Archives of Pharmaceutical Sciences Ain Shams University最新文献_第4页

The use of Nicotinamide in Parkinson’s disease; A Possible path to the future. Review Article 烟酰胺在帕金森病中的应用一条通往未来的可能之路。评论文章

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-06-01 DOI: 10.21608/aps.2023.204521.1116

Sarah Fahmy, Mona Alshahawy, Nourhan S. Mohamed, Nora Gamal, S. Abdelazim, Nadia Abdelsalam, Hend Abdelrahim, Reem Shehab, L. E. El Wakeel

{"title":"The use of Nicotinamide in Parkinson’s disease; A Possible path to the future. Review Article","authors":"Sarah Fahmy, Mona Alshahawy, Nourhan S. Mohamed, Nora Gamal, S. Abdelazim, Nadia Abdelsalam, Hend Abdelrahim, Reem Shehab, L. E. El Wakeel","doi":"10.21608/aps.2023.204521.1116","DOIUrl":"https://doi.org/10.21608/aps.2023.204521.1116","url":null,"abstract":"Increasing the prevalence of Parkinson‘s disease is an alarming sign that needs attention, so focusing on new medications and regimens which play an important role in prevention and treatment becomes a point of concern. Parkinson's disease is the second neurodegenerative disorder caused by the interplay between different mechanisms that are related to genetics, environment, and other factors. One of the potential treatment options under research is nicotinamide which may act as a neuroprotective agent. Although nicotinamide is accepted as a therapeutic agent in many diseases, its action as a Nicotinamide adenine dinucleotide (NAD) precursor against oxidative stress needs to be proved in Parkinson‘s disease. Here, based on the current literature, we provide a thorough overview of nicotinamide usage in medicine. We summarize chemistry, uses, side effects, different mechanisms, and all available preclinical and clinical data about the activity of nicotinamide. Nicotinamide increases cytoprotection, the release of dopamine, and decreases oxidative stress of mitochondria. As a consequence, we believe that nicotinamide may become a potential drug in the treatment of Parkinson‘s patients.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86253725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid nanocarriers encapsulating herbal drugs for brain diseases therapy 脂质纳米载体包封脑疾病草药治疗

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-06-01 DOI: 10.21608/aps.2023.202432.1115

S. Gad, Riham Elgogary, A. Geneidi, R. Hathout

{"title":"Lipid nanocarriers encapsulating herbal drugs for brain diseases therapy","authors":"S. Gad, Riham Elgogary, A. Geneidi, R. Hathout","doi":"10.21608/aps.2023.202432.1115","DOIUrl":"https://doi.org/10.21608/aps.2023.202432.1115","url":null,"abstract":"The blood-brain barrier (BBB) is an essential component in safeguarding the brain and preserving its equilibrium. The BBB represents a challenge for various types of drug delivery systems, particularly in the context of treating numerous neuropathological disorders wherein the therapeutic agents cannot cross the BBB. Nonetheless, existing neurotherapeutics have drawbacks such as toxicity and lack of specificity. Advances in nano drug delivery systems, particularly lipid-based nanocarriers, aim to deliver active therapeutics across the BBB to improve neurological conditions such as Alzheimer's, Parkinson's, and brain tumors, offering a novel treatment strategy with enhanced drug delivery, increased target specificity, enhanced efficacy, and more significantly, minimized toxicity in a biomimetic manner. In this context, this review sheds light on the use of lipid nanocarriers loaded with drugs of natural origin such as ferulic acid, resveratrol, curcumin, and rosmarinic acid for their brain delivery with better bioavailability and exceptional improvement in their therapeutic potential to treat major neurological disorders in future clinics.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86276183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Insights on the Carbapenem-resistant Gram Negative-associated-Infections: Challenges and Opportunities 碳青霉烯耐药革兰氏阴性相关感染的新认识:挑战与机遇

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-06-01 DOI: 10.21608/aps.2023.206876.1118

S. Mabrouk, Ghada R Abdellatif, A. Abu zaid, Khaled Aboshanab

{"title":"New Insights on the Carbapenem-resistant Gram Negative-associated-Infections: Challenges and Opportunities","authors":"S. Mabrouk, Ghada R Abdellatif, A. Abu zaid, Khaled Aboshanab","doi":"10.21608/aps.2023.206876.1118","DOIUrl":"https://doi.org/10.21608/aps.2023.206876.1118","url":null,"abstract":"Gram-negative bacterial (GNB) infections represent a worldwide serious public health challenge, especially with the increased global spread of carbapenem resistance (CR) among these pathogens. There are different forms of CR including, intrinsic and acquired mechanisms, one of the most significant of which is carbapenemase production. In the last decade, the widespread plasmid-mediated carbapenemase production, on top of the chromosomally encoded carbapenemases-already abundant since the 1990s-further complicated the situation and necessitated urgent intervention to further understand and tackle this issue. In this review, the phenotypic and genotypic methods for the detection of different types of carbapenemase have been discussed. Also, the different control measures and strategies that should be applied in an attempt to control the massive spread of GNB infections especially in healthcare facilities, have been elaborated on in this article. The challenges of GNB-associated infection in terms of the emergence of resistance to carbapenems, the last line of defense against GNB, and the continuing spread of this resistance left us with almost no options for treatment as well as their complication on the host. On the other hand, we explore the various opportunities for their control such as the development of new classes of antimicrobials and the structural modification of existing ones. It is also inevitable to explore novel treatment options including the association of antimicrobial agents with non-antimicrobials, inhibition of quorum sensing, bacteriophage therapy, photodynamic therapy, and monoclonal antibodies for treatment and prevention.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89302740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Meropenem/Antibiotic and Meropenem/Bacteriophage Combinations Against Carbapenem-Resistant Gram-Negative Uropathogens 美罗培南/抗生素和美罗培南/噬菌体联合体外治疗耐碳青霉烯革兰氏阴性尿路病原体的研究

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-06-01 DOI: 10.21608/aps.2023.198691.1111

A. Elshamy, S. Saleh, Khaled Aboshanab, M. Aboulwafa, Nadia Hassouna

引用次数: 0

Preparation and characterization of mangiferin-loaded lipid nanocapsules 载芒果苷脂质纳米胶囊的制备与表征

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2023-06-01 DOI: 10.21608/aps.2023.194792.1109

Sara Barakat, M. Nasr, N. Mortada, S. Badawy

引用次数: 0

Current progress of oral site-specific dosage forms: Emphasis on gastroretentive drug delivery systems 口服部位特异性剂型的最新进展:强调胃保留性给药系统

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-12-01 DOI: 10.21608/aps.2022.168128.1101

walaa Elsherbeeny, Riham I. El-Gogary, M. Nasr, O. Sammour

引用次数: 0

Taurine upregulated 1: Prognostic biomarker in breast cancer 牛磺酸上调1:乳腺癌的预后生物标志物

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-12-01 DOI: 10.21608/aps.2023.189963.1105

H. Azzam, M. El-Derany, S. Wahdan, R. Faheim, Gouda Kamel, Ebtehal El-Demerdash Zaki

引用次数: 0

Doxorubicin-induced testicular toxicity: possible underlying mechanisms and promising pharmacological treatments in experimental models. 阿霉素诱导的睾丸毒性:实验模型中可能的潜在机制和有希望的药理学治疗。

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-12-01 DOI: 10.21608/aps.2022.155127.1098

Shorouk A Alafifi, S. Wahdan, D. Elsherbiny, S. Azab

{"title":"Doxorubicin-induced testicular toxicity: possible underlying mechanisms and promising pharmacological treatments in experimental models.","authors":"Shorouk A Alafifi, S. Wahdan, D. Elsherbiny, S. Azab","doi":"10.21608/aps.2022.155127.1098","DOIUrl":"https://doi.org/10.21608/aps.2022.155127.1098","url":null,"abstract":"Chemotherapy is considered to be the most effective intervention in cancer treatment. The first use of chemotherapy began in the 1940s, unfortunately, its use result in many serious and debilitating side effects which affect human daily activities. Doxorubicin is a powerful antineoplastic drug FDA-approved for the management of a variety of cancer types including leukemia and lymphoma. However, its clinical use is limited due to its toxic effect on different tissues including testicular toxicity which has a bad impact on the quality of life of cancer survivors. DOX-induced testicular toxicity is accompanied by defects in sperm analysis including low sperm count, low sperm motility, and high sperm abnormalities in addition to affecting steroidogenesis. This review is intended to discuss the pharmacodynamics and the pharmacokinetics of doxorubicin, besides the possible underlying mechanisms that may be contributed to the damage of testicles caused by DOX including oxidative stress, inflammation, apoptosis, and autophagy. Moreover, the assessment of post-chemotherapy testicular toxicity in animals and the promising pharmacological treatment that has been studied in animal models were discussed.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87384054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of OCT-2 inhibitor Daclatasvir on Metformin pharmacokinetics and pharmacodynamics at two dose levels: A Bayesian approach using Markov-Chain Monte Carlo simulations OCT-2抑制剂Daclatasvir在两个剂量水平下对二甲双胍药代动力学和药效学的影响:使用马尔可夫链蒙特卡罗模拟的贝叶斯方法

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-12-01 DOI: 10.21608/aps.2022.153765.1096

Mohamed A. Raslan, Lamia Elwakeel, S. Shahin

引用次数: 0

Spectrofluorometric Determination of Baricitinib in Pure Form and Application on Pharmaceutical Dosage Form; Green Profile Evaluation via Eco-scale and GAPI Tools. 分光光度法测定巴西替尼的纯度及在药物剂型中的应用基于生态尺度和GAPI工具的绿色概况评价。

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-12-01 DOI: 10.21608/aps.2023.166675.1100

A. Saleh, Nermin Victor, Amira Elkosasy

引用次数: 1