Rodent endosonography to monitor esophageal cancer.

Navtej S Buttar, Maurits J Wiersema, Kenneth K Wang, Cathrine J DeMars, Ganapathy A Prasad, Lori S Lutzke
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引用次数: 3

Abstract

Animal models of luminal cancers are important to understand and assess chemopreventive and chemotherapeutic interventions. However, the ability to assess tumor growth and response without animal sacrifice is limited. We assessed the ability of luminal sonography to assess the presence of tumor and its size in a surgical esophagojejunostomy model of esophageal cancer. Luminal sonography had a sensitivity of 88%, specificity of 100%, and accuracy of 93% in identifying the esophageal cancers. The tumor dimensions on luminal sonography were within 11% of autopsy measurements. Minimal tumor dimension was 2 mm and maximum 6.2 mm. The procedure was feasible without technical difficulty. In conclusion, rodent endosonography is a useful technique that can accurately determine the presence of tumors as well as their dimensions.

啮齿动物超声监测食管癌。
动物模型对于了解和评估化学预防和化疗干预措施非常重要。然而,在不牺牲动物的情况下评估肿瘤生长和反应的能力是有限的。我们评估了腔内超声在食管癌手术食管空肠造口模型中评估肿瘤存在及其大小的能力。超声诊断食管癌的敏感性为88%,特异性为100%,准确率为93%。腔内超声检查的肿瘤尺寸在尸检测量值的11%以内。肿瘤最小尺寸2mm,最大尺寸6.2 mm。这个程序是可行的,没有技术上的困难。总之,啮齿动物超声是一种有用的技术,可以准确地确定肿瘤的存在及其尺寸。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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