Arthritis Care & Research最新文献

{"title":"Barriers and Facilitators for Implementing Resilience Coaching for Youth With Chronic Musculoskeletal Pain: Pediatric Rheumatologists' Perspectives.","authors":"Sabrina Gmuca, Anyun Chatterjee, Mackenzie McGill, Nellie Butler, Katherine S Kellom, Jami F Young, Tonya M Palermo, Pamela F Weiss, Abby R Rosenberg, Peter F Cronholm","doi":"10.1002/acr.25531","DOIUrl":"10.1002/acr.25531","url":null,"abstract":"<p><strong>Objective: </strong>Promoting Resilience in Stress Management (PRISM) is a resilience coaching program designed for adolescents with chronic illness. We aimed to examine the perceived feasibility, acceptability, and appropriateness of PRISM among pediatric rheumatologists treating adolescents with chronic musculoskeletal pain and obtain recommendations for improvement to inform future implementation efforts.</p><p><strong>Methods: </strong>We performed semistructured interviews with pediatric rheumatologists across several US institutions. Interviews were audio recorded and transcribed verbatim. Hybrid inductive-deductive coding was employed to capture emergent themes, guided by the Consolidated Framework for Implementation Research 2.0, and develop the codebook. We performed double coding for 20% (n = 2) of the transcriptions to develop the codebook and ensure interrater reliability.</p><p><strong>Results: </strong>Ten pediatric rheumatologists were interviewed, and feedback on PRISM was uniformly positive in terms of perceived clinical value and favorability for local implementation. Perceived facilitators included PRISM's brevity, remote delivery, and the potential for a peer group session. Finding the funding and having enough staff for such a program as well as the concerns around competing demands and building PRISM into adolescents' busy schedules were the primary perceived barriers for implementation.</p><p><strong>Conclusion: </strong>Pediatric rheumatologists report that PRISM would be valuable and of interest to their patients with chronic musculoskeletal pain, and the resilience coaching program could be further augmented by the addition of a peer support component. Implementation strategies are needed to support program costs and staffing to effectively deliver and sustain the program.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower or higher 25-hydroxyvitamin D levels associated with adverse pregnancy outcomes: comment on the article by Madanchi et al.","authors":"Gang Wang, Zhichun Liu","doi":"10.1002/acr.25545","DOIUrl":"10.1002/acr.25545","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Lupus International Collaborating Clinics Frailty Index Predicts Worsening Health-Related Quality of Life, Data From the Almenara Lupus Cohort.","authors":"Anubhav Singh, Rocío V Gamboa-Cárdenas, Victor Pimentel-Quiroz, Zoila Rodriguez-Bellido, Cesar Pastor-Asurza, Risto Perich-Campos, Graciela S Alarcón, Manuel Francisco Ugarte-Gil","doi":"10.1002/acr.25544","DOIUrl":"10.1002/acr.25544","url":null,"abstract":"<p><strong>Objective: </strong>The Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) as a predictor of quality of life (QoL) in patients with systemic lupus erythematosus (SLE) has not been evaluated longitudinally. We estimated the association of SLICC-FI scores with future QoL in our prevalent Latin American Mestizo cohort.</p><p><strong>Methods: </strong>Patients from a single-center SLE cohort were included. Health-related QoL was ascertained with the LupusQoL tool, and frailty was ascertained with the SLICC-FI. Generalized estimating equations were performed, using each domain of the LupusQoL as an outcome in the subsequent visit, and the SLICC-FI (as a continuous variable) in the previous visit. Alternative analyses were also conducted including the SLICC-FI as a categorical variable. In both approaches, the multivariable models were adjusted for possible confounders (age at diagnosis, sex, socioeconomic status, ethnicity, Systemic Lupus Erythematosus Disease Activity Index 2000, SLICC/American College of Rheumatology damage index [SDI], disease duration at baseline, prednisone daily dose, antimalarial and immunosuppressive drug treatment, and the same domain of the LupusQoL in the previous visit).</p><p><strong>Results: </strong>A total of 428 patients and 2,645 visits were included in this study, and they were observed for 4.71 ± 3.52 years. At baseline, the mean ± SD of disease duration, SDI scores, and SLICC-FI scores were 7.2 ± 6.6 years, 1.0 ± 1.3, and 0.17 ± 0.05, respectively. In the main analysis, after adjusting for possible confounders, higher SLICC-FI scores predicted a higher LupusQoL score in the domains of pain, planning, emotional health, and fatigue. In the alternative analyses, after adjustment, the frail and least fit categories were predictive of higher LupusQoL scores in the domain of fatigue, and frailty (SLICC-FI score of >0.21) predicted worse body image compared with least fit (SLICC-FI score 0.03-0.10).</p><p><strong>Conclusion: </strong>Higher SLICC-FI scores predicted worse health-related QoL as measured by higher LupusQoL scores from patients from the Almenara lupus cohort. Our findings reinforce the prognostic value of this tool in patients with SLE.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Michelle Petri, Andrea Fava, Daniel W Goldman, Nima Madanchi, Laurence S Magder","doi":"10.1002/acr.25546","DOIUrl":"10.1002/acr.25546","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Longitudinal Behavior of Serum Levels of Soluble Flt1 and Placental Growth Factor in Pregnant Patients With Systemic Lupus Erythematosus.","authors":"Nilson R de Jesús, Guilherme R de Jesús, Marcela I Lacerda, Flávia C Dos Santos, Jeane de S Nogueira, Luiz Cristóvão Porto, Evandro S F Coutinho, Evandro M Klumb","doi":"10.1002/acr.25536","DOIUrl":"10.1002/acr.25536","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzed longitudinal trajectories of soluble Flt1 (sFlt1) levels, placenta growth factor (PlGF) levels, and sFlt1:PlGF ratios in a cohort of pregnant patients with systemic lupus erythematosus (SLE).</p><p><strong>Methods: </strong>Blood samples were collected (14-18, 24-26, 30-32, 34-36, and 38-40 weeks), stored at -80°C, and evaluated for serum levels of sFlt1, PlGF, and sFlt1:PlGF ratios. Patients were classified as inactive SLE (Systemic Lupus Erythematosus Pregnancy Disease Activity Index [SLEPDAI] <4), active disease (SLEPDAI ≥4), or preeclampsia (PE). Medians and interquartile ranges were calculated for each group, and linear models with random effects were used.</p><p><strong>Results: </strong>A total of 527 samples were obtained from 163 patients, and all patients were subsequently classified as having inactive disease (109 patients [66.9%]), active disease (33 patients [20.2%]), and inactive disease with PE (21 patients [12.9%]). In exploratory analysis, patients with PE had higher mean serum levels of sFlt1 and sFlt1:PlGF ratios and lower PlGF levels than patients with inactive and active SLE (P = 0.01 to P < 0.001). Using linear models with random effects, there was no significant differences in mean serum levels of these angiogenic markers comparing inactive and active disease. Patients with PE showed a marked increase in sFlt1 levels from the 24th week, constantly low PlGF levels from the 14th week, and progressive increase of sFlt1:PlGF ratio during pregnancy. All these differences were statistically significant compared to the groups without PE.</p><p><strong>Conclusion: </strong>Pregnant patients with SLE who developed PE had higher sFlt1 levels and sFlt1:PlGF ratios and lower PlGF levels, and these last two changes were detected at the beginning of second trimester, before clinical manifestation. SLE activity did not interfere with longitudinal behavior of these angiogenic markers.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Consequences of Rheumatoid Arthritis.","authors":"Stevie Barry, Emily Sheng, Joshua F Baker","doi":"10.1002/acr.25537","DOIUrl":"10.1002/acr.25537","url":null,"abstract":"<p><p>Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long-term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a \"lipid paradox,\" with reduced low-density lipoprotein being associated with higher rates of cardiovascular disease. In this review, we discuss changes to body composition, insulin resistance, lipids, and blood pressure that often occur in patients with RA. We examine the current understanding of the mechanisms underlying disruptions in metabolic pathways in RA, their clinical effects, and how treatment affects these changes.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Higher Levels of High-Sensitivity C-Reactive Protein With Future Development of Psoriatic Arthritis in Psoriasis: A Prospective Cohort Study.","authors":"Lihi Eder, Xianwei Li, Vinod Chandran, Cheryl F Rosen, Richard J Cook, Dafna D Gladman","doi":"10.1002/acr.25539","DOIUrl":"10.1002/acr.25539","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to assess whether high-sensitivity C-reactive protein (hsCRP) levels could predict the development of psoriatic arthritis (PsA) in patients with psoriasis.</p><p><strong>Methods: </strong>We analyzed data from a prospective cohort of patients with psoriasis without PsA at enrollment. Participants were assessed annually by a rheumatologist for signs and symptoms of PsA. Information on patient demographics, psoriasis features, medications and musculoskeletal symptoms was collected. hsCRP levels were measured in serum samples collected at baseline using standard commercial assays. The association between hsCRP levels and risk of development of PsA was assessed using multivariable Cox proportional hazards model adjusted for age, sex, psoriasis severity and duration, nail lesions, body mass index (BMI), fatigue, and medication use.</p><p><strong>Results: </strong>A total of 589 patients with psoriasis observed from 2006 to 2019 were analyzed. During the follow up period, 57 patients developed PsA. The mean level of hsCRP was 3.1 ± 5.5 mg/L (hsCRP levels in patients with incident PsA, 5.4 ± 13.1 mg/L). Significantly higher levels of hsCRP at baseline were found in patients with arthralgia, obesity, and in women. Higher hsCRP levels were associated with future development of PsA in multivariable analyses (hazard ratio 1.04; 95% confidence interval 1.01-1.07; P = 0.007). Similar effect size was seen in men and women. No significant interaction was found between hsCRP and sex or BMI.</p><p><strong>Conclusion: </strong>Higher levels of systemic inflammation, as measured by hsCRP levels, are associated with future development of PsA.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoidable Hospitalizations in Persons With Rheumatoid Arthritis: A Population-Based Study Using Administrative Data.","authors":"Dani G Contreras, Claire E H Barber, J Antonio Aviña-Zubieta, Hude Quan, Seungwon Lee, James A King, Cheryl Barnabe","doi":"10.1002/acr.25541","DOIUrl":"10.1002/acr.25541","url":null,"abstract":"<p><strong>Objective: </strong>We estimated incidence rates of avoidable hospitalizations by persons with rheumatoid arthritis (RA) relative to the general population.</p><p><strong>Methods: </strong>We identified individuals meeting a validated case definition for RA based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and ICD-10-CA codes in years 2002 to 2023. Four general population controls were matched to each RA case by age and sex. We identified hospitalizations for ambulatory care sensitive conditions (ACSCs), including grand mal seizures, chronic lower respiratory diseases, asthma, diabetes, heart failure and pulmonary edema, hypertension, and angina, from 2007 to 2023 by established diagnostic codes. Incidence rate ratios (IRRs) three and five years from the date of diagnosis were calculated using a multivariable regression model adjusting for age, sex, and location of residence. A Cox proportional hazards model was used to identify predictors of avoidable hospitalizations among patients with RA.</p><p><strong>Results: </strong>Persons with RA (n = 83,811) had 1.12 times the risk of hospitalization for heart failure and pulmonary edema compared to those without RA (n = 190,304) (IRR 1.12, 95% confidence interval [CI] 1.01-1.25). Significant predictors of ACSC hospitalizations for RA cases were increasing age, prolonged exposure to glucocorticoids, and having comorbid conditions, especially if the comorbid condition was an ACSC (hazard ratio 10.1, 95% CI 7.8-13.0).</p><p><strong>Conclusion: </strong>Persons with RA are at a higher risk of potentially avoidable hospitalizations three and five years after diagnosis compared to those without RA. Improved ambulatory care access and quality, inclusive of primary care and subspecialty care, is proposed to prevent unnecessary hospitalizations and reduce burden on the acute care system.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Chronic Kidney Disease With Increased Glucose Uptake-Associated Metabolic Activity of Visceral Adipose and Subcutaneous Adipose Tissue in Patients With Gout.","authors":"Shunya Kaneshita, Sho Fukui, Soheil Niku, Kwanghoon Lee, Ernest Belezzuoli, Robert Terkeltaub, Monica Guma","doi":"10.1002/acr.25540","DOIUrl":"10.1002/acr.25540","url":null,"abstract":"<p><strong>Objective: </strong>We evaluate the ¹⁸F-fluorodeoxyglucose positron emission tomography (PET) standardized uptake value (SUV) by PET/computed tomography (CT) scans in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in patients with and without gout. Additionally, we investigate whether glucose uptake in these tissues predicts the progression of chronic kidney disease (CKD).</p><p><strong>Methods: </strong>We used International Classification of Diseases, Tenth Revision codes from the University of California San Diego patient database to identify patients with gout and controls, forming a cohort of individuals who underwent PET/CT scans. The mean VAT and SAT maximum SUV (SUVmax) were measured using PET/CT scans and adjusted for potential confounders using inverse probability of weighting analysis. We also employed multivariable linear regression to analyze changes in estimated glomerular filtration rate (eGFR) after PET/CT scans.</p><p><strong>Results: </strong>The study included 221 patients, with 120 diagnosed with gout. After the inverse probability of weighting adjustment, the mean VAT and SAT SUVmax were higher in patients with gout (mean VAT SUVmax: β = 0.09, 95% confidence interval [CI] 0.04-0.15; mean SAT SUVmax: β = 0.06, 95% CI 0.01-0.12). Additionally, in patients with gout with CKD stage ≥3, higher mean VAT and SAT SUVmax were associated with decreased eGFR in the 5 years following PET/CT scans (mean VAT SUVmax: β = -1.76, 95% CI -3.50 to -0.01; mean SAT SUVmax: β = -2.97, 95% CI -5.61 to -0.32).</p><p><strong>Conclusion: </strong>Elevated glucose uptake-associated metabolic activity in both VAT and SAT was observed in patients with gout, which may contribute to CKD progression among patients with both gout and CKD.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring of Juvenile Idiopathic Arthritis-Associated Uveitis in Long-Term Disease Remission: Consensus-Based Recommendations From the Multinational Interdisciplinary Working Group for Uveitis in Childhood.","authors":"Ivan Foeldvari, Ameenat Solebo, Harry Petrushkin, Sheila T Angeles-Han, Regitze Bangsgaard, Joan Calzada-Hernández, Tamas Constantin, Joke de Boer, Jesus Díaz-Cascajosa, Mia Glerup, Helene Ingels, Sebastian Kramer, Elisabetta Miserocchi, Ellen Nordal, Rotraud K Saurenmann, Gabriele Simonini, Joost F Swart, Jan Titz, Jordi Antón","doi":"10.1002/acr.25542","DOIUrl":"10.1002/acr.25542","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to develop consensus-based recommendations for the monitoring of children with juvenile idiopathic arthritis-associated uveitis (JIAU) in long-term remission, addressing the absence of international guidance on monitoring schedules for these children and young people.</p><p><strong>Methods: </strong>The Multinational Interdisciplinary Working Group for Uveitis in Childhood convened experts from 10 countries, including pediatric rheumatologists and ophthalmologists, alongside parents of affected children. A review of key longitudinal cohort studies informed a structured consensus process comprising discussion, recommendation development, and voting for adoption, with a consensus threshold of ≥80% needed for adoption. Recommendation development focused on three principal questions: stratification of the risk of poor outcomes, the natural history of JIAU postremission, and the impact of delayed examination.</p><p><strong>Results: </strong>The group established several key recommendations, including a standard monitoring frequency of every 4 months for the first four years following medication cessation, ongoing assessments for patients with structural complications, and low-frequency monitoring every 6 months for those in stable, drug-free remission for over four years. There was unanimous agreement on these recommendations.</p><p><strong>Conclusion: </strong>These consensus-based recommendations provide a framework for monitoring children with JIAU in remission, enhancing the quality of care and optimizing resource use in eye health services. Ongoing research is essential to refine these guidelines as new evidence emerges regarding biomarkers and imaging techniques for disease recurrence.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}