Applied Organometallic Chemistry最新文献

{"title":"Multi-Nodal Cobalt-Based MOF as a Photocatalyst for Efficient Antibiotic Degradation in Aqueous Environments","authors":"Lei Bao,&nbsp;Mithun Kumar Ghosh,&nbsp;Yun-Fei Ma,&nbsp;Jun-Cheng Jin,&nbsp;Mohd. Muddassir,&nbsp;Tanmay Kumar Ghorai,&nbsp;Xu-Cheng Fu","doi":"10.1002/aoc.70098","DOIUrl":"https://doi.org/10.1002/aoc.70098","url":null,"abstract":"<div>\u0000 \u0000 <p>A new metal–organic framework (MOF) {[NH₂(CH₃)₂][Co₅(BTC)₃(OAC)₂ (DMA)₂]_n·1.25DMA·2.25H₂O} (<b>1</b>), has been synthesized and characterized. The thermal stability, optical properties and photocatalytic activity of <b>1</b> were also evaluated. Thermogravimetric analysis revealed stable thermal behaviour up to 172°C, while UV–visible spectroscopy indicated an optical band gap of 1.6 eV, suggesting semiconducting properties. Photocatalytic tests demonstrated efficient degradation of antibiotic pollutants under UV light, with optimal performance in degrading Ornidazole (ODZ) at 40 ppm and 5 mg/L photocatalyst dosage, achieving a degradation efficiency of 83.69%. Reusability tests showed stable photocatalytic performance over multiple cycles. Additionally, the photocatalytic activity of <b>1</b> was assessed in different water mediums, and its performance was affected by the presence of common inorganic anions, highlighting its potential for environmental remediation applications.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Trend to Introduce a Biocompatible Drug Carrier Based on Immunoglobulin for Prolonged Release of Palladium (II) Complex as an Anticancer Agent: Drug Release and Cytotoxicity Assessment","authors":"Maryam Saeidifar,&nbsp;Hamid Reza Mirzaei,&nbsp;Ghazaleh Rahimi,&nbsp;Robert Macgregor,&nbsp;Seyed Mojtaba Daghighi","doi":"10.1002/aoc.70020","DOIUrl":"https://doi.org/10.1002/aoc.70020","url":null,"abstract":"<div>\u0000 \u0000 <p>Severe side effects and low chemotherapy efficacy remain challenges in cancer treatment. Therefore, this research is aimed at investigating a colloidal drug nanocarrier based on immunoglobulin nanoparticles (IgGNPs) for sustained release of an anticancer agent. A novel palladium (II) complex (PBD) loaded to IgGNPs and its formation (PBD@IgGNP) was characterized by FTIR, DLS, and AFM techniques. The size of designed system was 797 ± 121 nm, with a particle size distribution and surface charge greater than those of IgGNP indicating the conjugation of PBD and IgGNP. The release behavior indicated that 33.66% of PBD and 12.76% of encapsulated PBD in IgGNP were released at 579 h, while carboplatin was completely released at 216 h. The release mechanism followed Korsmeyer–Peppas model and non-Fickian law. Other kinetic parameters of the release are also presented. Furthermore, MTT assay showed that IC₅₀ values of PBD and PBD@IgGNP on breast cancer cells, 4T1, were 0.75 mM while 78% of the cells were viable at the same concentration of carboplatin. DAPI, AO/EB, and PCR staining indicated that the apoptotic induction of PBD@IgGNP was greater than PBD. Moreover, in vivo results confirmed the apoptotic induction and inhibition of tumor growth in the presence of PBD@IgGNP. These valuable achievements proposed a potential nanocarrier to increase the apoptotic induction and effectiveness of anticancer drugs and decrease their side effects.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ag Nanoparticles Containing Ocimum basilicum Leaf Extract on Complete Freund Adjuvant-Induced Arthritis and Methyl Prednisolone Sodium Succinate-Induced Osteoporosis in Rats","authors":"Qiang Li,&nbsp;Zigang Wu,&nbsp;Fengkun Ji,&nbsp;Sara Amirpour Amraii,&nbsp;Mika Sillanpää,&nbsp;Chenyang Liu","doi":"10.1002/aoc.70061","DOIUrl":"https://doi.org/10.1002/aoc.70061","url":null,"abstract":"<div>\u0000 \u0000 <p>In the current research, we developed and formulated an innovative therapeutic agent utilizing silver nanoparticles infused with the <i>Ocimum basilicum</i> leaves, aimed at addressing arthritis and osteoporosis. The AgNPs characterization was conducted using techniques such as field emission-scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), ultraviolet–visible spectroscopy (UV–Vis), and transmission electron microscopy (TEM). The distinct peak observed at 448 nm in the UV–Vis spectrum indicated the successful formation of silver nanoparticles. Furthermore, the TEM and FE-SEM images revealed that these NPs were predominantly spherical (10–50 nm). The potential for anti-osteoarthritic activity was assessed in vitro through protein denaturation methods involving egg albumin and bovine serum albumin, as well as membrane stabilization techniques, utilizing several concentrations (1–1000 μg/mL). In vivo evaluations were conducted using formaldehyde, CFA, and turpentine oil models at several doses. Additionally, the in vitro antioxidant capacity was evaluated through a reducing power assay. The findings demonstrated concentration-dependent inhibition of albumin denaturation, along with significant stabilization of RBC membranes, with optimal results achieved at 1000 μg/mL. Similarly, the nanoparticles demonstrated the anti-osteoarthritic effect with the highest activity noted at 1 mg/kg. The CFA model findings indicated a more pronounced protective efficacy against osteoarthritic lesions and changes in body weight. Furthermore, silver NPs reduced significantly rheumatoid parameters levels, ameliorated the altered hematological factors, and positively influenced both histopathological and radiographic alterations. Additionally, silver nanoparticles showed strong antioxidant qualities. In Wistar rats, osteoporosis was induced by the combination of MPSC (10 mg/kg, subcutaneously, three times a week for 4 weeks) and silver nanoparticles (5 μg/kg/day, oral, for 30 days). This treatment led to an elevation in serum levels of markers associated with bone mineral content, while simultaneously causing a reduction in both urinary and serum levels of bone resorption markers indicative. An increase in the tibia and femur strength was reported, especially at 5 μg/kg of silver NPs. The mechanisms by which silver nanoparticles may counteract glucocorticoid-induced osteoporosis likely include calcium homeostasis regulation, collagen synthesis, and free radicals neutralization. Collectively, these findings endorse the conventional application of silver nanoparticles as effective agents against osteoarthritis and osteoporosis in humans.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective and Rapid Pb (II) Adsorption by Core–Shell Zinc-Glutamate-MOF @Bth-TFPOT-COF: Thermodynamic and Kinetic Insights","authors":"Mahmoud Zare-Shahi,&nbsp;Mohsen Dehghani Ghanatghestani,&nbsp;Farid Moeinpour,&nbsp;Hossein Parvaresh","doi":"10.1002/aoc.70092","DOIUrl":"https://doi.org/10.1002/aoc.70092","url":null,"abstract":"<div>\u0000 \u0000 <p>Effectively reclaiming Pb (II) adsorbents is crucial for tackling environmental pollution. Metal–organic framework (MOF) and covalent organic framework (COF) composites, with their multiple functional groups, are anticipated to show outstanding Pb (II) adsorption capabilities. Nevertheless, creating and developing COF and MOF composite adsorbents for highly efficient Pb (II) removal remains a challenge. In this study, we synthesized a core–shell ZnGlu@Bth-TFPOT-COF (referred to as M@C) adsorbent via Schiff base reaction. Adsorbent demonstrated remarkable properties, including excellent durability, specificity, and straightforward solid–liquid separation. Under 298 K and pH 6.0 conditions, M@C effectively adsorbed Pb (II) and achieved 49.40 mg/g adsorption capacity within 15 min. Remarkably, it effectively eliminated Pb (II) from a solution containing multiple ions, demonstrating an adsorption efficiency of 99.80% and a <i>K</i>_<i>d</i> (partition coefficient) of 4.99 × 10⁶ mL/g in the presence of 10 other ions. The adsorption process was controlled by the Freundlich isotherm model, and the pseudo-second-order kinetic model validated that multilayer chemisorption was the mechanism for removing Pb (II). A thermodynamic study showed that the removal process was both spontaneous and exothermic. M@C exhibited outstanding adsorption performance, achieving a capacity of 476.19 mg/g, and demonstrated exceptional selectivity. This makes it an excellent material for the efficient and selective removal of Pb (II).</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Biological Evaluation, and Computational Insights of Organyltellurium(IV) Complexes With 5-Substituted Furan Ligand","authors":"Nidhi Antil,&nbsp;Mahak Dalal,&nbsp;Binesh Kumar,&nbsp;Jai Devi,&nbsp;Anjaneyulu Bendi,&nbsp;Sapana Garg","doi":"10.1002/aoc.70128","DOIUrl":"https://doi.org/10.1002/aoc.70128","url":null,"abstract":"<div>\u0000 \u0000 <p>Organyltellurium(IV) complexes have attracted significant attention due to their structural versatility and promising biological applications. In this study, a series of novel organyltellurium(IV) complexes with 5-substituted furan-based ligands were designed, synthesized, and evaluated for their antioxidant, antimicrobial, and anti-inflammatory properties. The synthesized compounds were characterized by ultraviolet–visible (UV–Vis), FT-IR, ¹H-NMR, ¹³C-NMR, mass spectrometry, molar conductance, elemental analysis, powder X-ray diffraction and thermal analyses which states that the bidentate Schiff base ligand (MeF4AP) coordinated via oxygen and nitrogen atom with tellurium giving hexa-coordinated tellurium(IV) complexes. In silico studies, including molecular docking, density functional theory (DFT) calculations, MESP and ADME profiling provided insights into their stability, electronic properties, and pharmacokinetic potential. The DPPH and BSA assays revealed that complexes 3c (IC₅₀ = 4.95 ± 0.02 μM), 3b (IC₅₀ = 7.12 ± 0.07 μM and 3f (IC₅₀ = 4.14 ± 0.11 μM) exhibited the highest antioxidant and anti-inflammatory activity compared to the ligand. Notably, complex 3b exhibited MIC of 0.20 mg/mL against <i>Candida albicans</i> nearly twice as potent as the standard drug griseofulvin (MIC = 0.50 mg/mL). The FMO studies supports the more bioactivity of complexes as compared to Schiff base. MESP of the compounds displayed their most reactive regions. The strong correlation between computational predictions and in vitro results highlights the potential of these organyltellurium(IV) complexes as multifunctional therapeutic candidates and pave the way for further exploration of their biomedical applications.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Conventional and Ultrasonic-Assisted Synthesis of Co(II)- and Cu(II)-Based MOFs for CO2 Adsorption","authors":"Mohammad Reza Ahmadi,&nbsp;Effat Jamalizadeh,&nbsp;S. Yousef Ebrahimipour,&nbsp;Ghasem Sargazi","doi":"10.1002/aoc.70083","DOIUrl":"https://doi.org/10.1002/aoc.70083","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, cobalt(II) and copper(II) metal–organic frameworks (MOFs) were synthesized using conventional reverse micelle (RM) and ultrasonic-assisted reverse micelle (UARM). The UARM method demonstrated superior efficacy in producing MOFs with improved properties. The CO₂ adsorption properties of the synthesized MOFs were investigated using a volumetric adsorption apparatus. The adsorption isotherms were analyzed using various isotherm models, including Langmuir, Freundlich, Dubinin–Radushkevich, and Temkin. Thermodynamic parameters were calculated to understand the nature of the adsorption process. Based on RSM optimization, the capability of Co-MOF was estimated to be about 8.48 mmol/g. The enhanced adsorption performance was attributed to the efficient surface area, surface properties, and strong interaction between the CO₂ molecules and the MOF surface.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Alternative Current Conduction Mechanisms on the α-LiFeO2-Based Cathode Materials","authors":"Abdulaziz Abdulmohsen Alnafea,&nbsp;Narimen Chakchouk,&nbsp;Hala Siddiq,&nbsp;Saleh M. Altarifi,&nbsp;Mohamed Houcine Dhaou,&nbsp;Abdallah Ben Rhaiem","doi":"10.1002/aoc.70088","DOIUrl":"https://doi.org/10.1002/aoc.70088","url":null,"abstract":"<div>\u0000 \u0000 <p>An improved solid-state synthesis method was used to create LiFeO₂ layered oxides. The produced material adopts a cubic system (Fm-3m space group) with a refined cell parameter of <i>a</i> = 4.156(9) Å, as indicated by Rietveld refinement of the crystal structure. A morphological investigation revealed that the sample is composed of small primary particles with sizes ranging from 0.20 to 0.75 μm. IR spectroscopy vibrational analysis revealed the presence of FeO₆ and LiO₆ groups. The compound's semiconductor nature was confirmed when the band gap energy was generated and discovered to be 2 eV. There is a tighter dispersion of localized states within the band gap, as indicated by the obtained Urbach energy (0.39 eV), which presents just 20% from the band gap energy. The material's dielectric characteristics were assessed between 0.1 and 107 Hz in frequency and between 333 K and 523 K in temperature. The presence of both space charge and dipolar polarization is suggested by the real component of the dielectric permittivity, which indicates a high dielectric constant (between 100 and 350) at low frequency. The circuits are made up of constant phase elements (CPE) and bulk resistance R coupled in parallel. Jonscher's law was applied to interpret the frequency-dependent conductivity. The outcomes of the charge transport investigation on LiFeO₂ imply that the layered oxide material possessed a large polaron tunneling (OLPT) paradigm with activation energy E_a of 0.26 eV. Comparing the polaron <i>R</i>_<i>ω</i> (2 &lt; <i>R</i>_<i>ω</i> &lt; 5 Å) optimal hopping length to the Li–O interatomic gap (2.077(9) Å), it is larger. We identified and examined a correlation between the ionic conductivity and the crystal structure.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Characterization, and Application of MOF/COF Hybrid Composite as a Highly Active and Recyclable Catalyst for Multicomponent Synthesis of Chromeno[4,3-b]quinoline-6-ones","authors":"Parvin Sanati-Tirgan,&nbsp;Hossein Eshghi","doi":"10.1002/aoc.70039","DOIUrl":"https://doi.org/10.1002/aoc.70039","url":null,"abstract":"<div>\u0000 \u0000 <p>The conjugation of metal–organic frameworks (MOFs) with covalent organic frameworks (COF), as a catalytically active nanocomposite with integrated properties, is a smart strategy for developing efficient catalytic systems. Herein, we report the design and synthesis of NH₂-Glu-MOF/MT-COF nanocomposite using the integration of glutamate MOF (NH₂-Glu-MOF) and melamine-terephthaldehyde COF (MT-COF) via imine bond connection. The synthesized NH₂-Glu-MOF/MT-COF nanocomposite has been fully characterized using FT-IR, XRD, BET, TEM, FE-SEM, EDX, EDX mapping, TGA, and ICP-OES techniques. Analyses demonstrate that NH₂-Glu-MOF/MT-COF nanocomposite has ideal structural and compositional properties such as good specific surface area (241.631 m² g⁻¹), high pore volume, and high thermal stability (530°C). Because of such unbeatable structural and compositional features, NH₂-Glu-MOF/MT-COF nanocomposite shows much better catalytic activity for the synthesis of a wide library chromeno[4,3-<i>b</i>]quinoline-6-one derivatives than parent materials (NH₂-Glu-MOF or MT-COF). Additionally, NH₂-Glu-MOF/MT-COF nanocomposite demonstrated supreme recyclability during five catalytic cycles.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of a New Bis-4-Cumyl Phenoxy Phthalocyaninato Silicon (IV) and Its Evaluation on Selectivity for Iron (III) Ions","authors":"Mehmet Salih Ağırtaş,&nbsp;Derya Güngördü Solğun","doi":"10.1002/aoc.70120","DOIUrl":"https://doi.org/10.1002/aoc.70120","url":null,"abstract":"<div>\u0000 \u0000 <p>Axial phthalocyanine compound carrying 4-cumyl phenoxy groups was obtained from the reaction of 4-cumyl phenol with silicon phthalocyanine dichloride (SiPcCl₂). The compound was characterized by ¹H NMR, UV–visible light, FTIR, and mass spectrum. Electronic properties and photochemical properties of the compound were investigated by UV–visible light spectra. Singlet oxygen production capacity for the compound was investigated, and the singlet oxygen production (Φ∆) value was found to be 0.14. The sensor potential of the compound was investigated by UV–visible light spectra against magnesium (II) ions (Mg²⁺), manganese (II) ions (Mn²⁺), sodium (I) ions (Na⁺), nickel (II) ions (Ni²⁺), zinc (II) ions (Zn²⁺), silver (I) ions (Ag⁺), barium (II) ions (Ba²⁺), cadmium (II) ions (Cd²⁺), copper (II) ions (Cu²⁺), cobalt (II) ions (Co²⁺), and iron (III) ions (Fe³⁺). The selective sensitivity of the phthalocyanine compound only to Fe³⁺ ions enables the practical analysis of Fe³⁺ ions in many environments. This study presents an alternative and practically applicable method for the sensitive determination of Fe³⁺ ions, which have widespread adverse effects on the environment, ecosystem and human health.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation, Chemical Characterization, and Determination of the Cytotoxicity and Anti-Thyroid Cancer Properties of Pomegranate Aqueous Extract Green-Synthesized Silver Nanoparticles Following the STAT3 and p53 Signaling Pathways","authors":"Mengxuan Mao,&nbsp;Zhanbin Cui,&nbsp;Xiaofei Wei,&nbsp;Tengfei Liu,&nbsp;Mingqiang Han","doi":"10.1002/aoc.70112","DOIUrl":"https://doi.org/10.1002/aoc.70112","url":null,"abstract":"<div>\u0000 \u0000 <p>The biogenic silver nanoparticles manufactured using pomegranate as a supporting material are described in this study. The plant's leaves effectively stabilized the produced silver nanoparticles (Ag NPs) and acted as a natural reducing agent. The physicochemical characteristics of the prepared NPs were examined using TEM, EDX, FE-SEM, and UV–Vis methods. According to the study's data, the antioxidant properties of nanoparticles may be related to how well they treat thyroid cancer in humans. The capacity of biologically produced nanoparticles to prevent thyroid cancer cells was assessed. As determined by the MTT assay, the silver nanoparticles had strong anti-thyroid cancer characteristics, effectively eliminating the BCPAP cancer cell in a way that depended on both concentration and time. Ag NPs decrease the anti-apoptotic marker Bcl-2 level while promoting cell death, which is associated with increased levels of pro-apoptotic indicators such as cleaved caspase-8 and Bax. Additionally, compared to the corresponding control group, silver nanoparticles show a reduction in colony development. The data of Ag NPs showed that p53 expression was much higher, and that the examined cell lines had lower levels of signal transducer and activator of transcription 3 (STAT3). This implies that the pomegranate extract-induced biological reactions in BCPAP human thyroid cancer cells depend critically on STAT3 and p53.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}