Liling Zheng, Yongluan Lin, Hong Zaifa, Dongyan Shen, Shuping Zhong
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引用次数: 0
摘要
Brf1 (tfiib相关因子1)是一种转录因子,特异性调节RNA聚合酶III依赖基因(RNA Pol III基因)的转录,如tRNAs和5S rRNA。trna和5S rRNA转录产物会随着Brf1表达的改变而改变。然而,Brf1和RNA Pol III基因的失调与细胞增殖、转化和肿瘤发生密切相关。近年来,新的研究表明,Brf1在癌症患者中表达增加。本文就Brf1在不同人类肿瘤中的异常表达研究进展进行综述,探讨其潜在机制及其临床意义,并展望其应用前景。随着Brf1研究的深入和生物技术的进步,Brf1的表达状况可能作为人类癌症早期发现和预后观察的普遍指标。
Brf1 (TFIIB-related factor 1) is a transcription factor, which specifically modulates the transcription of RNA polymerase III-dependent genes (RNA Pol III genes), such as tRNAs and 5S rRNA. The products of tRNAs and 5S rRNA transcription will be changed with the alteration of Brf1 expression. Whereas deregulation of Brf1 and RNA Pol III genes are tightly associated with cell proliferation and transformation, and tumorigenesis. In recent years, emerging studies indicate that Brf1 expression is increased in patients with cancers. In this review, we summarize the progress of the abnormal expression of Brf1 in different human cancers to explore an underlying mechanism and its clinical implication, as well as to prompt its application prospect. With the depth of the Brf1 study and the progress of biotechnology, the status of Brf1 expression may be used as a universal indicator of the early detection and prognosis observation of human cancers.