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Artificial cells, blood substitutes, and immobilization biotechnology最新文献

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Development of transmucosal patch using nanofibers. 纳米纤维经黏膜贴片的研制。
Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2012-02-01 Epub Date: 2011-12-22 DOI: 10.3109/10731199.2011.637924
Harleen Grewal, Sanjay R Dhakate, Amit K Goyal, Tanmay S Markandeywar, Basant Malik, Goutam Rath
{"title":"Development of transmucosal patch using nanofibers.","authors":"Harleen Grewal,&nbsp;Sanjay R Dhakate,&nbsp;Amit K Goyal,&nbsp;Tanmay S Markandeywar,&nbsp;Basant Malik,&nbsp;Goutam Rath","doi":"10.3109/10731199.2011.637924","DOIUrl":"https://doi.org/10.3109/10731199.2011.637924","url":null,"abstract":"<p><p>In the present work we have attempted to develop a novel transmucosal patch of diclofenac sodium using electrospun polycaprolactone (PCL) nanofibers. PCL nanofibers were prepared by electrospinning techniques using different polymer concentrations. Nanofibers formulations were characterized by SEM, FTIR, drug loading, and in-vitro release study using Franz diffusion cell. Studies revealed the nanofibers fabricated from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm diameter. Release studies demonstrated the sustained release behavior of PCL nanofibers. Nanofibers can be exploited for transmucosal drug delivery of NSAID with improved therapeutic efficacy.</p>","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.637924","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30343877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Effect of surfactants on the characteristics of fluconazole niosomes for enhanced cutaneous delivery. 表面活性剂对氟康唑niosomes增强皮肤给药特性的影响。
Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-12-01 Epub Date: 2011-09-27 DOI: 10.3109/10731199.2011.611476
Madhu Gupta, Bhuvaneshwar Vaidya, Neeraj Mishra, Suresh P Vyas
{"title":"Effect of surfactants on the characteristics of fluconazole niosomes for enhanced cutaneous delivery.","authors":"Madhu Gupta,&nbsp;Bhuvaneshwar Vaidya,&nbsp;Neeraj Mishra,&nbsp;Suresh P Vyas","doi":"10.3109/10731199.2011.611476","DOIUrl":"https://doi.org/10.3109/10731199.2011.611476","url":null,"abstract":"<p><p>Fluconazole-loaded niosomes were prepared by the film hydration method with different surfactants (Span and Brij series) and characterized for various parameters. Results showed that niosomes composed of Span 40, Span 60, and Brij 72 were most stable with smaller size, i.e. 0.378 ± 0.022 μm, 0.343 ± 0.063 μm, and 0.287 ± 0.012 μm, respectively, along with higher entrapment efficiency (approx. > 41%). In vitro skin permeation and retention studies suggested that cutaneous accumulation was affected by surfactant property and vesicle size. Therefore the niosomes consisting of Span 40, Span 60, and Brij 72 surfactant are seemingly accumulated and form localized drug depots in the skin, thereby releasing the contents in a sustained manner and able to greatly enhance cutaneous retention of the drug.</p>","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.611476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30168990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 66
Biocompatibility of acellular nerves of different mammalian species for nerve tissue engineering. 不同哺乳动物脱细胞神经在神经组织工程中的生物相容性。
Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-12-01 Epub Date: 2011-10-14 DOI: 10.3109/10731199.2011.618133
Hua Jia, Ying Wang, Xiao-Jie Tong, Gui-Bo Liu, Qi Li, Li-Xin Zhang, Xiao-Hong Sun
{"title":"Biocompatibility of acellular nerves of different mammalian species for nerve tissue engineering.","authors":"Hua Jia,&nbsp;Ying Wang,&nbsp;Xiao-Jie Tong,&nbsp;Gui-Bo Liu,&nbsp;Qi Li,&nbsp;Li-Xin Zhang,&nbsp;Xiao-Hong Sun","doi":"10.3109/10731199.2011.618133","DOIUrl":"https://doi.org/10.3109/10731199.2011.618133","url":null,"abstract":"<p><p>To explore the biocompatibility of acellular nerves of different mammalian species, for the acellular nerves derived from rats and rabbits, the morphology, immunocompatibility, and cytocompatibility with bone marrow stromal cells (BMSCs) were evaluated. The results indicated that the tridimensional architecture and main proteins of endoneurial tubes in both biomaterials were well retained. The nerve scaffolds did not show immunogenicity or cytotoxicity, but facilitated growth of BMSCs and secretion of neurotrophic factors in vitro. In conclusion, acellular nerves of different species possess favorable biocompatibility, and xenogenic acellular nerves combined with BMSCs have potential to replace allografts for peripheral nerve reconstruction.</p>","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.618133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30207414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Transit time affects the community stability of Lactobacillus and Bifidobacterium species in an in vitro model of human colonic microbiotia. 在体外人类结肠微生物群模型中，运输时间影响乳酸菌和双歧杆菌的群落稳定性。
Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-12-01 DOI: 10.3109/10731199.2011.622280
Laetitia Rodes, Arghya Paul, Michael Coussa-Charley, Hani Al-Salami, Catherine Tomaro-Duchesneau, Marc Fakhoury, Satya Prakash
{"title":"Transit time affects the community stability of Lactobacillus and Bifidobacterium species in an in vitro model of human colonic microbiotia.","authors":"Laetitia Rodes,&nbsp;Arghya Paul,&nbsp;Michael Coussa-Charley,&nbsp;Hani Al-Salami,&nbsp;Catherine Tomaro-Duchesneau,&nbsp;Marc Fakhoury,&nbsp;Satya Prakash","doi":"10.3109/10731199.2011.622280","DOIUrl":"https://doi.org/10.3109/10731199.2011.622280","url":null,"abstract":"<p><p>Retention time, which is analogous to transit time, is an index for bacterial stability in the intestine. Its consideration is of particular importance to optimize the delivery of probiotic bacteria in order to improve treatment efficacy. This study aims to investigate the effect of retention time on Lactobacilli and Bifidobacteria stability using an established in vitro human colon model. Three retention times were used: 72, 96, and 144 h. The effect of retention time on cell viability of different bacterial populations was analyzed with bacterial plate counts and PCR. The proportions of intestinal Bifidobacteria, Lactobacilli, Enterococci, Staphylococci and Clostridia populations, analyzed by plate counts, were found to be the same as that in human colonic microbiota. Retention time in the human colon affected the stability of Lactobacilli and Bifidobacteria communities, with maximum stability observed at 144 h. Therefore, retention time is an important parameter that influences bacterial stability in the colonic microbiota. Future clinical studies on probiotic bacteria formulations should take into consideration gastrointestinal transit parameters to improve treatment efficacy.</p>","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.622280","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40138680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Polymerized human placenta hemoglobin given before ischemia protects rat heart from ischemia reperfusion injury. 缺血前给予聚合人胎盘血红蛋白对大鼠心脏缺血再灌注损伤具有保护作用。
Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-12-01 DOI: 10.3109/10731199.2011.611472
Tao Li, Ronghua Zhou, Xujin Xiang, Da Zhu, Yanyan Li, Jin Liu, Wei Wu, Chengmin Yang
{"title":"Polymerized human placenta hemoglobin given before ischemia protects rat heart from ischemia reperfusion injury.","authors":"Tao Li,&nbsp;Ronghua Zhou,&nbsp;Xujin Xiang,&nbsp;Da Zhu,&nbsp;Yanyan Li,&nbsp;Jin Liu,&nbsp;Wei Wu,&nbsp;Chengmin Yang","doi":"10.3109/10731199.2011.611472","DOIUrl":"https://doi.org/10.3109/10731199.2011.611472","url":null,"abstract":"<p><p>This study was to investigate whether polymerized human placenta hemoglobin (PolyPHb) given before ischemia protects in vivo rat heart function against ischemia/reperfusion (I/R) injury. Forty-five male Sprague-Dawley rats were randomly divided (n = 15 per group) into a sham group, control group (pretreatment with Lactated Ringer's solution), or PolyPHb group (pretreatment with 0.1 gHb/kg PolyPHb). Rat hearts were subjected to 30-min ischemia by occlusion of left anterior descending, followed by 2-hr reperfusion. As compared to the control group, PolyPHb preserved cardiac function and reduced cardiac troponin-I release and histopathological changes. Therefore, PolyPHb pretreatment provided a profound cardioprotective effect on the in vivo rat heart.</p>","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.611472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40138683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Preparation and in vitro evaluation of simvastatin ethosome. 辛伐他汀酶体的制备及体外评价。
Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-12-01 Epub Date: 2011-10-25 DOI: 10.3109/10731199.2011.622281
Keyao An, Yong Sun, Lisa Xu, Xiangzhen Cui
{"title":"Preparation and in vitro evaluation of simvastatin ethosome.","authors":"Keyao An,&nbsp;Yong Sun,&nbsp;Lisa Xu,&nbsp;Xiangzhen Cui","doi":"10.3109/10731199.2011.622281","DOIUrl":"https://doi.org/10.3109/10731199.2011.622281","url":null,"abstract":"<p><p>To prepare ethosome loading simvastatin,an orthogonal test was applied to optimize the prescriptions, and the qualities of simvastatin ethosome were characterized by the shape, particle size, encapsulation efficiency (EE), and stability. The formation of 40% (v/v) ethanol, 0.02% (m/v) cholesterol, 2.0% (m/v) soy lecithin, and 5% (m/v) polyoxyethylene hydrogenated castor oil showed the maximal EE (69.3%). We observed the shape of simvastatin ethosome through TEM. The average size of the particles was 52.4 ± 3.24 nm, which was detected by a N5 submicron particle size analyzer. After 120 days storage in 4? and at room temperature, the simvastatin ethosome had no significant change.</p>","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.622281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30227093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Construction of a potentiometric glutamate biosensor for determination of glutamate in some real samples. 谷氨酸电位生物传感器的构建及其在实际样品中谷氨酸的测定。
Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-12-01 DOI: 10.3109/10731199.2011.611473
Demet Y Lmaz, Emine Karaku
{"title":"Construction of a potentiometric glutamate biosensor for determination of glutamate in some real samples.","authors":"Demet Y Lmaz,&nbsp;Emine Karaku","doi":"10.3109/10731199.2011.611473","DOIUrl":"https://doi.org/10.3109/10731199.2011.611473","url":null,"abstract":"<p><p>The potentiometric glutamate biosensor based on ammonium-selective poly(vinylchloride) (PVC) membrane electrode was constructed by chemically immobilizing glutamate oxidase. Ammonium ions produced after an enzymatic reaction were determined potentiometrically. We determined the optimum working conditions of the biosensor such as buffer concentration, buffer pH, lifetime, response time, linear working range, kinetic constants (K(m) and V(max)) of glutamate oxidase enzyme used for biosensor construction values, and other response characteristics. Additionally, glutamate assay in some real samples such as chicken bullion, healthy human serum, and commercial multipower amino acid mixture were also successfully carried out. The results showed good agreement with previously reported values.</p>","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.611473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40138681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Immune safety evaluation of polymerized porcine hemoglobin (pPolyHb): a potential red blood cell substitute. 聚合猪血红蛋白(polyhb)的免疫安全性评价:一种潜在的红细胞替代品。
Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-12-01 DOI: 10.3109/10731199.2011.631499
Hongli Zhu, Kunping Yan, Xiaodong Dang, He Huang, Erfang Chen, Bang Chen, Chao Luo, Thomas Ming Swi Chang, Penggao Dai, Chao Chen
{"title":"Immune safety evaluation of polymerized porcine hemoglobin (pPolyHb): a potential red blood cell substitute.","authors":"Hongli Zhu,&nbsp;Kunping Yan,&nbsp;Xiaodong Dang,&nbsp;He Huang,&nbsp;Erfang Chen,&nbsp;Bang Chen,&nbsp;Chao Luo,&nbsp;Thomas Ming Swi Chang,&nbsp;Penggao Dai,&nbsp;Chao Chen","doi":"10.3109/10731199.2011.631499","DOIUrl":"https://doi.org/10.3109/10731199.2011.631499","url":null,"abstract":"<p><p>Polymerized Porcine Hemoglobin (pPolyHb), a hemoglobin-based oxygen carrier (HBOC), was developed as a potential red blood substitute for clinical applications. Assessment of its effects on the immune system is an important component of the overall safety evaluation of HBOC. For this purpose, we assessed three inflammation indicators, including complement C3a, IL-6, and TNF-? in cultured cells and in a rat model when pPolyHb was incubated or administrated with the cells/animals. Our results suggested that the levels of these three indicators were not statistically changed upon pPolyHb stimulation, indicating that pPolyHb is not immunotoxic to cells and animals in this aspect.</p>","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.631499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40138684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Molecular diagnosis using multi drug delivery network and stability. 分子诊断利用多药传递网络和稳定性。
Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-12-01 Epub Date: 2011-10-14 DOI: 10.3109/10731199.2011.618134
M A Jalil, K Innate, N Suwanpayak, P P Yupapin, J Ali
{"title":"Molecular diagnosis using multi drug delivery network and stability.","authors":"M A Jalil,&nbsp;K Innate,&nbsp;N Suwanpayak,&nbsp;P P Yupapin,&nbsp;J Ali","doi":"10.3109/10731199.2011.618134","DOIUrl":"https://doi.org/10.3109/10731199.2011.618134","url":null,"abstract":"<p><p>By using a pair of tweezers to generate the intense optical vortices within the PANDA ring resonator, the required molecules (drug volumes) can be trapped and moved dynamically within the molecular bus networks, in which the required diagnosis or drug delivery targets can be performed within the network. The advantage of the proposed system is that the proposed diagnostic method can perform within the tiny system (thin film device or circuit), which can be available for a human embedded device for diagnostic use. The channel spacing of the trapped volumes (molecules) within the bus molecular networks can be provided.</p>","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.618134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30207415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Portion of a nerve trunk can be used as a donor nerve to reconstruct the injured nerve and donor site simultaneously. 部分神经干可用作供神经，同时重建损伤神经和供区。
Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-10-01 Epub Date: 2011-05-17 DOI: 10.3109/10731199.2011.574636
Xiao Feng Yin, Yu Hui Kou, Yan Hua Wang, Peixun Zhang, Hong Bo Zhang, Bao Guo Jiang
{"title":"Portion of a nerve trunk can be used as a donor nerve to reconstruct the injured nerve and donor site simultaneously.","authors":"Xiao Feng Yin,&nbsp;Yu Hui Kou,&nbsp;Yan Hua Wang,&nbsp;Peixun Zhang,&nbsp;Hong Bo Zhang,&nbsp;Bao Guo Jiang","doi":"10.3109/10731199.2011.574636","DOIUrl":"https://doi.org/10.3109/10731199.2011.574636","url":null,"abstract":"<p><p>This study aims to estimate the effects of using a portion of a nerve trunk to repair itself and the injured nerve simultaneously. Proximal 1/2 median nerve served as donor nerve to repair the distal 1/2 median and whole ulnar nerve. Four months postoperation, the number of myelinated axons and nerve conduction velocities of the distal half median and ulnar nerve were (2033 ± 135 and 24.6 ± 5.3 m/s) and (1138 ± 228 and 30.3 ± 7.2 m/s). It suggests that using a portion of a nearby nerve truck to reconstruct itself and the injured nerve simultaneously is a practical method for severe peripheral nerve injury.</p>","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.574636","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30188078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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