Systemic lupus international collaborating clinics frailty index (SLICC-FI) predicts worsening health-related quality of life, data from the almenara lupus cohort.
Anubhav Singh, Rocío V Gamboa-Cárdenas, Victor Pimentel-Quiroz, Zoila Rodriguez-Bellido, Cesar Pastor-Asurza, Risto Perich-Campos, Graciela S Alarcón, Manuel Francisco Ugarte-Gil
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引用次数: 0
Abstract
Objectives: Systemic Lupus International Collaborating Clinics-Frailty Index (SLICC-FI) as a predictor of quality of life (QoL) in systemic lupus erythematosus (SLE) patients has not been evaluated longitudinally. We estimated the association of SLICC-FI scores with future QoL in our prevalent Latin American Mestizo cohort.
Methods: Patients from a single-center SLE cohort were included. Health-related (HR) QoL was ascertained with the LupusQoL and frailty with the SLICC-FI. Generalized estimating equations were performed, using each domain of the LupusQoL as an outcome in the subsequent visit, and the SLICC-FI (as a continuous variable) in the previous visit. Alternative analyses were also carried out including the SLICC-FI as a categorical variable. In both approaches, the multivariable models were adjusted for possible confounders (age at diagnosis, sex, socioeconomic status, ethnicity, SLEDAI-2K, SLICC/ACR damage index (SDI), disease duration at baseline, prednisone daily dose, antimalarial and immunosuppressive drug use, and the same domain of the LupusQoL in the previous visit).
Results: Four-hundred and twenty-eight patients and 2645 visits were included in this study and they were followed for 4.71 (3.52) years. At baseline, the mean (SD) of disease duration (years), the SDI and the SLICC-FI were 7.2 (6.6), 1.0 (1.3) and 0.17 (0.05), respectively. In the main analyses, after adjusting for possible confounders, higher SLICC-FI scores predicted a worse LupusQoL in the domains of pain, planning, emotional health and fatigue. In the alternative analyses, after adjustment, frail and least fit categories were predictive of worse LupusQoL in the domain of fatigue, and frailty predicted worse body image, compared to least fit.
Conclusion: Higher SLICC-FI scores predicted worse HRQoL as measured by the LupusQoL in patients from the Almenara lupus cohort. Our findings reinforce the prognostic value of this tool in SLE.
期刊介绍：
Arthritis Care & Research, an official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the College), is a peer-reviewed publication that publishes original research, review articles, and editorials that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with rheumatic diseases, major topics are evidence-based practice studies, clinical problems, practice guidelines, educational, social, and public health issues, health economics, health care policy, and future trends in rheumatology practice.
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