Archives of Pharmacy and Pharmaceutical Sciences最新文献_第2页

Significance and Prospect of Brf1 Overexpression Brf1过表达的意义与展望

Archives of Pharmacy and Pharmaceutical Sciences Pub Date : 2023-08-22 DOI: 10.29328/journal.apps.1001043

Liling Zheng, Yongluan Lin, Hong Zaifa, Dongyan Shen, Shuping Zhong

引用次数: 0

Evaluation of the Antihyperglycaemic Activities, Safety and Phytochemical Profile of Celtis zenkeri Engl 荆芥抗高血糖活性、安全性及植物化学性质的评价

Archives of Pharmacy and Pharmaceutical Sciences Pub Date : 2023-07-14 DOI: 10.29328/journal.apps.1001042

Ayoola Marcus Durojaye, Oluwagbemi Moyinoluwa, Odediran Akintunde Samuel, Oladoja Farouk Adedeji, Kasumu Oluwabusayo Emmanuel

{"title":"Evaluation of the Antihyperglycaemic Activities, Safety and Phytochemical Profile of Celtis zenkeri Engl","authors":"Ayoola Marcus Durojaye, Oluwagbemi Moyinoluwa, Odediran Akintunde Samuel, Oladoja Farouk Adedeji, Kasumu Oluwabusayo Emmanuel","doi":"10.29328/journal.apps.1001042","DOIUrl":"https://doi.org/10.29328/journal.apps.1001042","url":null,"abstract":"Objective: The study evaluated the hyperglycaemia-lowering effects, safety, and phytochemical profile of Celtis zenkeri leaf extract in order to justify its antidiabetic folkloric usage. Methods: Modified OECD test guidelines were used to assess its acute and sub-acute toxicity while its effect on blood parameters such as blood glucose, and haematological and biochemical levels were evaluated using appropriate assays. Both in vitro and in vivo antihyperglycaemic assays were used for the antidiabetic studies while histology of the pancreas, liver, and kidney of the rats was examined after treatment with the extract at 250, 500, and 1000 mg/kg for 21 days. GC-MS analysis was used to determine the chemical constituents of the extract. Results: The results obtained showed that the leaf extract of C. zenkeri was not toxic in rats at 5000 mg/kg. It elicited a significant decrease in the blood glucose levels of the animals but did not affect the haematological and biochemical components of normal rats. It significantly inhibited α-amylase and α-glucosidase actions and gave comparable activity to glibenclamide (5 mg/kg) at all time points at 200 and 400 mg/kg. The extract comparably reduced blood glucose levels with glibenclamide at 100 and 200 mg/kg on days 10 and 14 in drug-induced diabetic rats and maintained the histoarchitecture of the liver, kidney, and pancreas at 250 and 500 mg/kg. Conclusion: The study justified the ethnomedicinal use of C. zenkeri in diabetes management.","PeriodicalId":8316,"journal":{"name":"Archives of Pharmacy and Pharmaceutical Sciences","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78240083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and Infrared Spectroscopic Study of Lapachol, β-Lapachone and Hydroxy-hydrolapachol 拉帕恰尔、β-拉帕恰尔和羟基拉帕恰尔的鉴定及红外光谱研究

Archives of Pharmacy and Pharmaceutical Sciences Pub Date : 2023-07-06 DOI: 10.29328/journal.apps.1001041

Gomes Miquéias Ferreira, Araújo Ginandrya Rodrigues, Silva Ziom Drak Souza, de Sousa Raquel Maria Ferreira, Dias Herbert Júnior

{"title":"Identification and Infrared Spectroscopic Study of Lapachol, β-Lapachone and Hydroxy-hydrolapachol","authors":"Gomes Miquéias Ferreira, Araújo Ginandrya Rodrigues, Silva Ziom Drak Souza, de Sousa Raquel Maria Ferreira, Dias Herbert Júnior","doi":"10.29328/journal.apps.1001041","DOIUrl":"https://doi.org/10.29328/journal.apps.1001041","url":null,"abstract":"Metabolites of Brazilian Cerrado species are considered an immense font of biologically active compounds The diversity of organic compounds generated by the secondary metabolism of various Cerrado plants draws attention especially because many of these compounds have the capacity to be structurally modified and, consequently, produce other very interesting derivatives for pharmacological purposes. Despite this, little is described in the literature about fast, easy, and accessible identification methods for any laboratory, such as infrared spectroscopy. In this sense, this work demonstrates the synthesis and elucidation through spectroscopic techniques of lapachol and its synthetic derivatives. Through quick and simple extractions or reactions, lapachol, β-lapachone, and hydroxy-hydrolapachol were obtained with adequate yields. From this, the main FTIR absorptions of the mentioned naphthoquinones are described, which facilitates the identification of these metabolites with high biological potential. The present work contributes could become a simpler source of data for extraction, synthesis, and spectroscopic characterization by FTIR of the compounds.","PeriodicalId":8316,"journal":{"name":"Archives of Pharmacy and Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86543980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic Effects of Aminotriles with Bioactive Potential: An Integrative Review 具有生物活性的氨基化合物的细胞毒作用:综合综述

Archives of Pharmacy and Pharmaceutical Sciences Pub Date : 2023-05-09 DOI: 10.29328/journal.apps.1001040

D'Antona Paola, Cavalcanti Lettícia Tenório, Dantas e Sousa Almeida Hélida Maravilha, de Sousa Oliveira Igor, Ferreira Sávio Benvindo

{"title":"Cytotoxic Effects of Aminotriles with Bioactive Potential: An Integrative Review","authors":"D'Antona Paola, Cavalcanti Lettícia Tenório, Dantas e Sousa Almeida Hélida Maravilha, de Sousa Oliveira Igor, Ferreira Sávio Benvindo","doi":"10.29328/journal.apps.1001040","DOIUrl":"https://doi.org/10.29328/journal.apps.1001040","url":null,"abstract":"Aminonitriles are pharmacological-interest bioactive due to their promising antimicrobial and antitumor activity. Since cytotoxicity tests are inherent to the new drug development process, this work aimed to verify reports in the scientific literature on the cytotoxic effects of aminonitriles. The method adopted was an integrative review of works published in the last 10 years in the PubMed, Embase, Web of Science, and Virtual Health Library (VHL) databases. Three articles that matched the selection and eligibility criteria were included in this review. A total of 33 aminonitriles were used in the cytotoxicity experiments, and of the nine molecules based on pyridine, two exerted moderate cytotoxic activity, of the twelve synthesized from benzimidazole, none showed cytotoxic activity, and of the twelve derived from renieramycins, all showed considerable cytotoxic activities. The studies used in this research evaluated the cytotoxic effects of aminonitriles with evident anticancer and antimicrobial activity. The importance of evaluating the cytotoxicity of aminonitriles is emphasized, as well as the need for investigative research that explores other evaluation methods in pre-clinical tests that may corroborate the existing findings, with a view to the development of therapies against emerging health problems.","PeriodicalId":8316,"journal":{"name":"Archives of Pharmacy and Pharmaceutical Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90753096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices 使用芯片上的器官扩展基于人类的预测模型能力:将人类iPSCs转移和共培养到微流体设备的标准化框架

Archives of Pharmacy and Pharmaceutical Sciences Pub Date : 2023-04-13 DOI: 10.29328/journal.apps.1001039

Rontard Jessica, Maisonneuve Benoît GC, Honegger Thibault

{"title":"Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices","authors":"Rontard Jessica, Maisonneuve Benoît GC, Honegger Thibault","doi":"10.29328/journal.apps.1001039","DOIUrl":"https://doi.org/10.29328/journal.apps.1001039","url":null,"abstract":"There is an urgent need for predictive preclinical models to enhance the success rate of clinical trial outcomes. One of the main reasons for drug attrition is the lack of translational models, methods using human cells are particularly in the spotlight of regulatory bodies as they offer an alternative to in vivo studies and have the potential to improve the translational of preclinical trials. Organs-on-Chips (OoCs) are sensible candidates to reduce the cost and the ethical burden of animal models while accelerating and de-risking drug development. The innovation of such systems is based on both the increased relevance of the cells used and the ability to build precise, yet physiologically relevant, complex architectures. The use of microfluidic technologies with human induced pluripotent stem cells (hiPSCs) opens new routes to create relevant in vitro approaches as they will soon be able to reproduce clinical characteristics of donors or specific populations. The adoption of OoC models by pharmaceutical industries, and in fine by regulatory agencies, still requires: (i) establishing standardized, reproducible, robust, and replicable cell culture protocols with specific validation and characterization criteria, (ii) evidence that the technology predicts human responses, thus allowing to contribute efficiently and reliably to clinical trials success of novel therapeutics, and (iii) evidence that the models refine and reduce animal testing without compromising with the quality and the pertinence of the data generated.","PeriodicalId":8316,"journal":{"name":"Archives of Pharmacy and Pharmaceutical Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77258038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and optimization of mRNAs encoding an Anti-TIGIT antibody with therapeutic potential for cancer in TIGIT-humanized BALB/c Mice 具有tigit人源化BALB/c小鼠肿瘤治疗潜力的抗tigit抗体编码mrna的设计与优化

Archives of Pharmacy and Pharmaceutical Sciences Pub Date : 2023-04-07 DOI: 10.29328/journal.apps.1001038

Jingmin Cui, Qiaerxie Gulisaina, Qin Hui, Long Feng, Wang Xi, Zhixin Yang, Du Peng, Cui Yong

{"title":"Design and optimization of mRNAs encoding an Anti-TIGIT antibody with therapeutic potential for cancer in TIGIT-humanized BALB/c Mice","authors":"Jingmin Cui, Qiaerxie Gulisaina, Qin Hui, Long Feng, Wang Xi, Zhixin Yang, Du Peng, Cui Yong","doi":"10.29328/journal.apps.1001038","DOIUrl":"https://doi.org/10.29328/journal.apps.1001038","url":null,"abstract":"mRNA drugs are synthesized using cell-free systems without complex and stringent manufacturing processes, which makes their preparation simple, efficient, and economical. Over the past few years, mRNAs encoding antibodies have been one of the research frontiers of antibody drug development. In cancer immunotherapy, mRNAs encoding immune checkpoint antibodies may be advantageous regarding antibody persistence and durability of the anti-tumor immune response of patients. In our previous study, a candidate antibody—AET2010—targeting the novel immune checkpoint TIGIT was reported. Its anti-tumor activity was also investigated using adoptive transfer of NK-92MI cells in a xenograft mouse model, but the limitations of the model did not facilitate precise evaluation. In the present study, we further investigated the therapeutic potential of AET2010 for cancer in TIGIT-humanized BALB/c mice. Next, we explored the design, synthesis, and optimization of mRNAs encoding AET2010 and ultimately obtained a candidate mRNA (mRNA-BU) with favorable in vitro and in vivo expression levels of active AET2010. Particularly, lipid-nanoparticle-encapsulated mRNA-BU delivered to mice produced AET2010 with significantly higher peak concentration and expression duration than an equivalent dose of original AET2010. This study provides a sound basis for developing novel drugs targeting TIGIT.","PeriodicalId":8316,"journal":{"name":"Archives of Pharmacy and Pharmaceutical Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81953636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospital-acquired infections and antibiotic use in a geriatric hospital: a point prevalence study 老年医院的医院获得性感染和抗生素使用:一项点流行研究

Archives of Pharmacy and Pharmaceutical Sciences Pub Date : 2023-03-03 DOI: 10.29328/journal.apps.1001037

M. Vittorio, Fortunato Corinna, detto Rinaldini Davide Mengarelli, Pascucci Lidia, Arsego Daniele, Ferrara Letizia

{"title":"Hospital-acquired infections and antibiotic use in a geriatric hospital: a point prevalence study","authors":"M. Vittorio, Fortunato Corinna, detto Rinaldini Davide Mengarelli, Pascucci Lidia, Arsego Daniele, Ferrara Letizia","doi":"10.29328/journal.apps.1001037","DOIUrl":"https://doi.org/10.29328/journal.apps.1001037","url":null,"abstract":"Background: Healthcare-Associated Infections (HAIs) are the most common healthcare-associated complications, particularly in elderly patients. The aim of this study is to describe the prevalence of HAIs and associated risk factors in the IRCCS INRCA of Ancona. Methods: A cross-sectional study has been carried out. Data has been collected in accordance with the European Centre for Disease Prevention and Control (ECDC) Point Prevalence Survey 2022-2023 (PPS3) protocol in the IRCCS INRCA of Ancona in November 2022. Results: Out of the 128 patients included in our study, 75.0% were over 78 years old and 9.1% presented an active HAI on the day of the survey. The prevalence of HAIs varied based on the length of the hospital stay (OR 1.1, CI 95% 1.05 - 1.17, p < 0.001) and hospitalization > 7 days (OR 5.9, CI 95% 1.2 - 28.7, p = 0.02). Conclusion: It is clear from our findings that HAIs are associated with advanced patient age, prolonged hospital stay, and use of medical devices, especially in those patients that, due to their clinical situation, are more vulnerable. Although some of these infections can easily be treated, it is important to develop effective infection control strategies thanks to antimicrobial stewardship programs.","PeriodicalId":8316,"journal":{"name":"Archives of Pharmacy and Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89747241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge of diabetic patients regarding diabetes management, diet, lifestyle modification and blood glucose monitoring 了解糖尿病患者有关糖尿病管理、饮食、生活方式改变和血糖监测的知识

Archives of Pharmacy and Pharmaceutical Sciences Pub Date : 2023-02-14 DOI: 10.29328/journal.apps.1001036

Qazi Zarmeena, Dawood Hafiz Muhammad

引用次数: 0

Is the informed consent form only a symbolic document in clinical trials? 在临床试验中，知情同意书只是一个象征性的文件吗?

Archives of Pharmacy and Pharmaceutical Sciences Pub Date : 2022-12-19 DOI: 10.29328/journal.apps.1001035

Gungor Buket

引用次数: 0

The value of medicine innovation 医药创新的价值

Archives of Pharmacy and Pharmaceutical Sciences Pub Date : 2022-12-15 DOI: 10.29328/journal.apps.1001034

Haider Rehan

{"title":"The value of medicine innovation","authors":"Haider Rehan","doi":"10.29328/journal.apps.1001034","DOIUrl":"https://doi.org/10.29328/journal.apps.1001034","url":null,"abstract":"Innovation is the usage of strain for development in healthcare. Predominant component science and sturdy personal quarter opposition have given a beginning to a revolution in new health technology. These are converted by using rigorous making an attempt into medicines, vaccines, devices and diagnostics that can additionally be used efficiently in numerous affected character populations. Innovation starts off evolved with invention and depends upon tasks. it truly is on the flip pushed via the incentives that have interaction with the private quarter in pursuit of a social welfare objective, greater fitness for all by ability to create the large majority of a new medication on the market nowadays, the non-public vicinity has created a unique - however fragile - mannequin for innovation that consists of with it sensible outcomes for the management of a load of sickness. Fitness-related applied sciences enhancements led thru the introduction of today’s medicine are estimated to have decreased human mortality with the resource by upwards of 50% between 1960 and 1990 [1]. Every advanced and growing international region has demonstrated this benefit. All areas have made improvement in human enhancement global places has dropped by way of extra than 1/2, from 1.1 billion in 1975 to five hundred tens of hundreds of thousands in 1999 [2]. accelerated global immunization insurance engaging in 80%-90% of infant inner the past due Nineteen Nineties [3] has had a giant effect at the infant mortality price, which all via the remaining 25 years fall thru 50% in the least developed global locations. Four for this cause Pharmaceutical innovation has been a necessary thing in assisting governments to reap their primary healthcare coverage desires.","PeriodicalId":8316,"journal":{"name":"Archives of Pharmacy and Pharmaceutical Sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81464868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0