Gláucia Maria Moraes de Oliveira, Ricardo Fontes-Carvalho, Nuno Cardim, Carlos Eduardo Rochitte
{"title":"The Best Articles of 2022 in the Arquivos Brasileiros de Cardiologia and Revista Portuguesa de Cardiologia.","authors":"Gláucia Maria Moraes de Oliveira, Ricardo Fontes-Carvalho, Nuno Cardim, Carlos Eduardo Rochitte","doi":"10.36660/abc.20230342","DOIUrl":"10.36660/abc.20230342","url":null,"abstract":"","PeriodicalId":8399,"journal":{"name":"Arquivos Brasileiros de Cardiologia","volume":"120 7","pages":"e20230342"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10548710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic Value of Three-Dimensional Speckle Tracking Imaging Strain Parameters for Detection of Cancer Chemotherapy-Related Cardiac Dysfunction: A Meta-Analysis.","authors":"Yingying Guan","doi":"10.36660/abc.20220370","DOIUrl":"https://doi.org/10.36660/abc.20220370","url":null,"abstract":"<p><strong>Background: </strong>Chemotherapeutic agents (e.g., anthracyclines, trastuzumab) commonly used for treating malignant tumors have been demonstrated to have cardiotoxic effects, which is associated with poor prognosis. Three-dimensional echocardiography has been used to predict cancer chemotherapy-induced cardiac dysfunction.</p><p><strong>Objectives: </strong>Evaluation of the diagnostic performance of strain parameters, global area strain (GAS), longitudinal strain (GLS), circumferential strain (GCS), and radial strain (GRS) by meta-analysis.</p><p><strong>Methods: </strong>Relevant studies were searched from the Embase, PubMed, and Web of Science databases. Statistical analysis was performed using Stata 12. The summary receiver operating characteristic curve, sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and corresponding 95% confidence interval for the four strain parameters were pooled. P<0.05 was considered statistically significant.</p><p><strong>Results: </strong>Nine studies involving 650 participants were included. GAS and GLS showed significant diagnostic advantages over GCS and GRS. For GAS, the sensitivity was 0.85 (0.70, 0.93) and specificity was 0.82(0.78, 0.86) with PLR of 4.76 (3.55, 6.39) and NLR of 0.18 (0.09, 0.39) and an area under the curve (AUC) of 0.85 (0.82, 0.88). For GLS, the sensitivity was 0.81 (0.74, 0.86) and specificity was 0.81(0.68, 0.90) with PLR of 4.35(2.42, 7.80) and NLR of 0.23 (0.17, 0.33) and an AUC of 0.85 (0.82, 0.88). The GCS showed a sensitivity of 0.63 and a specificity of 0.79 with an AUC of 0.77. The GRS showed a sensitivity of 0.74 and a specificity of 0.66 with an AUC of 0.73.</p><p><strong>Conclusion: </strong>3D-STI strain parameters GAS and GLS showed good performance in detecting early cardiac dysfunction in patients with tumors receiving chemotherapy.</p>","PeriodicalId":8399,"journal":{"name":"Arquivos Brasileiros de Cardiologia","volume":"120 8","pages":"e20220370"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10548685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manoel Ângelo Gomes Palácio, Edison Ferreira de Paiva, Gustavo Bernardes de Figueiredo Oliveira, Luciano César Pontes de Azevedo, Bruno Gregnanin Pedron, Elizabete Silva Dos Santos, Ari Timerman
{"title":"Use of a Portable Mechanical Ventilator during Cardiopulmonary Resuscitation is Feasible, Improves Respiratory Parameters, and Prevents the Decrease of Dynamic Lung Compliance.","authors":"Manoel Ângelo Gomes Palácio, Edison Ferreira de Paiva, Gustavo Bernardes de Figueiredo Oliveira, Luciano César Pontes de Azevedo, Bruno Gregnanin Pedron, Elizabete Silva Dos Santos, Ari Timerman","doi":"10.36660/abc.20220564","DOIUrl":"10.36660/abc.20220564","url":null,"abstract":"<p><strong>Background: </strong>For practical and protective ventilation during cardiopulmonary resuscitation (CPR), a 150-grams mechanical ventilator (VLP2000E) that limits peak inspiratory pressure (PIP) during simultaneous ventilation with chest compressions was developed.</p><p><strong>Objectives: </strong>To evaluate the feasibility of VLP2000E ventilation during CPR and to compare monitored parameters versus bag-valve ventilation.</p><p><strong>Methods: </strong>A randomized experimental study with 10 intubated pigs per group. After seven minutes of ventricular fibrillation, 2-minute CPR cycles were delivered. All animals were placed on VLP2000E after achieving return of spontaneous circulation (ROSC).</p><p><strong>Results: </strong>Bag-valve and VLP2000E groups had similar ROSC rate (60% vs. 50%, respectively) and arterial oxygen saturation in most CPR cycles, different baseline tidal volume [0.764 (0.068) vs. 0.591 (0.123) L, p = 0.0309, respectively] and, in 14 cycles, different PIP [52 (9) vs. 39 (5) cm H2O, respectively], tidal volume [0.635 (0.172) vs. 0.306 (0.129) L], ETCO2[14 (8) vs. 27 (9) mm Hg], and peak inspiratory flow [0.878 (0.234) vs. 0.533 (0.105) L/s], all p < 0.0001. Dynamic lung compliance (≥ 0.025 L/cm H2O) decreased after ROSC in bag-valve group but was maintained in VLP2000E group [0.019 (0.006) vs. 0.024 (0.008) L/cm H2O, p = 0.0003].</p><p><strong>Conclusions: </strong>VLP2000E ventilation during CPR is feasible and equivalent to bag-valve ventilation in ROSC rate and arterial oxygen saturation. It produces better respiratory parameters, with lower airway pressure and tidal volume. VLP2000E ventilation also prevents the significant decrease of dynamic lung compliance observed after bag-valve ventilation. Further preclinical studies confirming these findings would be interesting.</p>","PeriodicalId":8399,"journal":{"name":"Arquivos Brasileiros de Cardiologia","volume":"120 7","pages":"e20220564"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10176188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Antonio Marin-Neto, Anis Rassi, Gláucia Maria Moraes Oliveira, Luís Claudio Lemos Correia, Alberto Novaes Ramos Júnior, Alejandro Ostermayer Luquetti, Alejandro Marcel Hasslocher-Moreno, Andréa Silvestre de Sousa, Angelo Amato Vincenzo de Paola, Antônio Carlos Sobral Sousa, Antonio Luiz Pinho Ribeiro, Dalmo Correia Filho, Dilma do Socorro Moraes de Souza, Edecio Cunha-Neto, Felix Jose Alvarez Ramires, Fernando Bacal, Maria do Carmo Pereira Nunes, Martino Martinelli Filho, Maurício Ibrahim Scanavacca, Roberto Magalhães Saraiva, Wilson Alves de Oliveira Júnior, Adalberto Menezes Lorga-Filho, Adriana de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Alvaro Valentim Lima Sarabanda, Ana Yecê das Neves Pinto, Andre Assis Lopes do Carmo, Andre Schmidt, Andréa Rodrigues da Costa, Barbara Maria Ianni, Brivaldo Markman Filho, Carlos Eduardo Rochitte, Carolina Thé Macêdo, Charles Mady, Christophe Chevillard, Cláudio Marcelo Bittencourt das Virgens, Cleudson Nery de Castro, Constança Felicia De Paoli de Carvalho Britto, Cristiano Pisani, Daniela do Carmo Rassi, Dário Celestino Sobral Filho, Dirceu Rodrigues de Almeida, Edimar Alcides Bocchi, Evandro Tinoco Mesquita, Fernanda de Souza Nogueira Sardinha Mendes, Francisca Tatiana Pereira Gondim, Gilberto Marcelo Sperandio da Silva, Giselle de Lima Peixoto, Gustavo Glotz de Lima, Henrique Horta Veloso, Henrique Turin Moreira, Hugo Bellotti Lopes, Ibraim Masciarelli Francisco Pinto, João Marcos Bemfica Barbosa Ferreira, João Paulo Silva Nunes, José Augusto Soares Barreto-Filho, José Francisco Kerr Saraiva, Joseli Lannes-Vieira, Joselina Luzia Menezes Oliveira, Luciana Vidal Armaganijan, Luiz Cláudio Martins, Luiz Henrique Conde Sangenis, Marco Paulo Tomaz Barbosa, Marcos Antonio Almeida-Santos, Marcos Vinicius Simões, Maria Aparecida Shikanai Yasuda, Maria da Consolação Vieira Moreira, Maria de Lourdes Higuchi, Maria Rita de Cassia Costa Monteiro, Mauro Felippe Felix Mediano, Mayara Maia Lima, Maykon Tavares de Oliveira, Minna Moreira Dias Romano, Nadjar Nitz Silva Lociks de Araujo, Paulo de Tarso Jorge Medeiros, Renato Vieira Alves, Ricardo Alkmim Teixeira, Roberto Coury Pedrosa, Roque Aras Junior, Rosalia Morais Torres, Rui Manoel Dos Santos Povoa, Sergio Gabriel Rassi, Silvia Marinho Martins Alves, Suelene Brito do Nascimento Tavares, Swamy Lima Palmeira, Telêmaco Luiz da Silva Júnior, Thiago da Rocha Rodrigues, Vagner Madrini Junior, Veruska Maia da Costa Brant, Walderez Ornelas Dutra, João Carlos Pinto Dias
{"title":"SBC Guideline on the Diagnosis and Treatment of Patients with Cardiomyopathy of Chagas Disease - 2023.","authors":"José Antonio Marin-Neto, Anis Rassi, Gláucia Maria Moraes Oliveira, Luís Claudio Lemos Correia, Alberto Novaes Ramos Júnior, Alejandro Ostermayer Luquetti, Alejandro Marcel Hasslocher-Moreno, Andréa Silvestre de Sousa, Angelo Amato Vincenzo de Paola, Antônio Carlos Sobral Sousa, Antonio Luiz Pinho Ribeiro, Dalmo Correia Filho, Dilma do Socorro Moraes de Souza, Edecio Cunha-Neto, Felix Jose Alvarez Ramires, Fernando Bacal, Maria do Carmo Pereira Nunes, Martino Martinelli Filho, Maurício Ibrahim Scanavacca, Roberto Magalhães Saraiva, Wilson Alves de Oliveira Júnior, Adalberto Menezes Lorga-Filho, Adriana de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Alvaro Valentim Lima Sarabanda, Ana Yecê das Neves Pinto, Andre Assis Lopes do Carmo, Andre Schmidt, Andréa Rodrigues da Costa, Barbara Maria Ianni, Brivaldo Markman Filho, Carlos Eduardo Rochitte, Carolina Thé Macêdo, Charles Mady, Christophe Chevillard, Cláudio Marcelo Bittencourt das Virgens, Cleudson Nery de Castro, Constança Felicia De Paoli de Carvalho Britto, Cristiano Pisani, Daniela do Carmo Rassi, Dário Celestino Sobral Filho, Dirceu Rodrigues de Almeida, Edimar Alcides Bocchi, Evandro Tinoco Mesquita, Fernanda de Souza Nogueira Sardinha Mendes, Francisca Tatiana Pereira Gondim, Gilberto Marcelo Sperandio da Silva, Giselle de Lima Peixoto, Gustavo Glotz de Lima, Henrique Horta Veloso, Henrique Turin Moreira, Hugo Bellotti Lopes, Ibraim Masciarelli Francisco Pinto, João Marcos Bemfica Barbosa Ferreira, João Paulo Silva Nunes, José Augusto Soares Barreto-Filho, José Francisco Kerr Saraiva, Joseli Lannes-Vieira, Joselina Luzia Menezes Oliveira, Luciana Vidal Armaganijan, Luiz Cláudio Martins, Luiz Henrique Conde Sangenis, Marco Paulo Tomaz Barbosa, Marcos Antonio Almeida-Santos, Marcos Vinicius Simões, Maria Aparecida Shikanai Yasuda, Maria da Consolação Vieira Moreira, Maria de Lourdes Higuchi, Maria Rita de Cassia Costa Monteiro, Mauro Felippe Felix Mediano, Mayara Maia Lima, Maykon Tavares de Oliveira, Minna Moreira Dias Romano, Nadjar Nitz Silva Lociks de Araujo, Paulo de Tarso Jorge Medeiros, Renato Vieira Alves, Ricardo Alkmim Teixeira, Roberto Coury Pedrosa, Roque Aras Junior, Rosalia Morais Torres, Rui Manoel Dos Santos Povoa, Sergio Gabriel Rassi, Silvia Marinho Martins Alves, Suelene Brito do Nascimento Tavares, Swamy Lima Palmeira, Telêmaco Luiz da Silva Júnior, Thiago da Rocha Rodrigues, Vagner Madrini Junior, Veruska Maia da Costa Brant, Walderez Ornelas Dutra, João Carlos Pinto Dias","doi":"10.36660/abc.20230269","DOIUrl":"10.36660/abc.20230269","url":null,"abstract":"","PeriodicalId":8399,"journal":{"name":"Arquivos Brasileiros de Cardiologia","volume":"120 6","pages":"e20230269"},"PeriodicalIF":2.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10177940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Telecardiology and its Potential in Remote Areas.","authors":"Simone Farah","doi":"10.36660/abc.20230281","DOIUrl":"https://doi.org/10.36660/abc.20230281","url":null,"abstract":"","PeriodicalId":8399,"journal":{"name":"Arquivos Brasileiros de Cardiologia","volume":"120 5","pages":"e20230281"},"PeriodicalIF":2.6,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10051286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving Outcomes of Patients with Acute Coronary Disease in Real Life: The Case of Applying in Practice What We Already Know from Clinical Studies.","authors":"Stefano Garzon, Pedro A Lemos","doi":"10.36660/abc.20230283","DOIUrl":"https://doi.org/10.36660/abc.20230283","url":null,"abstract":"","PeriodicalId":8399,"journal":{"name":"Arquivos Brasileiros de Cardiologia","volume":"120 5","pages":"e20230283"},"PeriodicalIF":2.6,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9672747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Auricular Vagus Nerve Stimulation in Heart Failure: Critical Analysis and Future Perspectives.","authors":"Denise Tessariol Hachul","doi":"10.36660/abc.20230298","DOIUrl":"10.36660/abc.20230298","url":null,"abstract":"Short Editorial related to the article: Auricular Vagal Neuromodulation and its Application in Patients with Heart Failure and Reduced Ejection Fraction","PeriodicalId":8399,"journal":{"name":"Arquivos Brasileiros de Cardiologia","volume":"120 5","pages":"e20230298"},"PeriodicalIF":2.6,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10046966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victoria B Milan, Yasmin F S Alves, Guilherme P Machado, Gustavo Neves de Araujo, Ana Maria Krepsky, Angelo Chies, Matheus Niches, Julia Fracasso, Sandro Cadaval Goncalves, Marco Wainstein, Carisi Anne Polanczyk
{"title":"Sex Differences in Outcomes of ST Elevation Myocardial Infarction Patients Submitted to Primary Percutaneous Coronary Intervention.","authors":"Victoria B Milan, Yasmin F S Alves, Guilherme P Machado, Gustavo Neves de Araujo, Ana Maria Krepsky, Angelo Chies, Matheus Niches, Julia Fracasso, Sandro Cadaval Goncalves, Marco Wainstein, Carisi Anne Polanczyk","doi":"10.36660/abc.20220673","DOIUrl":"10.36660/abc.20220673","url":null,"abstract":"<p><strong>Background: </strong>Several studies have shown that women are usually undertreated and have worse outcomes after ST-segment elevation myocardial infarction (STEMI), hence the need to investigate questions related to sex in Brazil to better deal with the problem.</p><p><strong>Objective: </strong>To determine whether female sex is still associated with adverse events in a contemporary cohort of patients with STEMI undergoing primary percutaneous coronary intervention (pPCI).</p><p><strong>Methods: </strong>This was a prospective cohort study of STEMI patients submitted to pPCI in a tertiary university hospital between March 2011 and December 2021. Patients were categorized into groups based on their sex at birth. The primary clinical outcome was long-term MACCE. Patients were followed-up for up to five years. All hypothesis tests had a two-sided significance level of 0.05.</p><p><strong>Results: </strong>Among 1457 patients admitted with STEMI in the study period, 1362 were included and 468 (34.4%) were women. Female patients had a higher prevalence of hypertension (73% vs. 60%, p <0.001), diabetes (32% vs. 25%, p=0.003) and Killip class 3-4 at hospital admission (17% vs. 12%, p=0.01); TIMI risk score was higher among women (4 [2, 6] vs. 3 [2, 5], p<0.001). In-hospital mortality was not different between groups (12.8% vs. 10.5%, p=0.20). In-hospital MACCE (16.0% vs. 12.6%, p=0.085) and long-term MACCE (28.7% vs. 24.4%, p=0.089) were numerically higher in women, with borderline significance. After multivariate analysis, female sex was not associated with MACCE (HR = 1.14; 95% CI 0.86 - 1.51; p = 0.36).</p><p><strong>Conclusion: </strong>In a prospective cohort of STEMI patients submitted to pPCI, female patients were older and had more comorbidities at baseline, but no significant differences were found in terms of long-term adverse outcomes.</p>","PeriodicalId":8399,"journal":{"name":"Arquivos Brasileiros de Cardiologia","volume":"120 6","pages":"e20220673"},"PeriodicalIF":2.6,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10263405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10174593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metabolic and Inflammatory Relationship between Covid-19 and Non-HDL-C.","authors":"Renato Jorge Alves","doi":"10.36660/abc.20230304","DOIUrl":"https://doi.org/10.36660/abc.20230304","url":null,"abstract":"Correspondência: Renato Jorge Alves • Irmandade da Santa Casa de Misericórdia de São Paulo – Departamento de Medicina Rua Cesário Motta Jr, 112. CEP 04126-000, São Paulo, SP – Brasil E-mail: renatoalves178@gmail.com Palavras-chave Betacoronavirus/fisiologia; COVID-19/metabolismo; Pneumonia, Viral/transmissão; Não HDL-C; Aterosclerose; Doença Inflamatória; Lipoproteínas LDL/metabolismo O estudo “Valor prognóstico do colesterol não HDL na pneumonia por COVID-19” avaliou o valor preditivo do colesterol de lipoproteína não de alta densidade (não-HDL-C) em pacientes com SARS-CoV-2 para mortalidade na infecção por Covid-19. Os autores incluíram 1.435 pacientes entre janeiro de 2020 e junho de 2022. Os resultados mostraram que idade, proteína C-reativa e DHL estavam positivamente correlacionados com não HDL-C, e o grupo não sobrevivente era mais velho.1 Esses resultados corroboram os resultados dos estudos que demonstram que vários biomarcadores poderiam ser usados como valor preditivo para prognóstico e mortalidade na doença Covid-19.2 O não-HDL-C representa uma carga total de lipoproteínas aterogênicas, como LDL-C, VLDL-C, IDL-C, Lp(a) e remanescente de quilomícron.3 Pode ser usado como um preditor de risco, mesmo em amostras sem jejum, quando os triglicerídeos aumentam. Por outro lado, as infecções por COVID-19 diminuem os níveis de colesterol total, LDL-C, HDL-C e apolipoproteína AI, A-II e B, enquanto os níveis de triglicerídeos podem estar normais ou aumentados. O grau de redução do colesterol total, LDL-C, HDL-C e apolipoproteína AI poderia ser preditivo de mortalidade. Níveis reduzidos de HDL-C e apolipoproteína AI avaliados antes de infecções por COVID-19 estariam associados a um risco aumentado de infecções graves por Covid-19, enquanto níveis de LDL-C, apolipoproteína B, Lp (a) e triglicerídeos não estariam. As infecções por Covid-19 alteram os níveis de lipídios e lipoproteínas, e os níveis de HDL-C podem afetar o risco de desenvolver infecções por Covid-19.4 Curiosamente, a carga aterosclerótica de não-HDL-C estaria ligada a doenças inflamatórias e hipertrigliceridemia.5 Além disso, várias doenças inflamatórias crônicas (síndrome metabólica, psoríase, vírus da imunodeficiência humana, hepatoesteatose não alcoólica e síndrome da apneia obstrutiva do sono) estariam associadas à aterosclerose subclínica e maior risco cardiovascular.6-11 Vale ressaltar que os baixos níveis de HDL-C estão relacionados observacionalmente e geneticamente a riscos aumentados de doenças infecciosas, morte durante sepse, diabetes mellitus e doença renal crônica. Dados observacionais indicam associações de baixo HDL-C com várias doenças autoimunes, cânceres e mortalidade por todas as causas.12 A relação entre não-HDL-C e Covid-19 parece existir.","PeriodicalId":8399,"journal":{"name":"Arquivos Brasileiros de Cardiologia","volume":"120 6","pages":"e20230304"},"PeriodicalIF":2.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10233375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}