Archives of Pharmaceutical Sciences Ain Shams University最新文献_第5页

Mechanistic insights into the pathogenesis and management of acute pancreatitis 急性胰腺炎的发病机制和治疗

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-12-01 DOI: 10.21608/aps.2023.179734.1104

Haidy E. Michel, Naglaa Gamal, M. Tadros

{"title":"Mechanistic insights into the pathogenesis and management of acute pancreatitis","authors":"Haidy E. Michel, Naglaa Gamal, M. Tadros","doi":"10.21608/aps.2023.179734.1104","DOIUrl":"https://doi.org/10.21608/aps.2023.179734.1104","url":null,"abstract":"Acute pancreatitis (AP) is an inflammatory disorder of the pancreas; its incidence rate is increasing worldwide; it is around 34 cases per 100,000 persons /year. It may range from mild to severe cases and may be associated with morbidity and mortality mainly due to multiple organ dysfunction syndromes (MODS). Till now, there is no specific therapy for the disease and the treatment of AP is mainly supportive. Moreover, the underlying mechanisms included in its pathogenesis are not fully clear. However, it may include oxidative stress and inflammatory response, including critical mediators, such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), toll-like receptor-4 (TLR-4), nuclear factor-kappa B (NF-κB), and high-mobility group box protein1 (HMGB1). Thus, there is a pressing need for continuous search in this era to clarify different pathogenesis and the development of new treatment options for AP, also understanding the disease. While research on the human pancreas remains challenging, animal models of AP may help to elucidate the disease pathophysiology & to discover new target options for the development of new therapies. This review aims to revise several aspects related to AP diagnosis and management and to summarize different animal models of AP.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90607477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-irradiation effects of ectoine on radiation-induced cardiotoxicity in female Swiss albino mice model 外托碱对瑞士雌性白化小鼠模型辐射致心脏毒性的辐照前作用

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-12-01 DOI: 10.21608/aps.2022.148701.1094

Sameh F. Nakhla, Basma Albehery, Sana Shawky, Salwa Lotfi, M. Kotb, E. El-Bassiouni, Eman El-Abd

{"title":"Pre-irradiation effects of ectoine on radiation-induced cardiotoxicity in female Swiss albino mice model","authors":"Sameh F. Nakhla, Basma Albehery, Sana Shawky, Salwa Lotfi, M. Kotb, E. El-Bassiouni, Eman El-Abd","doi":"10.21608/aps.2022.148701.1094","DOIUrl":"https://doi.org/10.21608/aps.2022.148701.1094","url":null,"abstract":"Ectoine is a compatible solute that acts as a natural protectant. In the mice model, a single post-irradiation ectoine dose showed protective effects by modulating both inflammatory and oxidative stress pathways. The effect of ectoine has never been tested on mice cardiac tissue, thus the current study aimed to explore the pre-irradiation effect(s) of ectoine on radiation-induced cardiotoxicity. Forty female Swiss albino mice (17.6-23.1 g); controls (injected intraperitoneally for ten days with 0.2 mL saline), ectoine groups injected with 20 mg/kg of ectoine for ten days), irradiated groups (injected intraperitoneally for ten days with 0.2 mL saline then received six Gy whole body x-irradiation single dose), ectoine irradiated groups (injected with ectoine for ten days then irradiated). Animals were sacrificed on days seven, and 14 (five animals each). Hearts were examined for histological changes and immune-stained for Bax. Ectoine concentration in hearts was measured by HPLC. Serum cardiac troponin T, Total antioxidant capacity, and apoptosis-inducing factor were evaluated by mice with ready-to-use ELISA kits. Heart histological changes were documented in 40% of the 7- & 14-days post-irradiation. Ectoine concentrations (0.63 x 10 -4 mg/mg of heart weight) were higher in ectoine groups than ectoine irradiated groups (0.011 x 10 -4 mg/mg) 14-days post-treatment. Serum troponin T significantly differed between the 14 days groups ( p = 0.032). Apoptosis inducible factor significantly increased in ectoine irradiated group (at 14 days) than those of control ( p = 0.014), irradiated ( p = 0.020), and ectoine ( p = 0.033) groups. Bax showed strong to moderate immunostaining in ectoine and irradiated groups. In conclusion, Ectoine has pre-irradiation partial protective effects on heart cytotoxicity.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86062808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the neuroprotective properties of Biochanin-A 生物豆素a的神经保护特性研究

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-12-01 DOI: 10.21608/aps.2022.154272.1097

S. Hussein, M. Tolba, Haidy E. Michel, S. Azab

{"title":"Insights into the neuroprotective properties of Biochanin-A","authors":"S. Hussein, M. Tolba, Haidy E. Michel, S. Azab","doi":"10.21608/aps.2022.154272.1097","DOIUrl":"https://doi.org/10.21608/aps.2022.154272.1097","url":null,"abstract":"The global morbidity and mortality caused by neurological disorders are significant. Neurodegenerative disorders are anticipated to rise as the population ages because they typically manifest in mid-to-late life. The World Health Organization predicts that by 2050 two billion individuals would be 60 or older. So there is an emerging need for neuroprotective agents derived from natural sources with favorable efficacy and high safety profile. One of these natural agents is biochanin A(BIO-A), an isoflavone belonging to phytoestrogens, mainly found in red clover, soy, and chickpea, commercially available tablets. It has a wide range of pharmacological effects, such as antioxidant, anti-inflammatory, anti-apoptotic, antimicrobial, Estrogen-like, glucose and lipid metabolism modulatory, anticancer, and neuroprotective effects. BIO-A was proven to be promising when investigated in multiple models of neurological diseases such as Alzheimer’s disease and Parkinson’s disease, multiple sclerosis, stroke, brain injury, depression, anxiety, and glioblastoma. This review focuses on the possible molecular mechanisms responsible for the neuroprotective effects of BIO-A in various neurological disorders.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90760242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colistin Pharmacokinetics in Pediatric Cancer Patients in Egypt 埃及儿童癌症患者的粘菌素药代动力学

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-12-01 DOI: 10.21608/aps.2022.166621.1099

Yosr Abou Sedira, L. E. El Wakeel, Mervat Mostafa Omran, I. Sidhom, S. Shouman

{"title":"Colistin Pharmacokinetics in Pediatric Cancer Patients in Egypt","authors":"Yosr Abou Sedira, L. E. El Wakeel, Mervat Mostafa Omran, I. Sidhom, S. Shouman","doi":"10.21608/aps.2022.166621.1099","DOIUrl":"https://doi.org/10.21608/aps.2022.166621.1099","url":null,"abstract":"Colistin has been reintroduced to clinical practice after the emergence of multidrug-resistant gram-negative (MDR-GN) and the failure of other antibiotics. Pharmacokinetics and pharmacodynamic data in the pediatric population are scarce. This study aimed to highlight the pharmacokinetics of 2 colistin doses, 2.5, and 5 mg/kg/day, in febrile neutropenia pediatric cancer patients regarding patient outcomes. In a prospective, comparative study, patients suffering from MDR-GN infection were randomly recruited to receive either 2.5 or 5 mg/kg/day colistin doses. The demographic, microbiological, and treatment outcomes were collected before and after treatment. Colistin levels were determined using HPLC/MS/MS. Peak, trough, area under the concentration-time curve (AUC 24 ), and the ratio of AUC 24 to the minimum inhibitory concentration (AUC 24 /MIC) were assessed. Clinical cure was achieved in 14 (77.8%) cases in the Low-Dose (LD) group vs. 13 (81.3%) in the High-Dose (HD) group. Four (25%) patients vs. 4 (33.3%) in the LD and HD group (P= 0.69) attained an optimal plasma AUC 24 /MIC, respectively, while the therapeutic level of colistin was reached in all patients in the LD group compared to 14/16 (87.5%) in the HD group. Microbiological eradication was achieved in 93.8% and 91.6% of patients in the LD and HD groups, respectively. However, the median time to clearance was significantly lower in the LD group, 4 days vs. 7 days in the HD group (P= 0.022). In conclusion, the current study suggests that LD may be as efficacious and safe as HD in treating MDR-GN infection. However, LD colistin was associated with a shorter clearance time than HD colistin.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82085924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct Acting Antiviral Drugs: Pharmacokinetics and Drug-Drug Interactions 直接作用抗病毒药物:药物动力学和药物之间的相互作用

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-12-01 DOI: 10.21608/aps.2023.189971.1106

Marina Barakat, S. Wahdan, A. Awad, Ebtehal El-Demerdash Zaki

引用次数: 0

Empirical-colistin inhalation improves ventilatory parameters and severity scoring in VAP caused by Gram-negative bacteria 经验性粘菌素吸入可改善革兰氏阴性菌引起的VAP的通气参数和严重程度评分

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-06-01 DOI: 10.21608/aps.2022.130440.1087

Nourhan O. Abu-Thuraya, Lamia Elwakeel, Mohamed O. Elghoemi, Alia Abdelfattah

引用次数: 0

Optimization of the colloidal properties of chitosan nanoparticles encapsulating alpha-arbutin 壳聚糖纳米粒包封α -熊果苷胶体性能的优化

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-06-01 DOI: 10.21608/aps.2022.121464.1081

S. Hatem, Nada ElHoffy, Reham S. Elezaby, M. Nasr, Amany Osama, S. Elkheshen

引用次数: 1

Biologically Active Saponins of Genus Cestrum L.: A Comprehensive Review 牛蹄草属生物活性皂苷类化合物综述

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-06-01 DOI: 10.21608/aps.2022.129734.1085

Dina M. Bahgat, Haidy A. Gad, E. Elsayed, O. Eldahshan, A. Singab

引用次数: 1

HPLC Method for Determination of Chlorhexidine in Pharmaceutical Formulations alone and in presence of Hexamidine and p-chlorocresol, and in Spiked Human Saliva 高效液相色谱法测定药物制剂中单独氯己定、含有氯己定和对氯甲酚以及加标人唾液中氯己定的含量

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-06-01 DOI: 10.21608/aps.2022.108801.1075

Ahmed E. Sobaih, Lobna Abd El Aziz, Nancy Nassif

引用次数: 1

Effect of adding exogenous acyl homoserine lactone signal to Pseudomonas aeruginosa premature culture and prediction of signal binding domain in Rhamnolipids RhlA enzyme 添加外源性酰基同丝氨酸内酯信号对铜绿假单胞菌过早培养的影响及鼠李糖脂RhlA酶信号结合域的预测

Archives of Pharmaceutical Sciences Ain Shams University Pub Date : 2022-06-01 DOI: 10.21608/aps.2022.128953.1084

Masarra M. Sakr, Ghadir S. El-Housseiny, Noha M. Elsayed

{"title":"Effect of adding exogenous acyl homoserine lactone signal to Pseudomonas aeruginosa premature culture and prediction of signal binding domain in Rhamnolipids RhlA enzyme","authors":"Masarra M. Sakr, Ghadir S. El-Housseiny, Noha M. Elsayed","doi":"10.21608/aps.2022.128953.1084","DOIUrl":"https://doi.org/10.21608/aps.2022.128953.1084","url":null,"abstract":"The hierarchy of the quorum-sensing system plays a crucial role in Pseudomonas (P.) aeruginosa virulence and the production of important industrial bacterial products like rhamnolipids and proteases. In this study, the effect of adding exogenous acyl-homoserine lactone synthetic signal to the premature culture of P. aeruginosa on the production of protease and rhamnolipids was investigated. At the early exponential phase, induction of rhamnolipid production showed a more rapid response than protease production. Prediction of the 3D structure of the acyltransferase RhlA enzyme, which is the first key enzyme in rhamnolipid synthesis, was then done using the I-Tasser program to investigate the possible protein structure that might influence the response to N-acyl-homoserine lactone (AHL) presence. With a good C-score, 3D modeling showed RhlA to have AHL binding pocket where ten ligand binding site residues were elucidated in the protein. Multiple sequence alignment revealed low homology with LuxR proteins. Although conserved residues were depicted from the alignment, they were different from the ligand-binding residues suggesting that AHL binds to RhlA with a different mechanism than LuxR proteins. After further bioinformatics analysis, we found that RhlA binds to AHL in a mechanism similar to the lactonase enzyme. In conclusion, the in silico domain and protein alignment analysis revealed an AHL binding site in the RhlA enzyme protein structure.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80760913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0