Asia Pacific Allergy最新文献

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Identification of fungi causing humidifier lung: 2 rare cases and a review of the literature. 加湿器肺部真菌鉴定:2例罕见病例及文献复习。
IF 1.7
Asia Pacific Allergy Pub Date : 2022-10-28 eCollection Date: 2022-10-01 DOI: 10.5415/apallergy.2022.12.e43
Kai Ryu, Yuma Fukutomi, Kiyoshi Sekiya, Akemi Saito, Yuto Hamada, Kentaro Watai, Yosuke Kamide, Masami Taniguchi, Jun Araya, Kazuyoshi Kuwano, Katsuhiko Kamei
{"title":"Identification of fungi causing humidifier lung: 2 rare cases and a review of the literature.","authors":"Kai Ryu,&nbsp;Yuma Fukutomi,&nbsp;Kiyoshi Sekiya,&nbsp;Akemi Saito,&nbsp;Yuto Hamada,&nbsp;Kentaro Watai,&nbsp;Yosuke Kamide,&nbsp;Masami Taniguchi,&nbsp;Jun Araya,&nbsp;Kazuyoshi Kuwano,&nbsp;Katsuhiko Kamei","doi":"10.5415/apallergy.2022.12.e43","DOIUrl":"https://doi.org/10.5415/apallergy.2022.12.e43","url":null,"abstract":"<p><strong>Background: </strong>Humidifier lung (HL) is a hypersensitivity pneumonitis resulting from exposure to humidifiers, with fungi from the humidifier as one of the etiologic agents. However, identification of the fungal species responsible for each case can be challenging because of difficulties in culturing fungi, their accurate identification, and interpreting the results of specific serum IgG testing.</p><p><strong>Objective: </strong>To clarify the best way to determine the causative fungal species of each HL case.</p><p><strong>Methods: </strong>We report 2 cases with HL in which rare fungi were identified as causative agents. In addition, we searched MEDLINE for previous publications on HL caused by fungi and performed a literature review focusing on clinical testing for the determination of causal fungal species.</p><p><strong>Results: </strong>In our 2 cases, we identified <i>Fusarium oxysporum</i> species complex, <i>Purpureocillium lilacinum, Acremonium sclerotigenum/egyptiacum</i> as the causative fungal species, based on findings that these could be cultured from humidifier water (HW) and precipitins against these fungi were also positive. The literature review identified 31 HL cases in which the causative fungal species had been documented. In more than half of the cases (17 of 31) there was a concordance between the fungal species cultured from HW and the presence of specific IgG in the blood.</p><p><strong>Conclusion: </strong>We recommend performing culture of fungi from HW and specific serum IgG testing for the accurate determination of the causative fungal species in HL, and concordance between them serves as a rationale for the determination of causative fungal species.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"12 4","pages":"e43"},"PeriodicalIF":1.7,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/58/apa-12-e43.PMC9669469.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40492760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
How physicians approach hereditary angioedema: a single center study. 医生如何处理遗传性血管性水肿:一项单中心研究。
IF 1.6
Asia Pacific Allergy Pub Date : 2022-10-27 eCollection Date: 2022-10-01 DOI: 10.5415/apallergy.2022.12.e40
Kadriye Terzioglu, Dane Ediger, Ebru Ozdemir, Raziye TulumenOzturk, Fatma Oflu Dogan, Ozgur Sancar
{"title":"How physicians approach hereditary angioedema: a single center study.","authors":"Kadriye Terzioglu, Dane Ediger, Ebru Ozdemir, Raziye TulumenOzturk, Fatma Oflu Dogan, Ozgur Sancar","doi":"10.5415/apallergy.2022.12.e40","DOIUrl":"10.5415/apallergy.2022.12.e40","url":null,"abstract":"<p><strong>Background: </strong>Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by C1-inhibitor deficiency. It is characterized by recurrent attacks of cutaneous and upper respiratory tract swelling, and abdominal pain due to mucosal edema. Early detection and treatment prevent unnecessary interventions, improves quality of life, and prevents potentially fatal attacks.</p><p><strong>Objective: </strong>The present study aims to investigate physicians level of knowledge and awareness regarding HAE.</p><p><strong>Methods: </strong>A questionnaire about HAE was applied to 393 physicians from a university hospital. Participants were requested to choose one or several answers to multiple-choice questions.</p><p><strong>Results: </strong>Seven and three tenths percent of study participants stated to have never heard of HAE. Twenty-seven physicians (7.4%) chose the exact correct answers regarding diagnostic tests, and 2 (0.8%) chose the exact correct answers regarding emergency management. A composite of internists, pediatrists and emergency medicine specialists had a significantly higher mean score than other physicians (<i>p</i> = 0.047). Physicians from internal medical sciences scored significantly higher than physicians from surgical medical sciences (<i>p</i> = 0.022).</p><p><strong>Conclusion: </strong>The present study reveals that physician awareness about HAE is low, and physicians misdiagnose HAE attacks as histaminergic angioedema attacks, and therefore provide ineffective treatment. Although HAE is a rare disease, physician awareness must be increased, because early diagnosis and effective treatment are vital for the patients.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"12 4","pages":"e40"},"PeriodicalIF":1.6,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/f4/apa-12-e40.PMC9669465.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40492756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Melbourne epidemic thunderstorm asthma event 2016: a 5-year longitudinal study. 2016年墨尔本流行性雷暴哮喘事件:一项5年纵向研究。
IF 1.7
Asia Pacific Allergy Pub Date : 2022-10-27 eCollection Date: 2022-10-01 DOI: 10.5415/apallergy.2022.12.e38
Felicity Huang, David H Wang, Chuan T Foo, Alan C Young, Jie Shen Fok, Francis Thien
{"title":"The Melbourne epidemic thunderstorm asthma event 2016: a 5-year longitudinal study.","authors":"Felicity Huang,&nbsp;David H Wang,&nbsp;Chuan T Foo,&nbsp;Alan C Young,&nbsp;Jie Shen Fok,&nbsp;Francis Thien","doi":"10.5415/apallergy.2022.12.e38","DOIUrl":"https://doi.org/10.5415/apallergy.2022.12.e38","url":null,"abstract":"<p><strong>Background: </strong>In 2016, Melbourne was struck by the world's largest and most devastating epidemic thunderstorm asthma (ETSA) episode. While affected individuals displayed worsened short-term asthma control, little is known about their longer-term natural history, nor about interventions that restore control.</p><p><strong>Objective: </strong>We assessed the asthma symptomatology and related behaviours of ETSA-affected individuals through a single-centre prospective 5-year longitudinal study. We embedded an open-label observational trial investigating the role of grass pollen sublingual tablet (Oralair) allergen immunotherapy in improving asthma and allergic rhinitis symptoms.</p><p><strong>Methods: </strong>Allergic rhinitis symptom severity, frequency of asthma symptoms and inhaled corticosteroid usage were assessed via questionnaire yearly. In 2018, a subgroup of participants was enrolled in an observational study of Oralair treatment compared to control. The active group received Oralair from 2019 to 2021; both groups were followed-up for 5 years. Subgroup analyses were performed for participants with complete datasets, and who completed the trial per-protocol.</p><p><strong>Results: </strong>Year-on-year data across 5 years was available for 30 participants. The rate of persistent asthma symptoms declined from 37% to 7% in 2016 to 2021. Only 10%-27% of participants reported being completely asymptomatic in any given year. The inhaled preventer prescription rate was 67%, with only 35% being adherent. Twenty-seven participants with available data completed the Oralair trial per-protocol. No significant difference was noted between control and active groups for allergic rhinitis symptoms or asthma control, although the Oralair group saw a significant improvement in asthma control comparing 2019 with 2021.</p><p><strong>Conclusion: </strong>This is the longest documented follow-up of ETSA-affected individuals. Five years following sentinel event, there was progressive reduction but some persistence in asthma symptoms. Oralair allergen immunotherapy did not further improve allergic rhinitis or asthma symptoms compared to control, but there were no further ETSA events to test a protective effect during the study period.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"12 4","pages":"e38"},"PeriodicalIF":1.7,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/2e/apa-12-e38.PMC9669468.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40492757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Level of knowledge among healthcare professionals regarding anaphylaxis. 医疗保健专业人员关于过敏反应的知识水平。
IF 1.7
Asia Pacific Allergy Pub Date : 2022-10-27 eCollection Date: 2022-10-01 DOI: 10.5415/apallergy.2022.12.e41
Sevgi Sipahi Cimen, Sena Baykara Sayili
{"title":"Level of knowledge among healthcare professionals regarding anaphylaxis.","authors":"Sevgi Sipahi Cimen,&nbsp;Sena Baykara Sayili","doi":"10.5415/apallergy.2022.12.e41","DOIUrl":"https://doi.org/10.5415/apallergy.2022.12.e41","url":null,"abstract":"<p><strong>Background: </strong>Anaphylaxis is defined as a severe, life-threatening systemic hypersensitivity reaction. Healthcare professionals must recognize the symptoms, apply correct treatment immediately, and provide epinephrine auto-injectors (EAI) to patients who experience anaphylaxis.</p><p><strong>Objective: </strong>In this study, we aimed to investigate the knowledge of healthcare professionals regarding anaphylaxis.</p><p><strong>Methods: </strong>This cross-sectional study, which was conducted between February 2022 and March 2022, included healthcare professionals working in various hospitals in Turkey. A survey consisting of 21 questions which concerned with the demographic data, personal experience and level of knowledge about anaphylaxis was applied to healthcare professionals.</p><p><strong>Results: </strong>The study included a total of 301 participants, comprising 160 specialist physicians (53.16%), 86 resident physicians (28.57%), 31 family physicians (10.3%), and 24 allied health personnel (7.97%). Most of the healthcare professionals (93%) chose epinephrine as the first-line treatment for anaphylaxis. Two hundred ten participants (69.77%) knew the correct dose of epinephrine in the treatment of anaphylaxis, and allied healthcare professionals had least knowledge (<i>p</i> = 0.009). The participants who received anaphylaxis training and had experience with anaphylaxis had a higher knowledge about epinephrine dosing (<i>p</i> < 0.001 and <i>p</i> = 0.003, respectively). Only 49.17% of the participants knew the epinephrine doses of EAIs, and only 19% of participants had prescribed an EAI.</p><p><strong>Conclusion: </strong>Our results showed that healthcare professionals' knowledge about epinephrine doses in the treatment of anaphylaxis was not sufficient. Furthermore, the prescribing rate of EAIs was still inadequate. There is a need for national training programs to increase and update the knowledge of healthcare professionals to reduce anaphylaxis mortality.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"12 4","pages":"e41"},"PeriodicalIF":1.7,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/3e/apa-12-e41.PMC9669473.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40490696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Natural history and clinical course of patients with dermographism in a tropical country: a questionnaire-based survey. 热带国家人口统计学患者的自然史和临床病程:一项基于问卷的调查。
IF 1.7
Asia Pacific Allergy Pub Date : 2022-10-27 eCollection Date: 2022-10-01 DOI: 10.5415/apallergy.2022.12.e39
Chuda Rujitharanawong, Papapit Tuchinda, Leena Chularojanamontri, Yanisorn Nanchaipruek, Nuttagarn Jantanapornchai, Visanu Thamlikitkul, Kanokvalai Kulthanan
{"title":"Natural history and clinical course of patients with dermographism in a tropical country: a questionnaire-based survey.","authors":"Chuda Rujitharanawong,&nbsp;Papapit Tuchinda,&nbsp;Leena Chularojanamontri,&nbsp;Yanisorn Nanchaipruek,&nbsp;Nuttagarn Jantanapornchai,&nbsp;Visanu Thamlikitkul,&nbsp;Kanokvalai Kulthanan","doi":"10.5415/apallergy.2022.12.e39","DOIUrl":"https://doi.org/10.5415/apallergy.2022.12.e39","url":null,"abstract":"<p><strong>Background: </strong>Dermographism is the most common form of chronic inducible urticaria. However, the natural history and clinical course of patients with dermographism in tropical countries has not fully been described.</p><p><strong>Objective: </strong>To examine clinical features, natural history and clinical course of dermographism in Thai patients according to their experiences.</p><p><strong>Methods: </strong>A cross-sectional, internet-based survey was conducted in 2021. All study respondents completed a 45-item questionnaire that was circulated on social media regarding dermographism.</p><p><strong>Results: </strong>Among the 2,456 respondents who reported dermographism, 1,900 had symptomatic dermographism (SD), while 556 had simple dermographism (SimD). Of the respondents who reported SD and SimD, the female to male ratio was 2.2:1 and 2.4:1, respectively. The median age of the first episode of SD and SimD was 16 and 15 years, respectively. Older age, greater body weight, cardiovascular diseases, allergic conjunctivitis, atopic dermatitis, changes in temperature, and family history of dermographism were all factors linked to an increased probability of SD. Half of the respondents with SD reported moderate itch severity. Moreover, about half of SD and almost all of SimD respondents let the wheal resolve on its own. Second generation H<sub>1</sub>-antihistamines were most commonly prescribed while over-the-counter medicines were taken by both SD and SimD respondents.</p><p><strong>Conclusion: </strong>This survey highlights several aspects of dermographism in Thai patients which can be useful for healthcare providers. SD is troublesome and affects the quality of life of many patients, leading some to seek medication themselves.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"12 4","pages":"e39"},"PeriodicalIF":1.7,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/74/apa-12-e39.PMC9669471.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40492758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Case report of clindamycin graded challenge in an AIDS patient allergic to clindamycin. 克林霉素过敏的艾滋病患者克林霉素分级激射一例报告。
IF 1.7
Asia Pacific Allergy Pub Date : 2022-10-17 eCollection Date: 2022-10-01 DOI: 10.5415/apallergy.2022.12.e36
Thitinun Raknoo, Orawan Sae-Lim, Sutthiporn Pattharachayakul, Siripen Kanchanasuwan
{"title":"Case report of clindamycin graded challenge in an AIDS patient allergic to clindamycin.","authors":"Thitinun Raknoo,&nbsp;Orawan Sae-Lim,&nbsp;Sutthiporn Pattharachayakul,&nbsp;Siripen Kanchanasuwan","doi":"10.5415/apallergy.2022.12.e36","DOIUrl":"https://doi.org/10.5415/apallergy.2022.12.e36","url":null,"abstract":"<p><p>The aim of this study was to report the success of a clindamycin graded challenge. The patient was a 39-year-old human immunodeficiency virus-infected male with toxoplasmic encephalitis (TE) with a history of trimethoprim/sulfamethoxazole (TMP/SMX) and clindamycin allergy. He developed a reaction during TMP/SMX desensitization. Following the reaction, a graded challenge with clindamycin was performed in this study, and he became tolerant to clindamycin. No adverse drug reactions developed during the graded challenge. He successfully continued suppressive therapy with no further reactions or recurrences.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"12 4","pages":"e36"},"PeriodicalIF":1.7,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/af/apa-12-e36.PMC9669470.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40490692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Anaphylaxis is rare due to CoronaVac in a population of healthcare workers. 过敏反应是罕见的,由于冠状病毒在卫生保健工作者人群。
IF 1.7
Asia Pacific Allergy Pub Date : 2022-10-17 eCollection Date: 2022-10-01 DOI: 10.5415/apallergy.2022.12.e35
Betül Özdel Öztürk, İrem Akdemir, Alpay Azap, Gülfem Çelik, Sevim Bavbek, Dilşad Mungan
{"title":"Anaphylaxis is rare due to CoronaVac in a population of healthcare workers.","authors":"Betül Özdel Öztürk,&nbsp;İrem Akdemir,&nbsp;Alpay Azap,&nbsp;Gülfem Çelik,&nbsp;Sevim Bavbek,&nbsp;Dilşad Mungan","doi":"10.5415/apallergy.2022.12.e35","DOIUrl":"https://doi.org/10.5415/apallergy.2022.12.e35","url":null,"abstract":"<p><strong>Background: </strong>CoronaVac, the first coronavirus disease 2019 vaccine administered in our country, was found safe in clinical trials.</p><p><strong>Objective: </strong>We aimed to reveal the rate and features of CoronaVac vaccine-associated allergic reactions among vaccinated healthcare workers (HCWs) in real-life.</p><p><strong>Methods: </strong>This study was planned as a questionnaire-based study. Participants who reported a postvaccination allergic reaction were interviewed on phone and their medical records were also checked for confirmation.</p><p><strong>Results: </strong>A total of 2,488 HCWs took part in the study and 4,054 postvaccination complete questionnaire-responses were obtained. Twenty-one HCWs (female: male, 17:4) with a mean age of 40.95 ± 10.09 stated that they had an allergic reaction after a total of 23 vaccine injections. Accordingly, the reaction rate was 0.56% among all vaccine doses. The most common reactions were systemic skin reactions (2.7%) consisting of generalized pruritus, diffuse pruritic erythema, urticaria, and maculopapular rash. That was followed by local injection site reaction (0.12%). Anaphylaxis was reported in 4 cases (0.09%) with a mean onset time of 12 ± 6 minutes. One of them had a history of anaphylaxis with 2 drugs, another had venom and food allergy. Three of the subjects had level 2 diagnostic certainty according to the Brighton Collaboration criteria and one had level 3. All anaphylaxis cases were discharged within 24 hours and none of them required intensive care.</p><p><strong>Conclusion: </strong>Our study demonstrated that allergic reactions to CoronaVac were rare and mostly mild. Although anaphylaxis was also rare, the importance of early intervention with close follow-up was once again emphasized.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"12 4","pages":"e35"},"PeriodicalIF":1.7,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/b7/apa-12-e35.PMC9669466.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40490694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Case of hypereosinophilic syndrome with gastrointestinal involvement showing tissue eosinophil cytolysis. 高嗜酸性粒细胞综合征累及胃肠道1例,表现为组织嗜酸性粒细胞溶解。
IF 1.7
Asia Pacific Allergy Pub Date : 2022-10-17 eCollection Date: 2022-10-01 DOI: 10.5415/apallergy.2022.12.e37
Shin-Ichiro Hagiwara, Shigeharu Ueki, Ken Watanabe, Keinosuke Hizuka, Yuri Etani
{"title":"Case of hypereosinophilic syndrome with gastrointestinal involvement showing tissue eosinophil cytolysis.","authors":"Shin-Ichiro Hagiwara,&nbsp;Shigeharu Ueki,&nbsp;Ken Watanabe,&nbsp;Keinosuke Hizuka,&nbsp;Yuri Etani","doi":"10.5415/apallergy.2022.12.e37","DOIUrl":"https://doi.org/10.5415/apallergy.2022.12.e37","url":null,"abstract":"<p><p>Hypereosinophilic syndrome (HES), which is characterized by eosinophilia in the peripheral blood, often causes various organ disorders, including those of the gastrointestinal (GI) tract. The eosinophils play a key role in inflammation in eosinophilic GI disorders (EGIDs), including HES with GI involvement. Here, we report a case of HES with GI involvement that showed major basic proteins (MBPs) deposition in the absence of marked eosinophilic infiltration in the mucosa of the GI tract. An 11-year-old boy presented with nausea and epigastric pain for one week. He had a history of idiopathic HES with eosinophilic cystitis, diagnosed at the age of 2 years. He had been taking a low dose of corticosteroids for 9 years. The peripheral blood eosinophil count was 2,254/μL. Endoscopy revealed a swelling of the duodenal bulb mucosa. Histological findings of the duodenal mucosa revealed chronic inflammation, but no evidence of significant eosinophil infiltration and we could not diagnose him with HES with GI involvement or EGID. Immunofluorescent staining for MBP and galectin-10 was performed to detect intact and cytolytic eosinophils (eosinophil extracellular trap cell death: EETosis). Marked MBP deposition was evident in a small number of intact eosinophils in tissues from the duodenum, gastric antrum, and terminal ileum. The current case illustrates the utility of immunostaining for the detection of persistent eosinophilic inflammation, especially when cytolytic eosinophils are dominant.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"12 4","pages":"e37"},"PeriodicalIF":1.7,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/ed/apa-12-e37.PMC9669462.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40490695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Measures for food allergy emergency in nurseries. 托儿所食物过敏应急措施。
IF 1.7
Asia Pacific Allergy Pub Date : 2022-10-17 eCollection Date: 2022-10-01 DOI: 10.5415/apallergy.2022.12.e34
Mitsunobu Kaneko, Tomoko Miyoshi, Yoshihiro Miyashita, Riku Hayashi, Takuji Hashimoto
{"title":"Measures for food allergy emergency in nurseries.","authors":"Mitsunobu Kaneko,&nbsp;Tomoko Miyoshi,&nbsp;Yoshihiro Miyashita,&nbsp;Riku Hayashi,&nbsp;Takuji Hashimoto","doi":"10.5415/apallergy.2022.12.e34","DOIUrl":"https://doi.org/10.5415/apallergy.2022.12.e34","url":null,"abstract":"<p><strong>Background: </strong>As food allergy potentially can induce life-threatening anaphylaxis, measures for food allergy are required at nurseries caring for food allergy children, but a large-scale factual investigation has not been carried out.</p><p><strong>Objective: </strong>We evaluated measures for food allergy emergency in nurseries.</p><p><strong>Methods: </strong>A questionnaire survey regarding emergency measures in all authorized nurseries (411 facilities including 20,586 children) was conducted in Kawasaki city, Japan.</p><p><strong>Results: </strong>The recovery rate of the questionnaire was 46.5%, which include 14,343 children of 191 facilities in total. A total of 637 children (4.4%) in 157 facilities (82.2%) requires elimination diets that were suggested by physicians. Among them, 22 children had been suggested to undergo the use of epinephrine auto-injection kit for emergency. 161 facilities (84.3%) had set a specific manual for emergency of food allergy. Emergency cases over the past one year were 4 cases and there was no case that had been suggested to use epinephrine auto-injection kit. All were anaphylaxis and the causes of these included 2 accidental digestion of culprit foods and the causes of other 2 cases were unknown. A case who required no elimination diet showed first episode of anaphylaxis. All cases were recovered.</p><p><strong>Conclusion: </strong>High percentage of nurseries in Kawasaki city has cared for food allergy children. While many children with food allergy have been in nurseries, only several cases of anaphylaxis have been reported for a 1 year. Among 4 cases of anaphylaxis, no specific cause has been recognized in 2 cases and 1 case has been the first episode of anaphylaxis. While most of nurseries have set specific measures for emergency of food allergy, there is certain possibility that nursery staffs can encounter the first episode of anaphylaxis even if there is no food allergy child. For all nurseries, emergency measures for food allergy are vital.</p>","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"12 4","pages":"e34"},"PeriodicalIF":1.7,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/cf/apa-12-e34.PMC9669463.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40492761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
APAAACI's activities and this issue. APAAACI的活动和这个问题。
IF 1.7
Asia Pacific Allergy Pub Date : 2022-07-29 eCollection Date: 2022-07-01 DOI: 10.5415/apallergy.2022.12.e33
Yoon-Seok Chang
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