made with delay, which contributes to high rates of metastatic disease at the time of diagnosis. The overall prognosis of SBA is poor with 5-year survival rates of 15-35%. For localized disease, complete surgical resection is the treatment of choice, whereas systemic chemotherapy is deemed indicated in tumors with metastatic spread. The optimal regimen has not been defined as yet. In October 2001, a 51-year-old woman with attenuated FAP, that had total proctocolectomy in 1994 was diagnosed with a jejunal adenocarcinoma. She subsequently underwent small bowel resection. Because a computed tomography (CT) scan in April 2002 revealed multiple liver metastases, chemotherapy with nine cycles FOLFOX6 was initiated. Afterwards, a small residual lesion in segment VIII was seen in CT scan but could not be identified by PET and at laparotomy in November 2002. In December 2003, again, a lesion was detected in S VIII. This solitary residual liver metastasis was resected in January 2004. Postoperatively, the patient received adjuvant chemotherapy with three cycles (with six applications in each cycle) 5-fluorouracil/folinic acid/irinotecan according to the AIO protocol. To date, more than 3 years after liver resection, the patient is still in complete remission and undergoes regular restaging investigations. Resection of liver metastases from SBA combined with neoadjuvant and adjuvant chemotherapy can result in extended disease-free survival and should undergo further investigation.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"37 2-3","pages":"94-7"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12029-007-0005-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27009124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the CXCR4 signaling in pancreatic cancer cells.","authors":"Daniel D Billadeau,&nbsp;Subrha Chatterjee,&nbsp;Patricia Bramati,&nbsp;Raghavakaimal Sreekumar,&nbsp;Vijay Shah,&nbsp;Karen Hedin,&nbsp;Raul Urrutia","doi":"10.1007/s12029-007-0011-7","DOIUrl":"https://doi.org/10.1007/s12029-007-0011-7","url":null,"abstract":"<p><p>CXCL12 and its receptor, CXCR4, are emerging as promising targets for modulating growth, angiogenesis, and metastasis in several human cancers. Indeed, blocking the receptor is sufficient to prevent metastasis and angiogenesis in experimental breast cancer xenografts. Recently, the biological effect of the CXCR4 in pancreatic cancer, one of the most deadly neoplastic diseases, has been reported. However, the molecular mechanism by which CXCR4 contributes to these properties is not completely understood. In this paper, we characterize the signaling pathways activated by CXCR4 in pancreatic cancer. We show that after CXCR4 activation, EGFR becomes tyrosine phosphorylated, and the kinase activity of this receptor, together with the activation of MMPs, Src, and PI3-Kinase, is required for CXCR4-mediated ERK activation. Analysis of this cascade in pancreatic cancer cells revealed that the ERK-mediated pathway regulates genes involved in angiogenesis, such as VEGF, CD44, HIF1alpha, and IL-8. Furthermore, ERK blockage inhibits the migration and tube formation of endothelial cells induced by CXCL12. Considering that inhibitors for several components of this pathway, including CXCR4 itself, are at different stages of clinical trials, this study provides theoretical justification for the clinical testing of these drugs in pancreatic cancer, thus extending the list of potential targets for treating this dismal disease.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"37 4","pages":"110-9"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12029-007-0011-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27206307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary adrenal metastasis in a patient with sigmoid colon cancer; report of a case.","authors":"Y Shoji,&nbsp;M Dohke,&nbsp;T Masuda,&nbsp;F Nakamura,&nbsp;T Yano,&nbsp;H Niizeki,&nbsp;N Kashimura,&nbsp;O Matsunami","doi":"10.1007/s12029-007-9001-z","DOIUrl":"https://doi.org/10.1007/s12029-007-9001-z","url":null,"abstract":"<p><p>A 73-year-old man had sigmoidectomy for sigmoid colon cancer in December 2001. Although he was followed regularly with chemotherapy, his serum carcinoembryonic antigen (CEA) increased on August 2002. Abdominal computed tomography and magnetic resonance imaging showed a right adrenal mass and no other abnormality. The preoperative diagnosis was a solitary adrenal metastasis from sigmoid colon cancer; the lesion was removed in September 2002. On pathology, adrenal metastasis was confirmed. Although the patient's serum CEA normalized soon thereafter, 12 months after adrenalectomy, the CEA again increased; the patient had local recurrence of the resected adrenal lesion and liver metastasis. Therefore, the patient was given systemic chemotherapy, but his condition deteriorated, and he died 38 months after adrenalectomy. Adrenal metastasis from colorectal cancer is not unusual; however, a solitary metastasis is rarely found and resected surgically. As surgical treatment of the metastatic lesion could improve patients' prognosis to some extent if it is detected early, the possibility of adrenal metastasis should be kept in mind when colorectal cancer patients are followed.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"37 4","pages":"120-3"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12029-007-9001-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27206308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacrococcycygeal teratoma in adult: report of a case.","authors":"Mario Jucá,&nbsp;Felipe Farias de Oliveira,&nbsp;Edmundo Guilherme Gomes,&nbsp;Edmond Le Campion","doi":"10.1007/s12029-007-0004-6","DOIUrl":"https://doi.org/10.1007/s12029-007-0004-6","url":null,"abstract":"<p><strong>Background: </strong>Sacrococcygeal teratomas are neoplasias, which are most frequently found in infants, with the sacrococcígea area being the most frequently found extragonadal location.</p><p><strong>Aim of the study: </strong>To describe a sacrococcygeal teratoma in a 51-year-old adult patient and discuss the diagnosis and management.</p><p><strong>Methods: </strong>The case of a 51-year-old woman who had a sacrococcygeal teratoma. Computed tomography showed a mass containing calcification. Early signs were when she experienced acute lower back pain upon leaning over or sitting.</p><p><strong>Results: </strong>The tumor appeared first as a sacral swelling. The patient also claimed disturbances in her bowel functioning. Computed tomography (CT) showed the tumor and its relationship inside the pelvic cavity. Surgical ablation was performed on the entire tumor and the coccyx was preserved.</p><p><strong>Conclusion: </strong>The surgical block was sent to pathological exam, which showed it to be a mature sacrococcygeal teratoma. A good clinical evolution took place after resection.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"37 2-3","pages":"91-3"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12029-007-0004-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27009123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid growth of mucinous cystic adenoma of the pancreas following pregnancy.","authors":"Hiroyuki Kitagawa,&nbsp;Takehiro Okabayashi,&nbsp;Isao Nishimori,&nbsp;Michiya Kobayashi,&nbsp;Takeki Sugimoto,&nbsp;Toyokazu Akimori,&nbsp;Takuhiro Kohsaki,&nbsp;Eiki Miyaji,&nbsp;Saburo Onishi,&nbsp;Keijiro Araki","doi":"10.1385/IJGC:37:1:45","DOIUrl":"https://doi.org/10.1385/IJGC:37:1:45","url":null,"abstract":"<p><p>A 25-yr-old woman delivered a healthy child by cesarean section. At 8 mo postpartum, she became aware of an upper abdominal tumor. Abdominal computed tomography and upper abdominal ultrasonography revealed a large cystic mass in the body of the pancreas. Endoscopic retrograde pancreatography showed no connection between the main pancreatic duct and the cystic lesion. The patient underwent tumor resection at 11 mo postpartum. Pathological examination of the tumor revealed mucin-producing columnar epithelial cells lining the cystic wall with ovarian-type stromal tissue and no findings indicative of malignancy, giving a diagnosis of mucinous cystic adenoma of the pancreas. Immunohistochemical studies revealed positive staining for progesterone receptor but not for estrogen receptor in the stromal cell nuclei. Postpartum rapid growth of a benign mucinous cystic neoplasm might be linked to the production of female sex hormones during lactation.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"37 1","pages":"45-8"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:37:1:45","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26600024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiorganic dissemination of a colorectal signet ring cell carcinoma with fulminant clinical course.","authors":"Raffaele Longo,&nbsp;Alessandro Morabito,&nbsp;Guido Carillio,&nbsp;Giovanna Lanzi,&nbsp;Maria Angela Castellana,&nbsp;Scolastica Amici,&nbsp;Massimo Fanelli,&nbsp;Domenico Gattuso,&nbsp;Giampietro Gasparini","doi":"10.1385/IJGC:37:1:49","DOIUrl":"https://doi.org/10.1385/IJGC:37:1:49","url":null,"abstract":"<p><p>Mucinous colorectal cancer with signet ring cell aspects is a rare form of adenocarcinoma representing about 2-5% of large bowel neoplasms. The tumor frequently presents with late-stage or peritoneal spreading. It can often affect young patients and diffusely infiltrate through all layers of the intestinal wall. Local recurrence and distant metastases are common in spite of surgical operation and adjuvant treatment, conditioning a poor prognosis. At the present, early diagnosis and complete resection are the most important approaches to improve the outcome. In our report we describe a case of a 41-yr-old patient with very aggressive untreated metastatic colorectal signet ring cell carcinoma. The fulminant tumor progression was really unexpected and misled every possible medical interpretation, leading to rapid worsening of the patient's clinical conditions and no chance for chemotherapy treatment. The tumor mimicked the picture observed in the acute leukemia, developing diffuse infiltration in all serosal membranes, liver, lung, kidneys, multiple lymph nodes, and meninges, as revealed by the post-mortem medical report.</p>","PeriodicalId":84927,"journal":{"name":"International journal of gastrointestinal cancer","volume":"37 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:37:1:49","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26600025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}