Applied Organometallic Chemistry最新文献

{"title":"Bimetallic Mn-MIL-53(Fe) Metal–Organic Framework Photo-Fenton Catalyst for Elimination of Crystal Violet in Aqueous Solution","authors":"Sayantan Adak,&nbsp;Rajib Ghosh Chaudhuri,&nbsp;Mrinal Kanti Mandal","doi":"10.1002/aoc.70412","DOIUrl":"https://doi.org/10.1002/aoc.70412","url":null,"abstract":"<div>\u0000 \u0000 <p>Bimetallic Mn-doped MIL-53(Fe) metal–organic framework (MOF) has been developed to remove crystal violet (CV) efficiently from wastewater through the photo-Fenton process. The key innovation of the work lies in enhanced visible light activity, lesser H₂O₂ oxidant content, and faster removal with less sludge generation. Comprehensive characterizations revealed a lower bandgap and rapid charge separation, which reflected on the improvement of the performance of the photocatalyst. The bimetallic MOF achieved 99.01% removal of CV under the visible 100 W Xe light source with six times faster rate than the pristine MIL-53(Fe) and also 82.42% CV removal under irradiation of sunlight in 60 min at optimized conditions of 20.0 ppm dye concentration, 444 ppm H₂O₂ concentration, and 1.0 g/L catalyst loading. The composite maintained good recyclability up to five consecutive cycles with a removal of 78.89% CV. The treated effluent exhibited lower toxicity in seed germination tests, demonstrating the potentiality of Mn-doped MIL-53(Fe) as a stable and efficient catalyst for wastewater treatment.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Template-Assisted Biologically Active Macrocyclic Complexes: Structural Characterization and Apoptotic Studies","authors":"Jai Kumar,&nbsp;Ramesh Kumar,&nbsp;Jitender Kumar Bhardwaj,&nbsp;Devender Singh,&nbsp;Harish Kumar,&nbsp;Arti Jangra,&nbsp;Parvin Kumar","doi":"10.1002/aoc.70418","DOIUrl":"https://doi.org/10.1002/aoc.70418","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel series of biologically active tetraazamacrocyclic complexes of type [M(L)X]X₂ and [M(L)X₂] was prepared by template condensation reaction of dimedone, isatin, and 3,4-diaminotoluene in the existence of trivalent and divalent transition metal ions taken in a 2:1:1:1 M ratio. All these complexes were characterized with the help of various techniques like electronic measurements, elemental analysis, molar conductance, IR, and mass spectral studies. All newly synthesized macrocyclic complexes were tested against various Gram-positive and Gram-negative microbial strains. The results of antimicrobial activities suggested that all complexes could show remarkable antimicrobial activity. Moreover, these complexes were also examined for their antioxidant potential in testicular tissues of the goat (<i>Capra hircus</i>) and compared with control and (as pesticide) glyphosate-impacted tissues. From this testing, it was found that all complexes have the potential to reduce the toxic effects of pesticides.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hierarchical Multi-Active N-Doped Yolk-Shell Wrapped Co3O4 Nanoreactors as Highly Active Peroxymonosulfate Activator for Tetracycline Degradation","authors":"Kun Su,&nbsp;Geng Li,&nbsp;Yuxin Zhao,&nbsp;Jiaxin Liang,&nbsp;Boyuan Chai,&nbsp;Peng Gao,&nbsp;Yuwei Pan,&nbsp;Ming Zhang,&nbsp;Guangyu Wu","doi":"10.1002/aoc.70399","DOIUrl":"https://doi.org/10.1002/aoc.70399","url":null,"abstract":"<div>\u0000 \u0000 <p>Advanced oxidation processes (AOPs) have attracted extensive attention at home and abroad as an emerging pollution control method based on sulfate radicals. Designing hollow nanoreactors with hierarchical interiors can greatly improve catalytic efficiency and show promising potential for the degradation of organic pollutants. In this paper, a novel N-doped yolk-shell wrapped Co₃O₄ (NYS Co₃O₄) nanoreactor was synthesized. Thanks to its outstanding structural features and unique spatial confinement effect, the as-prepared NYS Co₃O₄ nanoreactor demonstrated high efficiency in activating PMS, achieving 99.6% removal of tetracycline (TC) within 45 min. The influence of reaction parameters (pH value, co-existing ions, etc.) on the degradation of TC was systematically studied. Competitive radical scavenging tests revealed the primary role of h⁺ in TC removal. The HPLC-MS is used to identify the substances between the degradation of TC and suggest possible degradation pathways. The toxicities of the intermediate products were also analyzed. This work highlights that yolk-shell structured catalysts have broad application prospects in AOPs.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Naphthol-Derived Organosilane: Its Potential as a Chemosensor for the Detection of Vanadium (III), DFT Insight, Molecular Docking, and MD Simulation Study","authors":"Gurjaspreet Singh,&nbsp; Mithun,&nbsp;Sumesh Khurana,&nbsp;Manraj Singh,&nbsp; Vikas,&nbsp;Anita Devi,&nbsp; Sushma,&nbsp;Jandeep Singh,&nbsp;Nancy George","doi":"10.1002/aoc.70408","DOIUrl":"https://doi.org/10.1002/aoc.70408","url":null,"abstract":"<div>\u0000 \u0000 <p>Exposure to heavy metals, even at minimal levels, poses serious health risks to both humans and animals. Therefore, the demand for innovative and efficient sensing materials using advanced methodologies is rapidly increasing. In this research, a new series of naphthol-triazole linked organosilane (<b>6MNT</b>) was successfully synthesized via a Cu(I)-catalyzed click reaction and thoroughly characterized through FT-IR, ¹H and ¹³C NMR, and mass spectrometry. The UV–Visible and fluorescence spectroscopic analysis of <b>6MNT</b> revealed its remarkable selectivity toward V (III) in the presence of other metal cations. Detection limits (LOD) of V (III) were measured as 2.9 × 10⁻⁷ M and 4.4 × 10⁻⁸ M using absorption and emission spectroscopy, respectively. DFT calculations performed via Gaussian 09 software provided insight into the binding interactions between <b>6MNT</b> and V (III). The molecular docking and MD simulation studies indicated a strong binding affinity (−6.95 kcal/mol) and stable interactions of <b>6MNT</b> with the active sites of vanadium apochloroperoxidase protein, highlighting its potential biological relevance.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Chiral Sensor via a Modified Achiral Eu-MOF for Luminescence Sensing of Mandelic Acid Enantiomers","authors":"Wei Wei,&nbsp;Yi-Ying Chang,&nbsp;Chao Chen,&nbsp;Hao Wang,&nbsp;Chuan-Song Qi,&nbsp;Wei Li","doi":"10.1002/aoc.70414","DOIUrl":"https://doi.org/10.1002/aoc.70414","url":null,"abstract":"<div>\u0000 \u0000 <p>A new two-dimensional (2D) lanthanide metal–organic framework [Eu₂(ATA)₃(phen)₂]_n (<b>Eu-MOF</b>, H₂ATA = 2-amino terephthalic acid, phen = 1,10-phenanthroline) was successfully self-assembled via a simple solvothermal method. Then D-camphoric acid (D-Cam) was grafted onto <b>Eu-MOF</b> by post-synthetic modification (PSM) through a mechanochemical approach, successfully fabricating the chiral material <b>Eu-MOF-D-Cam</b>. Remarkably, this modification not only significantly enhanced the luminescent properties but also introduced the chiral sites for enantioselective sensing of mandelic acid (MA) enantiomers. The enantioselectivity factor α (α = <i>K</i>_<i>SV</i>(R-MA)/<i>K</i>_<i>SV</i>(S-MA)) of <b>Eu-MOF-D-Cam</b> was 2.56. These findings establish <b>Eu-MOF-D-Cam</b> as a promising photoluminescent sensor for chiral discrimination of R/S-MA enantiomers.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Characterization, Biological and Computational Insights of some Binuclear Azo Dye-Based Metal Complexes","authors":"Lizaranee Tripathy,&nbsp;Ashish Kumar Sarangi","doi":"10.1002/aoc.70407","DOIUrl":"https://doi.org/10.1002/aoc.70407","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel family of binuclear transition metal complexes was synthesized with M = Zinc (II), Cobalt (II), Nickel (II), Copper (II), and Manganese (II). These complexes, formulated as [M₂(L)Cl₂(H₂O)₆] and [M′₂(L)Cl₂(H₂O)₂], were prepared using (E)-2,4-dihydroxy-5-((3-hydroxyphenyl)diazenyl)benzoic acid (LH₂), a newly synthesized pentadentate/hexadentate azo dye ligand. Their coordination patterns and structural features were systematically investigated using a wide range of spectroscopic and analytical techniques, including Fourier Transform Infrared (FTIR) spectroscopy, UV–Vis spectroscopy, magnetic susceptibility measurements, elemental analysis, thermal studies (TGA/DTA), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), and energy-dispersive X-ray (EDX) analysis. An octahedral geometry surrounding the metal centers was confirmed by magnetic and spectroscopic evidence. XRD patterns indicated a hexagonal structure for the ligand and a cubic structure for the Cobalt (II) complex, with nanocrystalline sizes of ~20–29 nm. The complexes' electronic structures, frontier molecular orbitals (HOMO–LUMO gap), molecular electrostatic potential (MEP), optical responses, and ideal geometries were all investigated using Density Functional Theory (DFT) and Time-Dependent DFT (TD-DFT) computations. Both metal-to-ligand (MLCT) and ligand-to-metal (LMCT) charge-transfer transitions were visible in the simulated TD-DFT spectra. While HOMO-LUMO gaps ranged from 1.76 to 3.12 eV, suggesting varied reactivity across complexes. ESR spectroscopy of the Copper (II) complex indicated strong metal–ligand covalency and confirmed a binuclear configuration. Biological screening showed enhanced antibacterial activity for all complexes, especially against <i>Pseudomonas aeruginosa</i>. Antioxidant studies revealed the Ni (II) complex as the most potent (IC₅₀ ≈ 26.9 μM). Cytotoxicity assays (SRB) on MCF-7 cells showed that the Ni (II) complex exhibited the highest activity (IC₅₀ = <b>6.33 μM</b>), comparable to doxorubicin (5.15 μM), followed by LH₂ (22.97 μM) C,o (II) (44.28 μM), Zn (II) (59.41 μM), and Cu (II) (78.87 μM). Molecular docking with EGFR, HER2, and 1MBB confirmed strong binding, supported by QSAR and ADMET profiles suggesting drug-likeness and low toxicity. These results highlight their therapeutic and optoelectronic potential.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binuclear Ruthenium (II) Catalyzed Selective α-Alkenylation of Amide via Acceptorless Dehydrogenative Coupling of Alcohols","authors":"Sundar Saranya,&nbsp;Pennamuthiriyan Anandaraj,&nbsp;Rengan Ramesh,&nbsp;Sankar Monika","doi":"10.1002/aoc.70411","DOIUrl":"https://doi.org/10.1002/aoc.70411","url":null,"abstract":"<div>\u0000 \u0000 <p>Herein, we report an effective catalytic methodology for the construction of <i>α</i>,<i>β</i>-unsaturated amides via acceptorless dehydrogenative coupling (ADC) of alcohols using newly synthesized binuclear ruthenium (II) complex [(<i>η</i>⁶-p-cymene)₂Ru₂Cl₂(μ-L)] (where L = <i>N</i>′-4-fluoro benzoyl-4-fluorobenzohydrazide) as catalyst. The structural characterization of the newly synthesized ruthenium complex has been established using analytical and various spectroscopic techniques (FT-IR, UV–vis, and NMR). Further, the molecular structure of the complex has been authenticated by a single-crystal X-ray diffraction method. The catalytic system displaces a wide range of <i>α</i>,<i>β</i>-unsaturated amides (16 examples), which have been obtained from the reaction of diverse primary alcohols and aryl amide with maximum of 93% of yield. The protocol for α-alkenylation of amide involves through C-C bond formation utilizing 0.5 mol% of catalyst loading with the release of release water and hydrogen gas as the only by-products. The control experiments evidence the initial dehydrogenation of alcohols into their corresponding aldehydes and C=C bond formation through aldol condensation. In addition, a large-scale synthesis of one of the amides (E)-3-(4-methoxyphenyl)-N-phenyl acrylamide has been performed with the yield of 78%, which proves the effectiveness of the present catalytic protocol.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Microporous Crystal Zn-Cip With Anticancer Properties and Antibacterial Effects for Tumor Therapy","authors":"Heng Liu,&nbsp;Zhen Wang,&nbsp;Hongliu Yu,&nbsp;Wenwen Lu,&nbsp;Zhengfeng Wang,&nbsp;Bing Wang,&nbsp;Jie Shen,&nbsp;Wenxin Lin,&nbsp;Quan Hu","doi":"10.1002/aoc.70417","DOIUrl":"https://doi.org/10.1002/aoc.70417","url":null,"abstract":"<div>\u0000 \u0000 <p>The intratumoral microbiota plays a pivotal role in promoting cancer cells' proliferation and metastasis, and antibacterial agents exhibit significant efficacy in inhibiting cancer cells' migration. In this study, Zn-Cip was synthesized using Zn²⁺ and ciprofloxacin hydrochloride monohydrate as a ligand. Mn²⁺, which was known for its reactive oxygen species (ROS) generating capability, was incorporated into the Zn-Cip to construct the treatment system Mn-Zn-Cip. The material showed ideal antibacterial activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>, thereby effectively inhibiting cancer cells' migration. Meanwhile, Mn-Zn-Cip exhibited significant antitumor performances. This study emphasized the potential of Mn-Zn-Cip as an advanced platform for tumor treatment.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Benzo[c]Selenophenes and Their Analogues: Methods and Advances","authors":"Mohamed H. Helal,&nbsp;Rasha Jame,&nbsp;Moustafa A. Gouda","doi":"10.1002/aoc.70402","DOIUrl":"https://doi.org/10.1002/aoc.70402","url":null,"abstract":"<div>\u0000 \u0000 <p>The fusion of benzene with selenophene motifs in hybrid configurations yields two distinct structural types: condensed benzo[b]selenophenes and benzo[c]selenophenes. Benzo[<i>c</i>]selenophenes are distinguished by the placement of a selenium atom at the second position rather than the first. To date, no specific studies have focused exclusively on this scaffold, which has been predominantly utilized as a versatile building block in various applications. The synthesis of benzo[<i>c</i>]selenophenes and their analogues can be accomplished through multiple chemical pathways, including (i) selenation reactions using reagents like Woollins' reagent, Na₂Se₂/DMSO, 1,1,1,3,3,3-hexabutyldistannaselenane in toluene, selenium/NMP, and Na₂Se in THF; (ii) Suzuki, Stille, and Sonogashira coupling reactions; (iii) photocyclization reactions; (iv) nucleophilic and metallic substitution reactions; (v) [2 + 2 + <i>n</i>] cycloaddition reactions; and (vi) organometallic reactions, among other methods.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Multifunctional Platinum (IV) Complexes Incorporating Cannabidiol Active Moieties Elicit Mitochondrial Damage and Synergistically Boost Antitumor Efficacy","authors":"Rong Lv,&nbsp;Pengmin Shi,&nbsp;Jing Yang,&nbsp;Jian Zhao,&nbsp;Bo Yang,&nbsp;Chuanzhu Gao","doi":"10.1002/aoc.70416","DOIUrl":"https://doi.org/10.1002/aoc.70416","url":null,"abstract":"<div>\u0000 \u0000 <p>This study focuses on the synthetic modification of satraplatin through axial position substitution by introducing the bioactive molecule cannabidiol (CBD) at the axial position, leading to novel multifunctional antitumor complexes S1–S5. The results demonstrate that the target complexes exhibit significantly optimized physicochemical properties with improved lipo–hydro partition coefficients, combining both lipophilic and hydrophilic characteristics that favor drug metabolism. Remarkably enhanced in vitro antitumor activity was observed: S3 showed 4.3-fold higher cytotoxicity than satraplatin in HCT-116 cells, with superior efficacy against drug-resistant cells. S5 demonstrated 22-fold greater antiproliferative activity than both parental satraplatin and CBD alone in A549 cells, likely attributable to its haloacetic axial group enhancing mitochondrial targeting for trifunctional synergistic antitumor effects. Mechanistic studies revealed that the complexes are reduced by ascorbic acid in vivo to release both CBD and Pt (II). CBD disrupts redox homeostasis through ROS accumulation and impairs mitochondrial membrane potential, synergizing with Pt (II)-induced DNA damage to promote cancer cell apoptosis. The introduction of bioactive moieties like CBD with excellent biological functions into the axial position of Pt (IV) complexes not only optimizes physicochemical properties but also enriches antitumor functionality. Compared with conventional platinum drugs, these complexes demonstrate significantly enhanced cytotoxicity (S3 is 9.5-fold more toxic than cisplatin in HCT-116 cells; S5 shows 33-fold higher antiproliferative activity in A549 cells) while maintaining superior activity against resistant cells through CBD-Pt (II) synergy. This study provides valuable insights for overcoming limitations of traditional platinum drugs and developing synergistic antitumor agents with enhanced efficacy.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}