Applied Organometallic Chemistry最新文献

{"title":"Plant Leaf Aqueous Extract Green-Formulated Zinc Nanoparticles Ameliorate Functional Dyspepsia","authors":"Xinyan Li","doi":"10.1002/aoc.70379","DOIUrl":"https://doi.org/10.1002/aoc.70379","url":null,"abstract":"<div>\u0000 \u0000 <p>The current investigation unveils the utilization of <i>Lycopus lucidus</i> extract for the eco-friendly production of zinc nanoparticles and a study on the efficacy of NPs on dyspepsia in mice. The NPs were characterized by several methods. The XRD analysis confirms the crystallinity of ZnNPs@<i>L. lucidus</i> with the formula of ZnO and a crystal size of 28.4 nm. The particle size of ZnNPs@<i>L. lucidus</i> is revealed through FE-SEM imaging, displaying a spherical structure measuring 40 nm in size. The efficacy of ZnNPs@<i>L. lucidus</i> in improving functional dyspepsia was demonstrated through the assessment of the gut microbiome, gastrointestinal motility, and hormonal changes in mice with reserpine-induced functional dyspepsia. The gut microbiome data indicated that ZnNPs@<i>L. lucidus</i> could regulate the restoration of homeostasis and microbiome structure by reducing harmful bacterial abundance. The use of ZnNPs@<i>L. lucidus</i> resulted in an enhancement of gastrointestinal motility, including an increase in the rates of small intestinal transit and gastric emptying.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vinyl Addition Polymerization of Norbornene Derivatives by Palladium(II) Catalytic System: Comparison of In Situ Versus Complex Catalysts","authors":"Nhi Thi Xuan Nguyen,&nbsp;Saira Nayab,&nbsp;Minyoung Yoon,&nbsp;Hyosun Lee,&nbsp;Sang-Ho Lee","doi":"10.1002/aoc.70383","DOIUrl":"https://doi.org/10.1002/aoc.70383","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, 2-(piperidin-1-ylmethyl)quinoline (<b>L</b>_<b>A</b>) and 1-(naphthalen-2-ylmethyl)piperidine (<b>L</b>_<b>B</b>) ligands were utilized alongside palladium(II) acetate [Pd(OAc)₂] and <i>N,N</i>-Dimethylanilinium tetrakis (pentafluorophenyl)borate as a cocatalyst for the in situ addition polymerization of norbornene (NB). The ligand <b>L</b>_<b>B</b> system demonstrated superior catalytic performance compared with that of the ligand <b>L</b>_<b>A</b> system, achieving 99% versus 94% conversion for NB to polynorbornene (PNB) at 25°C in chlorobenzene. To validate the catalytic activities of these in situ catalytic systems, Pd (II) complexes, <b>[L</b>_<b>A</b><b>Pd(OAc)</b>_<b>2</b><b>]</b> and <b>[L</b>_<b>B</b><b>Pd(μ-OAc)]</b>_<b>2</b>, were synthesized and characterized. X-ray structure analysis revealed that <b>[L</b>_<b>A</b><b>Pd(OAc)</b>_<b>2</b><b>]</b> adopted a square planar geometry, whereas <b>[L</b>_<b>B</b><b>Pd(μ-OAc)]</b>_<b>2</b> exhibited a distinctive clamshell structure. These complexes were also employed for the vinyl addition polymerization of NB under the same conditions as in situ catalytic systems. The active real Pd(II) complexes demonstrated slightly lower conversions compared with those of the in situ catalytic systems, achieving over 90% conversions for both <b>[L</b>_<b>A</b><b>Pd(OAc)</b>_<b>2</b><b>]</b> and <b>[L</b>_<b>B</b><b>Pd(μ-OAc)]</b>_<b>2</b>. Furthermore, both catalytic systems were subsequently used for the (co)polymerization of NB and its derivatives, such as 5-butylbicyclo[2.2.1]hept-2-ene (Bu-NB), methyl bicyclo[2.2.1]hept-5-ene-2-carboxylate (Me-NB), and bicyclo[2.2.1]hept-5-en-2-ylmethyl acetate (AAc-NB), yielding relatively lower conversions.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-Friendly Bio-Fabrication of Silver Nanoparticles by Cenchrus biflorus (Roxb.): Their Characterization and Biological Activity Exploration","authors":"Mushtaq Ahmed,&nbsp;Komal Qazi,&nbsp;Nadia Mushtaq,&nbsp;Abdul Qadir Khan,&nbsp;Naila Sher","doi":"10.1002/aoc.70237","DOIUrl":"https://doi.org/10.1002/aoc.70237","url":null,"abstract":"<div>\u0000 \u0000 <p>Silver nanoparticles (AgNP) have extensive and exceptional applications in a variety of sectors, particularly medicine. We developed an eco-friendly method to synthesize AgNPs from an extract of <i>Cenchrus biflorus</i>. CB extract was used to make AgNPs using an environmentally friendly process. UV–Vis. spectroscopy was used to obtain an absorbance of 1.9 and a prominent peak at 440 nm. Fourier-transform infrared spectroscopy revealed some peaks, indicating the presence of distinct phytochemicals that produce AgNPs. AgNPs ~20 nm in diameter and spherical in shape were identified via scanning electron microscopy. The desired bands at 2<i>θ</i> values of 32.34^o, 38.16^o, and 46.3^o obtained using X-ray diffraction verified the crystal structure of the AgNPs with a size of 14.59 nm. AgNPs and the plant extract exhibited strong antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl, H₂O₂, and ABTS (2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid) with maximum Scavenging activities of 82.2% and 75.5%, 72.2% and 65.5%, and 66.2% and 53.5%, respectively. AgNPs and the plant extract also exhibited antimicrobial activity against certain fungal and bacterial strains with a maximum inhibition of 40.2 ± 0.04 and 35.5 ± 0.9 mm against <i>Aspergillus niger</i>, 37.2 ± 0.08 and 31.5 ± 0.9 mm against <i>Aspergillus</i> flavus, 13 ± 0.9 and 10.5 ± 0.5 mm against methicillin-resistant <i>Staphylococcus aureus</i>, 14.25 ± 0.09 and 11.5 ± 0.9 mm against <i>Streptococcus pyogens</i>, 11 ± 0.9 and 10 ± 0.8 mm against <i>Escherichia coli,</i> and 12 ± 0.9 and 11 ± 0.8 mm against <i>Klebsiella pneumoniae</i>. AgNPs and the plant extract possessed good antidiabetic properties with a maximum inhibition of 65.2% and 53.5%, respectively. Both the plant extract and AgNPs revealed a type of inhibition that competes because their Vmax values remained constant as Km values increased. The anti-Alzheimer property of AgNPs and the plant extract exhibited a maximum inhibition of 88.6% and 62.2%, and AgNPs and the plant extract confirmed an aspect of noncompetitive inhibition due to which Vmax decreased and Km remained unchanged as the AgNP and plant extract concentrations increased.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water-Soluble Silver Coordination Polymers Constructed From Bridging Pyrazine Ligands: Syntheses, X-Ray Structures, Anticancer, and Antimicrobial Investigations","authors":"Mostafa A. El-Naggar,&nbsp;Morsy A. M. Abu-Youssef,&nbsp;Matti Haukka,&nbsp;Assem Barakat,&nbsp;M. Ali,&nbsp;Ayman El-Faham,&nbsp;Saied M. Soliman,&nbsp;Amal Yousri","doi":"10.1002/aoc.70394","DOIUrl":"https://doi.org/10.1002/aoc.70394","url":null,"abstract":"<div>\u0000 \u0000 <p>Two novel polymeric complexes were synthesized from the reaction of AgClO₄ with 3-amino-6-(chloromethyl)-2-pyrazinecarbonitrile 4-oxide (<b>L1-Cl</b>) or 3-aminopyrazine-2-carboxylic acid (<b>HL2</b>) to give <b>[Ag(L1-OCH</b>_<b>3</b><b>)(<i>μ</i>-OClO</b>_<b>3</b><b>)]</b>_<b>n</b>; (<b>1</b>) or <b>[Ag (HL2)(OClO</b>_<b>3</b><b>)]</b>_<b>n</b><b>.nH</b>_<b>2</b><b>O</b>; (<b>2</b>), respectively. 3-Amino-6-(methoxymethyl)-2-pyrazinecarbonitrile 4-oxide (<b>L1-OCH</b>_<b>3</b>) is formed by the etherification process that occurred during the synthesis of complex <b>1</b>. The complexes architectures were investigated by single-crystal XRD (SC-XRD). Both complexes have novel and different polymeric forms based on the pyrazine moiety that adopt a bridging mode between the Ag(I) sites with the difference of donor atoms in each complex. The silver(I) centers in the polymeric chain of complex <b>1</b> are connected to one another through the bridging pyrazine ligand and perchlorate anions in an alternative manner. In complex <b>2</b>, <b>HL2</b> does not only act as a linker between the silver centers but also as a bidentate ligand. Hirshfeld surface analysis demonstrated the importance of H···O contacts in the supramolecular structures of <b>1</b> (41.7%) and <b>2</b> (30.2%). Biological investigations indicated promising antimicrobial and anticancer properties of these water-soluble complexes. Particularly, complex <b>1</b> displays interesting activity against A-549 (IC₅₀ = 10.53 ± 0.44 <i>𝜇</i>M) and MCF-7 (IC₅₀ = 8.41 ± 0.31 <i>𝜇</i>M) cell lines when contrasted to <i>cis</i>-platin. Regarding antibacterial action, the most promising MIC value and inhibition zone diameter are 8 <i>μ</i>g/mL and 20 mm, respectively, for <b>1</b> against <i>B. subtilis</i>.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis and Characterization of Silver and Zinc Nanoparticles Using Pyracantha coccinea M. Roem and Their Biological Activities","authors":"Nuran Gökdere,&nbsp;Suna Sibel Rizvanoğlu,&nbsp;Erdal Emir,&nbsp;Hayrani Eren Bostanci,&nbsp;Müjde Eryilmaz,&nbsp;Orhan Atakol,&nbsp;İsmail Murat Palabiyik","doi":"10.1002/aoc.70391","DOIUrl":"https://doi.org/10.1002/aoc.70391","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, silver nanoparticles (AgNPs) and zinc nanoparticles (ZnO NPs) were synthesized using extracts prepared from the fruits of <i>Pyracantha coccinea</i> M. Roem with a green chemistry method. Synthesized nanoparticles were characterized using UV–visible spectrophotometry, scanning electron microscopy (SEM), X-ray diffraction technique (XRD), and Fourier transform infrared spectroscopy (FTIR). After characterization studies, antibacterial, antibiofilm, antiquorum sensing, and anticancer activities of AgNPs and ZnO NPs were investigated. According to the results of antibacterial activity tests performed using the broth dilution method, ZnO NPs were found to be effective against <i>Staphylococcus aureus</i> ATCC 29213 (MSSA) and <i>S. aureus</i> ATCC 43300 (MRSA), and AgNPs were found to be effective against <i>Pseudomonas aeruginosa</i> ATCC 27853. Besides, AgNPs and ZnO NPs showed 88.5% and 39.98% antibiofilm activity, respectively. The synthesized nanoparticles did not show any antiquorum sensing activity. L929 (mouse fibroblast cell line) used as a control healthy cell line, and MCF7 (breast cancer), C6 (rat glioblastoma), and HT-29 (colon cancer) cells were used in cell culture studies as cancer cell lines. As a result of the cell culture studies, it was determined that the two nanoparticles had cytotoxic effects on both the MCF7 and HT29 cell lines. However, both nanoparticles did not show a cytotoxic effect on glioma cells. Flow cytometry studies were performed with the structures found to be active. Apoptosis and cell cycle studies also gave results parallel to the MTT results and proved the activity of the new synthetic structures. The findings indicate that AgNPs and ZnO NPs synthesized by <i>Pyracantha coccinea</i> M. Roem with an environmentally friendly approach can be evaluated as potential antimicrobial and anticancer agents in various biomedical applications.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrothermal Synthesis of Bimetallic Spinel MCo2O4/MXene (M = Ni, Zn) Composites as Efficient Supercapacitor Electrodes","authors":"Komal Ali Rao,&nbsp;Muhammad Rizwan Saleem,&nbsp;Muhammad Ehsan Mazhar,&nbsp;Javed Ahmad,&nbsp;Muhammad Imran Khan,&nbsp;Muhammad Bilal,&nbsp;Waseem Abbas,&nbsp;Nargis Bano,&nbsp;Aqsa Naz,&nbsp;Abdallah Shanableh,&nbsp;Mehak Bukhari,&nbsp;Rafael Luque","doi":"10.1002/aoc.70390","DOIUrl":"https://doi.org/10.1002/aoc.70390","url":null,"abstract":"<div>\u0000 \u0000 <p>MXene is an ideal choice for electrode material in supercapacitors due to its outstanding metallic conductivity, hydrophilic nature, and surface redox activity as well as superior chemical stability. The two-dimensional (2D) metal carbide NbC₂Tₓ-MXene exhibits significant potential as a pseudocapacitive electrode material for energy storage applications. Restacking of MXene's layers makes, however, difficult access of ions, which lowers volumetric performance and also reduces ion and electron transport. To overcome this challenge, different metal-based oxides with MXene composites, namely, MCo₂O₄/composite (where M = Ni and Zn), were synthesized using a simple cost-effective hydrothermal method through a self-assembly process. These heterostructure composites reduced the specific capacitance loss brought on by volumetric variations by preventing MXene layers from restacking and at the same time improving the exposure of electrochemically active sites in MCo₂O₄/composite. Structural, morphological, and electrochemical analysis revealed that both composites have efficient and remarkable electrochemical properties with unique morphology. Detailed electrochemical analysis revealed that NiCo₂O₄/MXene have pseudocapacitive behavior with greater specific capacitance as compared with ZnCo₂O₄/MXene. NiCo₂O₄/MXene exhibited specific capacitance of 1575 F g⁻¹ at 1 A g⁻¹ with 89% cyclic stability over 10,000 cycles. Moreover, asymmetric supercapacitors constructed using NiCo₂O₄@Nb₂C as cathode and commercial activated carbon (AC) as anode demonstrated a high energy density of 31.2 Wh kg⁻¹ at a power density of 800 W kg⁻¹ Additionally, they exhibited excellent long-term cycling stability, retaining 81.2% of their initial capacitance after 5000 cycles.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145021967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis of Novel Cyclopenta[1,2-d]pyrimidins Using Ag/Fe3O4@GO Nanocatalyst: Characterization and Biological Activity","authors":"Ali Varasteh Moradi","doi":"10.1002/aoc.70376","DOIUrl":"https://doi.org/10.1002/aoc.70376","url":null,"abstract":"<div>\u0000 \u0000 <p>In this research, novel derivatives of cyclopenta[1,2-d]pyrimidin with a high level of efficiency were synthesized using Ag/Fe₃O₄@Graphene oxide (Ag/Fe₃O₄@GO) employing multicomponent reaction including vinylidenes, aldehydes, ethyl 2-amino-4-dioxo-4-arylbutanoates, alkyl bromides, and guanidine in water at room temperature. The produced compounds exhibit antioxidant activity as a result of the evaluation processes conducted on their NH group. Furthermore, an evaluation was performed on the antibacterial effectiveness of newly created pyridines using a disk diffusion technique, utilizing two different strains of Gram-negative bacteria. Significantly, the substances that were evaluated showed inhibitory effects on the development of Gram-positive bacteria as well. This method has several benefits, including quick response times, high product yields, and easy separation of catalyst and product using simple procedures.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptorless Dehydrogenation of Alcohols to Carboxylic Acids Catalyzed by Nickel (II) Complexes Under Air","authors":"Jharna Mahato,&nbsp;Shyam Sundar Mondal,&nbsp;Reetika Ravi,&nbsp;Tanmoy Kumar Saha","doi":"10.1002/aoc.70392","DOIUrl":"https://doi.org/10.1002/aoc.70392","url":null,"abstract":"<div>\u0000 \u0000 <p>Here, we have synthesized two air stable, phosphine-free nickel–Schiff base complexes, <b>1a</b>, [Ni(L₁)₂](ClO₄)₂ (L₁ = <i>N</i>-phenyl-1-(pyridin-2-yl)methanimine) and <b>1b</b>, [Ni(L₂)₂](ClO₄)₂ (L₂ = 1-(6-bromopyridin-2-yl)-<i>N</i>-(4-methoxyphenyl)methanimine), and used them efficiently to catalyze the acceptorless dehydrogenation reaction of primary alcohols to carboxylic acids under aerobic conditions at 100°C. This methodology offers an atom-economical and sustainable approach for preparing various carboxylic acid derivatives by employing alcohols with KOH in the presence of the catalyst. The protocol was scrutinized across a range of aliphatic and aromatic alcohols, providing corresponding carboxylic acids with moderate to excellent yield. Additionally, mechanistic insights of the reaction were also investigated through intermediate mass analysis and controlled experiments.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Characterization of a Polyoxotungstate-Based Magnetic Composite MOF Catalyst for Efficient A3 Coupling Reactions","authors":"Fatemeh Etessamifar,&nbsp;Mojtaba Bagherzadeh,&nbsp;Arshad Bayrami,&nbsp;Mohsen Chegeni","doi":"10.1002/aoc.70318","DOIUrl":"https://doi.org/10.1002/aoc.70318","url":null,"abstract":"<div>\u0000 \u0000 <p>This research investigates the development and implementation of 11-tungstocupro (II)-silicate incorporated into a magnetic metal–organic framework (MOF) Fe₃O₄/MIL-101(Cr) to serve as a catalyst. For this purpose, the catalyst Fe₃O₄/MIL-101(Cr)@POM underwent synthesis through the co-precipitation procedure, and its structure was perfectly confirmed by various techniques such as FT-IR, XRD, FE-SEM/EDX, and ICP-OES. Following that, during tests of a three-component reaction that combines amine and alkyne compounds with an aldehyde under the A³ coupling reaction, the as-catalyst demonstrated an effectiveness profile, with the reaction conditions optimized to achieve 68.4% efficiency through a 24-h chloroform reflux procedure, whereas the solvent-free reaction route attained 64.5% efficiency, finishing in only 18 h. The reusable catalyst endured minimal degradation in activity while undergoing five cycles. Furthermore, the leaching test detected no leakage in Cu metal concentration for the filtrated solution after the catalytic reaction. This study could properly resolve solubility obstacles and separation limitations that typically restrict homogeneous polyoxometalate catalysts by incorporating polyoxotungstate into the magnetic MOF structure while developing an effective practical solution for field implementations.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(S)-(4-(Prop-1-en-2-yl)cyclohex-1-enyl)methanol Substituted Phthalocyanines: Synthesis, Photochemical and Photophysical Properties, and Enzyme Inhibition Behaviors","authors":"Tenzile Alagöz,&nbsp;Ahmet T.Bilgiçli,&nbsp;Wiem Marzouk,&nbsp;Eda Mehtap Özden,&nbsp;Armağan Günsel,&nbsp;İlhami Gülçin,&nbsp;Meryem N. Yarasir,&nbsp;Hayriye Genc Bilgicli","doi":"10.1002/aoc.70378","DOIUrl":"https://doi.org/10.1002/aoc.70378","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, (S)-4-((4-(prop-1-en-2-yl)cyclohex-1-enyl)methoxy)phthalonitrile, as a novel phthalonitrile derivative, which is the starting material for phthalocyanine synthesis, was prepared and characterized. Then, its symmetric metal-free [H₂Pc (<b>2</b>)] and metallophthalocyanine derivatives [ZnPc (<b>3</b>), CuPc (<b>4</b>), and CoPc (<b>5</b>)] were successfully synthesized, and their structures were characterized with the combination of suitable spectroscopic methods. The solubility and aggregation properties of novel phthalocyanines were investigated. Also, the photophysical and photochemical properties of the newly synthesized H₂Pc (<b>2</b>) and ZnPc (<b>3</b>) were studied in solution media. The singlet oxygen quantum values are 0.45 for H₂Pc (<b>2</b>) and 0.75 for ZnPc (<b>3</b>). According to these results, the peripheral perillyl alcohol substitution of phthalocyanines increased the therapeutic efficacy. At the same time, the newly synthesized phthalocyanines (<b>2</b>–<b>5</b>) displayed the strongest inhibitory effect. The results indicate a high affinity and selectivity for carbonic anhydrases. This underscores their potential as promising lead compounds for developing therapeutic agents to treat conditions such as glaucoma, epilepsy, and certain types of cancer.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}