欧洲癌症研究和治疗组织生活质量问卷:胰腺癌预后的影响。

Digant Gupta, Christopher G Lis, James F Grutsch
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引用次数: 21

摘要

背景:本研究的目的是评估在社区医院综合癌症中心接受治疗的胰腺癌患者的生活质量(QoL)与生存率之间的关系。患者和方法:在2004年4月至2004年11月期间,在中西部地区医学中心的美国癌症治疗中心连续研究了55例组织学证实的胰腺癌患者。采用EORTC QLQ-C30评估患者的生活质量。采用Kaplan-Meier法计算生存率。采用Log-rank检验研究生存分布的平稳性。然后进行多因素Cox回归分析,以评估这些生活质量和单因素分析显示的预后临床因素的联合预后意义。结果:55例患者中28例为新诊断,27例有既往治疗史。中位年龄为55岁(范围33-74岁)。大多数(34例)在诊断时为IV期。QLQ-C30参数显示与生存率有统计学显著关联的是身体、角色和情绪功能量表以及疲劳、食欲减退、便秘和腹泻症状量表。结论:我们发现,通过QLQ-C30身体功能量表测量的患者生活质量,为胰腺癌患者提供了有用的预后信息,独立于多种癌症症状。虽然这些发现需要在大量患者队列中进一步调查,但它们可能对临床试验中的患者分层具有重要意义,并有助于临床决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The European organization for research and treatment of cancer quality of life questionnaire: implications for prognosis in pancreatic cancer.

Background: The goal of this study was to evaluate the association between patient quality of life (QoL) and survival in pancreatic cancer patients undergoing care in a community hospital comprehensive cancer center.

Patients and methods: A consecutive case series of 55 histologically confirmed pancreatic cancer treated at Cancer Treatment Centers of America® at Midwestern Regional Medical Center was studied between 04/01 and 11/04. The EORTC QLQ-C30 was utilized to assess patient QoL. Kaplan-Meier method was used to calculate survival. Log-rank test was used to study the equality of survival distributions. Multivariate Cox regression analyses were then performed to evaluate the joint prognostic significance of those QoL and clinical factors that were shown to be prognostic upon univariate analyses.

Results: Of the 55 patients, 28 were newly diagnosed and 27 had prior treatment history. The median age was 55 years (range 33-74 years). Majority (34) had stage IV disease at diagnosis. The QLQ-C30 parameters to show statistically significant associations with survival were physical, role, and emotional functioning scales and fatigue, appetite loss, constipation, and diarrhea symptom scales.

Conclusions: We found that patient QoL, as measured by the QLQ-C30 physical functioning scale, provides useful prognostic information, independent of multiple cancer symptoms, in patients with pancreatic cancer. While these findings require further investigation in large patient cohorts, they may have important implications for patient stratification in clinical trials, as well as aid in clinical decision making.

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