拉帕恰尔、β-拉帕恰尔和羟基拉帕恰尔的鉴定及红外光谱研究

Gomes Miquéias Ferreira, Araújo Ginandrya Rodrigues, Silva Ziom Drak Souza, de Sousa Raquel Maria Ferreira, Dias Herbert Júnior
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引用次数: 0

摘要

巴西塞拉多植物的代谢物被认为是一种巨大的生物活性化合物,各种塞拉多植物次生代谢产生的有机化合物的多样性引起了人们的注意,特别是因为许多这些化合物具有结构修饰的能力,从而产生其他非常有趣的药理衍生物。尽管如此,文献中很少描述任何实验室的快速,简单和可访问的识别方法,如红外光谱。在这个意义上,本工作展示了通过光谱技术合成和阐明拉帕恰尔及其合成衍生物。通过快速、简单的提取或反应,得到了拉帕恰尔、β-拉帕恰尔酮和羟基-水拉帕恰尔,收率高。由此描述了上述萘醌类化合物的主要FTIR吸收谱,便于鉴定这些具有较高生物潜力的代谢物。本研究为化合物的提取、合成和FTIR光谱表征提供了更简单的数据来源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification and Infrared Spectroscopic Study of Lapachol, β-Lapachone and Hydroxy-hydrolapachol
Metabolites of Brazilian Cerrado species are considered an immense font of biologically active compounds The diversity of organic compounds generated by the secondary metabolism of various Cerrado plants draws attention especially because many of these compounds have the capacity to be structurally modified and, consequently, produce other very interesting derivatives for pharmacological purposes. Despite this, little is described in the literature about fast, easy, and accessible identification methods for any laboratory, such as infrared spectroscopy. In this sense, this work demonstrates the synthesis and elucidation through spectroscopic techniques of lapachol and its synthetic derivatives. Through quick and simple extractions or reactions, lapachol, β-lapachone, and hydroxy-hydrolapachol were obtained with adequate yields. From this, the main FTIR absorptions of the mentioned naphthoquinones are described, which facilitates the identification of these metabolites with high biological potential. The present work contributes could become a simpler source of data for extraction, synthesis, and spectroscopic characterization by FTIR of the compounds.
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