Yuting Wang, Guiyao Jin, Wenlong Wang, Fanzhang Meng, Chen Li
{"title":"A call for individualized approaches to tuberculosis screening practices among new users of biologic or targeted synthetic disease-modifying antirheumatic drugs: comment on the article by Roberts et al.","authors":"Yuting Wang, Guiyao Jin, Wenlong Wang, Fanzhang Meng, Chen Li","doi":"10.1002/acr.25534","DOIUrl":"10.1002/acr.25534","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eric T Roberts, Matthew Murrill, Gabriela Schmajuk, Jinoos Yazdany
{"title":"Reply.","authors":"Eric T Roberts, Matthew Murrill, Gabriela Schmajuk, Jinoos Yazdany","doi":"10.1002/acr.25533","DOIUrl":"10.1002/acr.25533","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C Scott
{"title":"Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review.","authors":"Natasha Cox, Saeed Farooq, Helen Twohig, Ian C Scott","doi":"10.1002/acr.25532","DOIUrl":"10.1002/acr.25532","url":null,"abstract":"<p><p>As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross-sectional data. To better understand potential causality, longitudinal studies are required. This narrative review examines the relationship between pain and depression in patients with IA participating in observational longitudinal studies (spanning association strengths, direction of effect, and causal factors) and summarizes the literature on causal pathways in general populations alongside guideline recommendations/systematic reviews on assessing pain/depression in IA. Fourteen longitudinal studies in IA largely indicate an association between pain and depression, albeit with a small-to-modest effect size and a focus on pain intensity. This relationship appears to be bidirectional. Evidence on causal pathways is sparse in IA and limited in non-IA populations (with structural/function brain changes, altered sensory/pain thresholds, and sleep disturbance implicated) highlighting a need for further research. Although many patient-reported outcome measures exist to assess pain and depression in IA, evidence for their psychometric properties is often limited, and IA guidelines offer incomplete advice on pain/depression assessment. A simple approach of using a single-item pain intensity score (eg, a Numeric Rating Scale, which has strong clinimetric properties) in routine IA consultations, with screening for depression where relevant, appears appropriate. Further research is needed to understand how this could be achieved in different health care settings.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Ahmed, Gail Kerr, Hans J Moore, Janani Rangaswami, Charles Faselis, Richard M Allman
{"title":"Withholding acetaminophen for older adults with osteoarthritis? Not so fast: comment on the article by Kaur et al.","authors":"Ali Ahmed, Gail Kerr, Hans J Moore, Janani Rangaswami, Charles Faselis, Richard M Allman","doi":"10.1002/acr.25538","DOIUrl":"10.1002/acr.25538","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa R Sammaritano, Anca Askanase, Bonnie L Bermas, Maria Dall'Era, Alí Duarte-García, Linda T Hiraki, Brad H Rovin, Mary Beth F Son, Anthony Alvarado, Cynthia Aranow, April Barnado, Anna Broder, Hermine I Brunner, Vaidehi Chowdhary, Gabriel Contreras, Christele Felix, Elizabeth D Ferucci, Keisha L Gibson, Aimee O Hersh, Peter M Izmirly, Kenneth Kalunian, Diane Kamen, Brandi Rollins, Benjamin J Smith, Asha Thomas, Homa Timlin, Daniel J Wallace, Michael Ward, Muayad Azzam, Christie M Bartels, Joanne S Cunha, Kimberly DeQuattro, Andrea Fava, Gabriel Figueroa-Parra, Shivani Garg, Jessica Greco, Maria C Cuéllar-Gutiérrez, Priyanka Iyer, Andrew S Johannemann, April Jorge, Shanthini Kasturi, Hassan Kawtharany, Jana Khawandi, Kyriakos A Kirou, Alexandra Legge, Kelly V Liang, Megan M Lockwood, Alain Sanchez-Rodriguez, Marat Turgunbaev, Jessica N Williams, Amy S Turner, Reem A Mustafa
{"title":"2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis.","authors":"Lisa R Sammaritano, Anca Askanase, Bonnie L Bermas, Maria Dall'Era, Alí Duarte-García, Linda T Hiraki, Brad H Rovin, Mary Beth F Son, Anthony Alvarado, Cynthia Aranow, April Barnado, Anna Broder, Hermine I Brunner, Vaidehi Chowdhary, Gabriel Contreras, Christele Felix, Elizabeth D Ferucci, Keisha L Gibson, Aimee O Hersh, Peter M Izmirly, Kenneth Kalunian, Diane Kamen, Brandi Rollins, Benjamin J Smith, Asha Thomas, Homa Timlin, Daniel J Wallace, Michael Ward, Muayad Azzam, Christie M Bartels, Joanne S Cunha, Kimberly DeQuattro, Andrea Fava, Gabriel Figueroa-Parra, Shivani Garg, Jessica Greco, Maria C Cuéllar-Gutiérrez, Priyanka Iyer, Andrew S Johannemann, April Jorge, Shanthini Kasturi, Hassan Kawtharany, Jana Khawandi, Kyriakos A Kirou, Alexandra Legge, Kelly V Liang, Megan M Lockwood, Alain Sanchez-Rodriguez, Marat Turgunbaev, Jessica N Williams, Amy S Turner, Reem A Mustafa","doi":"10.1002/acr.25528","DOIUrl":"10.1002/acr.25528","url":null,"abstract":"<p><strong>Objective: </strong>The objective is to provide evidence-based and expert guidance for the screening, treatment, and management of lupus nephritis.</p><p><strong>Methods: </strong>The Core Team developed clinical questions for screening, treatment, and management of lupus nephritis using the PICO format (population, intervention, comparator, and outcome). Systematic literature reviews were completed for each PICO question, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to assess the quality of evidence and to formulate recommendations. The Voting Panel achieved a consensus ≥70% on the direction (for or against) and strength (strong or conditional) of each recommendation.</p><p><strong>Results: </strong>We present 28 graded recommendations (7 strong, 21 conditional) and 13 ungraded, consensus-based good practice statements for the screening and management of lupus nephritis. Our recommendations focus on the unifying principle that lupus nephritis therapy is continuous and ongoing, rather than consisting of discrete induction/initial and maintenance/subsequent therapies. Therapy should include pulse glucocorticoids followed by oral glucocorticoid taper and two additional immunosuppressive agents for 3-5 years for those achieving complete renal response.</p><p><strong>Conclusion: </strong>This guideline provides direction for clinicians regarding screening and treatment decisions for management of lupus nephritis. These recommendations should not be used to limit or deny access to therapies, as treatment decisions may vary due to the unique clinical situation and personal preferences of each individual patient.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Astia Allenzara, Kathleen Bush, M Elaine Husni, Soumya M Reddy, Jose U Scher, Ethan Craig, Joelle Koplin, Jessica A Walsh, Alexis Ogdie
{"title":"Diverse Treatment Goals in Psoriatic Arthritis: Insights From Participants in the PARC Cohort.","authors":"Astia Allenzara, Kathleen Bush, M Elaine Husni, Soumya M Reddy, Jose U Scher, Ethan Craig, Joelle Koplin, Jessica A Walsh, Alexis Ogdie","doi":"10.1002/acr.25527","DOIUrl":"10.1002/acr.25527","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine patient-reported treatment goals among individuals with psoriatic arthritis.</p><p><strong>Methods: </strong>Participants in the Psoriatic Arthritis Research Consortium completed standardized assessments, including patient-reported outcome (PROs) instruments, between 2017 and 2020. Additionally, participants were asked two open-ended questions at enrollment or therapy initiation to identify patients' top improvement priority and their treatment impact goals, respectively: \"If you could improve one thing about your disease, what would it be?\" and \"What would an effective treatment change for you?\" We categorized each response into a theme. The themes were matched to constructs measured by PRO items (ie, pain, fatigue, skin, etc). We describe themes and scores from matched PRO items.</p><p><strong>Results: </strong>Assessments were completed by 193 participants. Decreasing pain (56%) and improving skin (12%) were the most common improvement priorities. Impact goals were more diverse and included decreasing pain (24%), general improvement in life (18%), and the ability to be more active (15%), participate in recreational activities (9%), function at work (11%), and exercise (5%). Of note, responses were often matched to more than one PRO item or instrument. The scores for PRO items that matched the patient's improvement priority or the impact goal were higher than scores for the remainder of the population (ie, fatigue item scores were higher among individuals identifying fatigue as their improvement priority).</p><p><strong>Conclusion: </strong>The heterogeneity of treatment goals underscores the importance of eliciting patient treatment goals to guide personalized management. Specific items within PROs may be helpful in identifying and following patient-specific treatment goals.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lower environmental temperature and higher relative humidity had significant associations with worsened Raynaud phenomenon in systemic sclerosis: comment on the article by Taylor et al.","authors":"Gang Wang, Zhichun Liu","doi":"10.1002/acr.25529","DOIUrl":"10.1002/acr.25529","url":null,"abstract":"","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johanna M Borst, Severin Ruoss, Ian Palmer, Trevor Smith, Kenneth Kalunian, Samuel R Ward
{"title":"Placebo Effect Sizes in Clinical Trials of Knee Osteoarthritis Using Intra-Articular Injections of Biologic Agents.","authors":"Johanna M Borst, Severin Ruoss, Ian Palmer, Trevor Smith, Kenneth Kalunian, Samuel R Ward","doi":"10.1002/acr.25526","DOIUrl":"10.1002/acr.25526","url":null,"abstract":"<p><strong>Objective: </strong>Patients with knee osteoarthritis rely on symptomatic treatments, in which up to 75% of the pain reduction can be attributed to the placebo effect. This effect may vary based on treatment type (eg, biologics vs nonbiologic injection) and route of administration (eg, intra-articular vs topical vs oral). The placebo effect is an integral part of treatment effect size calculation; thus, network analyses comparing efficacies of different treatments may be inaccurate. The objective of this study was to test the hypothesis that placebo effects differ between treatment types and route of delivery.</p><p><strong>Methods: </strong>A systematic literature search was conducted in August 2019. Randomized trials comparing pain outcomes of oral, topical, or intra-articular placebo interventions to active treatments were included. The outcome measure of interest was change in pain scores from baseline. Data were stratified by length of follow-up and treatment subcategory.</p><p><strong>Results: </strong>A total of 129 articles were included with 9,218 patients receiving placebo treatments. Reduction in pain from baseline occurred in 93% of the subcategory data points. Biologic intra-articular placebo injections had the greatest pain reduction at one month (mean ± SD visual analog scale -32.2 ± 24.6; mean ± SD Western Ontario and McMaster Universities Arthritis Index -16.3 ± 3.81). At one month and two months, placebo intra-articular injections had a greater pain reduction than oral placeboes (P ≤ 0.01).</p><p><strong>Conclusion: </strong>The robust placebo effect is influenced by the active treatment category and changes over time. The variation in placebo response despite analogous placebo methodologies implies using network meta-analyses to compare treatments from different active treatment categories by evaluating the change from placebo is inaccurate.</p>","PeriodicalId":8406,"journal":{"name":"Arthritis Care & Research","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}