{"title":"A Fog-Delayed Flight and the Story of Sir Michael Anthony Epstein (1921-2024) and Yvonne Margaret Barr (1932-2016).","authors":"Alejandro Donoso Fuentes, Daniela Arriagada Santis","doi":"10.5546/aap.2025-10694.eng","DOIUrl":"https://doi.org/10.5546/aap.2025-10694.eng","url":null,"abstract":"<p><p>The Epstein-Barr virus, was discovered in 1964, and was the first identified human oncogenic virus that can persist asymptomatically for life. It is associated with a broad spectrum of diseases in the pediatric population, including benign pathologies such as infectious mononucleosis or severe ones such as hemophagocytic lymphohistiocytosis, among others.Professor Sir Anthony Epstein (1921-2024), an English pathologist and virologist, was its co-discoverer with the Irish virologist Yvonne Barr (1932-2016). We will review the history, and the particularities of the serendipitous character that ended with the virus identification, together with the biography of both scientists who gave rise to this famous eponym, which endures to this day.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202510694"},"PeriodicalIF":0.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María I Urteneche, Norma E González, Eugenia Ginestet, Edith Macha Marín, Rosana Pereda, Pablo M Pablo M Cassanelli
{"title":"Diagnosis of central nervous system tuberculosis in pediatric patients.","authors":"María I Urteneche, Norma E González, Eugenia Ginestet, Edith Macha Marín, Rosana Pereda, Pablo M Pablo M Cassanelli","doi":"10.5546/aap.2024-10592.eng","DOIUrl":"10.5546/aap.2024-10592.eng","url":null,"abstract":"<p><p>Introduction. Central nervous system tuberculosis (CNS TB) represents a severe form of Mycobacterium tuberculosis (Mtb) infection. Late diagnosis is associated with increased mortality and neurological sequelae. Objective. To characterize CNS TB diagnosed in a pediatric hospital and describe the diagnostic elements, estimating their sensitivity. Materials and methods. An observational, retrospective study included CNS TB cases diagnosed between January 2013 and February 2022. Medical and laboratory records were reviewed, and epidemiological, clinical, imaging, cerebrospinal fluid cytochemical, and bacteriological data for mycobacteria were recorded. Results. Twenty-six cases of CNS TB were diagnosed, and 22 had pulmonary involvement. Ninety-six percent had neurological symptoms, with sensitivities of 46% for focal symptoms, 92% for meningeal symptoms, and 73% for the presence of fever. Hydrocephalus was more frequently observed in children under 5 years of age. In the study of cerebrospinal fluid, the clear aspect (92%) and proteins upon 1 g/L (50%) showed higher sensitivity, with higher levels in children under 5 years of age. As for microbiological results, smear microscopy was negative in all cases, while molecular biology and culture showed 61% and 75% sensitivity, respectively. The detection time was significantly shorter for molecular biology than for culture (p < 0.01). Conclusions. The presence of neurological symptoms, compatible cerebrospinal fluid, epidemiological link, and pulmonary involvement showed high sensitivity. Molecular biology allowed for earlier microbiological confirmation.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410592"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expectations of medical students and pediatric residents in their professional development.","authors":"Francisco Tonini, Marcela Urtasun","doi":"10.5546/aap.2024-10606.eng","DOIUrl":"10.5546/aap.2024-10606.eng","url":null,"abstract":"<p><p>Introduction. The number of vacancies for medical residencies in Argentina, especially in pediatrics, has increased. Knowing some aspects of medical students (MS) and postgraduate students (PS) in pediatrics could explain this phenomenon. Objectives. Describe the motivational profile, the intention to migrate, and the perception of primary care in MS and PS in pediatrics. Population and methods. A cross-sectional study was conducted in a pediatric hospital in the City of Buenos Aires, on a self-administered survey between October 2023 and September 2024. Results. Eighty-two MSs and 48 PSs participated; 96.9% presented high intrinsic motivation, 29.2% had high extrinsic motivation, 17% intended to migrate, and 60.8% had a positive perception of primary health care. Conclusions. The majority showed high intrinsic motivation. The intention to migrate was low. More than half perceived primary health care positively.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410606"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Participation and education: the Declaration of Helsinki in today's context.","authors":"María E Serra","doi":"10.5546/aap.2024-10585.eng","DOIUrl":"10.5546/aap.2024-10585.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410585"},"PeriodicalIF":0.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jader M Perdomo Muñoz, Silvia Morise, María B Pallitto, Oscar Patiño, Gonzalo Ortiz, Georgia Silvestri, Gabriela Messere, Román Bigliardi
{"title":"Recurrent acute pancreatitis in pediatrics: characteristics and risk factors.","authors":"Jader M Perdomo Muñoz, Silvia Morise, María B Pallitto, Oscar Patiño, Gonzalo Ortiz, Georgia Silvestri, Gabriela Messere, Román Bigliardi","doi":"10.5546/aap.2024-10437.eng","DOIUrl":"10.5546/aap.2024-10437.eng","url":null,"abstract":"<p><p>Recurrent acute pancreatitis (RAP) affects 15-36% of children with acute pancreatitis (AP) and may progress to chronicity. To determine the etiology and evolution of RAP, a descriptive retrospective cohort study was conducted in patients aged 1-18 years. Twelve patients with RAP were included out of 79 with AP, and demographic, etiological, clinical, analytical, and imaging data were collected. The results showed that the median age was 11 years for RAP and 13 years for AP. There were no significant differences between sexes or initial severity. Significant associations were found in the weight percentile, ultrasound findings, and genetic studies. These factors may influence the progression of RAP. Biliary lithiasis was the most common etiology in both groups. The multidisciplinary approach allows for avoiding its progression to chronicity.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410437"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Florencia I Palmieri, Mirta G Gryngarten, Andrea J Arcari, Verónica Umido, Analía V Freire
{"title":"Endocrine disruptors as risk factors for idiopathic premature thelarche in girls: A case-control study.","authors":"Florencia I Palmieri, Mirta G Gryngarten, Andrea J Arcari, Verónica Umido, Analía V Freire","doi":"10.5546/aap.2024-10501.eng","DOIUrl":"10.5546/aap.2024-10501.eng","url":null,"abstract":"<p><p>Introduction. Idiopathic premature thelarche (IPT) is defined as breast growth in girls before age 8 without activation of the gonadotrophic axis. Among the probable etiologies, endocrine disruptors (ED) with estrogenic action have been suggested. Objective. To evaluate whether there is an association between exposure and degree of exposure to the main EDs with estrogenic action in our environment and the development of IPT. Population and methods. Structured survey of caregivers of girls aged 3 to 8 years diagnosed with IPT and controls. The exposure evaluated included different EDs: bisphenol A (BPA), phytoestrogens, phthalates, and parabens, considering the degree of exposure according to weekly frequency. Results. Caregivers of 50 cases (7.2±1.3 years) and 48 controls (6.7±1.5 years) were interviewed. An association was found between IPT and exposure to phytoestrogens in food (OR: 14.6; 95%CI 1.8-118; p<0.01), the use of BPA containers exposed to temperature changes (OR 2.6; 95%CI 1.1-6.5; p<0.05), contact with phthalates (OR 2.9; 95%CI 1.2-7.5; p<0.05) and parabens (OR 2.7; 95%CI 1.2-6,1; p<0.05). In all the detailed EDs, we also found an association of IPT according to their degree of exposure. Conclusions. Exposure and degree of exposure to different sources of phytoestrogens, BPA, parabens, and phthalates were associated with the development of IPT.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410501"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Middle ear ventilation tubes and water precautions: A survey of otolaryngologists and pediatricians on their recommendations.","authors":"Federico Herranz, Gabriela Pérez Raffo","doi":"10.5546/aap.2024-10521.eng","DOIUrl":"10.5546/aap.2024-10521.eng","url":null,"abstract":"<p><p>Introduction. Middle-ear ventilation tubes are commonly placed in pediatric patients because of the high frequency of otitis media. Although avoidance of water activity has been recommended to prevent otorrhea, studies indicate that exposure to water does not increase these episodes. However, a survey in the northwestern United States showed low adherence to these guidelines. This study evaluates the current recommendations of otolaryngologists and pediatricians on water exposure in patients with ventilation tubes. Population and methods. We surveyed 235 health professionals from Argentina, Brazil, Chile, and other countries, including general otolaryngologists, pediatric otolaryngologists, otologists, residents, and pediatricians. The questionnaire addressed tubing preferences, swimming recommendations, and depth limits. Results. A total of 87.62% of respondents preferred diabolos as ventilation tubes. Regarding swimming, 54% recommended protection, such as earplugs or caps, while 28.5% prohibited aquatic activity. Permissiveness varied according to age and specialty; residents and pediatricians were the most permissive. One-third allowed only shallow swimming, and 20% imposed no limits. Conclusion. Young professionals and pediatricians were the most permissive concerning water exposure. Within the subspecialties, pediatric otolaryngologists and pediatricians were the respondents who indicated the least restrictions on their patients.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410521"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bronchial asthma in preschool children.","authors":"Maximiliano Salim","doi":"10.5546/aap.2024-10587.eng","DOIUrl":"10.5546/aap.2024-10587.eng","url":null,"abstract":"","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410587"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liliana Cáceres, Anabella Boto, Sandra Cagnasia, Manuel Clavijo, Carlos Luaces, Otto Maliarchuk, Bárbara Mousten, César Santos, Julieta Vilar, Pedro Rino
{"title":"Current situation of pediatric emergency departments in Argentine public hospitals.","authors":"Liliana Cáceres, Anabella Boto, Sandra Cagnasia, Manuel Clavijo, Carlos Luaces, Otto Maliarchuk, Bárbara Mousten, César Santos, Julieta Vilar, Pedro Rino","doi":"10.5546/aap.2024-10506.eng","DOIUrl":"10.5546/aap.2024-10506.eng","url":null,"abstract":"<p><p>Introduction. The quality improvement cycle in health care requires surveys and measurements. This study, based on data from a Latin American collaborative research project, aimed to describe the situation of pediatric emergency departments (PEDs) in Argentina and identify opportunities for improvement. Methods. Retrospective descriptive study. Data from 2019 were collected in PEDs of public hospitals with pediatric intensive care units (PICU). Continuous variables are presented as median and range, categorical variables as percentages, and productivity/resource ratios as ratios. Bivariate analysis was performed. Results. Out of 66 services, 62 (94%) participated. There was a deficit of isolation and specific pediatric care sectors; 21 (33.9%) PEDs had >70% of the equipment evaluated for the treatment of critical patients. Triage was performed in 34 (54.8%) PEDs. The median number of annual visits/observation beds was 7333 (IQR: 4,998-13,377); the median number of daily visits/consulting rooms was 37.6 (IQR 20.6-60.3). The number of beds increased by 75% at the seasonal peak. The median daily visits were 43/physician and 40.2/nurse. In 32 (51.6%) PEDs, there was 1 physician and 1 referring nurse per shift. Data were electronically recorded in 51 (82.2%) PEDs. Five critical care protocols were used in 44 (71%) PEDs, and 18 (29%) had a quality improvement plan. Five (8%) PEDs followed defined schedules for academic activities. Conclusion. This survey allowed us to know the situation of SEPs in Argentina's public hospitals and to identify opportunities for improvement.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410506"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New Argentine head circumference references for people with achondroplasia from 0 to 21 years of age.","authors":"Mariana Del Pino, Virginia Fano","doi":"10.5546/aap.2024-10565.eng","DOIUrl":"10.5546/aap.2024-10565.eng","url":null,"abstract":"<p><p>Introduction. Macrocephaly is a phenotypic feature of achondroplasia (ACH), the most common form of disproportionate short stature. In 2011, we published head circumference (HC) references for this population, but due to the scarcity of data about older ages, the centiles were estimated only up to 6 years of age. Objective. To estimated centiles of the HC between birth and 21 years of age for ACH. Population and methods. Data from children with ACH assisted between 1992 an 2024 at a thirdlevel hospital in Argentina were used for its estimation. The growth curves were adjusted using the LMS method. To evaluate the magnitude of the differences between the Argentine references of ACH and those of the general population, the 3, 50, and 97 centiles at different ages were plotted comparatively. Results. The HC of ACH was more significant at all ages than the general population's references. During the first year of life, males and females reach 84% and 86% of adult size, respectively, completing growth after 20 years of age. Conclusions. Due to the difference in cephalic size between the general population and ACH, it is essential to have specific references for this population. This will allow us to detect growth trajectories not attributed to ACH and to suspect deviations that require a rapid interdisciplinary approach.</p>","PeriodicalId":8338,"journal":{"name":"Archivos argentinos de pediatria","volume":" ","pages":"e202410565"},"PeriodicalIF":0.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}