Heng Liu, Zhen Wang, Hongliu Yu, Wenwen Lu, Zhengfeng Wang, Bing Wang, Jie Shen, Wenxin Lin, Quan Hu
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A Microporous Crystal Zn-Cip With Anticancer Properties and Antibacterial Effects for Tumor Therapy
The intratumoral microbiota plays a pivotal role in promoting cancer cells' proliferation and metastasis, and antibacterial agents exhibit significant efficacy in inhibiting cancer cells' migration. In this study, Zn-Cip was synthesized using Zn2+ and ciprofloxacin hydrochloride monohydrate as a ligand. Mn2+, which was known for its reactive oxygen species (ROS) generating capability, was incorporated into the Zn-Cip to construct the treatment system Mn-Zn-Cip. The material showed ideal antibacterial activity against Staphylococcus aureus and Escherichia coli, thereby effectively inhibiting cancer cells' migration. Meanwhile, Mn-Zn-Cip exhibited significant antitumor performances. This study emphasized the potential of Mn-Zn-Cip as an advanced platform for tumor treatment.
期刊介绍：
All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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